Microrobotics in endodontics: A perspective DOI Open Access
Alaa Babeer, Sarah Bukhari,

Rayan Al-Rehaili

et al.

International Endodontic Journal, Journal Year: 2024, Volume and Issue: 57(7), P. 861 - 871

Published: May 18, 2024

Microorganisms are the primary aetiological factor of apical periodontitis. The goal endodontic treatment is to prevent and eliminate infection by removing microorganisms. However, microbial biofilms complex root canal anatomy impair disinfection process. Effective precise therapy could potentially be achieved using advanced multifunctional technologies that have ability access hard-to-reach surfaces perform simultaneous biofilm killing, removal, detection Advances in microrobotics providing novel therapeutic diagnostic opportunities with high precision efficacy address current biofilm-related challenges biomedicine. Concurrently, magnetic microrobots been developed overcome approaches disrupt, kill, retrieve enhancing therapy. This article reviews recent advances healthcare particularly endodontics, provides perspectives for future research field.

Language: Английский

Magnetically Actuated Continuum Medical Robots: A Review DOI Creative Commons
Zhengxin Yang, Haojin Yang, Yanfei Cao

et al.

Advanced Intelligent Systems, Journal Year: 2023, Volume and Issue: 5(6)

Published: March 1, 2023

The magnetic field has unique advantages in manipulating miniature robots working inside the human body, such as high transparency to biological tissue and good controllability for generation. Generally, actuated robot can be classified into two categories: tethered devices like intravascular microcatheters untethered helical swimmers. Among these, have a long history clinical application prospects, considering their high‐dose delivery easy removal after procedure. As an evolution of traditional continuum medical devices, integration with actuation provides them better scalability improved dexterity. Although rapidly developed last decades, requires further advancements terms design, fabrication, modeling, control, especially applications. Herein, recent progress magnetically is focused on, intending offer readers comprehensive survey state‐of‐the‐art technologies information collection future system design.

Language: Английский

Citations

69
Fully Recyclable, Healable, Soft, and Stretchable Dynamic Polymers for Magnetic Soft Robots DOI Creative Commons
Guangda Zhu, Yi Hou, Neng Xia

et al.

Advanced Functional Materials, Journal Year: 2023, Volume and Issue: 33(31)

Published: April 14, 2023

Abstract Magnetic soft robots capable of wirelessly controlled programmable deformation and locomotion are desirable for diverse applications. Such multi‐variable actuation ideally requires a polymer matrix with well‐defined range softness stretchability (Young's modulus 0.1–10 MPa, high >200%). However, this defined mechanical excludes most candidates, leaving only limited number available polymers (e.g., PDMS, Ecoflex) covalently cross‐linked networks that may lead to non‐recyclable further potential threats environment. Herein, based on the synergistic effects reduced cross‐linking density intermolecular hydrogen bonding, dynamic covalent polyimine is newly designed as magnetic microparticles fillers, integrate stretchability, full chemical recyclability, rapid room‐temperature healability multimodal into single robot. The stretchable enough process in various geometries by simple laser cutting, without need pre‐design geometry suit target scenarios. Through cyclic depolymerization/repolymerization, recycling restores 100% robots’ properties deformability/mobility their original level within seconds heals quickly minutes when damaged, facilitating ideal material economy

Language: Английский

Citations

43
Light-triggered multi-joint microactuator fabricated by two-in-one femtosecond laser writing DOI Creative Commons
Xin Chen,

Zhongguo Ren,

Leran Zhang

et al.

Nature Communications, Journal Year: 2023, Volume and Issue: 14(1)

Published: July 17, 2023

Inspired by the flexible joints of humans, actuators containing soft have been developed for various applications, including grippers, artificial muscles, and wearable devices. However, integrating multiple microjoints into robots at micrometer scale to achieve multi-deformation modalities remains challenging. Here, we propose a two-in-one femtosecond laser writing strategy fabricate composed hydrogel metal nanoparticles, develop multi-joint microactuators with (>10), requiring short response time (30 ms) low actuation power (<10 mW) deformation. Besides, independent joint deformation control linkage deformation, co-planar spatial linkage, enables microactuator reconstruct variety complex human-like modalities. Finally, as proof concept, collection microcargos different locations is achieved double-joint micro robotic arm. Our will bring many potential application opportunities in microcargo collection, microfluid operation, cell manipulation.

Language: Английский

Citations

43
Materials consideration for the design, fabrication and operation of microscale robots DOI
Chuanrui Chen, Shichao Ding, Joseph Wang

et al.

Nature Reviews Materials, Journal Year: 2024, Volume and Issue: 9(3), P. 159 - 172

Published: Feb. 8, 2024

Language: Английский

Citations

34
Engineered Probiotic Bio‐heterojunction with Robust Antibiofilm Modality via “Eating” Extracellular Polymeric Substances for Wound Regeneration DOI

Miao Qin,

Xiumei Zhang, Haiyang Ding

et al.

Advanced Materials, Journal Year: 2024, Volume and Issue: 36(35)

Published: June 25, 2024

The compact three-dimensional (3D) structure of extracellular polymeric substances (EPS) within biofilms significantly hinders the penetration antimicrobial agents, making biofilm eradication challenging and resulting in persistent biofilm-associated infections. To address this challenge, a solution is proposed: probiotic bio-heterojunction (P-bioHJ) combining Lactobacillus rhamnosus with MXene (Ti

Language: Английский

Citations

28
Chemical multiscale robotics for bacterial biofilm treatment DOI Creative Commons
Carmen C. Mayorga‐Martinez, Li Zhang, Martin Pumera

et al.

