Nutrients,
Journal Year:
2024,
Volume and Issue:
16(1), P. 172 - 172
Published: Jan. 4, 2024
Today,
type
2
diabetes
mellitus
(T2DM)
and
skeletal
muscle
atrophy
(SMA)
have
become
increasingly
common
occurrences.
Whether
the
onset
of
T2DM
increases
risk
SMA
or
vice
versa
has
long
been
under
investigation.
Both
conditions
are
associated
with
negative
changes
in
health,
which
can,
turn,
lead
to
impaired
physical
function,
a
lowered
quality
life,
an
increased
mortality.
Poor
nutrition
can
exacerbate
both
SMA.
linked
by
vicious
cycle
events
that
reinforce
worsen
each
other.
Muscle
insulin
resistance
appears
be
pathophysiological
link
between
To
explore
this
association,
our
review
(i)
compiles
evidence
on
clinical
association
SMA,
(ii)
reviews
mechanisms
underlying
biochemical
muscles
people
at
(iii)
examines
how
nutritional
therapy
activity
as
muscle-targeted
treatments
benefit
population.
Based
evidence,
we
conclude
effective
treatment
patients
T2DM-SMA
depends
restoration
maintenance
mass.
We
thus
propose
regular
intake
key
functional
nutrients,
along
guidance
for
activity,
help
maintain
euglycemia
improve
status
all
Nutrition Reviews,
Journal Year:
2025,
Volume and Issue:
unknown
Published: Jan. 15, 2025
Dietary
protein
is
recommended
for
sarcopenia-a
debilitating
condition
of
age-related
loss
muscle
mass
and
strength
that
affects
27%
older
adults.
The
effects
on
health
may
depend
quality.
aim
was
to
synthesize
randomized
controlled
trial
(RCT)
data
comparing
plant
with
animal
health.
Forty-three
eligible
RCTs
were
sourced
from
Medline,
Embase,
Scopus,
Web
Science,
CENTRAL
databases.
Four
reviewers
(R.J.R.-M.,
S.F.B.,
N.A.W.,
D.L.)
extracted
(study
setting,
population,
intervention
characteristics,
outcomes,
summary
statistics)
conducted
quality
assessment
using
the
Cochrane
Risk
Bias
2.0.
Standardized
mean
differences
(SMDs)
(95%
CIs)
combined
a
random-effects
meta-analysis
forest
plots
generated.
I2
statistics
calculated
test
statistical
heterogeneity.
Thirty
(70%)
all
examined
outcomes.
Compared
protein,
resulted
in
lower
following
(SMD
=
-0.20;
95%
CI:
-0.37,
-0.03;
P
.02),
stronger
younger
(<60
years;
SMD
.02)
than
(≥60
-0.05;
-0.32,
0.23;
.74)
There
no
pooled
effect
difference
between
soy
milk
-0.02;
-0.20,
0.16;
.80)
(n
17
RCTs),
yet
improved
compared
non-soy
proteins
(rice,
chia,
oat,
potato;
-0.58;
-1.06,
-0.09;
5
RCTs)
plant-based
diets
-0.51;
-0.91,
-0.11;
.01)
7
RCTs).
No
significant
found
or
14
physical
performance
trials
sarcopenia
as
an
outcome.
Animal
have
small
beneficial
over
mass;
however,
research
into
wider
range
needed.
PROSPERO
registration
no.
CRD42020188658.
Frontiers in Nutrition,
Journal Year:
2023,
Volume and Issue:
10
Published: Feb. 2, 2023
Skeletal
muscle
is
the
foundation
of
human
function
and
plays
a
key
role
in
producing
exercise,
bone
protection,
energy
metabolism.
Sarcopenia
systemic
disease,
which
characterized
by
degenerative
changes
skeletal
mass,
strength,
function.
Therefore,
sarcopenia
often
causes
weakness,
prolonged
hospitalization,
falls
other
adverse
consequences
that
reduce
quality
life,
even
lead
to
death.
In
recent
years,
has
become
focus
in-depth
research.
Researchers
have
suggested
some
molecular
mechanisms
for
according
different
physiology.
These
cover
neuromuscular
junction
lesion,
imbalance
protein
synthesis
breakdown,
satellite
cells
dysfunction,
etc.
We
summarize
latest
research
progress
on
mechanism
this
review
order
provide
new
ideas
future
researchers
find
valuable
therapeutic
targets
develop
relevant
prevention
strategies.
