Colonization with the enteric protozoa Blastocystis is associated with increased diversity of human gut bacterial microbiota DOI Creative Commons
Christophe Audebert, Gaël Even,

Amandine Cian

et al.

Scientific Reports, Journal Year: 2016, Volume and Issue: 6(1)

Published: May 5, 2016

Abstract Alterations in the composition of commensal bacterial populations, a phenomenon known as dysbiosis, are linked to multiple gastrointestinal disorders, such inflammatory bowel disease and irritable syndrome, or infections by diverse enteric pathogens. Blastocystis is one most common single-celled eukaryotes detected human faecal samples. However, clinical significance this widespread colonization remains unclear, its pathogenic potential controversial. To address issue pathogenicity, we investigated impact protist on gut microbiota. For that purpose, conducted cross-sectional study including 48 -colonized patients -free subjects performed an Ion Torrent 16S rDNA gene sequencing decipher -associated Here, report higher diversity microbiota colonized patients, abundance Clostridia well lower Enterobacteriaceae. Our results contribute suggesting usually associated with healthy microbiota, rather than dysbiosis generally observed metabolic infectious diseases tract.

Language: Английский

The Gut Microbiota in Immune-Mediated Inflammatory Diseases DOI Creative Commons

Jessica D. Forbes,

Gary Van Domselaar, Çharles N. Bernstein

et al.

Frontiers in Microbiology, Journal Year: 2016, Volume and Issue: 7

Published: July 11, 2016

The collection of microbes and their genes that exist within on the human body, collectively known as microbiome has emerged a principal factor in health disease. Humans have established symbiotic association over time, perturbations this been linked to several immune-mediated inflammatory diseases (IMID) including bowel disease, rheumatoid arthritis multiple sclerosis. IMID is term used describe group chronic, highly disabling affect different organ systems. Though cornerstone commonality between idiopathic nature considerable portion pathobiology overlaps epidemiological co-occurrence, genetic susceptibility loci environmental risk factors. At present, it clear persons with an are at increased for developing comorbidities, additional IMID. Advancements sequencing technologies parallel explosion 16S rDNA metagenomics community profiling studies allowed characterization microbiomes throughout body gut, myriad health. main challenge now determine if alterations gut flora common or, particular changes fact specific single Herein, we review discuss relationships microbiota Keywords: microbiome, systems microbiology metagenome, chronic immune mediated

Language: Английский

Citations

385
Bifidobacteria and Their Health-Promoting Effects DOI
Claudio Hidalgo-Cantabrana, Susana Delgado, Lorena Ruíz

et al.

Microbiology Spectrum, Journal Year: 2017, Volume and Issue: 5(3)

Published: May 19, 2017

ABSTRACT Bifidobacteria are members of the intestinal microbiota mammals and other animals, some strains able to exert health-promoting effects. The genus Bifidobacterium belongs Actinobacteria phylum. Firmicutes , Bacteroidetes constitute most abundant phyla in human microbiota, being predominant adults, breast-fed infants, where bifidobacteria can reach levels higher than 90% total bacterial population. They among first microbial colonizers intestines newborns, play key roles development their physiology, including maturation immune system use dietary components. Indeed, nutrients, such as milk oligosaccharides, important drivers bifidobacterial development. Some considered probiotic microorganisms because beneficial effects, they have been included bioactive ingredients functional foods, mainly dairy products, well food supplements pharma alone, or together with, microbes substrates. Well-documented scientific evidence activities is currently available for bifidobacteria-containing preparations extraintestinal pathologies. In this review, we focus on role probiotics prevention treatment disease.

Language: Английский

Citations

379
The dormant blood microbiome in chronic, inflammatory diseases DOI Creative Commons

Marnie Potgieter,

Janette Bester, Douglas B. Kell

et al.

