Links between COVID-19 and Parkinson’s disease/Alzheimer’s disease: reciprocal impacts, medical care strategies and underlying mechanisms

Translational Neurodegeneration, Journal Year: 2023, Volume and Issue: 12(1)

Published: Jan. 30, 2023

Abstract The impact of coronavirus disease 2019 (COVID-19) pandemic on patients with neurodegenerative diseases and the specific neurological manifestations COVID-19 have aroused great interest. However, there are still many issues concern to be clarified. Therefore, we review current literature complex relationship between an emphasis Parkinson’s (PD) Alzheimer’s (AD). We summarize infection symptom severity, progression, mortality rate PD AD, discuss whether could trigger AD. In addition, susceptibility prognosis in AD also included. order achieve better management patients, modifications care strategies, drug therapies, vaccines during listed. At last, mechanisms underlying link reviewed.

Language: Английский

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Addressing loneliness and social isolation in 52 countries: a scoping review of National policies

BMC Public Health, Journal Year: 2024, Volume and Issue: 24(1)

Published: May 1, 2024

Abstract Background Even prior to the advent of COVID-19 pandemic, there was ample evidence that loneliness and social isolation negatively impacted physical mental health, employability, are a financial burden on state. In response, has been significant policy-level attention tackling loneliness. The objective this scoping review conduct policy landscape analysis across 52 countries UN European country groups. Our sought highlight commonalities differences between different national approaches manage loneliness, with goal provide actionable recommendations for consideration policymakers wishing develop, expand or existing policies. Methods We searched governmental websites using Google search engine publicly available documents related isolation. Seventy-eight were identified in total, from which 23 retained. Exclusion based predetermined criteria. A structured content approach used capture key information documents. Contextual data captured configuration matrix common unique themes. Results could show most policies describe as phenomenon addressed varying degrees domains such social, geographical, economic political. Limited found regarding funding suggested interventions. synthesised makers focusing use language, prioritisation interventions, revisiting previous campaigns, sharing best practice borders, setting out vision, evaluating need rapid sustainable scalability Conclusions study provides first overview landscape, highlighting increasing major public health societal issue. findings suggest can sustain momentum strengthen their strategies by incorporating rigorous, evidence-based intervention evaluations fostering international collaborations knowledge sharing. believe more effectively address directing funds develop implement interventions impact individual, community society.

Language: Английский

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COVID-19 risk, course and outcome in people with mental disorders: a systematic review and meta-analyses

Epidemiology and Psychiatric Sciences, Journal Year: 2023, Volume and Issue: 32

Published: Jan. 1, 2023

Abstract Aims It has been suggested that people with mental disorders have an elevated risk to acquire severe acute respiratory syndrome coronavirus 2 and be disproportionally affected by disease 19 (COVID-19) once infected. We aimed analyse the COVID-19 infection rate, course outcome, including mortality long COVID, in anxiety, depressive, neurodevelopmental, schizophrenia spectrum substance use relative control subjects without these disorders. Methods This study constitutes a preregistered systematic review random-effects frequentist Bayesian meta-analyses. Major databases were searched up until 27 June 2023. Results Eighty-one original articles included reporting 304 cross-sectional prospective effect size estimates (median n per effect-size = 114837) regarding associations of interest. Infection was not significantly increased for any disorder we investigated samples The COVID-19, however, is relatively severe, COVID COVID-19-related hospitalization are more likely all patient investigated. odds dying from high most types disorders, except those anxiety neurodevelopmental non-patient (pooled ORs range, 1.26–2.57). analyses confirmed findings approach complemented them strength evidence. Conclusions Once infected, pre-existing at mortality, despite increased.

Language: Английский

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Pexidartinib (PLX3397) through restoring hippocampal synaptic plasticity ameliorates social isolation-induced mood disorders

International Immunopharmacology, Journal Year: 2022, Volume and Issue: 113, P. 109436 - 109436

Published: Nov. 14, 2022

Language: Английский

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The impact of social isolation and loneliness on cardiovascular disease risk factors: a systematic review, meta-analysis, and bibliometric investigation

Scientific Reports, Journal Year: 2024, Volume and Issue: 14(1)

