Integrating Bacteria with a Ternary Combination of Photosensitizers for Monochromatic Irradiation-Mediated Photoacoustic Imaging-Guided Synergistic Photothermal Therapy

ACS Nano, Journal Year: 2023, Volume and Issue: 17(5), P. 5059 - 5071

Published: Feb. 27, 2023

Photosensitizer-based therapy often suffers from unitary and easily attenuated photosensitive effects, limited tumor penetration retention, requirement of multiple irradiation for combination therapy, which largely restrict its application. Here, bacteria are integrated with a monochromatic irradiation-mediated ternary photosensitizers photoacoustic imaging-guided synergistic photothermal therapy. Bacteria that bioengineered to express natural melanin decorated dual synthetic by nanodeposition indocyanine green polydopamine under cytocompatible condition. The combined photosensitizers, share an adequate excitation at 808 nm, endow stable triple effect irradiation. Due their living characteristics, these preferentially colonize hypoxic tissue homogeneous distribution durable retention generate uniform imaging signals sufficient heating upon laser Supported significantly inhibited growth extended survival animals in different tumor-bearing murine models, our work proposes the development bacteria-based innovative

Language: Английский

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Self-triggered thermoelectric nanoheterojunction for cancer catalytic and immunotherapy

Nature Communications, Journal Year: 2023, Volume and Issue: 14(1)

Published: Aug. 23, 2023

The exogenous excitation requirement and electron-hole recombination are the key elements limiting application of catalytic therapies. Here a tumor microenvironment (TME)-specific self-triggered thermoelectric nanoheterojunction (Bi0.5Sb1.5Te3/CaO2 nanosheets, BST/CaO2 NSs) with self-built-in electric field facilitated charge separation is fabricated. Upon exposure to TME, CaO2 coating undergoes rapid hydrolysis, releasing Ca2+, H2O2, heat. resulting temperature difference on BST NSs initiates effect, driving reactive oxygen species production. H2O2 not only serves as substrate supplement for ROS generation but also dysregulates Ca2+ channels, preventing efflux. This further exacerbates calcium overload-mediated therapy. Additionally, promotes DC maturation antigen presentation, facilitating immunotherapy. It worth noting that NP hydrolyzes very slowly in normal cells, O2 without causing any adverse effects. Tumor-specific combined therapy, ion interference immunotherapy exhibit excellent antitumor performance female mice.

Language: Английский

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Two-dimensional porous vermiculite-based nanocatalysts for synergetic catalytic therapy

Biomaterials, Journal Year: 2023, Volume and Issue: 295, P. 122031 - 122031

Published: Jan. 28, 2023

Language: Английский

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Biomimetic piezoelectric nanomaterial-modified oral microrobots for targeted catalytic and immunotherapy of colorectal cancer

Science Advances, Journal Year: 2024, Volume and Issue: 10(19)

Published: May 8, 2024

Lactic acid (LA) accumulation in the tumor microenvironment poses notable challenges to effective immunotherapy. Here, an intelligent treatment microrobot based on unique physiological structure and metabolic characteristics of

Language: Английский

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Catalytic activity of violet phosphorus-based nanosystems and the role of metabolites in tumor therapy

Nature Communications, Journal Year: 2024, Volume and Issue: 15(1)

Published: Aug. 8, 2024

Although nanocatalytic medicine has demonstrated its advantages in tumor therapy, the outcomes heavily relie on substrate concentration and metabolic pathways are still indistinct. We discover that violet phosphorus quantum dots (VPQDs) can catalyze production of reactive oxygen species (ROS) without requiring external stimuli catalytic substrates confirmed to be (O2) hydrogen peroxide (H2O2) through computational simulation experiments. Considering short O2 H2O2 at site, we utilize calcium (CaO2) supply for VPQDs construct nanoparticles together with them, named VPCaNPs. VPCaNPs induce oxidative stress cells, particularly characterized by a significant increase hydroxyl radicals superoxide radicals, which cause substantial damage structure function ultimately leading cell apoptosis. Intriguingly, provided CaO2 degrade slowly, degradation product, phosphate, as well CaO2-generated ions, promote calcification. Antitumor immune activation less metastasis also observed administrated animals. In conclusion, our study unveils anti-tumor activity catalysts generating cytotoxic ROS products calcification, providing promising strategy treating tumors.