FEMS Microbiology Reviews, Journal Year: 2015, Volume and Issue: 39(4), P. 567 - 591

Published: May 3, 2015

Blood in healthy organisms is seen as a 'sterile' environment: it lacks proliferating microbes. Dormant or not-immediately-culturable forms are not absent, however, intracellular dormancy well established. We highlight here that great many pathogens can survive blood and inside erythrocytes. 'Non-culturability', reflected by discrepancies between plate counts total counts, commonplace environmental microbiology. It overcome improved culturing methods, we asked how common this would be blood. A number of recent, sequence-based ultramicroscopic studies have uncovered an authentic microbiome non-communicable diseases. The chief origin these microbes the gut (especially when shifts composition to pathogenic state, known 'dysbiosis'). Another source translocated from oral cavity. 'Dysbiosis' also used describe translocation cells into other tissues. To avoid ambiguity, use term 'atopobiosis' for appear places than their normal location. Atopobiosis may contribute dynamics variety inflammatory Overall, seems more chronic, non-communicable, diseases microbial component presently considered, treatable using bactericidal antibiotics vaccines.

Language: Английский

Citations

373
Control of lupus nephritis by changes of gut microbiota DOI Creative Commons

Qinghui Mu,

Husen Zhang,

Xiaofeng Liao

et al.

Microbiome, Journal Year: 2017, Volume and Issue: 5(1)

Published: July 11, 2017

Systemic lupus erythematosus, characterized by persistent inflammation, is a complex autoimmune disorder with no known cure. Immunosuppressants used in treatment put patients at higher risk of infections. New knowledge disease modulators, such as symbiotic bacteria, can enable fine-tuning parts the immune system, rather than suppressing it altogether.

Language: Английский

Citations

360
Lupus nephritis is linked to disease-activity associated expansions and immunity to a gut commensal DOI Creative Commons
Doua F. Azzouz,

Aidana Omarbekova,

Adriana Heguy

et al.

Annals of the Rheumatic Diseases, Journal Year: 2019, Volume and Issue: 78(7), P. 947 - 956

Published: Feb. 19, 2019

Background/Purpose To search for a transmissible agent involved in lupus pathogenesis, we investigated the faecal microbiota of patients with systemic erythematosus (SLE) candidate pathobiont(s) and evaluated them special relationships host immunity. Methods In cross-sectional discovery cohort, matched blood samples from 61 female SLE were obtained. Faecal 16 S rRNA analyses performed, sera profiled antibacterial autoantibody responses, findings validated two independent cohorts. Results Compared controls, microbiome showed decreased species richness diversity, reductions taxonomic complexity most pronounced those high disease activity index (SLEDAI). Notably, had an overall 5-fold greater representation Ruminococcus gnavus ( RG ) Lachnospiraceae family, individual communities also displayed reciprocal contractions putative protective properties. Gut abundance correlated serum antibodies to only 1/8 strains tested. Anti-RG directly SLEDAI score antinative DNA levels, but inversely C3 C4. These primarily against antigen(s) strain-restricted pool cell wall lipoglycans. Novel structural features these purified lipoglycans characterised by mass spectrometry NMR. Highest levels anti- detected active nephritis (including Class III IV) Conclusion suggest novel paradigm which specific gut commensal may contribute immune pathogenesis nephritis.

Language: Английский

Citations

356
Role of the Gut Microbiome in Uremia: A Potential Therapeutic Target DOI
Ali Ramezani, Ziad A. Massy, Björn Meijers

et al.

American Journal of Kidney Diseases, Journal Year: 2015, Volume and Issue: 67(3), P. 483 - 498

Published: Nov. 15, 2015

Language: Английский

Citations

339
Gut microbiota-derived metabolites in the regulation of host immune responses and immune-related inflammatory diseases DOI Open Access
Wenjing Yang, Yingzi Cong

Cellular and Molecular Immunology, Journal Year: 2021, Volume and Issue: 18(4), P. 866 - 877

Published: March 11, 2021

Language: Английский

Citations

333
Quantitative metagenomics reveals unique gut microbiome biomarkers in ankylosing spondylitis DOI Creative Commons
Chengping Wen,

Zhijun Zheng,

Tiejuan Shao

et al.

