International Journal of Molecular Sciences,
Journal Year:
2025,
Volume and Issue:
26(2), P. 720 - 720
Published: Jan. 16, 2025
Staphylococcus
aureus,
a
common
pathogen,
is
capable
of
producing
significant
array
toxins
and
can
develop
biofilms
or
small
colony
variants
(SCVs)
to
evade
detection
by
the
immune
system
resist
effects
antibiotics.
Its
ability
persist
for
extended
periods
within
host
cells
has
led
increased
research
interest.
This
review
examines
process
internalization
S.
highlighting
impact
its
adhesion
factors
on
cells.
It
elucidates
intricate
interactions
between
them
cellular
environment,
thereby
offering
potential
strategies
treatment
prevention
aureus
infections.
Antibiotics,
Journal Year:
2023,
Volume and Issue:
12(2), P. 328 - 328
Published: Feb. 4, 2023
Most
bacteria
attach
to
biotic
or
abiotic
surfaces
and
are
embedded
in
a
complex
matrix
which
is
known
as
biofilm.
Biofilm
formation
especially
worrisome
clinical
settings
it
hinders
the
treatment
of
infections
with
antibiotics
due
facilitated
acquisition
antibiotic
resistance
genes
(ARGs).
Environmental
now
considered
pivotal
for
driving
biofilm
formation,
biofilm-mediated
development
dissemination.
Several
studies
have
demonstrated
that
environmental
biofilms
can
be
hotspots
dissemination
ARGs.
These
encoded
on
mobile
genetic
elements
(MGEs)
such
conjugative
mobilizable
plasmids
integrative
(ICEs).
ARGs
rapidly
transferred
through
horizontal
gene
transfer
(HGT)
has
been
shown
occur
more
frequently
than
planktonic
cultures.
models
promising
tools
mimic
natural
study
via
HGT.
This
review
summarizes
state-of-the-art
techniques
visualize
three
main
HGT
mechanisms
biofilms:
transformation,
transduction,
conjugation.
Frontiers in Cellular and Infection Microbiology,
Journal Year:
2023,
Volume and Issue:
13
Published: April 6, 2023
Bacterial
biofilms
are
complex
microbial
communities
encased
in
extracellular
polymeric
substances.
Their
formation
is
a
multi-step
process.
Biofilms
significant
problem
treating
bacterial
infections
and
one
of
the
main
reasons
for
persistence
infections.
They
can
exhibit
increased
resistance
to
classical
antibiotics
cause
disease
through
device-related
non-device
(tissue)
-associated
infections,
posing
severe
threat
global
health
issues.
Therefore,
early
detection
search
new
alternative
treatments
essential
suppressing
biofilm-associated
In
this
paper,
we
systematically
reviewed
biofilms,
associated
methods,
potential
treatment
strategies,
aiming
provide
researchers
with
latest
progress
biofilms.
Journal of Genetic Engineering and Biotechnology,
Journal Year:
2021,
Volume and Issue:
19(1), P. 140 - 140
Published: Sept. 23, 2021
Bacterial
biofilms
are
aggregation
or
collection
of
different
bacterial
cells
which
covered
by
self-produced
extracellular
matrix
and
attached
to
a
substratum.
Generally,
under
stress
in
unfavorable
conditions,
free
planktonic
bacteria
transform
themselves
into
become
sessile.Various
mechanisms
involving
interaction
between
antimicrobial
biofilm
components,
reduced
growth
rates,
genes
conferring
antibiotic
resistance
have
been
described
contribute
enhanced
resistance.
Quorum
sensing
multi-drug
efflux
pumps
known
regulate
the
internal
environment
within
as
well
formation;
they
also
protect
from
attack
immune
attacks.
This
review
summarizes
data
supporting
importance
exopolysaccharides
during
formation
its
role
resistance.Involvement
quorum
association
with
exopolysaccharides.
Also,
strategies
overcome
provided.
