Long Noncoding RNA Metastasis-Associated Lung Adenocarcinoma Transcript 1 Promotes HIV-1 Replication through Modulating microRNAs in Macrophages DOI
Zhihong Yuan, Yunlong Huang, Ruxana T. Sadikot

et al.

Journal of Virology, Journal Year: 2023, Volume and Issue: 97(6)

Published: May 31, 2023

Macrophages can serve as a reservoir for human immunodeficiency-1 (HIV-1) virus in host cells, constituting barrier to eradication, even patients who are receiving antiretroviral therapy. Although many noncoding RNAs have been characterized regulators HIV-1/AIDS-induced immune response and pathogenesis, only few long (lncRNAs) demonstrated close association with HIV-1 replication, the molecular mechanisms remain unknown. In this study, we investigated how lncRNA metastasis-associated lung adenocarcinoma transcript 1 (MALAT1), related microRNAs, key inflammatory genes alter replication macrophages. Our data show that infection modulates expression of miR-155 miR-150-5p time-dependent manner, which is regulated by MALAT1. MALAT1 induced suppressor cytokine signaling (SOCS1) sponging HIV-1-infected macrophages stimulated mediators triggering receptor expressed on myeloid cells/cold inducible RNA binding protein (TREM 1/CIRP) ligand/receptor. The immunoprecipitation (RIP) assay validated direct interaction within MALAT1/miR-150-5p/SOCS1 axis. infection-mediated upregulation MALAT1, SOCS1, Gag was attenuated SN50 (an NF-кB p50 inhibitor). antisense oligonucleotides (ASOs) suppressed p24 production gene decreased well proinflammatory cytokines conclusion, induces attenuates increases SOCS1 expression, promoting reactivation. These provide new insights into alters macrophage microenvironment subsequently promotes viral suggest potential role targeting therapeutic approach eliminate reservoirs. IMPORTANCE Viral reservoirs constitute an obstacle curing diseases, despite HIV long-term latency. Recent studies shown lncRNAs modulate virus-host interactions, but underlying not fully understood. demonstrate contributes through modulation miR-150/SOCS1 axis findings identify therapies eliminating cells.

Language: Английский

Global, regional, and national burden of HIV and other sexually transmitted infections in older adults aged 60–89 years from 1990 to 2019: results from the Global Burden of Disease Study 2019 DOI Creative Commons
Leiwen Fu, Tian Tian, Bingyi Wang

et al.

The Lancet Healthy Longevity, Journal Year: 2024, Volume and Issue: 5(1), P. e17 - e30

Published: Jan. 1, 2024

BackgroundSexually active older adults are often more susceptible to HIV and other sexually transmitted infections (STIs) due various health conditions (especially a weakened immune system) low use of condoms. We aimed assess the global, regional, national burdens trends STIs in from 1990 2019.MethodsWe retrieved data Global Burden Diseases, Injuries, Risk Factors Study (GBD) 2019 on incidence disability-adjusted life-years (DALYs) (syphilis, chlamydia, gonorrhoea, trichomoniasis, genital herpes) for aged 60–89 years 204 countries territories 2019. Estimated annual percentage changes age-standardised DALY rates STIs, by age, sex, Socio-demographic Index (SDI), were calculated quantify temporal trends. Spearman correlation analysis was used examine relationship between SDI.FindingsIn 2019, among globally, there an estimated 77 327 (95% uncertainty interval 59 443 97 648) new cases (age-standardised rate 7·6 [5·9 9·6] per 100 000 population) 26 414 267 (19 777 666 34 860 678) (2607·1 [1952·1 3440·8] 000). The decreased average 2·02% year CI –2·38 –1·66) remained stable (–0·02% [–0·06 0·01]) number DALYs globally 1 905 099 UI 670 056 2 242 807) 132 033 83 512 225 630) STIs. with change 0·97% –0·54 2·50) but 1·55% –1·66 –1·43) Despite global decrease people many regions showed increases, largest increases seen eastern Europe (average 17·84% [14·16 21·63], central Asia (14·26% [11·35 17·25]), high-income Pacific (7·52% [6·54 8·51]). Regionally, SDI.InterpretationAlthough either declined or regional demographic disparities. Health-care providers should be aware effects ageing societies societal factors risk adults, develop age-appropriate interventions. disparities allocation health-care resources different SDIs addressed.FundingNatural Science Foundation China, Fujian Province's Third Batch Flexible Introduction High-Level Medical Talent Teams, Technology Innovation Team (Tianshan Team) Project Xinjiang Uighur Autonomous Region, Cure Alzheimer's Fund, Helse Sør-Øst, Research Council Norway, Molecule/VitaDAO, NordForsk Foundation, Akershus University Hospital, Civitan Norges Forskningsfond Alzheimers Sykdom, Czech Republic-Norway KAPPA programme, Rosa Sløyfe/Norwegian Cancer Society & Norwegian Breast Society.

