International Journal of Molecular Sciences,
Journal Year:
2021,
Volume and Issue:
23(1), P. 218 - 218
Published: Dec. 25, 2021
Obesity
and
its
complications
have
become
a
prominent
global
public
health
problem
that
severely
threatens
human
health.
Melatonin,
originally
known
as
an
effective
antioxidant,
is
endogenous
hormone
found
throughout
the
body
serves
various
physiological
functions.
In
recent
decades,
increasing
attention
has
been
paid
to
unique
function
in
regulating
energy
metabolism,
especially
glucose
lipid
metabolism.
Accumulating
evidence
established
relationship
between
melatonin
obesity;
nevertheless,
not
all
preclinical
clinical
indicates
anti-obesity
effect
of
melatonin,
which
makes
it
remain
conclude
fight
against
obesity.
this
review,
we
summarized
current
knowledge
obesity-related
symptoms,
with
emphasis
on
underlying
mechanisms.
The
role
profile,
adipose
tissue,
oxidative
stress,
inflammation,
well
interactions
circadian
rhythm,
gut
microbiota,
sleep
disorder,
α7nAChR,
opioidergic
system,
exosomes,
make
promising
agent
open
new
avenues
intervention
Journal of Experimental Botany,
Journal Year:
2022,
Volume and Issue:
73(17), P. 5928 - 5946
Published: May 30, 2022
Abstract
Melatonin
(N-acetyl-5-methoxytryptamine)
is
an
indole
molecule
widely
found
in
animals
and
plants.
It
well
known
that
melatonin
improves
plant
resistance
to
various
biotic
abiotic
stresses
due
its
potent
free
radical
scavenging
ability
while
being
able
modulate
signaling
response
pathways
through
mostly
unknown
mechanisms.
In
recent
years,
increasing
number
of
studies
have
shown
plays
a
crucial
role
improving
crop
quality
yield
by
participating
the
regulation
aspects
growth
development.
Here,
we
review
effects
on
vegetative
reproductive
development,
systematically
summarize
molecular
regulatory
network.
Moreover,
effective
concentrations
exogenously
applied
different
crops
or
at
stages
same
are
analysed.
addition,
compare
endogenous
phytomelatonin
organs,
evaluate
potential
function
circadian
rhythms.
The
prospects
approaches
regulating
exogenous
application
appropriate
melatonin,
modification
metabolism-related
genes,
use
nanomaterials
other
technologies
improve
utilization
efficiency
also
discussed.
Journal of Hematology & Oncology,
Journal Year:
2022,
Volume and Issue:
15(1)
Published: March 4, 2022
The
circadian
rhythm
is
an
evolutionarily
conserved
time-keeping
system
that
comprises
a
wide
variety
of
processes
including
sleep-wake
cycles,
eating-fasting
and
activity-rest
coordinating
the
behavior
physiology
all
organs
for
whole-body
homeostasis.
Acute
disruption
may
lead
to
transient
discomfort,
whereas
long-term
irregular
will
result
in
dysfunction
organism,
therefore
increasing
risks
numerous
diseases
especially
cancers.
Indeed,
both
epidemiological
experimental
evidence
has
demonstrated
intrinsic
link
between
dysregulated
cancer.
Accordingly,
rapidly
understanding
molecular
mechanisms
rhythms
opening
new
options
cancer
therapy,
possibly
by
modulating
clock.
In
this
review,
we
first
describe
general
regulators
their
functions
on
addition,
provide
insights
into
underlying
how
several
types
(including
sleep-wake,
eating-fasting,
activity-rest)
can
drive
progression,
which
expand
our
development
from
clock
perspective.
Moreover,
also
summarize
potential
applications
treatment,
optional
therapeutic
strategy
patients.
International Journal of Molecular Sciences,
Journal Year:
2023,
Volume and Issue:
24(4), P. 3392 - 3392
Published: Feb. 8, 2023
Availability
of
artificial
light
and
light-emitting
devices
have
altered
human
temporal
life,
allowing
24-hour
healthcare,
commerce
production,
expanding
social
life
around
the
clock.
However,
physiology
behavior
that
evolved
in
context
24
h
solar
days
are
frequently
perturbed
by
exposure
to
at
night.
This
is
particularly
salient
circadian
rhythms,
result
endogenous
biological
clocks
with
a
rhythm
~24
h.
Circadian
rhythms
govern
features
behavior,
set
precisely
primarily
during
day,
though
other
factors,
such
as
timing
meals,
can
also
affect
rhythms.
significantly
affected
night
shift
work
because
nocturnal
light,
electronic
devices,
shifts
meals.
Night
workers
increased
risk
for
metabolic
disorder,
well
several
types
cancer.
Others
who
exposed
or
late
mealtimes
show
disrupted
cardiac
disorders.
It
imperative
understand
how
alter
function
develop
strategies
mitigate
their
negative
effects.
