Applied Biological Chemistry, Journal Year: 2025, Volume and Issue: 68(1)
Published: April 26, 2025
Language: Английский
Nutrients, Journal Year: 2023, Volume and Issue: 15(1), P. 224 - 224
Published: Jan. 1, 2023
In 2010, the Mediterranean diet was recognized by UNESCO as an Intangible Cultural Heritage of Humanity. Olive oil is most characteristic food this due to its high nutraceutical value. The positive effects olive have often been attributed minor components; however, oleic acid (OA) content (70-80%) responsible for many health properties. OA effective biomolecule, although mechanism which mediates beneficial physiological not fully understood. influences cell membrane fluidity, receptors, intracellular signaling pathways, and gene expression. may directly regulate both synthesis activities antioxidant enzymes. anti-inflammatory effect be related inhibition proinflammatory cytokines activation ones. best-characterized highlights a natural activator sirtuin 1 (SIRT1). Oleoylethanolamide (OEA), derived from OA, endogenous ligand peroxisome proliferator-activated receptor alpha (PPARα) nuclear receptor. OEA regulates dietary fat intake energy homeostasis has therefore suggested potential therapeutic agent treatment obesity. effects. actions OEA. New evidence suggests that influence epigenetic mechanisms, opening new avenue in exploration therapies based on these mechanisms. can exert regulating microRNA review, we examine cellular reactions processes triggered T cells, macrophages, neutrophils order better understand immune modulation exerted OA.
Language: Английский
Citations
106
Peptides, Journal Year: 2021, Volume and Issue: 148, P. 170696 - 170696
Published: Nov. 29, 2021
Immunomodulatory peptides are a complex class of bioactive that encompasses substances with different mechanisms action. could also be used in vaccines as adjuvants which would extremely desirable, especially response to pandemics. Thus, immunomodulatory food plant origin regarded both valuable suplements novel functional preparation and/or precursors or possible active ingredients for drugs design treatment variety conditions arising from impaired function immune system. Given mechanisms, tests required assess effects peptides. Some those show good correlation vivo results but others, less so. Certain peptides, such defensins, and antimicrobial effect, makes them interesting candidates feed, well templates synthetic
Language: Английский
Citations
71
Antioxidants, Journal Year: 2022, Volume and Issue: 11(4), P. 742 - 742
Published: April 8, 2022
This review paper gives an insight into the effective delivery mechanisms for health-promoting substances and highlights challenges of using antioxidants bioactives in foods. The selection criteria choosing their extraction bioavailable form with adequate incorporation techniques are covered. Moreover, overview existing methods determination bioactivity is given. importance scientifically evaluating effects foods or food components on consumer health before making claims about healthiness aligned. Finally, a scientific perspective how to respond booming demand products given, we acknowledge that despite work done, there still many need be overcome.
Language: Английский
Citations
52
Frontiers in Microbiology, Journal Year: 2024, Volume and Issue: 15
Published: Jan. 24, 2024
Chromobacterium is a rod-shaped, Gram-negative, facultatively anaerobic bacteria with cosmopolitan distribution. Just about 160 violaceum incidents have been reported globally, but then once infected, it has the ability to cause deadly septicemia, and infections in lungs, liver, brain, spleen, lymphatic systems that might lead death. C. produces utilizes violacein kill compete an ecological niche. Violacein hydrophobic bisindole delivered through efficient transport route termed outer membrane vesicles (OMVs) aqueous environment. OMVs are small, spherical segments detached from of Gram-negative bacteria. OMV secretions controlled by mechanism called quorum sensing system CviI / CviR , which enables cell-to-cell communication between them regulation various virulence factors such as biofilm formation, biosynthesis. Another factor bacterial type 3 secretion (T3SS) divided into two types: Cpi-1 Cpi-2 . ’s needle rod effector proteins perhaps recognized NAIP receptors humans mice, activating NLRC4 inflammasome cascade, effectively clearing spleen via pyroptosis, cytotoxicity mediated IL-18-driven Natural killer (NK) cells liver. In this paper, we attempt interrelate quorum-controlled production, delivery T3SS protein production host immunological effects against Cpi1 T3SS. We suggest research path natural bioactive molecule like palmitic acid can act anti-quorum agent reducing expression well immunomodulatory augment innate immune defense hyperactivation hence dramatically purge infections.
Language: Английский
Citations
11
Nutrients, Journal Year: 2021, Volume and Issue: 13(4), P. 1269 - 1269
Published: April 13, 2021
Honey has exerted a high impact in the field of alternative medicine over many centuries. In addition to its wound healing, anti-microbial and antioxidant properties, several lines evidence have highlighted efficiency honey associated bioactive constituents as anti-tumor agents against range cancer types. Mechanistically, was shown inhibit cell growth through pro-apoptotic, anti-proliferative anti-metastatic effects. However, potential regulate immune responses is relatively unexplored. A small number vitro vivo studies demonstrated ability modulate system by inducing immunostimulatory well anti-inflammatory present review, we summarize findings from different that aimed investigate immunomodulatory properties flavonoid components relation cancer. While these provide promising data, additional research needed further elucidate honey, enable utilization an adjuvant therapy
Language: Английский
Citations
55
Cancer Cell International, Journal Year: 2022, Volume and Issue: 22(1)
Published: Dec. 28, 2022
Abstract Cancer is a heterogeneous disease with multifaceted drug resistance mechanisms (e.g., tumour microenvironment [TME], heterogeneity, and immune evasion). Natural products are interesting repository of bioactive molecules, especially those anticancer activities. Prodigiosin, red pigment produced by Serratia marcescens , possesses inherent characteristics, showing antitumour activities in different cancers breast, gastric) low or without harmful effects on normal cells. The present review discusses the potential role prodigiosin modulating reprogramming metabolism various cells TME, such as T B lymphocytes, tumour-associated macrophages (TAMs), natural killer (NK) cells, dendritic (TADCs), myeloid-derived suppressor (MDSCs) which turn might introduce an immunomodulator cancer therapy.
