Bioactive Materials,
Journal Year:
2024,
Volume and Issue:
34, P. 414 - 421
Published: Jan. 10, 2024
Tumor
hypoxia
diminishes
the
effectiveness
of
traditional
type
II
photodynamic
therapy
(PDT)
due
to
oxygen
consumption.
Type
I
PDT,
which
can
operate
independently
oxygen,
is
a
viable
option
for
treating
hypoxic
tumors.
In
this
study,
we
have
designed
and
synthesized
JSK@PEG-IR820
NPs
that
are
responsive
tumor
microenvironment
(TME)
enhance
PDT
through
glutathione
(GSH)
depletion.
Our
approach
aims
expand
sources
therapeutic
benefits
by
promoting
generation
superoxide
radicals
(O
Journal of the American Chemical Society,
Journal Year:
2022,
Volume and Issue:
144(33), P. 15391 - 15402
Published: Aug. 10, 2022
Fluorescence
imaging
in
the
second
near-infrared
window
(NIR-II,
1000–1700
nm)
using
small-molecule
dyes
has
high
potential
for
clinical
use.
However,
many
NIR-II
suffer
from
emission
quenching
effect
and
extremely
low
quantum
yields
(QYs)
practical
usage
forms.
The
AIE
strategy
been
successfully
utilized
to
develop
with
donor–acceptor
(D–A)
structures
acceptable
QYs
aggregate
state,
but
there
is
still
large
room
QY
improvement.
Here,
we
rationally
designed
a
emissive
dye
named
TPE-BBT
its
derivative
(TPEO-BBT)
by
changing
electron-donating
triphenylamine
unit
tetraphenylethylene
(TPE).
Their
nanoparticles
exhibited
ultrahigh
relative
of
31.5%
23.9%
water,
respectively.
By
an
integrating
sphere,
absolute
was
measured
be
1.8%
water.
Its
crystals
showed
10.4%,
which
highest
value
among
organic
small
molecules
reported
so
far.
optimized
D–A
interaction
higher
rigidity
state
are
believed
two
key
factors
QY.
Finally,
photoluminescence
(PL)
chemiluminescence
(CL)
bioimaging
through
successive
CL
resonance
energy
transfer
Förster
processes.
realized
excellent
PL
quality
mouse
blood
vessels
local
arthrosis
inflammation
mice
signal-to-background
ratio
130.
Thus,
design
presented
here
brings
new
possibilities
development
bright
technologies.
Chemical Society Reviews,
Journal Year:
2021,
Volume and Issue:
51(2), P. 566 - 593
Published: Dec. 20, 2021
The
real-time,
dynamic
optical
visualization
of
lesions
and
margins
ensures
not
only
complete
resection
the
malignant
tissues
but
also
better
preservation
vital
organs/tissues
during
surgical
procedures.
Most
imaging
probes
with
an
"always-on"
signal
encounter
high
background
noise
due
to
their
non-specific
accumulation
in
normal
tissues.
By
contrast,
activatable
molecular
"turn
on"
signals
upon
reaction
targeted
biomolecules
that
are
overexpressed
cells,
offering
target-to-background
ratios
specificity
sensitivity.
This
review
summarizes
recent
progress
diagnosis.
design
principle
mechanism
discussed,
followed
by
specific
emphasis
on
applications
ranging
from
fluorescence-guided
surgery
endoscopy
tissue
biopsy.
Finally,
potential
challenges
perspectives
field
probe-enabled
discussed.
Nature Communications,
Journal Year:
2022,
Volume and Issue:
13(1)
Published: June 13, 2022
Abstract
Although
two-dimensional
(2D)
layered
double
hydroxides
(LDHs)
have
been
widely
used
as
efficient
nanoagents
for
biological
diagnosis
and
treatment,
they
found
to
be
inert
photosensitizers
(PSs)
photodynamic
therapy
(PDT).
Herein,
we
report
the
defect
engineering
of
ultrathin
2D
CoMo-LDH
NiMo-LDH
nanosheets
highly
active
inorganic
PSs
PDT
in
third
near-infrared
(NIR-III)
window.
Hydrothermal-synthesized
are
etched
via
a
simple
acid
treatment
obtain
defect-rich
nanosheets.
Importantly,
exhibit
much
higher
activity
(~97
times)
generation
reactive
oxygen
species
than
that
pristine
under
NIR-III
1567
nm
laser
irradiation.
Therefore,
after
modification
with
polyethylene
glycol,
can
an
PS
efficiently
induce
cancer
cells
apoptosis
vitro
eradicate
tumors
vivo
Chemical Society Reviews,
Journal Year:
2023,
Volume and Issue:
52(13), P. 4392 - 4442
Published: Jan. 1, 2023
Metal
agents
have
made
incredible
strides
in
preclinical
research
and
clinical
applications,
but
their
short
emission/absorption
wavelengths
continue
to
be
a
barrier
distribution,
therapeutic
action,
visual
tracking,
efficacy
evaluation.
Chemical Society Reviews,
Journal Year:
2022,
Volume and Issue:
51(18), P. 7692 - 7714
Published: Jan. 1, 2022
This
paper
reviews
organic
and
inorganic
species
as
building
blocks
various
design
strategies
of
NIR-II
nanohybrids
for
intensity-based
lifetime-based
bioimaging
biosensing.
Angewandte Chemie International Edition,
Journal Year:
2022,
Volume and Issue:
61(24)
Published: March 16, 2022
Abstract
Photon
excitation
and
emission
at
the
NIR‐II
spectral
window
enable
high‐contrast
deep‐tissue
bioimaging.
However,
multiplexed
imaging
with
has
been
hampered
by
limited
chemical
strategies
to
develop
bright
fluorophores
tunable
absorption
in
this
regime.
Herein,
we
developed
a
series
of
heptamethine
cyanines
(HCs)
varied
absorption/emission
maxima
spanning
from
1100
1600
nm
through
physical
organic
approach.
A
bulky
counterion
paired
HCs
was
found
elicit
substantial
improvements
absorptivity
(7‐fold),
brightness
(14‐fold),
profiles
water,
addressing
notorious
quenching
problem
due
aggregation
polarization.
We
demonstrated
utilities
HC1222
HC1342
for
dual‐color
circulatory
system,
lymphatic
structures,
tumor,
organ
function
living
mice
under
1120
1319
excitation,
showing
as
promising
platform
non‐invasive
