Signal Transduction and Targeted Therapy,
Journal Year:
2021,
Volume and Issue:
6(1)
Published: Oct. 7, 2021
Abstract
Myeloid-derived
suppressor
cells
(MDSCs)
are
a
heterogenic
population
of
immature
myeloid
with
immunosuppressive
effects,
which
undergo
massive
expansion
during
tumor
progression.
These
not
only
support
immune
escape
directly
but
also
promote
invasion
via
various
non-immunological
activities.
Besides,
this
group
proved
to
impair
the
efficiency
current
antitumor
strategies
such
as
chemotherapy,
radiotherapy,
and
immunotherapy.
Therefore,
MDSCs
considered
potential
therapeutic
targets
for
cancer
therapy.
Treatment
targeting
have
shown
promising
outcomes
in
both
preclinical
studies
clinical
trials
when
administrated
alone,
or
combination
other
anticancer
therapies.
In
review,
we
shed
new
light
on
recent
advances
biological
characteristics
functions
MDSCs.
We
hope
propose
an
overview
MDSCs-targeting
therapies
so
provide
ideas
treatment.
Journal for ImmunoTherapy of Cancer,
Journal Year:
2018,
Volume and Issue:
6(1)
Published: June 18, 2018
Immune
checkpoint
antagonists
(CTLA-4
and
PD-1/PD-L1)
CAR
T-cell
therapies
generate
unparalleled
durable
responses
in
several
cancers
have
firmly
established
immunotherapy
as
a
new
pillar
of
cancer
therapy.
To
extend
the
impact
to
more
patients
broader
range
cancers,
targeting
additional
mechanisms
tumor
immune
evasion
will
be
critical.
Adenosine
signaling
has
emerged
key
metabolic
pathway
that
regulates
immunity.
is
an
immunosuppressive
metabolite
produced
at
high
levels
within
microenvironment.
Hypoxia,
cell
turnover,
expression
CD39
CD73
are
important
factors
adenosine
production.
through
A2a
receptor
expressed
on
cells
potently
dampens
inflamed
tissues.
In
this
article,
we
describe
role
regulating
immunity,
highlighting
potential
therapeutic
targets
pathway.
We
also
review
preclinical
data
for
each
target
provide
update
current
clinical
activity
field.
Together,
suggest
rational
combination
strategies
incorporate
inhibitors
hypoxia-CD39-CD73-A2aR
great
promise
further
improving
outcomes
patients.