Genome biology, Journal Year: 2017, Volume and Issue: 18(1)

Published: July 27, 2017

The assessment and characterization of the gut microbiome has become a focus research in area human autoimmune diseases. Ankylosing spondylitis is an inflammatory disease evidence showed that ankylosing may be microbiome-driven disease. To investigate relationship between spondylitis, quantitative metagenomics study based on deep shotgun sequencing was performed, using microbial DNA from 211 Chinese individuals. A total 23,709 genes 12 metagenomic species were shown to differentially abundant patients healthy controls. Patients characterized by form dysbiosis more prominent than previously reported cases with bowel Specifically, demonstrated increases abundance Prevotella melaninogenica, copri, sp. C561 decreases Bacteroides spp. It noteworthy Bifidobacterium genus, which commonly used probiotics, accumulated patients. Diagnostic algorithms established subset these biomarkers. Alterations are associated development spondylitis. Our data suggest biomarkers identified this might participate pathogenesis or process providing new leads for diagnostic tools potential treatments.

Language: Английский

Citations

322
The Oral Microbiota Is Modified by Systemic Diseases DOI
Dana T. Graves, Jôice Dias Corrêa, Tarcı́lia Aparecida Silva

et al.

Journal of Dental Research, Journal Year: 2018, Volume and Issue: 98(2), P. 148 - 156

Published: Oct. 25, 2018

Periodontal diseases are initiated by bacteria that accumulate in a biofilm on the tooth surface and affect adjacent periodontal tissue. Systemic such as diabetes, rheumatoid arthritis (RA), systemic lupus erythematosus (SLE) increase susceptibility to destructive diseases. In human studies animal models, these have been shown enhance inflammation periodontium risk or severity of periodontitis. All 3 linked decrease bacterial taxa associated with health an disease. Although there is controversy regarding specific oral changes each disease, it has reported diabetes increases levels Capnocytophaga, Porphyromonas, Pseudomonas, while Prevotella Selenomonas increased RA Selenomonas, Leptotrichia, SLE. model, pathogenicity microbiome, inflammation, osteoclastogenesis, bone loss when transferred normal germ-free hosts. Moreover, diabetic animals, could be substantially reversed inhibition IL-17, indicating host altered microbial pathogenicity. Increased IL-17 also SLE, RA, leukocyte adhesion deficiency may contribute Successful treatment anti-inflammatory drugs partially reverses dysbiosis. Together, data demonstrate characterized enhanced disturb microbiota point key mediator this process.

Language: Английский

Citations

307
Intestinal dysbiosis and probiotic applications in autoimmune diseases DOI Open Access
Gislane Lelis Vilela de Oliveira,

Aline Zazeri Leite,

Bruna Stevanato Higuchi

et al.

Immunology, Journal Year: 2017, Volume and Issue: 152(1), P. 1 - 12

Published: May 29, 2017

In humans, a complex interaction between the host immune system and commensal microbiota is required to maintain gut homeostasis. this symbiotic relationship, provides carbohydrate fermentation digestion, vitamin synthesis gut-associated lymphoid tissue development, as well preventing colonization by pathobionts, whereas offers niche nutrients for survival of microbiota. However, when mutualistic relationship compromised an altered cells microorganisms occurs, may cause or contribute establishment infectious diseases trigger autoimmune diseases. Researchers have made efforts clarify role in disease development find new therapeutic approaches treat immune-mediated exact mechanisms involved dysbiosis breakdown epithelial barrier are currently unknown. Here, we provide general overview studies describing perturbations animal models diseases, such type 1 diabetes, multiple sclerosis, rheumatoid arthritis systemic lupus erythematosus. Moreover, include main concerning humans critical discussion existing data on use probiotics these

Language: Английский

Citations

299