Language: Английский

Citations

22
Immunocompromised Host Pneumonia: Definitions and Diagnostic Criteria: An Official American Thoracic Society Workshop Report DOI
Guang-Shing Cheng, Kristina Crothers, Stefano Aliberti

et al.

Annals of the American Thoracic Society, Journal Year: 2023, Volume and Issue: 20(3), P. 341 - 353

Published: March 1, 2023

Section:ChooseTop of pageAbstract <

Language: Английский

Citations

40
Macrophages: Key Cellular Players in HIV Infection and Pathogenesis DOI Creative Commons
Marie Woottum, Sen Yan, Sophie Sayettat

et al.

Viruses, Journal Year: 2024, Volume and Issue: 16(2), P. 288 - 288

Published: Feb. 13, 2024

Although cells of the myeloid lineages, including tissue macrophages and conventional dendritic cells, were rapidly recognized, in addition to CD4+ T lymphocytes, as target HIV-1, their specific roles pathophysiology infection initially largely neglected. However, numerous studies performed over past decade, both vitro cell culture systems vivo monkey humanized mouse animal models, led growing evidence that play important direct indirect HIV-1 pathogenesis. It has been recently proposed are likely involved all stages pathogenesis, virus transmission dissemination, but above all, viral persistence through establishment, together with latently infected reservoirs many host tissues, major obstacle eradication people living HIV. Infected indeed found, very often multinucleated giant expressing antigens, almost lymphoid non-lymphoid tissues HIV-1-infected patients, where they can probably persist for long period time. In addition, also participate, directly targets or indirectly key regulators innate immunity inflammation, chronic inflammation associated clinical disorders observed HIV, even patients receiving effective antiretroviral therapy. The main objective this review is therefore summarize recent findings, revisit older data, regarding critical functions infection, found well during different

Language: Английский

Citations

15
Mechanisms and treatment of pulmonary arterial hypertension DOI
Hossein A. Ghofrani, Mardi Gomberg‐Maitland, Lan Zhao

et al.

Nature Reviews Cardiology, Journal Year: 2024, Volume and Issue: unknown

Published: Aug. 7, 2024

Language: Английский

Citations

11
Alveolar macrophages from persons with HIV mount impaired TNF signaling networks to M. tuberculosis infection DOI Creative Commons
Khanyisile Kgoadi, Prashant Bajpai,

Chris Ibegbu

et al.

Nature Communications, Journal Year: 2025, Volume and Issue: 16(1)

Published: March 10, 2025

People living with HIV (PLWH) have an increased risk for developing tuberculosis after M. infection, despite anti-retroviral therapy (ART). To delineate the underlying mechanisms, we conducted single cell transcriptomics on bronchoalveolar lavage cells from PLWH ART and uninfected healthy controls infected ex vivo. We identify M1-like proinflammatory alveolar macrophage subset that sequentially acquires TNF signaling capacity in but not PLWH. Cell-cell communication analyses reveal interactions between macrophages effector memory T within superfamily, chemokine, costimulatory networks airways of controls. These interaction were lacking tuberculosis, where anti-inflammatory M2-like regulatory dominated along dysregulated signatures. Our data support a model which impaired TNF-TNFR signaling, aberrant macrophage-T crosstalk, lead to ineffective immunity ART. are at high development Mycobacterium (Mtb) infection. Here authors compare BAL upon vivo Mtb infection find (AM) reduced expression M1-AM

Language: Английский

Citations

1
Pulmonary Immune Dysregulation and Viral Persistence During HIV Infection DOI Creative Commons

Yulia Alexandrova,

Cecilia T. Costiniuk, Mohammad‐Ali Jenabian

et al.

Frontiers in Immunology, Journal Year: 2022, Volume and Issue: 12

Published: Jan. 4, 2022

Despite the success of antiretroviral therapy (ART), people living with HIV continue to suffer from high burdens respiratory infections, lung cancers and chronic disease at a higher rate than general population. The mucosa, previously neglected reservoir site, is particular importance in this phenomenon. Because ART does not eliminate virus, residual levels that remain deep tissues lead immune activation pulmonary inflammatory pathologies. In turn, continuous systemic inflammation cause cell exhaustion dysregulation, creating pro-inflammatory environment ideal for persistence. Moreover, smoking, gut dysbiosis co-infections further fuel vicious cycle viral replication which, contributes proliferation, maintaining reservoir. Herein, we discuss recent evidence supporting notion lungs serve as an We will explore how changes microbiome, common seen PLWH contribute persistence, rates infectious non-infectious among these individuals.

