Remodeling Tumor‐Associated Neutrophils to Enhance Dendritic Cell‐Based HCC Neoantigen Nano‐Vaccine Efficiency

Advanced Science, Journal Year: 2022, Volume and Issue: 9(11)

Published: Feb. 10, 2022

Abstract Hepatocellular carcinoma (HCC) commonly emerges in an immunologically “cold” state, thereafter protects it away from cytolytic attack by tumor‐infiltrating lymphocytes, resulting poor response to immunotherapy. Herein, acidic/photo‐sensitive dendritic cell (DCs)‐based neoantigen nano‐vaccine has been explored convert tumor immune state into “hot”, and remodel tumor‐associated neutrophils potentiate anticancer for enhancing immunotherapy efficiency. The is constructed SiPCCl 2 ‐hybridized mesoporous silica with coordination of Fe(III)‐captopril, coating exfoliated membrane matured DCs H22‐specific stimulation. nano‐vaccines actively target H22 tumors induce immunological death boost antigen release the generation excess 1 O through photodynamic therapy, which act as situ vaccination strengthen antitumor T‐cell against primary growth. Interestingly, are also home lymph nodes directly activation proliferation neoantigen‐specific T cells suppress primary/distal Moreover, acidic‐triggered captopril microenvironment can polarize protumoral N2 phenotype N1 improving effects achieve complete regression (83%) H22‐bearing mice prolong survival time. This work provides alternative approach developing novel HCC strategies.

Language: Английский

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ER-Targeting PDT Converts Tumors into In Situ Therapeutic Tumor Vaccines

ACS Nano, Journal Year: 2022, Volume and Issue: 16(6), P. 9240 - 9253

Published: June 17, 2022

A therapeutic tumor vaccine is a promising approach to cancer treatment. One of its strategies treat patient-derived cells in vitro and then administer them vivo induce an adaptive immune response achieve Here, we want explore the possibility converting tissue into through induced immunogenic cell death (ICD) situ. We loaded indocyanine green (ICG) liposomes (ICG-Lipo) modified it with pardaxin peptide realize endoplasmic reticulum (ER)-targeting function (Par-ICG-Lipo). microfluidic technique was developed for loading ICG, water-soluble molecule, high encapsulation efficiency (greater than 90%). Under near-infrared (NIR) irradiation, ER-targeting photodynamic therapy (PDT) by Par-ICG-Lipo could promote release danger-signaling molecules (DAMPs) antigens (TAAs) vivo, which significantly enhanced immunogenicity thus stimulates strong antitumor response. This process would be further amplified adopting dendritic cells. In general, our strategy transformed situ vaccines PDT, provide clinically applicable effective

Language: Английский

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Combined Photodynamic and Photothermal Therapy and Immunotherapy for Cancer Treatment: A Review

International Journal of Nanomedicine, Journal Year: 2022, Volume and Issue: Volume 17, P. 6427 - 6446

Published: Dec. 1, 2022

Photoactivation therapy based on photodynamic (PDT) and photothermal (PTT) has been identified as a tumour ablation modality for numerous cancer indications, with photosensitisers conversion agents playing important roles in the phototherapy process, especially recent decades.In addition, iteration of nanotechnology strongly promoted development treatment.PDT can increase sensitivity cells to PTT by interfering microenvironment, whereas heat generated blood flow, improve oxygen supply enhance PDT therapeutic effect.In cell debris serve tumour-associated antigens, evoking antitumor immune responses.In this review, research progress phototherapy, its effects combination immunotherapy treatment tumours are mainly outlined, issues that may need continued attention future raised.

Language: Английский

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Triggered azobenzene-based prodrugs and drug delivery systems

Journal of Controlled Release, Journal Year: 2022, Volume and Issue: 345, P. 475 - 493

Published: March 23, 2022

Language: Английский

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Covalent organic framework nanomedicines: Biocompatibility for advanced nanocarriers and cancer theranostics applications

Bioactive Materials, Journal Year: 2022, Volume and Issue: 21, P. 358 - 380

Published: Sept. 14, 2022

Nanomedicines for drug delivery and imaging-guided cancer therapy is a rapidly growing research area. The unique properties of nanomedicines have massive potential in solving longstanding challenges existing drugs, such as poor localization at the tumor site, high doses toxicity, recurrence, immune response. However, inadequate biocompatibility restricts their clinical translation. Therefore, advanced nanomaterials with enhanced therapeutic efficiency are highly desired to fast-track translation nanomedicines. Intrinsic nanoscale covalent organic frameworks (nCOFs), suitable size, modular pore geometry porosity, straightforward post-synthetic modification via simple transformations, make them incredibly attractive future ability COFs disintegrate slightly acidic microenvironment also gives competitive advantage targeted delivery. This review summarizes recently published applications delivery, photo-immuno therapy, sonodynamic photothermal chemotherapy, pyroptosis, combination therapy. Herein we mainly focused on modifications enhance biocompatibility, efficacy will provide fundamental knowledge designing biocompatible nCOFs-based help rapid development carriers theranostics.

