SARS-CoV-2 positivity in offspring and timing of mother-to-child transmission: living systematic review and meta-analysis

BMJ, Journal Year: 2022, Volume and Issue: unknown, P. e067696 - e067696

Published: March 16, 2022

To assess the rates of SARS-CoV-2 positivity in babies born to mothers with infection, timing mother-to-child transmission and perinatal outcomes, factors associated status offspring.

Language: Английский

---

Pregnancy outcomes and vaccine effectiveness during the period of omicron as the variant of concern, INTERCOVID-2022: a multinational, observational study

The Lancet, Journal Year: 2023, Volume and Issue: 401(10375), P. 447 - 457

Published: Jan. 18, 2023

Language: Английский

---

Clinical risk factors of adverse outcomes among women with COVID-19 in the pregnancy and postpartum period: a sequential, prospective meta-analysis

American Journal of Obstetrics and Gynecology, Journal Year: 2022, Volume and Issue: 228(2), P. 161 - 177

Published: Aug. 24, 2022

Language: Английский

---

Risk Factors of Severe COVID-19: A Review of Host, Viral and Environmental Factors

Viruses, Journal Year: 2023, Volume and Issue: 15(1), P. 175 - 175

Published: Jan. 7, 2023

The clinical course and outcome of COVID-19 are highly variable, ranging from asymptomatic infections to severe disease death. Understanding the risk factors is relevant both in setting at epidemiological level. Here, we provide an overview host, viral environmental that have been shown or (in some cases) hypothesized be associated with outcomes. considered detail include age frailty, genetic polymorphisms, biological sex (and pregnancy), co- superinfections, non-communicable comorbidities, immunological history, microbiota, lifestyle patient; variation infecting dose; socioeconomic factors; air pollution. For each category, compile (sometimes conflicting) evidence for association factor outcomes (including strength effect) outline possible action mechanisms. We also discuss complex interactions between various factors.

Language: Английский

---

Evaluation of transplacental transfer of mRNA vaccine products and functional antibodies during pregnancy and infancy

Nature Communications, Journal Year: 2022, Volume and Issue: 13(1)

Published: July 30, 2022

Studies are needed to evaluate the safety and effectiveness of mRNA SARS-CoV-2 vaccination during pregnancy, levels protection provided their newborns through placental transfer antibodies. Here, we transplacental vaccine products functional anti-SARS-CoV-2 antibodies pregnancy early infancy in a cohort 20 individuals vaccinated late pregnancy. We find no evidence maternal blood, placenta tissue, or cord blood at delivery. However, time-dependent efficient IgG neutralizing neonate that persists infancy. Additionally, using phage immunoprecipitation sequencing, vaccine-specific signature Spike protein epitope binding is transplacentally transferred Timing critical ensure protective

Language: Английский

---

Immune evasion of neutralizing antibodies by SARS-CoV-2 Omicron

Cytokine & Growth Factor Reviews, Journal Year: 2023, Volume and Issue: 70, P. 13 - 25

Published: March 5, 2023

Language: Английский

---

Maternal SARS-CoV-2, Placental Changes and Brain Injury in 2 Neonates

PEDIATRICS, Journal Year: 2023, Volume and Issue: 151(5)

Published: April 6, 2023

Long-term neurodevelopmental sequelae are a potential concern in neonates following utero exposure to severe acute respiratory syndrome coronavirus disease 2 (SARS-CoV-2). We report born SARS-CoV-2 positive mothers, who displayed early-onset (day 1) seizures, acquired microcephaly, and significant developmental delay over time. Sequential MRI showed parenchymal atrophy cystic encephalomalacia. At birth, neither infant was (nasopharyngeal swab, reverse transcription polymerase chain reaction), but both had detectable antibodies increased blood inflammatory markers. Placentas from mothers SARS-CoV-2-nucleocapsid protein spike glycoprotein 1 the syncytiotrophoblast, fetal vascular malperfusion, significantly oxidative stress markers pyrin domain containing protein, macrophage βη, stromal cell-derived factor 1, interleukin 13, 10, whereas human chorionic gonadotropin markedly decreased. One (case experienced sudden unexpected death at 13 months of age. The deceased infant's brain evidence by immunofluorescence, with colocalization nucleocapsid around nucleus as well within cytoplasm. constellation clinical findings, placental pathology, immunohistochemical changes strongly suggests that second-trimester maternal infection placentitis triggered an response injury fetoplacental unit affected brain. demonstration also raises possibility directly contributed ongoing injury. In infants, neurologic findings birth mimicked presentation hypoxic-ischemic encephalopathy newborn progressed beyond neonatal period.

Language: Английский

---

A population-based matched cohort study of major congenital anomalies following COVID-19 vaccination and SARS-CoV-2 infection

Nature Communications, Journal Year: 2023, Volume and Issue: 14(1)

Published: Jan. 6, 2023

Abstract Evidence on associations between COVID-19 vaccination or SARS-CoV-2 infection and the risk of congenital anomalies is limited. Here we report a national, population-based, matched cohort study using linked electronic health records from Scotland (May 2020-April 2022) to estimate association and, separately, six weeks pre-conception 19 days gestation [1] any major anomaly [2] non-genetic anomaly. Mothers vaccinated in this pregnancy exposure period mostly received an mRNA vaccine (73.7% Pfizer-BioNTech BNT162b2 7.9% Moderna mRNA-1273). Of 6731 babies whose mothers were period, 153 had 120 Primary analyses find no (adjusted Odds Ratio [aOR] = 1.01, 95% Confidence Interval [CI] 0.83-1.24) (aOR 1.00, CI 0.81-1.22). also 1.02, 0.66-1.60) 0.94, 0.57-1.54). Findings are robust sensitivity analyses. These data provide reassurance safety vaccination, particular vaccines, just before early pregnancy.

Language: Английский

---

The influence of COVID-19 infection-associated immune response on the female reproductive system

Biology of Reproduction, Journal Year: 2022, Volume and Issue: 108(2), P. 172 - 182

Published: Sept. 29, 2022

Abstract Coronavirus disease 2019 (COVID-19) is a multi-system that has led to pandemic with unprecedented ramifications. The challenged scientists for the past 2 years and brought back previously abandoned research topics. COVID-19 infection causes myriad of symptoms ranging from mild flu-like severe illness requiring hospitalization. Case reports showed multiple systemic effects infection, including acute respiratory distress syndrome, fibrosis, colitis, thyroiditis, demyelinating syndromes, mania, indicating can affect most human body systems. Unsurprisingly, major concern women all over globe whether any long-term on their menstrual cycle, fertility, or pregnancy. Published data have suggested an effect reproductive health, we hypothesize reported adverse are due robust immune reaction against associated cytokine storm. While receptor (angiotensin converting enzyme, ACE2) expressed in ovaries, uterus, vagina, placenta, it plays less important role system. Cytokines glucocorticoids act hypothalamo–pituitary gonadal axis, arachidonic acid pathways, which leads disturbances pregnancy-related events such as preterm labor miscarriages. This hypothesis further supported by apparent lack health females, when storm its dampened, no longer affected.

Language: Английский

---

Effects of intrauterine exposure to SARS-CoV-2 on infants’ development: a rapid review and meta-analysis

European Journal of Pediatrics, Journal Year: 2023, Volume and Issue: 182(5), P. 2041 - 2055

Published: March 11, 2023

Language: Английский

---