Published: June 4, 2024

Abstract Data on the association between social isolation, loneliness, and risk of incident coronary heart disease (CVD) are conflicting. The objective this study is to determine relationship isolation developing cardiovascular in middle age elderly using meta-analysis. purpose bibliometric analysis systematically evaluate existing literature middle-aged individuals. A comprehensive search through four electronic databases (MEDLINE, Google Scholar, Scopus, Web Science) was conducted for published articles that determined and/or loneliness from June 2015 May 2023. Two independent reviewers reviewed titles abstracts records. We followed Preferred Reporting Items Systematic Reviews Meta-Analyses guideline conduct systematic review obtained Scopus database analyzed VOSviewer Bibliometrix applications. Six studies involving 104,511 patients were included final qualitative meta-analysis after screening prevalence ranged 5 65.3%, 2 56.5%. total 5073 events recorded follow-up, ranging 4 13 years. Poor relationships associated with a 16% increase CVD (Hazard Ratio new when comparing high versus low or 1.16 (95% Confidence Interval (CI) 1.10–1.22). shows rapidly growing field (9.77% annual growth) common collaboration (6.37 co-authors/document, 26.53% international). US leads research output, by UK Australia. Top institutions include University College London, Inserm, Glasgow. Research focuses "elderly," "cardiovascular disease," "psychosocial stress," recent trends "mental health," "social determinants," "COVID-19". Social worsen outcomes diseases. However, observed effect estimate small, may be attributable residual confounding incomplete measurement potentially mediating factors. results highlight multidimensional nature research, covering factors such as social, psychological, environmental determinants, well their interplay various demographic health-related variables.

Language: Английский

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The Faster the Healthier: China’s High-Speed Rail Expansion and Mental Health

Socio-Economic Planning Sciences, Journal Year: 2025, Volume and Issue: unknown, P. 102199 - 102199

Published: March 1, 2025

Language: Английский

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Social isolation and loneliness in non-communicable chronic diseases: impact of COVID-19 pandemic, population aging and technological progress.

Nutrition Metabolism and Cardiovascular Diseases, Journal Year: 2025, Volume and Issue: unknown, P. 104015 - 104015

Published: March 1, 2025

Social isolation and loneliness have increasingly emerged as closely linked to onset progression of non-communicable chronic diseases (NCDs). The aim this review is highlight the importance addressing social in prevention management NCDs such obesity, type 2 diabetes, cardiovascular order hinder their development improve outcomes. affect a significant portion older adult population, due decrease interactions, illnesses sensory impairments. However, many other vulnerable populations may experience because psychiatric or disabling health conditions, substances abuse, low socioeconomic status, unemployment belonging ethnic marginalized minorities. unprecedented COVID-19-related distancing can be taken proof-of-concept detrimental role poor interactions not only at individual level but also public perspective. Indeed, has been unhealthy lifestyle choices, disrupted sleep quality, utilization healthcare, preventive services adherence treatments. Underlying mechanisms like inflammation stress responses play association between worse negatively impacts on development, NCDs. Effective interventions for should address both societal factors healthcare-related needs. To counteract effects during COVID-19 pandemic, use telemedicine was implemented. always available, legislative age-related barriers persist.

Language: Английский

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Transdisciplinary Dimensions of NEW HEALTH: The New Paradigm of Medicine

Published: Jan. 1, 2025

Language: Английский

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A longitudinal examination of loneliness in left-behind children: the interaction between self-esteem and academic self-efficacy matters

BMC Psychology, Journal Year: 2025, Volume and Issue: 13(1)

Published: April 2, 2025

Language: Английский

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Unveiling Coronasomnia: Pandemic Stress and Sleep Problems During the COVID-19 Outbreak

Nature and Science of Sleep, Journal Year: 2024, Volume and Issue: Volume 16, P. 543 - 553

Published: May 1, 2024

Abstract: The COVID-19 pandemic posed an unprecedented challenge to public well-being, necessitating examination of its health impact. This review discusses the relationship between pandemic-induced stressors and individual sleep patterns quality. include lockdown or physical distancing measures, direct virus exposure, dissemination misinformation disinformation. led delayed sleep-wake cycles, except for healthcare professionals, worsened prevalence insomnia was higher women due pre-existing conditions susceptibility such as stress family responsibilities. Healthcare who experienced work during pandemic, reported rates difficulties infection anxiety post-traumatic from exposure. For general population, stemmed social isolation under overwhelming false information available online, resulting in problems. Taken together, findings highlight importance promoting interactions, providing psychological support services, caution navigating information. In summary, this underscores need individual- group-centered approaches ongoing research interventions address pandemic-related issues COVID-19. Keywords: health, disturbance, insomnia, infodemic

Language: Английский

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