COVID-19 vaccines in patients with cancer: immunogenicity, efficacy and safety

Nature Reviews Clinical Oncology, Journal Year: 2022, Volume and Issue: 19(6), P. 385 - 401

Published: March 11, 2022

Language: Английский

---

A Prospective Cohort Study of COVID-19 Vaccination, SARS-CoV-2 Infection, and Fertility

American Journal of Epidemiology, Journal Year: 2022, Volume and Issue: 191(8), P. 1383 - 1395

Published: Jan. 14, 2022

Some reproductive-aged individuals remain unvaccinated against coronavirus disease 2019 (COVID-19) because of concerns about potential adverse effects on fertility. Using data from an internet-based preconception cohort study, we examined the associations COVID-19 vaccination and severe acute respiratory syndrome 2 (SARS-CoV-2) infection with fertility among couples trying to conceive spontaneously. We enrolled 2,126 self-identified female participants aged 21-45 year residing in United States or Canada during December 2020-September 2021 followed them through November 2021. Participants completed questionnaires every 8 weeks sociodemographics, lifestyle, medical factors, partner information. fit proportional probabilities regression models estimate between self-reported SARS-CoV-2 both partners fecundability (i.e., per-cycle probability conception), adjusting for confounders. was not appreciably associated either (female ratio (FR) = 1.08, 95% confidence interval (CI): 0.95, 1.23; male FR CI: 0.83, 1.10). Female strongly (FR 1.07, 0.87, 1.31). Male a transient reduction (for within 60 days, 0.82, 0.47, 1.45; after 1.16, 0.92, 1.47). These findings indicate that may be short-term decline does impair partner.

Language: Английский

---

Global, regional, and national prevalence and trends of infertility among individuals of reproductive age (15–49 years) from 1990 to 2021, with projections to 2040

Human Reproduction, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 3, 2025

Abstract STUDY QUESTION What is the prevalence and trend of infertility among individuals childbearing age at global, regional, national levels by sex socio-demographic index (SDI) across 21 regions 204 countries territories? SUMMARY ANSWER Our findings reveal a growing aged 15–49 years worldwide from 1990 to 2021, with an expected continued increase through 2040. WHAT IS KNOWN ALREADY Infertility persistent global reproductive health issue, leading significant societal consequences. No study has specifically described current infertility, its secular trend, or variations between different SDI levels. DESIGN, SIZE, DURATION A sex- SDI-stratified systematic analysis territories 2021 been performed. PARTICIPANTS/MATERIALS, SETTING, METHODS We retrieved data Global Burden Disease Study (GBD) on count crude rate for 2021. In GBD framework, defined as absence live birth in couple who have union least 5 are actively trying conceive, since their last birth, no use contraceptives during this period. Estimated annual percent change was calculated quantify temporal age-standardized rates (ASPRs) sex, age, SDI. The Bayesian age-period-cohort model used project ASPRs 2022 MAIN RESULTS AND ROLE OF CHANCE estimated 55 000 818 men 110 089 459 women were living worldwide, corresponding approximately 1820.6 cases per 100 population (1.8%) males 3713.2 (3.7%) females. Regionally, highest observed middle regions, such East South Asia Eastern Europe. primarily affected group 35–39 females most some notable exceptions. Between increased average 0.49% (95% CI 0.34–0.63) 0.68% (0.51–0.86) Additionally, fastest female occurred high while rise male seen low-middle areas. Furthermore, ASPR projected more rapidly than that LIMITATIONS, REASONS FOR CAUTION primary sources burden population-based surveys; however, less-developed often lack complete statistics, potential reporting bias these areas due sparsity incompleteness. could not separately assess trends secondary infertility. does provide attributable proportion each cause infertility; hence, we cannot compare contribution causes location. WIDER IMPLICATIONS THE FINDINGS Sexual crucial individuals’ health, economic development, overall human wellbeing. It essential governments public recognize severity prioritize implementation targeted interventions enhance health. FUNDING/COMPETING INTEREST(S) This supported grants Science Technology Project Jiangmen (2020030103110009027). authors declared conflict interest. TRIAL REGISTRATION NUMBER N/A.