Language: Английский

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Symmetrical Localized Built-in Electric Field by Induced Polarization Effect in Ionic Covalent Organic Frameworks for Selective Imaging and Killing Bacteria

ACS Nano, Journal Year: 2024, Volume and Issue: 18(5), P. 4539 - 4550

Published: Jan. 23, 2024

Photocatalytic materials are some of the most promising substitutes for antibiotics. However, antibacterial efficiency is still inhibited by rapid recombination photogenerated carriers. Herein, we design a cationic covalent organic framework (COF), which has symmetrical localized built-in electric field due to induced polarization effect caused electron-transfer reaction between Zn-porphyrin unit and guanidinium unit. Density functional theory calculations indicate that there electrophilic/nucleophilic region in COF structure, results from increased electron density around The formed local can further inhibit carriers driving transfer under light irradiation, greatly increases yield reactive oxygen species. This wrapped DSPE-PEG2000 selectively target lipoteichoic acid Gram-positive bacteria electrostatic interaction, be used selective discrimination imaging bacteria. Furthermore, this nanoparticle rapidly kill including 99.75% Staphylococcus aureus 99.77% Enterococcus faecalis at an abnormally low concentration (2.00 ppm) irradiation 20 min. work will provide insight into designing photoresponsive COFs through engineering charge behavior.

Language: Английский

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Surface oxygen vacancy engineering in weak Bi–O bonded ferroelectric bismuth sodium titanate for boosting the photocatalytic CO₂ reduction reaction

Journal of Materials Chemistry A, Journal Year: 2024, Volume and Issue: 12(16), P. 9661 - 9671

Published: Jan. 1, 2024

A novel ferroelectric photocatalyst modulated by the surface and polarization states is developed to promote CO 2 reduction reaction, lattice distortion elemental coordination environment are elaborated in detail.

Language: Английский

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Fabrication of Interface Engineered S‐Scheme Heterojunction Nanocatalyst for Ultrasound‐Triggered Sustainable Cancer Therapy

Advanced Science, Journal Year: 2024, Volume and Issue: 11(15)

Published: Feb. 11, 2024

Abstract In order to establish a set of perfect heterojunction designs and characterization schemes, step‐scheme (S‐scheme) BiOBr@Bi 2 S 3 nanoheterojunctions that enable the charge separation expand scope catalytic reactions, aiming promote development improvement engineering is developed. this kind system, Fermi levels mediate formation internal electric field at interface guide recombination weak redox carriers, while strong carriers are retained. Thus, these high‐energy electrons holes able catalyze variety substrates in tumor microenvironment, such as reduction oxygen carbon dioxide superoxide radicals monoxide (CO), oxidation H O hydroxyl radicals, thus achieving sonodynamic therapy CO combined therapy. Mechanistically, generated reactive species damage DNA inhibit cancer cell energy levels, respectively, synergistically induce apoptosis. This study provides new insights into realization high efficiency low toxicity from unique perspective materials design. It anticipated therapeutic method will garner significant interest sonocatalytic nanomedicine field.

Language: Английский

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A high-valence bismuth(V) nanoplatform triggers cancer cell death and anti-tumor immune responses with exogenous excitation-free endogenous H2O2- and O2-independent ROS generation

Nature Communications, Journal Year: 2025, Volume and Issue: 16(1)

Published: Jan. 20, 2025

Language: Английский

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Nanoheterojunction‐Mediated Thermoelectric Strategy for Cancer Surgical Adjuvant Treatment and β‐Elemene Combination Therapy

Advanced Materials, Journal Year: 2022, Volume and Issue: 35(8)

Published: Nov. 9, 2022

As an indispensable strategy for tumor treatment, surgery may cause two major challenges: recurrence and wound infection. Here, a thermoelectric therapeutic is provided as either independent cancer therapy or surgical adjuvant treatment. Bi0.5 Sb1.5 Te3 (BST) Bi2 Te2.8 Se0.2 (BTS) nanoplates composed of Z-scheme heterojunction (BST/BTS) are fabricated via two-step hydrothermal processes. The contact between BST BTS constructs interfacial electric field due to Fermi energy level rearrangement, guiding electrons in the conductive band (CB) combine with holes valance (VB) BST, leaving stronger reduction/oxidation potentials CB VB BTS. Moreover, under mild temperature gradient, another self-built-in formed facilitating migration their surfaces. Based on PEGylated BST/BTS heterojunction, novel platform developed through intravenous injection external cooling tumors. This also proved effective combination β-elemene. hydrogel administrated after surgery, achieving efficient residual treatment antibacterial effects.

Language: Английский

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