Communicating clocks shape circadian homeostasis

Science, Journal Year: 2021, Volume and Issue: 371(6530)

Published: Feb. 11, 2021

Regulating multiple body clocks Circadian rhythms that affect tissues and organ systems are aligned with the dark-light cycle other external inputs such as feeding. But how is time keeping modulated throughout complex anatomical regions? Koronowski Sassone-Corsi reviewed central regulators in brain peripheral organs can behave cooperatively or independently to modulate circadian rhythms. This systemic view of rhythm modulation important understand behavior disease, because dysregulated associated metabolic syndrome cancer. Science , this issue p. eabd0951

Language: Английский

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Systematic analysis of differential rhythmic liver gene expression mediated by the circadian clock and feeding rhythms

Proceedings of the National Academy of Sciences, Journal Year: 2021, Volume and Issue: 118(3)

Published: Jan. 15, 2021

The circadian clock and feeding rhythms are both important regulators of rhythmic gene expression in the liver. To further dissect respective contributions clock, we analyzed differential rhythmicity liver tissue samples across several conditions. We developed a statistical method tailored to compare messenger RNA (mRNA) mouse knockout models multiple genes, as well PARbZip output transcription factors (Hlf/Dbp/Tef). Mice were exposed ad libitum or night-restricted under regular light-dark cycles. During feeding, genetic ablation core attenuated rhythmic-feeding patterns, which could be restored by regimen. High-amplitude mRNA wild-type livers driven but also contributed expression, albeit with significantly lower amplitudes. observed that Bmal1 Cry1/2 knockouts differed their residual expression. Differences mean levels between wild types correlated type. Surprisingly, mice, targets more strongly impacted than rhythms, potentially due activity D-box-repressor NFIL3. Genes lost identified indirect targets. Our findings provide insights into diurnal transcriptome regulators. In addition, gained on specific effects feeding-fasting cycle.

Language: Английский

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Space-time logic of liver gene expression at sub-lobular scale

Nature Metabolism, Journal Year: 2021, Volume and Issue: 3(1), P. 43 - 58

Published: Jan. 11, 2021

Language: Английский

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The liver-clock coordinates rhythmicity of peripheral tissues in response to feeding

Nature Metabolism, Journal Year: 2021, Volume and Issue: 3(6), P. 829 - 842

Published: May 31, 2021

Language: Английский

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Interorgan rhythmicity as a feature of healthful metabolism

Cell Metabolism, Journal Year: 2024, Volume and Issue: 36(4), P. 655 - 669

Published: Feb. 8, 2024

Language: Английский

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Brain-muscle communication prevents muscle aging by maintaining daily physiology

Science, Journal Year: 2024, Volume and Issue: 384(6695), P. 563 - 572

Published: May 2, 2024

A molecular clock network is crucial for daily physiology and maintaining organismal health. We examined the interactions importance of intratissue networks in muscle tissue maintenance. In arrhythmic mice showing premature aging, we created a basic module involving central peripheral (muscle) clock. Reconstituting brain-muscle sufficient to preserve fundamental homeostatic functions prevent aging. However, achieving whole requires contributions from other clocks. Mechanistically, acts as gatekeeper, selectively suppressing detrimental signals while integrating important functions. Our research reveals interplay between clocks function underscores impact eating patterns on these interactions.

Language: Английский

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Circadian clock communication during homeostasis and ageing

Nature Reviews Molecular Cell Biology, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 3, 2025

Language: Английский

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Circadian clocks in the digestive system

Nature Reviews Gastroenterology & Hepatology, Journal Year: 2021, Volume and Issue: 18(4), P. 239 - 251

Published: Feb. 2, 2021

Language: Английский

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Interconnections between circadian clocks and metabolism

Journal of Clinical Investigation, Journal Year: 2021, Volume and Issue: 131(15)

Published: Aug. 1, 2021

Circadian rhythms evolved through adaptation to daily light/dark changes in the environment; they are believed be regulated by core circadian clock interlocking feedback loop. Recent studies indicate that each component executes general and specific functions metabolism. Here, we review current understanding of role these genes regulation metabolism using various genetically modified animal models. Additionally, emerging evidence shows exposure environmental stimuli, such as artificial light, unbalanced diet, mistimed eating, exercise, remodels physiological processes causes metabolic disorders. This Review summarizes reciprocal between metabolism, highlights remaining gaps knowledge about examines potential applications human health disease.

Language: Английский

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Integration of feeding behavior by the liver circadian clock reveals network dependency of metabolic rhythms

Science Advances, Journal Year: 2021, Volume and Issue: 7(39)

Published: Sept. 22, 2021

The mammalian circadian clock, expressed throughout the brain and body, controls daily metabolic homeostasis. Clock function in peripheral tissues is required, but not sufficient, for this task. Because of lack specialized animal models, it unclear how tissue clocks interact with extrinsic signals to drive molecular oscillations. Here, we isolated interaction between feeding liver clock by reconstituting Bmal1 exclusively hepatocytes (Liver-RE), otherwise clock-less mice, controlling timing food intake. We found that cooperative action BMAL1 transcription factor CEBPB regulates transcriptional programs. Functionally, rhythm are sufficient temporal carbohydrate By contrast, rhythms tied redox lipid metabolism required communication skeletal muscle demonstrating cross-talk. Our results highlight inner workings system rely on communicating maintain metabolism.

Language: Английский

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