Nutraceuticals and Cancer: Potential for Natural Polyphenols

Nutrients, Journal Year: 2021, Volume and Issue: 13(11), P. 3834 - 3834

Published: Oct. 27, 2021

Cancer is one of the leading causes death globally, associated with multifactorial pathophysiological components. In particular, genetic mutations, infection or inflammation, unhealthy eating habits, exposition to radiation, work stress, and/or intake toxins have been found contribute development and progression cancer disease states. Early detection proper treatment enhance chances survival healing, but side effects anticancer drugs still produce detrimental responses that counteract benefits in terms hospitalization survival. Recently, several natural bioactive compounds were possess properties, capable killing transformed cancerous cells without being toxic their normal counterparts. This effect occurs when products are conventional treatments, thereby suggesting nutraceutical supplementation may successful therapy. review aims discuss current literature on four extracts mostly characterized by a specific polyphenolic profile. activities reported support treatment: (1) inhibition cell proliferation, (2) antioxidant activity, (3) anti-inflammatory activity. On other hand, owing attenuation therapies, antioxidants improving compliance patients undergoing treatment. Thus, supplementation, along drug treatment, be considered for better cancer. It should noted, however, data from studies plant preparations discussed, it appropriate ensure experiments conducted accordance accepted pharmacological research practices so as not disclose information only partially correct.

Language: Английский

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Hyperoside: A review on its sources, biological activities, and molecular mechanisms

Phytotherapy Research, Journal Year: 2022, Volume and Issue: 36(7), P. 2779 - 2802

Published: May 13, 2022

Abstract Hyperoside is a natural flavonol glycoside in various plants, such as Crataegus pinnatifida Bge, Forsythia suspensa , and Cuscuta chinensis Lam. Medical research has found that hyperoside possesses broad spectrum of biological activities, including anticancer, anti‐inflammatory, antibacterial, antiviral, antidepressant, organ protective effects. These pharmacological properties lay the foundation for its use treating multiple diseases, sepsis, arthritis, colitis, diabetic nephropathy, myocardial ischemia–reperfusion, pulmonary fibrosis, cancers. obtained from plants chemical synthesis. This study aims to provide comprehensive overview on sources activities insights into therapeutic potential, basis high‐quality studies determine clinical efficacy this compound.

Language: Английский

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Curcumin nanoformulations: Beneficial nanomedicine against cancer

Phytotherapy Research, Journal Year: 2022, Volume and Issue: 36(3), P. 1156 - 1181

Published: Feb. 7, 2022

Abstract Curcumin is a phytochemical achieved from the plant turmeric. It extensively utilized for treatment of several types diseases such as cancers. Nevertheless, its efficiency has been limited because rapid metabolism, low bioavailability, poor water solubility, and systemic elimination. Scientists have tried to solve these problems by exploring novel drug delivery systems lipid‐based nanoparticles (NPs) (e.g., solid lipid NPs, nanostructured carriers, liposomes), polymeric micelles, nanogels, cyclodextrin, gold, mesoporous silica NPs. Among these, liposomes most expansively studied. This review mainly focuses on different curcumin nanoformulations their use in cancer therapy vitro, vivo, clinical studies. Despite development curcumin‐containing NPs cancer, potentially serious side effects, including interactions with other drugs, some toxicity aspects may occur that require more high‐quality investigations firmly establish efficacy.

Language: Английский

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Chemistry, pharmacokinetics, pharmacological activities, and toxicity of Quercitrin

Phytotherapy Research, Journal Year: 2022, Volume and Issue: 36(4), P. 1545 - 1575

Published: March 7, 2022

Quercitrin is a naturally available type of flavonoid that commonly functions as the dietary ingredient and supplement. So far, wide spectrum bioactivities quercitrin have been revealed, including antioxidative stress, antiinflammation, anti-microorganisms, immunomodulation, analgesia, wound healing, vasodilation. Based on these various pharmacological activities, increasing studies focused potency in diverse diseases recent years, such bone metabolic diseases, gastrointestinal cardiovascular cerebrovascular others. In this paper, by collecting summarizing publications from natural sources, activities roles pharmacokinetics, structure-activity relationship, well toxicity were systematically reviewed. addition, underlying molecular mechanisms treating related dose-effect relationships, novel preparations discussed purpose broadening application prospect functional food providing reference for its clinical application. Notably, are insufficient at present, further high-quality needed to firmly establish efficacy quercitrin.

Language: Английский

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Plant-Derived Nutraceuticals and Immune System Modulation: An Evidence-Based Overview

Vaccines, Journal Year: 2020, Volume and Issue: 8(3), P. 468 - 468

Published: Aug. 22, 2020

Immunomodulators are agents able to affect the immune system, by boosting defences improve body reaction against infectious or exogenous injuries, suppressing abnormal response occurring in disorders. Moreover, immunoadjuvants can support system acting on nonimmune targets, thus improving response. The modulation of inflammatory pathways and microbiome also contribute control function. Some plant-based nutraceuticals have been studied as possible immunomodulating due their multiple pleiotropic effects. Being usually more tolerable than pharmacological treatments, adjuvant contribution is approached a desirable nutraceutical strategy. In present review, up date knowledge about properties polysaccharides, fatty acids labdane diterpenes analyzed, order give scientific basic clinical evidence practical use. Since promising preclinical studies, limited sometimes confusing results highlighted trials, likely low methodological quality lacking standardization. More investigations high specificity required describe depth usefulness these plant-derived modulation, for health promoting disease preventing purposes.