Chemical Society Reviews, Journal Year: 2024, Volume and Issue: 53(5), P. 2284 - 2299

Published: Jan. 1, 2024

A biofilm constitutes a bacterial community encased in sticky matrix of extracellular polymeric substances. These intricate microbial communities adhere to various host surfaces such as hard and soft tissues well indwelling medical devices. aggregates form robust substances (EPSs), leading the majority human infections. Such infections tend exhibit high resistance treatment, often progressing into chronic states. The EPS protects bacteria from hostile environment prevents penetration antibacterial agents. Modern robots at nano, micro, millimeter scales are highly attractive candidates for biomedical applications due their diverse functionalities, navigating confined spaces targeted multitasking. In this tutorial review, we describe key milestones strategies developed removal eradication biofilms using different sizes shapes. It can be seen that useful effective tools treating biofilms, thus preventing persistent infections, loss costly implanted devices, additional costs associated with hospitalization therapies.

Language: Английский

Citations

21
Micro- and nanorobots for biofilm eradication DOI
Bonan Sun, Staffan Kjelleberg, Joseph J.�Y. Sung

et al.

Nature Reviews Bioengineering, Journal Year: 2024, Volume and Issue: 2(5), P. 367 - 369

Published: March 15, 2024

Language: Английский

Citations

21
Low-Friction Soft Robots for Targeted Bacterial Infection Treatment in Gastrointestinal Tract DOI Creative Commons
Ben Wang,

Yunrui Chen,

Zhicheng Ye

et al.

Cyborg and Bionic Systems, Journal Year: 2024, Volume and Issue: 5

Published: Jan. 1, 2024

Untethered and self-transformable miniature robots are capable of performing reconfigurable deformation on-demand locomotion, which aid the traversal toward various lumens, bring revolutionary changes for targeted delivery in gastrointestinal (GI) tract. However, viscous non-Newtonian liquid environment plicae gastricae obstacles severely hamper high-precision actuation payload delivery. Here, we developed a low-friction soft robot by assembly densely arranged cone structures grafting hydrophobic monolayers. The magnetic orientation encoded can move multiple modes, with substantially reduced drag, terrain adaptability, improved motion velocity across liquids. Notably, stiffness be reversibly controlled magnetically induced hardening, enabling on-site scratching destruction antibiotic-ineradicable polymeric matrix biofilms low-frequency field. Furthermore, magnetocaloric effect utilized to eradicate bacteria under high-frequency alternating To verify potential applications inside body, clinical imaging-guided platforms were vision-based control robots. show their high perform bacterial infection therapy lumens body.

Language: Английский

Citations

18
Biohybrid microrobots locally and actively deliver drug-loaded nanoparticles to inhibit the progression of lung metastasis DOI Creative Commons
Fangyu Zhang, Zhongyuan Guo, Zhengxing Li

et al.

Science Advances, Journal Year: 2024, Volume and Issue: 10(24)

Published: June 12, 2024

Lung metastasis poses a formidable challenge in the realm of cancer treatment, with conventional chemotherapy often falling short due to limited targeting and low accumulation lungs. Here, we show microrobot approach using motile algae for localized delivery drug-loaded nanoparticles address lung challenges. The biohybrid [denoted “algae-NP(DOX)-robot”] combines green microalgae red blood cell membrane–coated containing doxorubicin, representative chemotherapeutic drug. Microalgae provide autonomous propulsion lungs, leveraging controlled drug release enhanced dispersion exert antimetastatic effects. Upon intratracheal administration, algae-NP(DOX)-robots efficiently transport their payload deep into lungs while maintaining continuous motility. This strategy leads rapid distribution, improved tissue accumulation, prolonged retention compared passive free controls. In melanoma model, exhibit substantial improvement therapeutic efficacy, reducing metastatic burden extending survival control groups.

Language: Английский

Citations

18
A Bioinspired Virus‐Like Mechano–Bactericidal Nanomotor for Ocular Multidrug‐Resistant Bacterial Infection Treatment DOI Open Access
Hengrui Zhang, Dewei Li,

Huifang Ren

et al.

Advanced Materials, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 13, 2025

Abstract Multidrug‐resistant (MDR) bacteria and their associated biofilms are major causative factors in eye infections, often resulting blindness presenting considerable global health challenges. Presently, mechano–bactericidal systems, which combine distinct topological geometries with mechanical forces to physically induce bacterial apoptosis, show promising potential. However, the physical interaction process between current systems is generally based on passive diffusion or Brownian motion lacks force required for biofilm penetration; thus, featuring low antibacterial efficacy. Here, a biomimetic nanomotor (VMSNT) synthesized by functionalizing COOH‐PEG‐phenylboronic acid (PBA) virus‐like mesoporous silica, subsequent partial coating of Au caps. Enhanced self‐thermophoresis capabilities shapes, VMSNT significantly improves effects penetration. In addition, scanning electron microscope (SEM) confocal laser (CLSM) analyses demonstrate that can precisely target within infection microenvironment, facilitated PBA's ability recognize bind peptidoglycan surfaces. Remarkably, also effective eliminating MDR reducing inflammation mice models methicillin‐resistant Staphylococcus aureus (MRSA) ‐infected keratitis endophthalmitis, minimal adverse effects. Overall, such presents approach addressing challenges ocular infections.

Language: Английский

Citations

2