Frontiers in Bioengineering and Biotechnology,
Journal Year:
2022,
Volume and Issue:
10
Published: March 24, 2022
β-Secretase1
(BACE1)
catalyzes
the
rate-limiting
step
in
generation
of
amyloid-β
peptides,
that
is,
principal
component
involved
pathology
Alzheimer's
disease
(AD).
Recent
research
studies
show
correlation
between
blood
and
cerebrospinal
fluid
(CSF)
levels
BACE1
with
pathophysiology
AD.
In
this
study,
we
report
one-step
synthesized
reduced
graphene
oxide
(rGO),
activated
via
carbodiimide
chemistry,
conjugated
antibody
(Ab),
immobilized
on
fluorine-doped
tin
(FTO)
electrodes
for
rapid
detection
antigen
(Ag)
AD
diagnosis.
The
synthesis
fabrication
steps
were
characterized
using
different
types
spectroscopic,
X-ray
analytic,
microscopic,
voltametric
techniques.
Various
parameters
including
nanomaterial/Ab
concentration,
response
time,
pH,
temperature,
rate
scan
standardized
maximum
current
output
modified
electrode.
Final
validation
was
performed
Ag
ranging
from
1
fM
to
µM,
a
limit
0.64
buffer
samples
spiked
serum
samples,
as
well
negligible
cross-reactivity
neurofilament
buffer,
serum,
artificial
CSF.
proposed
immunosensor
gave
quick
result
30
s,
good
repeatability
storage
stability
month,
making
it
promising
candidate
sensitive,
specific,
early
diagnosis
Thus,
fabricated
electrochemical
biosensor
BACE-1
improves
performance
compared
existing
sensors
reduces
time
cost,
signifying
its
potential
clinical
samples.
Journal of Food Biochemistry,
Journal Year:
2020,
Volume and Issue:
44(9)
Published: July 20, 2020
In
this
review,
the
concept
of
phenolic
antioxidants,
mechanisms
action,
and
applications
have
been
reviewed.
Phenolic
compounds
(PCs)
acts
as
an
antioxidant
by
reacting
with
a
variety
free
radicals.
The
mechanism
actions
involved
either
hydrogen
atom
transfer,
transfer
single
electron,
sequential
proton
loss
electron
chelation
transition
metals.
foods,
PCs
act
antioxidants
which
are
measured
several
in
vitro
spectroscopic
methods.
found
milk
wide
range
dairy
products
sole
purposes
color,
taste,
storage
stability,
quality
enhancement.
role
three
types
food
additives,
that
is,
antimicrobial,
antioxidant,
flavoring
agents
critically
literature
revealed
present
foods
possess
health
benefits
such
antibacterial,
antihyperlipidemic,
anticancer,
cardioprotective,
neuroprotective,
antidiabetic
properties.
Practical
strong
safer
than
synthetic
antioxidants.
occurrence
plant
warranted
continuous
review
applications.
This
therefore,
presented
updated
comprehensive
overview
concept,
mechanism,
foods.
Cells,
Journal Year:
2021,
Volume and Issue:
10(6), P. 1309 - 1309
Published: May 25, 2021
Alzheimer's
disease
(AD)
is
the
number
one
neurovegetative
disease,
but
its
treatment
options
are
relatively
few
and
ineffective.
In
efforts
to
discover
new
strategies
for
AD
therapy,
natural
products
have
aroused
interest
in
research
community
pharmaceutical
industry
their
neuroprotective
activity,
targeting
different
pathological
mechanisms
associated
with
AD.
A
wide
variety
of
from
origins
been
evaluated
preclinically
clinically
preventing
attenuating
multifactorial
pathologies
This
review
mainly
focuses
on
possible
that
may
be
beneficial
product
mixtures
or
extracts
sources
demonstrated
activity
preclinical
and/or
clinical
studies.
It
believed
containing
multiple
bioactive
compounds
can
work
additively
synergistically
exhibit
might
an
effective
approach
drug
discovery.
Frontiers in Bioengineering and Biotechnology,
Journal Year:
2022,
Volume and Issue:
9
Published: Jan. 27, 2022
Bioactive
compounds
can
provide
health
benefits
beyond
the
nutritional
value
and
are
originally
present
or
added
to
food
matrices.
However,
because
they
part
of
matrices,
most
bioactive
remain
in
agroindustrial
by-products.
Agro-industrial
by-products
generated
large
quantities
throughout
production
chain
can—when
not
properly
treated—affect
environment,
profit,
proper
distribution
people.
Thus,
it
is
important
adopt
processes
that
increase
use
these
by-products,
including
biological
approaches,
which
enhance
extraction
obtention
compounds,
enables
their
application
pharmaceutical
industries.
Biological
have
several
advantages
compared
nonbiological
processes,
provision
extracts
with
high
quality
bioactivity,
as
well
low
toxicity
environmental
impact.
Among
from
enzymes
fermentation
stand
out
tools
for
obtaining
various
agro-industrial
wastes.
In
this
sense,
article
provides
an
overview
main
components
found
strategies
extraction.
We
also
information
especially
Molecules,
Journal Year:
2021,
Volume and Issue:
26(17), P. 5327 - 5327
Published: Sept. 2, 2021
Natural
products
derived
from
plants,
as
well
their
bioactive
compounds,
have
been
extensively
studied
in
recent
years
for
therapeutic
potential
a
variety
of
neurodegenerative
diseases
(NDs),
including
Alzheimer’s
(AD),
Huntington’s
(HD),
and
Parkinson’s
(PD)
disease.
These
are
characterized
by
progressive
dysfunction
loss
neuronal
structure
function.
There
has
little
progress
designing
efficient
treatments,
despite
impressive
breakthroughs
our
understanding
NDs.