Clinical Science,
Journal Year:
2022,
Volume and Issue:
136(10), P. 747 - 769
Published: May 1, 2022
Abstract
Pneumonia
and
its
sequelae,
acute
lung
injury,
present
unique
challenges
for
pulmonary
critical
care
healthcare
professionals,
these
have
recently
garnered
global
attention
due
to
the
ongoing
Sars-CoV-2
pandemic.
One
limitation
translational
investigation
of
including
most
severe
manifestation
(acute
respiratory
distress
syndrome,
ARDS)
has
been
heterogeneity
resulting
from
clinical
physiologic
diagnosis
that
represents
a
wide
variety
etiologies.
Recent
efforts
improved
our
understanding
approach
by
defining
sub-phenotypes
ARDS
although
significant
gaps
in
knowledge
remain.
Improving
mechanistic
injury
common
cause,
infectious
pneumonia,
can
advance
precision
targeted
interventions.
Here,
we
review
pathogenesis
pneumonia
how
infections
disrupt
homoeostasis,
provide
an
overview
microbial
pathogenesis,
microbiome,
interventions
demonstrated
improve
outcomes—or
not—in
human
trials.
AIMS Microbiology,
Journal Year:
2022,
Volume and Issue:
8(3), P. 239 - 277
Published: Jan. 1, 2022
<abstract>
<p>Biofilms
are
aggregates
of
bacteria,
in
most
cases,
which
resistant
usually
to
broad-spectrum
antibiotics
their
typical
concentrations
or
even
higher
doses.
A
trend
increasing
multi-drug
resistance
biofilms,
responsible
for
emerging
life-threatening
nosocomial
infections,
is
becoming
a
serious
problem.
Biofilms,
however,
at
various
sensitivity
levels
environmental
factors
and
versatile
infectivity
depending
on
virulence
factors.
This
review
presents
the
fundamental
information
about
biofilms:
formation,
antibiotic
resistance,
impacts
public
health
alternatives
conventional
approaches.
Novel
developments
micro-biosystems
that
help
reveal
new
treatment
tools
by
sensing
characterization
biofilms
will
also
be
discussed.
Understanding
structure,
physiology
properties
better
helps
eliminate
them
usage
appropriate
control
novel
therapy
approaches,
such
as
anti-biofilm
molecules,
effective
gene
editing,
drug-delivery
systems
probiotics.</p>
</abstract>
Antibiotics,
Journal Year:
2022,
Volume and Issue:
12(1), P. 12 - 12
Published: Dec. 22, 2022
Bacteria
can
form
biofilms
in
natural
and
clinical
environments
on
both
biotic
abiotic
surfaces.
The
bacterial
aggregates
embedded
are
formed
by
their
own
produced
extracellular
matrix.
Staphylococcus
aureus
(S.
aureus)
is
one
of
the
most
common
pathogens
biofilm
infections.
formation
protect
bacteria
from
being
attacked
host
immune
system
antibiotics
thus
be
persistent
against
external
challenges.
Therefore,
treatments
for
infections
currently
encountering
difficulty.
To
address
this
critical
challenge,
a
new
effective
treatment
method
needs
to
developed.
A
comprehensive
understanding
regulation
mechanisms
may
provide
meaningful
insights
antibiotic
resistance
due
biofilms.
In
review,
we
discuss
an
overview
S.
including
process,
structural
functional
properties
matrix,
mechanism
regulating
formation.
Fundamental Research,
Journal Year:
2021,
Volume and Issue:
1(2), P. 193 - 212
Published: Feb. 21, 2021
The
emergence
of
multi-drug
resistance
makes
bacterial
infection
a
major
threat
to
public
health
and
economy.
formation
biofilms
is
one
the
main
reasons
resistance.
complexity
chemical
composition
physical
structure
elimination
mature
difficult
problem.
highly
antibiotic
resistant
property
urgently
calls
for
potent
antimicrobial
agents
novel
antibiofilm
strategies.
Researchers
have
made
lot
efforts
in
this
field.
Here
we
review
current
strategies
eliminate
progress
related
drug
delivery
nanosystems,
with
aim
inspiring
researchers
design
new
systems.
