Akkermansia muciniphila and Gut Immune System: A Good Friendship That Attenuates Inflammatory Bowel Disease, Obesity, and Diabetes

Frontiers in Immunology, Journal Year: 2022, Volume and Issue: 13

Published: July 7, 2022

Akkermansia muciniphila is a Gram-negative anaerobic mucus-layer-degrading bacterium that colonizes the intestinal mucosa of humans and rodents. Metagenomic data have shown an inverse correlation between abundance A. diseases such as inflammatory bowel disease (IBD), obesity, diabetes. Thus, in recent decades, potential this immunomodulatory probiotic for autoimmune chronic has been explored experimental models. Corroborating these human data, it reported slows down development progression diabetes, IBD mice. Consequently, clinical studies with obese diabetic patients are being performed, preliminary results very promising. Therefore, mini review highlights main findings regarding beneficial roles its action mechanisms diseases.

Language: Английский

---

Fucoidan Ameliorated Dextran Sulfate Sodium-Induced Ulcerative Colitis by Modulating Gut Microbiota and Bile Acid Metabolism

Journal of Agricultural and Food Chemistry, Journal Year: 2022, Volume and Issue: 70(47), P. 14864 - 14876

Published: Nov. 15, 2022

Gut dysbiosis and bile acid (BA) metabolism disturbance are involved in the pathogenesis of ulcerative colitis. This study aimed to investigate effect fucoidan on BA gut microbiota dextran sulfate sodium-induced colitis mice. Our results showed that effectively suppressed colonic inflammation repaired barrier. In addition, increased relative abundance Lachnospiraceae family, such as Turicibacter, Muribaculum, Parasutterella, Colidextribacter, followed by an increase short-chain fatty acids, especially butyrate. Moreover, modulated elevating cholic acid, ursodeoxycholic deoxycholic lithocholic decreasing β-muricholic which led activation FXR TGR5 further enhanced barrier inflammation. revealed alleviating was largely mediated microbiota, confirmed fecal transplantation experiment. Collectively, these findings provided basis for a potential functional food

Language: Английский

---

Lactobacillus rhamnosus GG ameliorates osteoporosis in ovariectomized rats by regulating the Th17/Treg balance and gut microbiota structure

Gut Microbes, Journal Year: 2023, Volume and Issue: 15(1)

Published: March 20, 2023

Background With increasing knowledge about the gut – bone axis, more studies for treatments based on regulation of postmenopausal osteoporosis by microbes are being conducted. Based our previous work, this study was conducted to further investigate therapeutic effects Lactobacillus rhamnosus GG (LGG) ovariectomized (OVX) model rats and immunological microecological mechanisms involved.Results We found a protective effect LGG treatment in OVX through changes microarchitecture, biomechanics, CTX-I, PINP, Ca, RANKL expression levels. advantageous promoting osteogenesis, which may be responsible alleviation osteoporosis. Th17 cells were imbalanced with Treg mediastinal lymph nodes marrow, RORγt FOXP3 following similar trend. TNF-α IL-17 colon marrow increased, while TGF-β IL-10 decreased; however, modulated these improved Th17/Treg balance significantly. Regarding intestinal barrier, we that ameliorated estrogen deficiency-induced inflammation mucosal damage increased GLP-2 R tight junction proteins. Importantly, 16S rRNA sequencing showed significant increase Firmicutes/Bacteroidetes ratio during deficiency. Dominant flora differences composition; regulated various genera OVX, along modifying those did not change significantly other groups respect development, bile acid metabolism.Conclusions Overall, regulating microbiome barrier stimulating bone.

Language: Английский

---

Akkermansia muciniphila as a Next-Generation Probiotic in Modulating Human Metabolic Homeostasis and Disease Progression: A Role Mediated by Gut–Liver–Brain Axes?

International Journal of Molecular Sciences, Journal Year: 2023, Volume and Issue: 24(4), P. 3900 - 3900

Published: Feb. 15, 2023

Appreciation of the importance Akkermansia muciniphila is growing, and it becoming increasingly relevant to identify preventive and/or therapeutic solutions targeting gut–liver–brain axes for multiple diseases via muciniphila. In recent years, its components such as outer membrane proteins extracellular vesicles have been known ameliorate host metabolic health intestinal homeostasis. However, impacts on disease are complex, both potentially beneficial adverse effects mediated by derivatives, in some cases, these dependent upon physiology microenvironment forms, genotypes, strain sources Therefore, this review aims summarize current knowledge how interacts with influences homeostasis progression. Details will be discussed including biological genetic characteristics; functions anti-obesity, anti-diabetes, anti-metabolic-syndrome, anti-inflammation, anti-aging, anti-neurodegenerative disease, anti-cancer therapy functions; strategies elevate abundance. Key events referred specific states, should facilitate identification muciniphila-based probiotic axes.