In
the
prevention
therapy
NDs,
use
natural
may
provide
great
opportunities;
however,
many
clinical
issues
emerged
regarding
use,
primarily
based
on
lack
scientific
support
or
proof
effectiveness
patient
safety.
Since
neurodegeneration
is
associated
with
myriad
pathological
processes,
targeting
multi-mechanisms
action
neuroprotection
approaches
that
include
preventing
cell
death
restoring
function
damaged
neurons
should
be
employed.
treatment
AD
PD,
neuroprotective
agents.
This
current
review
will
highlight
numerous
compounds
thatexert
effects
pathologies
International Journal of Molecular Sciences,
Journal Year:
2023,
Volume and Issue:
24(7), P. 6328 - 6328
Published: March 28, 2023
Neuroinflammation
is
a
critical
factor
in
developing
and
progressing
numerous
brain
diseases,
including
neurodegenerative
diseases.
Chronic
or
excessive
neuroinflammation
can
lead
to
neurotoxicity,
causing
damage
contributing
the
onset
progression
of
various
Therefore,
understanding
mechanisms
strategies
control
them
crucial
for
treating
Studies
have
shown
that
plays
vital
role
such
as
Alzheimer's
(AD)
Parkinson's
(PD),
stroke.
Additionally,
effects
PM
Arabian Journal of Chemistry,
Journal Year:
2023,
Volume and Issue:
16(8), P. 104881 - 104881
Published: April 11, 2023
Lifestyle
is
an
important
factor
in
health,
and
researchers
are
trying
to
see
the
adverse
effect
on
human
health
of
a
change
lifestyle.
Many
people
follow
unhealthy
lifestyles,
which
affect
physical
mental
health.
Millions
suffer
from
various
problems
like
cardiovascular
disease,
overweight,
malnutrition,
hypertension,
stress,
violence,
etc.
There
many
medicines
that
can
cure
these
diseases,
but
they
have
side
effects.
When
man
consumes
green
leaves
vegetables
his
diet,
chances
reducing
risk
any
disease
increase.
Every
plant
has
primary
secondary
metabolites.
Flavonoid
metabolite
found
plants
plays
role
survival
by
performing
physiological
activities
being
able
withstand
effects
environment.
Quercetin
one
such
bioflavonoid
plants,
onions,
citrus
fruits,
parsley,
It
comes
under
category
flavone,
with
five
hydroxy
groups
chromen-4-one
skeletal
structure.
applications,
include
anti-cancer,
anti-bacterial,
anti-viral,
anti-inflammatory,
anti-diabetic,
However,
use
quercetin
limited
due
its
poor
bioavailability,
aqueous
solubility,
lower
stability
gastrointestinal
tract,
first-pass
effect.
To
enhance
application
quercetin,
derivatives
metal
complex
required
water
soluble,
helps
them
reach
target
site
without
provides
stability.
This
review
divided
into
three
main
sections:
The
first
section
explains
about
flavonoids
their
types;
second
methods
synthesis,
derivatives,
complex;
last
represents
complete
applications
drawbacks
how
overcome
or
deal
drawbacks.
International Journal of Molecular Sciences,
Journal Year:
2021,
Volume and Issue:
22(16), P. 8570 - 8570
Published: Aug. 9, 2021
Peptides
present
in
foods
are
involved
nutritional
functions
by
supplying
amino
acids;
sensory
related
to
taste
or
solubility,
emulsification,
etc.;
and
bioregulatory
various
physiological
activities.
In
particular,
peptides
have
a
wide
range
of
functions,
including
as
anticancer
agents
lowering
blood
pressure
serum
cholesterol
levels,
enhancing
immunity,
promoting
calcium
absorption.
Soy
protein
can
be
partially
hydrolyzed
enzymatically
physiologically
active
soy
(or
soybean)
(SPs),
which
not
only
exert
but
also
help
acid
absorption
the
body
reduce
bitterness
hydrolyzing
hydrophobic
acids
from
C-
N-terminus
proteins.
They
possess
significant
gel-forming,
emulsifying,
foaming
abilities.
SPs
expected
able
prevent
treat
atherosclerosis
inhibiting
reabsorption
bile
digestive
system,
thereby
reducing
cholesterol,
low-density
lipoprotein,
fat
levels.
addition,
contains
pressure-lowering
that
inhibit
angiotensin-I
converting
enzyme
activity
antithrombotic
platelet
aggregation,
well
anticancer,
antioxidative,
antimicrobial,
immunoregulatory,
opiate-like,
hypocholesterolemic,
antihypertensive
animal
models,
neuroprotective
cognitive
capacity
cardiovascular
been
reported.
chronic
kidney
disease
tumor
cell
growth
regulating
expression
genes
associated
with
apoptosis,
inflammation,
cycle
arrest,
invasion,
metastasis.
Recently,
soybeans,
their
applied
health-oriented
foods,
functional
pharmaceuticals,
cosmetics.
This
review
introduces
some
current
results
on
role
bioactive
found
soybeans
health
functions.
Pharmaceutics,
Journal Year:
2021,
Volume and Issue:
13(7), P. 1042 - 1042
Published: July 8, 2021
Treatment
of
neurodegenerative
diseases
has
become
one
the
most
challenging
topics
last
decades
due
to
their
prevalence
and
increasing
societal
cost.
The
crucial
point
non-invasive
therapeutic
strategy
for
neurological
disorder
treatment
relies
on
drugs'
passage
through
blood-brain
barrier
(BBB).
Indeed,
this
biological
is
involved
in
cerebral
vascular
homeostasis
by
its
tight
junctions,
example.
One
way
overcome
limit
deliver
neuroprotective
substances
brain
nanotechnology-based
approaches.
Poly(lactic-
