Anti‐Quenching NIR‐II J‐Aggregates of Benzo[c]thiophene Fluorophore for Highly Efficient Bioimaging and Phototheranostics

Advanced Materials, Journal Year: 2023, Volume and Issue: 35(20)

Published: March 3, 2023

Molecular fluorophores with the second near-infrared (NIR-II) emission hold great potential for deep-tissue bioimaging owing to their excellent biocompatibility and high resolution. Recently, J-aggregates are used construct long-wavelength NIR-II emitters as optical bands show remarkable red shifts upon forming water-dispersible nano-aggregates. However, wide applications in fluorescence imaging impeded by limited varieties of J-type backbone serious quenching. Herein, a bright benzo[c]thiophene (BT) J-aggregate fluorophore (BT6) anti-quenching effect is reported highly efficient phototheranostics. The BT manipulated have Stokes shift over 400 nm aggregation-induced (AIE) property conquering self-quenching issue fluorophores. Upon BT6 assemblies an aqueous environment, absorption 800 1000 boosted more than 41 26 folds, respectively. In vivo visualization whole-body blood vessel imaging-guided phototherapy results verify that NPs agent cancer This work develops strategy precisely properties biomedical applications.

Language: Английский

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Fluorination Enhances NIR‐II Emission and Photothermal Conversion Efficiency of Phototheranostic Agents for Imaging‐Guided Cancer Therapy

Advanced Materials, Journal Year: 2022, Volume and Issue: 35(3)

Published: Oct. 27, 2022

Phototheranostics with second near-infrared (NIR-II) imaging and photothermal effect have become a burgeoning biotechnology for tumor diagnosis precise treatment. As important parameters of phototheranostic agents (PTAs), fluorescence quantum yield (QY) conversion efficiency (PCE) are usually considered as pair contradictions that is difficult to be simultaneously enhanced. Herein, fluorination strategy designing A-D-A type PTAs synchronously improved QY PCE proposed. Experimental results show the molar extinction coefficient (ε), NIR-II QY, all fluorinated nanoparticles (NPs) definitely compared chlorinated counterparts. Theoretical calculation demonstrate can maximize electrostatic potential difference by virtue high electronegativity fluorine, which may increase intra/intermolecular D-A interactions, tighten molecule packing, further promote ε, ultimately leading enhanced PCE. In these PTA NPs, FY6-NPs display emission extended 1400 nm highest (4.2%) (80%). These features make perform well in high-resolution vasculature imaging-guided therapy (PTT) tumors. This study develops valuable guideline constructing organic performance.

Language: Английский

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Recent progress in NIR-II fluorescence imaging-guided drug delivery for cancer theranostics

Advanced Drug Delivery Reviews, Journal Year: 2023, Volume and Issue: 197, P. 114821 - 114821

Published: April 9, 2023

Language: Английский

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J‐Aggregation Strategy toward Potentiated NIR‐II Fluorescence Bioimaging of Molecular Fluorophores

Advanced Materials, Journal Year: 2023, Volume and Issue: 36(1)

Published: Aug. 1, 2023

Molecular fluorophores emitting in the second near-infrared (NIR-II, 1000-1700 nm) window with strong optical harvesting and high quantum yields hold great potential for vivo deep-tissue bioimaging high-resolution biosensing. Recently, J-aggregates are harnessed to engineer long-wavelength NIR-II emitters show unique superiority tumor detection, vessel mapping, surgical navigation, phototheranostics due their bathochromic-shifted bands required slip-stacked arrangement aggregation state. However, despite preliminary progress of theoretical study structure-property relationships, further paradigms remain scarce lack on aggregated fashion. In this effort, how utilize specific molecular structure form packing motifs J-type exciton coupling is emphatically elucidated. First, several regulating strategies achieve containing intermolecular interactions external conditions positively summarized deeply analyzed. Then, recent reports theranostics systematically provide a clear reference direction promoting development organic fluorophores. Eventually, prospective efforts ameliorating clinical practices outlined.

Language: Английский

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Engineered NIR-II fluorophores with ultralong-distance molecular packing for high-contrast deep lesion identification

Nature Communications, Journal Year: 2023, Volume and Issue: 14(1)

Published: Aug. 18, 2023

The limited signal of long-wavelength near-infrared-II (NIR-II, 900-1880 nm) fluorophores and the strong background caused by diffused photons make high-contrast fluorescence imaging in vivo with deep tissue disturbed still challenging. Here, we develop NIR-II fluorescent small molecules aggregation-induced emission properties, high brightness, maximal beyond 1200 nm enhancing electron-donating ability reducing donor-acceptor (D-A) distance, to complement scarce bright emissive organic dyes. convincing single-crystal evidence D-A-D molecular structure reveals inhibition π-π stacking ultralong packing distance exceeding 8 Å. delicately-designed nanofluorophores signals extending 1900 match background-suppressed window, enabling signal-to-background ratio image reach over 100 thickness ~4-6 mm. In addition, intraluminal lesions negatively stained can be identified almost zero background. This method provide new avenues for future design biomedical highly scattering tissues.