Language: Английский

---

The impact of COVID-19 vaccines on fertility-A systematic review and meta-analysis

Vaccine, Journal Year: 2022, Volume and Issue: 40(42), P. 6023 - 6034

Published: Sept. 12, 2022

Language: Английский

---

Reported Adverse Effects and Attitudes among Arab Populations Following COVID-19 Vaccination: A Large-Scale Multinational Study Implementing Machine Learning Tools in Predicting Post-Vaccination Adverse Effects Based on Predisposing Factors

Vaccines, Journal Year: 2022, Volume and Issue: 10(3), P. 366 - 366

Published: Feb. 26, 2022

Background: The unprecedented global spread of coronavirus disease 2019 (COVID-19) has imposed huge challenges on the healthcare facilities, and impacted every aspect life. This led to development several vaccines against COVID-19 within one year. study aimed assess attitudes side effects among Arab communities after receiving a vaccine use machine learning (ML) tools predict post-vaccination based predisposing factors. Methods: An online-based multinational survey was carried out via social media platforms from 14 June 31 August 2021, targeting individuals who received at least dose 22 countries. Descriptive statistics, correlation, chi-square tests were used analyze data. Moreover, extensive ML utilized 30 post vaccination adverse their severity 15 importance distinct factors in predicting particular determined using feature employing gradient boost as AutoML. Results: A total 10,064 participants 19 countries included this study. Around 56% female 59% aged 20 39 years old. high rate hesitancy (51%) reported participants. Almost 88% vaccinated with three vaccines, including Pfizer-BioNTech (52.8%), AstraZeneca (20.7%), Sinopharm (14.2%). About 72% experienced effects. reports statistically significant associations (p < 0.01) between various post-vaccinations In terms effects, boost, random forest, XGBoost outperformed other methods. most important for certain (i.e., tiredness, fever, headache, injection site pain swelling, myalgia, sleepiness laziness) revealed be number doses, gender, type vaccine, age, receive vaccine. Conclusions: following populations are usually non-life-threatening; flu-like symptoms pain. Certain have greater weight input data Based data, can also these effects; people predicted may require additional medical attention, or possibly hospitalization.

Language: Английский

---

In Vitro Fertilization and Early Pregnancy Outcomes After Coronavirus Disease 2019 (COVID-19) Vaccination

Obstetrics and Gynecology, Journal Year: 2022, Volume and Issue: unknown

Published: Jan. 25, 2022

To assess whether coronavirus disease 2019 (COVID-19) mRNA vaccination is associated with controlled ovarian hyperstimulation or early pregnancy outcomes.This retrospective cohort study included patients who underwent single euploid frozen-thawed embryo transfer at a academic center. Patients fully vaccinated COVID-19 vaccine were compared unvaccinated cycled during the same time period. The primary outcome was fertilization rate for and clinical transfer. Secondary outcomes eggs retrieved, mature oocytes ratio, blastulation rate, rate. ongoing biochemical loss rate.Among 222 983 cycles between February September 2021, there no association on adjusted analysis (β=0.02±0.02, P=.20) any of secondary assessed: retrieved (β=0.01±0.57, P=.99), (β=0.26±0.47, P=.58), ratio (β=0.02±0.01, P=.12), P=.27), (β=0.05±0.03, P=.08). Among 214 733 undergoing transfer, demonstrated significant (adjusted odds [aOR] 0.79, 95% CI 0.54-1.16) outcomes: (aOR 0.88, 0.58-1.33), 0.90, 0.61-1.31), 1.21, 0.69-2.14), 1.02, 0.51-2.06).Administration vaccines not an adverse effect stimulation after IVF. Our findings contribute to growing body evidence regarding safety in women are trying conceive.

Language: Английский

---

COVID-19 and vaccination: myths vs science

Expert Review of Vaccines, Journal Year: 2022, Volume and Issue: 21(11), P. 1603 - 1620

Published: Aug. 18, 2022

Introduction Several vaccines against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) have been developed since the inception of disease 2019 (COVID-19) in December 2019, at unprecedented speed. However, these rapidly raised many questions related to efficacy and safety different communities across globe. Various hypotheses regarding COVID-19 its were generated, them also answered with scientific evidence. Still, there are myths/misinformation vaccines, which create hesitancy for vaccination, must be addressed critically achieve success battle pandemic.Area Covered The development anti-SARS-CoV-2 COVID-19, their efficacy, relating presented.Expert Opinion In this pandemic, we seen a global collaborative effort researchers, governments, industry, supported by billions dollars funding, allowed far more quickly than past. Vaccines go through rigorous testing, analysis, evaluations clinical settings prior approval, even if they approved emergency use. Despite myths, vaccination represents an important strategy get back normality.