Language: Английский

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An Activatable Near‐Infrared Afterglow Theranostic Prodrug with Self‐Sustainable Magnification Effect of Immunogenic Cell Death

Angewandte Chemie International Edition, Journal Year: 2022, Volume and Issue: 61(40)

Published: Aug. 2, 2022

Abstract Herein, we report an activatable near‐infrared (NIR) afterglow theranostic prodrug that circumvents high background noise interference caused by external light excitation. The can release hydroxycamptothecin (HCPT) in response to the intratumoral peroxynitrite level associated with immunogenic cell death (ICD), and synchronously activate signal monitor drug process cold‐to‐hot tumor transformation. itself is ICD inducer achieved photodynamic therapy (PDT). PDT initiates recruits first‐arrived neutrophils secrete trigger HCPT release. Intriguingly, demonstrate significantly amplify PDT‐mediated process. thus shows a self‐sustainable magnification effect establishing “ICD‐HCPT release‐amplified ICD” cycling loop. In vivo studies eradicate existing tumors prevent further recurrence through antitumor immune response.

Language: Английский

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A mitochondria-localized iridium(iii) photosensitizer for two-photon photodynamic immunotherapy against melanoma

Chemical Science, Journal Year: 2023, Volume and Issue: 14(6), P. 1461 - 1471

Published: Jan. 1, 2023

Conventional photodynamic therapy mainly causes a therapeutic effect on the primary tumor through localized generation of reactive oxygen species, while metastatic tumors remain poorly affected. Complementary immunotherapy is effective in eliminating small, non-localized distributed across multiple organs. Here, we report Ir(iii) complex Ir-pbt-Bpa as highly potent immunogenic cell death inducing photosensitizer for two-photon against melanoma. can produce singlet and superoxide anion radicals upon light irradiation, causing by combination ferroptosis death. In mouse model with two physically separated melanoma tumors, although only one was irradiated, strong reduction both observed. Upon not induced immune response CD8

Language: Английский

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Cell membrane biomimetic nanomedicines for cancer phototherapy

Deleted Journal, Journal Year: 2023, Volume and Issue: 1(2)

Published: Feb. 21, 2023

Abstract Phototherapy, mainly including photothermal therapy (PTT) and photodynamic (PDT), can kill cancer cells by generating heat or reactive oxygen species, which has the advantages of being minimally invasive, high efficiency, low toxicity. However, traditional phototherapeutic agents face challenges such as poor tumor targeting, susceptibility to passive immune clearance, suboptimal biocompatibility, limit their clinical application. Recently, cell membrane biomimetic technology endows with unique biological functions, promoted escape, prolonged in vivo circulation time, improved enhanced anti‐tumor efficacy. In addition, phototherapy mediated (CCM) membrane‐modified promote broad immunity. this review, we deeply analyze mechanisms PTT PDT, systematically discuss synthesis strategies functions nanomaterials, focus on progress based nanomaterials synergistic therapies chemotherapy, radiotherapy, immunotherapy, sonodynamic therapy. Finally, address opportunities future prospects field phototherapy. This comprehensive review is expected provide insights into promoting translation agents.

Language: Английский

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Photodynamic therapy combined with immunotherapy: Recent advances and future research directions

Coordination Chemistry Reviews, Journal Year: 2023, Volume and Issue: 495, P. 215350 - 215350

Published: Aug. 19, 2023

Innovative anticancer therapies based on the activation of immune system offer promise in battle against cancers resistant to traditional treatments. Examples such therapeutic approaches include, along with various types immunotherapies, photodynamic therapy (PDT). PDT is a photochemistry-based strategy that results not only from its direct effects cancer cells but also disruption tumor vasculature and host system. However, achieve success manifested eradication primary distant metastases, it necessary design suitable photosensitizers (PSs) desired optical photophysical properties enable efficient generation ROS under microenvironmental (TME) conditions, especially hypoxia. Thus, this review particular attention paid photochemical PSs, notably sufficiently long-lived triplet states mechanisms energy/electron transfer reactions. Photogenerated initiate inflammatory reaction, expression heat-shock proteins, infiltration long-term memory. These unique features give new possibilities combine agents stimulating response as well immunotherapy, PD-1/PD-L1 blockade. Most systems explored aspect so far are either derivatives naturally occurring metal complexes (Heme, Chlorophyll a, Bacteiochorophyll - inspired PSs), synthetic (metallo)porphyrins, (metallo)phthalocyanines or hybrid materials containing nanoparticles. This work summarizes recent reports synthesis antibody-PS conjugates spectroscopic enhanced selectivity biological activity. Finally, most notable drawbacks presented, scenario outlined for development alone, combined immunotherapy overcome these challenges future.

Language: Английский

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Innovative strategies for photodynamic therapy against hypoxic tumor

Asian Journal of Pharmaceutical Sciences, Journal Year: 2023, Volume and Issue: 18(1), P. 100775 - 100775

Published: Jan. 1, 2023

Photodynamic therapy (PDT) is applied as a robust therapeutic option for tumor, which exhibits some advantages of unique selectivity and irreversible damage to tumor cells. Among which, photosensitizer (PS), appropriate laser irradiation oxygen (O2) are three essential components PDT, but the hypoxic microenvironment (TME) restricts O2 supply in tissues. Even worse, metastasis drug resistance frequently happen under condition, further deteriorate antitumor effect PDT. To enhance PDT efficiency, critical attention has been received by relieving hypoxia, innovative strategies on this topic continue emerge. Traditionally, supplement strategy considered direct effective relieve TME, whereas it confronted with great challenges continuous supply. Recently, O2-independent provides brand new can avoid influence TME. In addition, synergize other strategies, such chemotherapy, immunotherapy, photothermal (PTT) starvation therapy, remedy inadequate hypoxia conditions. paper, we summarized latest progresses development improve efficacy against were classified into O2-dependent synergistic therapy. Furthermore, deficiencies various also discussed envisage prospects future study.

Language: Английский

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