Language: Английский

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Organic Optoelectronic Materials: A Rising Star of Bioimaging and Phototherapy

Advanced Materials, Journal Year: 2023, Volume and Issue: 36(17)

Published: Aug. 19, 2023

Abstract Recently, many organic optoelectronic materials (OOMs), especially those used in light‐emitting diodes (OLEDs), solar cells (OSCs), and field‐effect transistors (OFETs), are explored for biomedical applications including imaging photoexcited therapies. In this review, recently developed OOMs fluorescence imaging, photoacoustic photothermal therapy, photodynamic summarized. Relationships between their molecular structures, nanoaggregation photophysical mechanisms, properties various discussed. Mainly four kinds of covered: thermally activated delayed OLEDs, conjugated small molecules polymers OSCs, charge‐transfer complexes OFETs. Based on the unique optical properties, excitation light wavelength exciton dynamics, they respectively exploited suitable applications. This review is intended to serve as a bridge researchers area devices Moreover, it provides guidance selecting or modifying high‐performance uses. Current challenges future perspectives also discussed with hope inspiring further development efficient

Language: Английский

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Neutral Cyanine: Ultra‐Stable NIR‐II Merocyanines for Highly Efficient Bioimaging and Tumor‐Targeted Phototheranostics

Advanced Materials, Journal Year: 2024, Volume and Issue: 36(31)

Published: May 21, 2024

Fluorescence imaging (FLI)-guided phototheranostics using emission from the second near-infrared (NIR-II) window show significant potential for cancer diagnosis and treatment. Clinical imaging-used polymethine ionic indocyanine green (ICG) dye is widely adopted NIR fluorescence imaging-guided photothermal therapy (PTT) research due to its exceptional photophysical properties. However, ICG has limitations such as poor photostability, low conversion efficiency (PCE), short-wavelength peak, liver-targeting issues, which restrict wider use. In this study, two derivatives are transformed into neutral merocyanines (mCy) achieve much-enhanced performance NIR-II phototheranostics. Initial designs of dyes similar drawbacks in terms photostability performance. One modified molecules, mCy890, shows significantly improved stability, an peak over 1000 nm, a high PCE 51%, all considerably outperform ICG. vivo studies demonstrate that nanoparticles mCy890 can effectively accumulate at tumor sites guided by imaging. This provides valuable insights development enhanced

Language: Английский

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Biomedical applications of NIR-II organic small molecule fluorescent probes in different organs

Coordination Chemistry Reviews, Journal Year: 2024, Volume and Issue: 519, P. 216122 - 216122

Published: Aug. 6, 2024

Language: Английский

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Aggregation-induced emission fluorophores towards the second near-infrared optical windows with suppressed imaging background

Coordination Chemistry Reviews, Journal Year: 2022, Volume and Issue: 472, P. 214792 - 214792

Published: Sept. 5, 2022

Language: Английский

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Electron‐Withdrawing Substituents Allow Boosted NIR‐II Fluorescence in J‐Type Aggregates for Bioimaging and Information Encryption

Angewandte Chemie International Edition, Journal Year: 2023, Volume and Issue: 62(47)

Published: Oct. 11, 2023

Developing molecular fluorophores with enhanced fluorescence in aggregate state for the second near-infrared (NIR-II) imaging is highly desirable but remains a tremendous challenge due to lack of reliable design guidelines. Herein, we report an aromatic substituent strategy construct bright NIR-II J-aggregates. Introduction electron-withdrawing substituents at 3,5-aryl and meso positions classic boron dipyrromethene (BODIPY) skeleton can promote slip-stacked J-type arrangement further boost J-aggregates via increased electrostatic repulsion intermolecular hydrogen bond interaction. Notably, NOBDP-NO2 three nitro groups (-NO2 ) shows intense 1065 nm high absolute quantum yield 3.21 % solid state, which be successfully applied bioimaging, high-level encoding encryption, information storage. Moreover, guided by this strategy, other skeletons (thieno-fused BODIPY, aza-BODIPY, heptamethine cyanine) modified -NO2 are converted into aggregates fluorescence, showing great potential convert aggregation caused emission quenching (ACQ) dyes brilliant This study provides universal method construction strong emissive rationally manipulating packing establishing relationships among structures, interactions, properties.

Language: Английский

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