Language: Английский

Citations

38
The role of oral microbiota in cancer DOI Creative Commons
Zhou Lan, Weijia Liu, Hao Cui

et al.

Frontiers in Microbiology, Journal Year: 2023, Volume and Issue: 14

Published: Oct. 24, 2023

Cancer remains a significant global challenge, with an estimated 47% increase in cancer patients from 2020 to 2040. Increasing research has identified microorganism as risk factor for development. The oral cavity, second only the colon, harbors more than 700 bacterial species and serves crucial microbial habitat. Although numerous epidemiological studies have reported associations between microorganisms major systemic tumors, relationship cancers largely unclear. Current primarily focuses on respiratory digestive system tumors due their anatomical proximity cavity. relevant mechanism mainly involves dominant population that can be cultured vitro . However, further exploration is necessary elucidate mechanisms underlying association microbiota tumors. This review systematically summarizes correlations common while also outlining potential may guide biological tumor treatment.

Language: Английский

Citations

20
Analyses of Factors Associated with Acute Exacerbations of Chronic Obstructive Pulmonary Disease: A Review DOI Creative Commons

Yang Qian,

Chenting Cai,

Mengqing Sun

et al.

International Journal of COPD, Journal Year: 2023, Volume and Issue: Volume 18, P. 2707 - 2723

Published: Nov. 1, 2023

Abstract: Acute exacerbations of chronic obstructive pulmonary disease (AECOPD) is the exacerbation a range respiratory symptoms during stable phase (COPD). AECOPD thus dangerous stage and key event in course COPD, as its deterioration frequency seriously affects quality life patients shortens their survival. occur develop due to many factors such infection, tobacco smoke inhalation, air pollution, comorbidities, airflow limitation, various biomarkers, history previous deterioration, natural killer cell abnormalities, immunoglobulin G deficiency, genetics, abnormal muscle nutritional status, negative psychology, seasonal temperature changes. There relatively limited research on impact role standardized management alleviation AECOPD. However, with establishment relevant prevention systems promotion artificial intelligence technology Internet medical approaches, long-term effective COPD may help achieve prognosis reduce risk AE. Keywords: disease, acute exacerbation, related

Language: Английский

Citations

20
HIV-associated lung disease DOI
Ioannis Konstantinidis, Kristina Crothers, Ken M. Kunisaki

et al.

Nature Reviews Disease Primers, Journal Year: 2023, Volume and Issue: 9(1)

Published: July 27, 2023

Language: Английский

Citations

19
Faster lung function decline in people living with HIV despite adequate treatment: a longitudinal matched cohort study DOI
Rebekka Faber Thudium, Andreas Ronit, Shoaib Afzal

et al.

Thorax, Journal Year: 2023, Volume and Issue: 78(6), P. 535 - 542

Published: Jan. 13, 2023

Introduction Chronic lung disease is common among people living with HIV (PLWH). We hypothesised that PLWH receiving antiretroviral therapy (ART) have faster function decline than matched controls. Methods performed a prospective cohort study by including ART-treated from the Copenhagen Co-morbidity in Infection Study (n=705) and INSIGHT Strategic Timing of Antiretroviral Treatment Pulmonary Substudy (n=425) frequency population controls General Population (n=2895) 1:3 ratio. Eligible participants were ≥25 years old had two spirometry tests separated at least 2 follow-up. Forced expiratory volume 1 s (FEV ) (mL/year) was compared between using linear mixed model adjusted for age, sex, ethnicity smoking status. Effect modification investigated subgroup analyses. Results The majority virally suppressed (96.1%). mean annual FEV 36.4 (95% CI 33.7 to 39.1) vs 27.9 26.9 28.8) mL/year, yielding difference 8.5 5.6 11.4) mL/year. association modified smoking, largest current smokers (difference: 16.8 10.5 23.0) mL/year) smallest never-smokers 5.0 0.7 9.3) mL/year). >40 mL/year more prevalent (adjusted OR: 1.98 1.67 2.34)). Conclusion Well-treated seems modify this association, suggesting may lead rapid

Language: Английский

Citations

17