Clinical Science,
Journal Year:
2024,
Volume and Issue:
138(14), P. 863 - 882
Published: July 1, 2024
Abstract
As
a
result
of
advances
in
medical
treatments
and
associated
policy
over
the
last
century,
life
expectancy
has
risen
substantially
continues
to
increase
globally.
However,
disconnect
between
lifespan
‘health
span’
(the
length
time
spent
healthy,
disease-free
state)
also
increased,
with
skeletal
muscle
being
substantial
contributor
this.
Biological
ageing
is
accompanied
by
declines
both
mass
function,
termed
sarcopenia.
The
mechanisms
underpinning
sarcopenia
are
multifactorial
known
include
marked
alterations
protein
turnover
adaptations
neural
input
muscle.
date,
relative
contribution
each
factor
remains
largely
unexplored.
Specifically,
synthetic
responses
key
anabolic
stimuli
blunted
advancing
age,
whilst
components,
spanning
from
motor
cortex
motoneuron
excitability
neuromuscular
junction,
may
explain
greater
magnitude
function
losses
when
compared
mass.
consequences
these
can
be
devastating
for
individuals,
their
support
networks,
healthcare
services;
clear
detrimental
impacts
on
clinical
(e.g.,
mortality,
frailty,
post-treatment
complications)
societal
independence
maintenance)
outcomes.
Whether
quantity
quality
an
inevitable
component
completely
understood.
Nevertheless,
strategies
mitigate
vital
importance
improve
health
span
older
adults.
This
review
aims
provide
overview
describes
wide-ranging
implications
declines,
finally
suggests
them,
including
merits
emerging
pharmaceutical
agents.
Proceedings of The Nutrition Society,
Journal Year:
2024,
Volume and Issue:
unknown, P. 1 - 16
Published: Oct. 17, 2024
Loss
of
skeletal
muscle
strength
and
mass
(sarcopenia)
is
common
in
older
adults
associated
with
an
increased
risk
disability,
frailty
premature
death.
Finding
cost-effective
prevention
treatment
strategies
for
sarcopenia
the
growing
ageing
population
therefore
great
public
health
interest.
Although
nutrition
considered
important
factor
aetiology
sarcopenia,
its
potential
and/or
still
being
evaluated.
Nutrition
research
utilises
three
main
approaches
to
understand
muscle-nutrition
relationships,
evaluating:
single
nutrients,
whole
foods
diet
effects
-
both
alone
or
combined
exercise.
Applying
these
approaches,
we
summarise
recent
evidence
from
qualitative
quantitative
syntheses
findings
observational
intervention
studies
healthy
adults,
those
sarcopenia.
We
consider
protein
supplements,
(fruits
vegetables)
Mediterranean
as
exemplars.
There
some
beneficial
supplementation
≥
0·8
g/kg
body
weight/d
on
when
exercise
training
sarcopenic
adults.
In
contrast,
function
(strength
physical
performance)
inconclusive.
reasonably
consistent
epidemiological
suggesting
benefits
higher
fruits
vegetables
consumption
better
performance.
Similarly,
adherence
studies.
However,
are
lacking.
This
review
discusses
how
current
may
inform
development
preventive
optimal
nutritional
policy
aimed
at
combatting
International Journal of General Medicine,
Journal Year:
2024,
Volume and Issue:
Volume 17, P. 1861 - 1876
Published: May 1, 2024
Objective:
This
bibliometric
analysis
and
review
aimed
to
examine
the
current
research
status
trends
in
combination
of
nutrition
exercise
training
for
sarcopenia.
Additionally,
it
sought
provide
researchers
with
future
directions
this
field.
Methods:
Relevant
publications
were
obtained
from
Web
Science
Core
Collection
(WoSCC)
database,
covering
period
January
1995
October
2023.
The
collected
analyzed
using
CiteSpace,
VOSviewer,
Bibliometrix,
Review
Manager.
Results:
Out
2528
retrieved
publications,
United
States
emerged
as
leading
contributor
terms
publication
volume.
University
Texas
System
was
identified
most
productive
institution.
Luc
J
C
van
Loon
published
author
Analysis
keywords
revealed
recent
hot
topics
emerging
areas
interest,
such
"gut
microbiota"
"mechanisms".
Upon
further
evaluation,
resistance
(RT)
protein
supplementation
commonly
employed
effective
methods.
Conclusion:
RT
are
widely
recognized
strategies.
Future
should
focus
on
investigating
molecular
aspects
Moreover,
potential
therapeutic
role
gut
microbiota
sarcopenia
requires
comprehensive
investigation
human
subjects
establish
its
correlation.
Keywords:
sarcopenia,
nutrition,
exercise,
analysis,