Language: Английский
Citations
27
Frontiers in Veterinary Science, Journal Year: 2024, Volume and Issue: 11
Published: May 27, 2024
The aim of this experiment was to investigate the modulation effect Acanthopanax senticosus polysaccharide (ASPS-PD) extracted with deep eutectic solvent on cyclophosphamide-induced immunosuppression in broilers and its gut microbiota broilers. 108 one-day-old were divided into six groups, including control group, Cyclophosphamide (CY) model ASPS-PD ASPA-PD high low dose groups Astragalus group. Body weight, feed intake, conversion ratio, immune organ index at 7, 14, 21 days determined; IL-2, IFN-γ, lgG1 levels determined by enzyme-linked immunosorbent assay (ELISA); Broiler caeca feces analyzed amplification 16S rRNA sequencing. results showed that can restore growth performance, increase improve serum cytokine IL-2 IFN-γ immunoglobulin CY-treated analysis cecum flora promote proliferation beneficial bacteria reduce number harmful bacteria, regulating intestinal flora. Therefore, may be a potential novel immunomodulator ameliorate CY-induced dysregulation broiler.
Language: Английский
Citations
5
Scientific Reports, Journal Year: 2024, Volume and Issue: 14(1)
Published: Nov. 6, 2024
In present study the green synthesis of silver oxide nanoparticles has been effectively achieved using novel plant extract Phragmanthera Macrosolen. This method provides sustainable alternative for nanoparticle synthesis, demonstrating potential Macrosolen as a reducing and stabilizing agent in production Ag2O NPs. The synthesized were characterized their structural, morphological, optical properties, confirming successful formation applications various fields. effects different pH values annealing temperature samples on properties NPs formations, well photo-catalytic activities towards Toluidine Blue dye degradations, studied. Powder XRD reveals that crystallite natures long with crystalline size ranges from 25.85 to 35.90 nm. FIB-SEM HR-TEM images displayed spherical shapes. UV-vis spectroscopy belong direct-band gap 2.1–2.6 eV. FTIR- shown may be steadied via interfaces –OH C = O groups carbohydrate, flavonoid, tannin, phenolic acid existing P. macrosolen L. leaf. chemical states, electron-hole recombinations purity Ag confirmed through X-ray Photoelectron Spectroscopy (XPS) PL analysis respectively. Fascinatingly, at 12 high degradations TB dyes. dyes monitored spectro-photo-metrically wave-length 200–900 nm, efficiency (98.50%) half-life 9.5798 min kinetic rate constant 0.07234 min−1, was obtained after 45 reactions. From this study, it can concluded aqueous are promising remediation environmental pollution water treatment. light, reports address cost-effective, eco-friendly, ways.
Language: Английский
Citations
5
Biomedicines, Journal Year: 2021, Volume and Issue: 9(9), P. 1266 - 1266
Published: Sept. 18, 2021
The worldwide transmission of acute respiratory syndrome coronavirus 2 (SARS-CoV-2) as a deadly or devastating disease is known to affect thousands people every day, many them dying all over the planet. main reason for massive effect COVID-19 on society its unpredictable spread, which does not allow proper planning management this disease. Antibiotics, antivirals, and other prescription drugs, necessary used in therapy, obviously have side effects (minor significant) affected person, there are still clear enough studies elucidate their combined specific treatment, existing protocols sometimes unclear uncertain. In contrast, it has been found that nutraceuticals, supplements, various herbs can be effective reducing chances SARS-CoV-2 infection, but also alleviating symptoms. However, details yet available, precise scientific validate approved benefits natural food additives, probiotics, herbs, nutraceuticals will need standardized according current regulations. These alternative treatments may direct virus reduce risk infection with it, these products certainly stimulate human immune system so body better prepared fight This paper aims at specialized literary foray precisely field “cures” provide real revelations therapy
Language: Английский
Citations
32
Open Life Sciences, Journal Year: 2024, Volume and Issue: 19(1)
Published: Jan. 1, 2024
This study explores the effects of Mediterranean diet, herbal remedies, and their phytochemicals on various gastrointestinal conditions reviews global use medicinal plants for common digestive problems. The review highlights key mechanisms action summarizes latest findings how plant-based products influence system they work. We searched sources literature databases, including Google Scholar, PubMed, Science Direct, MedlinePlus. Our focus was gathering relevant papers published between 2013 August 2023. Certain exhibit potential in preventing or treating diseases cancers. Notable examples include
Language: Английский
Citations
4