Language: Английский

---

Recent findings in Akkermansia muciniphila-regulated metabolism and its role in intestinal diseases

Clinical Nutrition, Journal Year: 2022, Volume and Issue: 41(10), P. 2333 - 2344

Published: Sept. 3, 2022

Language: Английский

---

The influence of Akkermansia muciniphila on intestinal barrier function

Gut Pathogens, Journal Year: 2024, Volume and Issue: 16(1)

Published: Aug. 3, 2024

Intestinal barriers play a crucial role in human physiology, both homeostatic and pathological conditions. Disruption of the intestinal barrier is significant factor pathogenesis gastrointestinal inflammatory diseases, such as bowel disease. The profound influence gut microbiota on diseases has sparked considerable interest manipulating it through dietary interventions, probiotics, fecal transplantation potential approaches to enhance integrity barrier. Numerous studies have underscored protective effects specific their associated metabolites. In recent years, an increasing body research demonstrated that Akkermansia muciniphila (A. muciniphila, Am) plays beneficial various including diabetes, obesity, aging, cancer, metabolic syndrome. It gaining popularity regulator influences flora recognized 'new generation probiotics'. Consequently, may represent target promising therapy option for diseases. This article systematically summarizes Am gut. Specifically, we carefully discuss key scientific issues need resolution future regarding bacteria represented by Am, which provide insights application drugs targeting clinical treatment.

Language: Английский

---

Gegen Qinlian decoction ameliorates TNBS-induced ulcerative colitis by regulating Th2/Th1 and Tregs/Th17 cells balance, inhibiting NLRP3 inflammasome activation and reshaping gut microbiota

Journal of Ethnopharmacology, Journal Year: 2024, Volume and Issue: 328, P. 117956 - 117956

Published: Feb. 29, 2024

Language: Английский

---

Achieving healthy aging through gut microbiota-directed dietary intervention: Focusing on microbial biomarkers and host mechanisms

Journal of Advanced Research, Journal Year: 2024, Volume and Issue: unknown

Published: March 1, 2024

Population aging has become a primary global public health issue, and the prevention of age-associated diseases prolonging healthy life expectancies are particular importance. Gut microbiota emerged as novel target in various host physiological disorders including aging. Comprehensive understanding on changes gut during aging, characteristics centenarians, can provide us possibility to achieving or intervene pathological through microbiota-directed strategies. This review aims summarize associated with explore potential biomarkers address microbiota-associated mechanisms focusing intestinal barrier immune status. By summarizing existing effective dietary strategies interventions, probability developing diet targeting future is provided. focused three key notions: Firstly, new for regulating status lifespan, its closely related age. Thus, we summarized aging-associated features at levels genus/species important metabolites comparing differences among elderly people younger people. Secondly, exploring discussing using regime/components targeted aging-related promote human lifespan. Thirdly, intervention effectively improve imbalance such probiotics, prebiotics, postbiotics, but their effects vary among.

Language: Английский

---

The Power of Psychobiotics in Depression: A Modern Approach through the Microbiota–Gut–Brain Axis: A Literature Review

Nutrients, Journal Year: 2024, Volume and Issue: 16(7), P. 1054 - 1054

Published: April 4, 2024

The microbiota-gut-brain (MGB) axis is a complex communication network linking the gut, microbiota, and brain, influencing various aspects of health disease. Dysbiosis, disturbance in gut microbiome equilibrium, can significantly impact MGB axis, leading to alterations microbial composition function. Emerging evidence highlights connection between microbiota neurological psychiatric disorders, including depression. This review explores potential psychobiotics managing depressive emphasizing their role restoring balance axis. Psychobiotics exhibit positive effects on intestinal barrier, immune response, cortisol levels, hypothalamic-pituitary-adrenal (HPA) Studies suggest that probiotics may serve as an adjunct therapy for depression, especially treatment-resistant cases. discusses key findings from studies interventions, gut-brain mental health. increasing acceptance expanded concept underscores importance microorganisms well-being. As our understanding microbiome's disease grows, emerge promising agents addressing issues, providing new avenues therapeutic interventions disorders.

Language: Английский

---

Role of interleukin-6-mediated inflammation in the pathogenesis of inflammatory bowel disease: focus on the available therapeutic approaches and gut microbiome

Journal of Cell Communication and Signaling, Journal Year: 2022, Volume and Issue: 17(1), P. 55 - 74

Published: Sept. 16, 2022

Language: Английский

---