In
this
review,
we
provide
an
introduction
physiological
regulation
homeostasis
suprachiasmatic
nucleus
(SCN),
SCN-mediated
hormones
display
including
melatonin
glucocorticoids.
Next,
discuss
circadian-gated
processes
sleep
food
intake,
followed
modern
lighting
disrupts
molecular
clock
Lastly,
identify
disruptions
metabolism
increase
susceptibility
syndrome
cardiovascular
diseases,
various
harmful
consequences
associated
on
health.
Nutrition Reviews,
Journal Year:
2022,
Volume and Issue:
81(1), P. 75 - 90
Published: June 30, 2022
Recent
studies
show
that
dietary
habits
and
obesity
seem
to
be
influenced
by
chronotype,
which
reflects
an
individual's
preference
for
the
timing
of
sleeping,
eating,
activity
in
a
24-hour
period.This
review
aimed
analyze
association
chronotype
with
habits,
namely
energy
macronutrient
intakes,
meal
timing,
eating
patterns,
as
well
obesity.PubMed/MEDLINE,
LILACS,
Google
Scholar
databases
were
searched
between
2004
2020.
Study
selection
was
performed
2
authors
independently;
disagreements
on
eligibility
articles
resolved
third
author.
After
assessment
12
060
abstracts,
43
(21
obesity;
13
food
consumption,
patterns;
9
addressed
both
behavior)
included.A
standard
form
used
extract
study
design,
country,
number
participants,
method
determination,
main
findings.Approximately
95%
included
showed
eveningness
at
least
1
unhealthy
habit.
Morningness
associated
regular
consumption
fresh
minimally
processed
foods.
In
addition,
about
47%
higher
late
types
obesity.Late
are
more
likely
present
such
night,
skipping
breakfast
often,
processed/ultraprocessed
foods,
while
early
have
healthy
protective
predominantly
fresh/minimally
Intermediate
tend
pattern
health
similar
than
types.
Late
also
weight
body
mass
index
or
intermediate
types.PROSPERO
registration
no.
CRD42021256078.
SLEEP,
Journal Year:
2023,
Volume and Issue:
46(5)
Published: Feb. 17, 2023
Abstract
The
onset
of
melatonin
secretion,
the
dim
light
(DLMO),
is
a
tool
for
determining
phase
circadian
timing
system.
Although
small
studies
have
investigated
impacts
age
and
methods
calculating
DLMO,
there
no
DLMO
reference
range.
In
current
study,
saliva
from
3579
participants
121
published
plasma
818
healthy
controls
31
(aged
3–73
years)
were
analyzed.
subset
53
papers
(1749
participants),
individual
Morningness
Eveningness
Questionaire
(MEQ)
scores
obtained
authors
or
mined
publications
range
was
constructed.
Saliva
earliest
in
children
to
10
years
latest
around
20
thereafter
advanced
with
by
30
min
oldest
participants.
Melatonin
assay
calculation
had
little
effect
on
determination
DLMO.
correlated
(p
<
0.001)
MEQ
score;
lower
associated
later
increased
age,
reflecting
tendency
toward
morningness.
An
evaluation
14
clinically
diagnosed
patients
living
delayed
sleep–wake
disorder
(mean
ages
revealed
mean
within
albeit
at
late
extreme.
Peak
levels
179
high
degree
variability
groups,
but
only
decline
between
50
lowest
after
70
years.
Biological reviews/Biological reviews of the Cambridge Philosophical Society,
Journal Year:
2024,
Volume and Issue:
99(5), P. 1772 - 1790
Published: April 30, 2024
Melatonin,
a
product
of
tryptophan
metabolism
via
serotonin,
is
molecule
with
an
indole
backbone
that
widely
produced
by
bacteria,
unicellular
eukaryotic
organisms,
plants,
fungi
and
all
animal
taxa.
Aside
from
its
role
in
the
regulation
circadian
rhythms,
it
has
diverse
biological
actions
including
cytoprotective
responses
other
functions
crucial
for
survival
across
different
species.
The
latter
properties
are
also
shared
metabolites
kynuric
products
generated
reactive
oxygen
species
or
phototransfomation
induced
ultraviolet
radiation.
Vitamins
D
related
photoproducts
originate
phototransformation
∆5,7
sterols,
which
7-dehydrocholesterol
ergosterol
examples.
Their
bonds
B
ring
absorb
solar
radiation
[290-315
nm,
(UVB)
radiation]
resulting
opening
to
produce
previtamin
D,
referred
as
secosteroid.
Once
formed,
can
either
undergo
thermal-induced
isomerization
vitamin
UVB
be
transformed
into
lumisterol
tachysterol.
Vitamin
well
tachysterol,
hydroxylated
cyochrome
P450
(CYP)
enzymes
biologically
active
hydroxyderivatives.
best
known
these
1,25-dihydroxyvitamin
(1,25(OH)
