Bioactive NIR-II gold clusters for three-dimensional imaging and acute inflammation inhibition DOI Creative Commons
Huizhen Ma, Xiaoning Zhang, Ling Liu

et al.

Science Advances, Journal Year: 2023, Volume and Issue: 9(31)

Published: Aug. 2, 2023

Strong fluorescence and high catalytic activities cannot be achieved simultaneously due to conflicts in free electron utilization, resulting a lack of bioactivity most near-infrared-II (NIR-II) fluorophores. To circumvent this challenge, we developed atomically precise Au22 clusters with strong NIR-II ranging from 950 1300 nm exhibiting potent enzyme-mimetic through atomic engineering create active Cu single-atom sites. The Au21Cu1 show 18-fold higher antioxidant, 90-fold catalase-like, 3-fold superoxide dismutase-like than clusters, negligible loss. Doping single atoms decreases the bandgap 1.33 1.28 eV by predominant contributions d states, lost states effectuates activities. renal clearable can monitor cisplatin-induced injury 20- 120-minute window visualize it three dimensions using light-sheet microscopy. Furthermore, inhibit oxidative stress inflammation cisplatin-treated mouse model, particularly kidneys brain.

Language: Английский

Near-infrared II fluorescence imaging DOI
E. Schmidt, Zihao Ou, Erving Ximendes

et al.

Nature Reviews Methods Primers, Journal Year: 2024, Volume and Issue: 4(1)

Published: April 4, 2024

Language: Английский

Citations

73
Molecular Programming of NIR‐IIb‐Emissive Semiconducting Small Molecules for In Vivo High‐Contrast Bioimaging Beyond 1500 nm DOI
Yi Yuan, Zhe Feng, Shengliang Li

et al.

Advanced Materials, Journal Year: 2022, Volume and Issue: 34(19)

Published: March 21, 2022

Materials with long-wavelength second near-infrared (NIR-II) emission are highly desired for in vivo dynamic visualizating of microstructures deep tissues. Herein, by employing an atom-programming strategy, a series fluorescent semiconducting oligomers (SOMs) tunable NIR-IIb emissions developed bioimaging applications. After self-assembly into nanoparticles (NPs), they show good brightness, high photostability, and satisfactory biocompatibility. The SOM NPs applied as probes high-resolution imaging whole-body hind-limb blood vessels, biliary tract, bladder their over 1500 nm. This work demonstrates strategy constructing small molecules enhanced NIR-II fluorescence deep-tissue imaging, affording new insight advancing molecular design fluorophores.

Language: Английский

Citations

72
A Cascade Strategy Boosting Hydroxyl Radical Generation with Aggregation-Induced Emission Photosensitizers-Albumin Complex for Photodynamic Therapy DOI
Yulu Li, Di Zhang, Yuewen Yu

et al.

ACS Nano, Journal Year: 2023, Volume and Issue: 17(17), P. 16993 - 17003

Published: Aug. 22, 2023

Effective photodynamic therapy (PDT) requires photosensitizers (PSs) to massively generate type I reactive oxygen species (ROS) in a less oxygen-dependent manner the hypoxia tumor microenvironment. Herein, we present cascade strategy boost ROS, especially hydroxyl radical (OH·-), generation with an aggregation-induced emission (AIE) photosensitizer-albumin complex for hypoxia-tolerant PDT. The cationic AIE PS TPAQ-Py-PF6 (TPA = triphenylamine, Q anthraquinone, Py pyridine) contains three important moieties cooperatively enhance free generation: AIE-active TPA unit ensures effective triplet exciton aggregate, anthraquinone moiety possesses redox cycling ability promote electron transfer, while methylpyridinium cation further increases intramolecular charge transfer and separation processes. Inserting into hydrophobic domain of bovine serum albumin nanoparticles (BSA NPs) could greatly immobilize its molecular geometry increase generation, electron-rich microenvironment BSA ultimately leads OH·- generation. Both experimental theoretical results confirm effectiveness our cationization immobilization enhancing In vitro vivo experiments validate excellent antitumor PDT performance NPs, superior conventional polymeric encapsulation approach. Such multidimensional specially boosting shall hold great potential related applications.

Language: Английский

Citations

59
Tracking tumor heterogeneity and progression with near‐infrared II fluorophores DOI Creative Commons
Xin Qi, Huizhen Ma, Hao Wang

et al.

Exploration, Journal Year: 2023, Volume and Issue: 3(2)

Published: March 16, 2023

Abstract Heterogeneous cells are the main feature of tumors with unique genetic and phenotypic characteristics, which can stimulate differentially progression, metastasis, drug resistance. Importantly, heterogeneity is pervasive in human malignant tumors, identification degree tumor individual progression a critical task for treatment. However, current medical tests cannot meet these needs; particular, need noninvasive visualization single‐cell heterogeneity. Near‐infrared II (NIR‐II, 1000–1700 nm) imaging exhibits an exciting prospect non‐invasive monitoring due to high temporal‐spatial resolution. More importantly, NIR‐II displays more extended tissue penetration depths reduced backgrounds because significantly lower photon scattering autofluorescence than traditional near‐infrared I (NIR‐I) imaging. In this review, we summarize systematically advances made imaging, especially detection as well As visual inspection modality, shows promising prospects understanding differences envisioned have potential be used clinically.

Language: Английский

Citations

58
Bioactive NIR-II gold clusters for three-dimensional imaging and acute inflammation inhibition DOI Creative Commons
Huizhen Ma, Xiaoning Zhang, Ling Liu

et al.

Science Advances, Journal Year: 2023, Volume and Issue: 9(31)

Published: Aug. 2, 2023

Strong fluorescence and high catalytic activities cannot be achieved simultaneously due to conflicts in free electron utilization, resulting a lack of bioactivity most near-infrared-II (NIR-II) fluorophores. To circumvent this challenge, we developed atomically precise Au22 clusters with strong NIR-II ranging from 950 1300 nm exhibiting potent enzyme-mimetic through atomic engineering create active Cu single-atom sites. The Au21Cu1 show 18-fold higher antioxidant, 90-fold catalase-like, 3-fold superoxide dismutase-like than clusters, negligible loss. Doping single atoms decreases the bandgap 1.33 1.28 eV by predominant contributions d states, lost states effectuates activities. renal clearable can monitor cisplatin-induced injury 20- 120-minute window visualize it three dimensions using light-sheet microscopy. Furthermore, inhibit oxidative stress inflammation cisplatin-treated mouse model, particularly kidneys brain.

Language: Английский

Citations

54