Language: Английский

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Sulforaphane: A review of its therapeutic potentials, advances in its nanodelivery, recent patents, and clinical trials

Phytotherapy Research, Journal Year: 2021, Volume and Issue: 35(10), P. 5440 - 5458

Published: June 28, 2021

Traditionally, herbal supplements have shown an exceptional potential of desirability for the prevention diseases and their treatment. Sulforaphane (SFN), organosulfur compound belongs to isothiocyanate (ITC) group is mainly found naturally in cruciferous vegetables. Several studies now revealed that SFN possesses broad spectrum activities has extraordinary as antioxidant, antitumor, anti‐angiogenic, anti‐inflammatory agent. In addition, proven be less toxic, non‐oxidizable, its administration individuals well tolerated, making it effective natural dietary supplement clinical trials. ability a promising future drug molecule management various due potent antioxidant properties. recent times, several newer delivery systems were designed developed this order enhance bioavailability, stability, reduce side effects. This review focuses cover numerous data supporting wide range pharmacological SFN, drug‐related issues, approaches improve physicochemical biological properties, including solubility, bioavailability. Recent patents ongoing trials on are also summarized.

Language: Английский

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A comprehensive review of the therapeutic potential of α‐arbutin

Phytotherapy Research, Journal Year: 2021, Volume and Issue: 35(8), P. 4136 - 4154

Published: March 16, 2021

Cosmetic dermatology preparations such as bleaching agents are ingredients with skin-related biological activities for increasing and improving skin beauty. The possibility of controlling hyperpigmentation disorders is one the most important research goals in cosmetic preparations. Recently, cosmetics containing herbal botanical have attracted many interests consumers products because these found safer than other synthetic components. However, high-quality trial studies larger samples needed to confirm safety clinical efficacy phytotherapeutic high therapeutic index. Arbutin (p-hydroxyphenyl-β-d-glucopyranoside) a bioactive hydrophilic polyphenol two isomers including alpha-arbutin (4-hydroxyphenyl-α-glucopyranoside) β-arbutin (4-hydroxyphenyl-β-glucopyranoside). It used medicinal plant phytopharmacy. Studies shown that 10 times more effective natural arbutin. A comparison IC50 values showed α-arbutin (with concentration 2.0 mM) has potent inhibitory activity on human tyrosinase against arbutin higher 30 mM). review recent could be beneficial treatment various diseases disorders, types cancers, central nervous system osteoporosis, diabetes, etc. This study was designed describe efficiencies

Language: Английский

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Pharmacological properties, therapeutic potential, and legal status of Cannabis sativa L.: An overview

Phytotherapy Research, Journal Year: 2021, Volume and Issue: 35(11), P. 6010 - 6029

Published: July 8, 2021

Marijuana, or Cannabis sativa L., is a common psychoactive plant used for both recreational and medicinal purposes. In many countries, cannabis‐based medicines have been legalized under certain conditions because of their immense prospects in applications. With comprehensive insight into the challenges associated with pharmacological use global trade C. , this mini‐review focuses on importance its legal status worldwide; compounds therapeutic potential along underlying public health concerns future perspective are herein discussed. The existence major including Δ 9 ‐tetrahydrocannabinol (Δ ‐THC), cannabidiol, cannabinol, cannabichromene contributes to effects cannabis plant. These also involved treatment various types cancer, epilepsy, Parkinson's disease displaying several mechanisms action. significant potential. However, aspects need an in‐depth understanding drug mechanism interaction other drugs. Only after addressing these concerns, legalization could be utilized full as medicine.

Language: Английский

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Quercetin promotes osteogenic differentiation and antioxidant responses of mouse bone mesenchymal stem cells through activation of the AMPK/SIRT1 signaling pathway

Phytotherapy Research, Journal Year: 2021, Volume and Issue: 35(5), P. 2639 - 2650

Published: Jan. 9, 2021

Decrepitude and apoptosis of bone mesenchymal stem cells (BMSCs) induced by reactive oxygen species (ROS) lead to inhibited osteogenic differentiation, causing decreased density osteoporosis. Quercetin, a bioactive component Solanum muricatum extracts, promotes the differentiation BMSCs ameliorates symptoms osteoporosis in vivo. However, detailed mechanism underlying this process remains unclear. The study aims reveal regulatory quercetin BMSCs. Mouse (mBMSCs) were isolated from marrow characterized flow cytometry. QRT-PCR western blot assays performed evaluate expression levels related genes proteins. Alkaline phosphatase (ALP) staining Oil Red O lipids used estimate osteogenesis adipogenesis mBMSCs, respectively. Quercetin treatment (2 5 μM) significant upregulation antioxidant enzymes, SOD1 SOD2, mBMSCs. promoted adipogenic enhanced phosphorylation AMPK protein upregulated SIRT1, thus activating AMPK/SIRT1 signaling pathway responses mBMSCs pathway.

Language: Английский

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Hitting the sweet spot: A systematic review of the bioactivity and health benefits of phenolic glycosides from medicinally used plants

Phytotherapy Research, Journal Year: 2021, Volume and Issue: 35(7), P. 3484 - 3508

Published: Feb. 21, 2021

Phenolic acid and flavonoid glycosides form a varied class of naturally occurring compounds, characterised by high polarity—resulting from the glycone moiety—and presence multiple phenol functionalities, which often leads to strong antioxidant activity. glycosides, in particular may possess bioactive properties with broad spectrum This systematic literature review provides detailed overview 28 studies examining biological activity phenolic plant sources, highlighting potential these compounds as therapeutic agents. The depends upon type, identity aglycone specific location moiety. From reporting both their respective aglycones, appear generally be storage/reserve pool precursors more compounds. glycosylated are likely bioavailable compared forms, due sugar moieties. Hydrolysis glycoside vivo environment would release free aglycone, potentiating However, further high‐quality needed firmly establish clinical efficacy many species studied.

Language: Английский

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