Histone lactylation regulates PRKN-Mediated mitophagy to promote M2 Macrophage polarization in bladder cancer

International Immunopharmacology, Journal Year: 2025, Volume and Issue: 148, P. 114119 - 114119

Published: Jan. 23, 2025

Language: Английский

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Wei-fu-chun tablet halted gastric intestinal metaplasia and dysplasia associated with inflammation by regulating the NF-κB pathway

Journal of Ethnopharmacology, Journal Year: 2023, Volume and Issue: 318, P. 117020 - 117020

Published: Aug. 9, 2023

Language: Английский

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Anti-papillary thyroid carcinoma effects of dioscorea bulbifera L. through ferroptosis and the PI3K/AKT pathway based on network pharmacology and experimental validation

Journal of Ethnopharmacology, Journal Year: 2024, Volume and Issue: 326, P. 117912 - 117912

Published: Feb. 20, 2024

Papillary thyroid carcinoma (PTC) is the predominant form of cancer with a rising global incidence. Despite favorable prognoses, significant recurrence rate persists. Dioscorea bulbifera L. (DBL), traditional Chinese medicine, has been historically used for thyroid-related disorders. However, its therapeutic effects and mechanisms action on PTC remain unclear. To explore potential effects, principal active components, molecular DBL in treatment through network pharmacology docking, experimental validation conducted to corroborate these findings. The Traditional Medicine Systems Pharmacology Database (TCMSP) was utilized as systematic tool collecting screening phytochemical components DBL, establishing associations between targets. Based this, data visually processed using Cytoscape software (version 3.8.0). Concurrently, precise docking studies their corresponding targets were Autodock software. Additionally, PTC-related genes selected GeneCards GEO databases. We further employed DAVID bioinformatics resources conduct comprehensive Gene Ontology (GO) Kyoto Encyclopedia Genes Genomes (KEGG) enrichment analyses intersecting PTC. These aid predicting actions action. validate findings, vitro also conducted. In this investigation, 14 bioactive compounds 195 identified, 127 common shared Molecular revealed strong binding affinities major target proteins. GO analysis unveiled key processes involved DBL's KEGG highlighted modulation PI3K/AKT signaling pathway. Experimental outcomes demonstrated inhibiting cell proliferation migration, suppressing pathway activation, promoting ferroptosis. conclusion, offers multifaceted approach PTC, targeting multiple entities influencing diverse biological pathways. Network shed light utility treatment, substantiated by validation. This study contributes valuable insights into promising agent management.

Language: Английский

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Liquiritigenin Induces Cell Cycle Arrest and Apoptosis in Lung Squamous Cell Carcinoma

Cell Biochemistry and Biophysics, Journal Year: 2024, Volume and Issue: 82(2), P. 1397 - 1407

Published: May 22, 2024

Language: Английский

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Direct targeting of S100A9 with Icariin counteracted acetaminophen‑induced hepatotoxicity

International Immunopharmacology, Journal Year: 2024, Volume and Issue: 136, P. 112296 - 112296

Published: May 28, 2024

Language: Английский

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A novel HDAC6 inhibitor attenuate APAP-induced liver injury by regulating MDH1-mediated oxidative stress

International Immunopharmacology, Journal Year: 2024, Volume and Issue: 131, P. 111861 - 111861

Published: March 13, 2024

Language: Английский

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Research Progress in the Medicine-Food Dual Use of Angelica sinensis in Digestive System Tumors

Natural Product Communications, Journal Year: 2025, Volume and Issue: 20(1)

Published: Jan. 1, 2025

Angelica sinensis (AS) is a widely used medicinal and culinary herb frequently considered critical in traditional prescriptions. Modern pharmacological studies have validated its beneficial effects, including nourishing, blood activation, anti-inflammatory analgesic properties, liver kidney protection, tumor inhibition. Due to the lack of existing reviews on AS treating digestive system tumors (DS-T), this study investigated effects primary active components combating DS-T from three main perspectives. First, we summarized mechanisms for various by analyzing vitro vivo experimental studies. Second, analyzed radiotherapy drugs determined potential ingredients reduce toxicity enhance efficacy. Additionally, can be integrated into both regular medicated diets, thereby effectively preventing development facilitating post-surgery recovery. In conclusion, exhibits as an anti-DS-T drug, providing theoretical foundation daily dietary clinical use offering insights future scientific research innovation.

Language: Английский

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Decoding Health: Exploring Essential Biomarkers Linked to Metabolic Dysfunction-Associated Steatohepatitis and Type 2 Diabetes Mellitus

Biomedicines, Journal Year: 2025, Volume and Issue: 13(2), P. 359 - 359

Published: Feb. 4, 2025

The investigation of biomarkers for metabolic diseases such as type 2 diabetes mellitus (T2DM) and dysfunction-associated steatohepatitis (MASH) reveals their potential advancing disease treatment addressing notable overlap. connection between MASH, obesity, T2DM highlights the need an integrative management approach mechanisms like insulin resistance chronic inflammation. Obesity contributes significantly to development MASH through lipid dysregulation, resistance, Selective biomarker targeting offers a valuable strategy detecting these comorbidities. Biomarkers CRP, IL-6, TNF-α serve indicators inflammation, while HOMA-IR, fasting insulin, HbA1c are essential evaluating resistance. Additionally, triglycerides, LDL, HDL crucial comprehending dysregulation. Despite growing importance digital biomarkers, challenges in research methodologies sample variability persist, necessitating further studies validate diagnostic tools improve health interventions. Future opportunities include developing non-invasive panels, using multiomics, machine learning enhance prognoses accuracy therapeutic outcomes.

Language: Английский

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Oridonin Preserves Retinal Pigmented Epithelial Cell Tight Junctions and Ameliorates Choroidal Neovascularization

Investigative Ophthalmology & Visual Science, Journal Year: 2025, Volume and Issue: 66(2), P. 56 - 56

Published: Feb. 21, 2025

To investigate the role and mechanism of oridonin (ORI), a bioactive diterpenoid extracted from Chinese herbal medicine Rabdosia rubescens, on integrity outer blood-retinal barrier (oBRB) during choroidal neovascularization (CNV). ARPE-19 cells were exposed to hypoxia treated with ORI. The expression ZO-1 occludin in axis TGFβR/SUV39H1/KLF11 was detected by WB, chromatin immunoprecipitation, luciferin report activity assay, immunofluorescence assay (IF), effect ORI properties studied. A laser-induced mouse CNV model constructed, administrated oral gavage. IF choroid flat mounts done confirm BRB integrity. Indocyanine green angiography retina-RPE-choroid performed determine formation retinal function. Hematoxylin eosin staining TUNEL carried out appraise ocular systemic cytotoxicity caused protected hypoxia-induced destruction promoted axis, maintaining hypoxia. improved mice mitigated without any or (n = 4-5 each group). ameliorates subsequent via regulating pathway RPE cells.

Language: Английский

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Polysaccharides from Anemarrhena asphodeloides Bge, the purification, characterization, biological activities and application of a traditional herbal medicine: A review

International Journal of Biological Macromolecules, Journal Year: 2025, Volume and Issue: unknown, P. 143497 - 143497

Published: April 1, 2025

Language: Английский

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