Language: Английский

---

Understanding on the possible routes for SARS CoV-2 invasion via ACE2 in the host linked with multiple organs damage

Infection Genetics and Evolution, Journal Year: 2022, Volume and Issue: 99, P. 105254 - 105254

Published: Feb. 23, 2022

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), accountable for causing the diseases 2019 (COVID-19), is already declared as a pandemic disease globally. Like previously reported SARS-CoV strain, novel SARS-CoV-2 also initiates viral pathogenesis via docking spike-protein with membranal angiotensin-converting enzyme (ACE2) - receptor on variety of cells in human body. Therefore, COVID-19 broadly characterized that targets multiple organs, particularly complications organ-specific accompanied by destruction ACE2

Language: Английский

---

Can COVID-19 Vaccines Induce Premature Non-Communicable Diseases: Where Are We Heading to?

Vaccines, Journal Year: 2023, Volume and Issue: 11(2), P. 208 - 208

Published: Jan. 17, 2023

According to the WHO, as of January 2023, more than 850 million cases and over 6.6 deaths from COVID-19 have been reported worldwide. Currently, death rate has reduced due decreased pathogenicity new SARS-CoV-2 variants, but major factor in rates is administration 12.8 billion vaccine doses globally. While vaccines are saving lives, serious side effects after vaccinations for several premature non-communicable diseases (NCDs). However, adverse events low number. The scientific community must investigate entire spectrum COVID-19-vaccine-induced complications so that necessary safety measures can be taken, current re-engineered avoid or minimize their effects. We describe depth severe metabolic, mental, neurological disorders; cardiovascular, renal, autoimmune diseases, reproductive health issues detected whether these causal incidental. In any case, it become clear benefits outweigh risks by a large margin. pre-existing conditions vaccinated individuals need taken into account prevention treatment events.

Language: Английский

---

Birth rate decline in the later phase of the COVID-19 pandemic: the role of policy interventions, vaccination programmes and economic uncertainty

Human Reproduction Open, Journal Year: 2024, Volume and Issue: 2024(3)

Published: Jan. 1, 2024

Abstract STUDY QUESTION What are the factors influencing decline in birth rates observed higher-income countries later phase of COVID-19 pandemic? SUMMARY ANSWER Our results suggest that economic uncertainty, non-pharmaceutical policy interventions, and first wave population-wide vaccination campaign were associated with during 2022. WHAT IS KNOWN ALREADY During pandemic, most briefly declined then shortly recovered, showing no common trends afterwards until early 2022, when they unexpectedly dropped. DESIGN, SIZE, DURATION This study uses data on monthly total fertility (TFRs) adjusted for seasonality calendar effects provided Human Fertility Database (HFD). Births taking place between November 2020 October 2022 correspond to conceptions occurring February January i.e. after onset pandemic but prior Russian invasion Ukraine. The cover 26 countries, including 21 Europe, USA, Canada, Israel, Japan, Republic Korea. PARTICIPANTS/MATERIALS, SETTING, METHODS First, we a descriptive analysis changes TFR. Second, employed linear fixed regression models estimate association explanatory seasonally TFRs. considered three broader sets factors: interventions restricting mobility social activities outside home, progression programmes. MAIN RESULTS AND THE ROLE OF CHANCE We found as measured by increased inflation (P &lt; 0.001), whereas unemployment did not show any link births = 0.677). stringency was linked postponement births, only lower institutional trust 0.003). In higher trust, stricter containment measures positively rates, both year 0.019) and, albeit weakly significant, 0.057). Furthermore, negative share population having received dose TFRs completed primary course (usually consisting two doses) recovery 0.001). LARGE SCALE DATA N/A. LIMITATIONS, REASONS FOR CAUTION research is restricted relatively strong support policies government well wide access modern contraception. allow analyses key characteristics, such age, order, status. WIDER IMPLICATIONS FINDINGS multi-country drivers pandemic. past, periods following epidemics health crises typically births. contrast, our gradual phasing out measures, allowing return more normal work life, contributed declining some countries. addition, indicates women avoided pregnancy completion protocol. FUNDING/COMPETING INTEREST(S) use external funding. authors acknowledge funding from their home institution, Vienna Institute Demography Austrian Academy Sciences, Open-Access Fund Sciences. For purpose open access, have applied CC BY public copyright licence Author Accepted Manuscript versions arising this submission. All declare conflicts interest.

Language: Английский

---