Polyphenols in Health and Disease: Gut Microbiota, Bioaccessibility, and Bioavailability

Compounds, Journal Year: 2023, Volume and Issue: 3(1), P. 40 - 72

Published: Jan. 5, 2023

Polyphenolic compounds (PC) are among the most abundant secondary metabolites in nature. They widely distributed world and can be found fruits, cereals, tea, coffee, beverages. Due to their structural diversity, polyphenols have many different properties biological effects. resistant acid of gastric tract, very few hydrolysed or absorbed stomach. Significant portions ingested reach large intestine interact with local bacteria, so-called gut microbiota. Epidemiological studies confirm that moderate prolonged intake foods rich could prevent development cancer chronic diseases, such as cardiovascular, neurodegenerative, type 2 diabetes, obesity. The current work aims provide an updated overview on nature occurrence polyphenols, quantification methods, bioaccessibility bioavailability, impact human health, namely through interactions

Language: Английский

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Oxidative stress, the blood–brain barrier and neurodegenerative diseases: The critical beneficial role of dietary antioxidants

Acta Pharmaceutica Sinica B, Journal Year: 2023, Volume and Issue: 13(10), P. 3988 - 4024

Published: July 16, 2023

In recent years, growing awareness of the role oxidative stress in brain health has prompted antioxidants, especially dietary to receive attention as possible treatments strategies for patients with neurodegenerative diseases (NDs). The most widely studied antioxidants include active substances such vitamins, carotenoids, flavonoids and polyphenols. Dietary are found usually consumed foods fresh fruits, vegetables, nuts oils gaining popularity due recently their potential preventive protective agents against NDs, well abundant natural sources, generally non-toxic nature, ease long-term consumption. This review article examines development explores ‘two-sidedness’ blood–brain barrier (BBB) a nervous system an impeding use drug medicinal products and/or supplements prevention therapy reviews BBB permeability common suplements efficacy treatment NDs. Finally, current challenges future directions NDs using discussed, useful information on is provided.

Language: Английский

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Polyphenols as Antioxidant/Pro-Oxidant Compounds and Donors of Reducing Species: Relationship with Human Antioxidant Metabolism

Processes, Journal Year: 2023, Volume and Issue: 11(9), P. 2771 - 2771

Published: Sept. 16, 2023

In this review, we have focused mainly on the study of their antioxidant and pro-oxidant capacity, analysis oxidation catechol group to o-quinone. The redox balance established between different oxidase reductase enzymes generates reducing species, H+ e−, allows polyphenolic groups quinones be reversible. This continuous these nucleophilic electrophilic substances activation NRF2/ARE axis, which regulates cellular responses against oxidative stress, as well cell proliferation. Understanding ambivalent character polyphenols, can act simultaneously antioxidants pro-oxidants, will allow design specific therapies that serve science medicine in tasks.

Language: Английский

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Unraveling the therapeutic efficacy of resveratrol in Alzheimer’s disease: an umbrella review of systematic evidence

Nutrition & Metabolism, Journal Year: 2024, Volume and Issue: 21(1)

Published: March 19, 2024

Abstract Context Resveratrol (RV), a natural compound found in grapes, berries, and peanuts, has been extensively studied for its potential treating Alzheimer’s disease (AD). RV shown promise inhibiting the formation of beta-amyloid plaques (Aβ) neurofibrillary tangles (NFTs), protecting against neuronal damage oxidative stress, reducing inflammation, promoting neuroprotection, improving function blood–brain barrier (BBB). However, conflicting results have reported, necessitating comprehensive umbrella review systematic reviews to provide an unbiased conclusion on therapeutic effectiveness AD. Objective The objective this study was systematically synthesize evaluate meta-analysis investigating role AD using data from both human animal studies. Data sources extraction Of 34 examining association between that were collected, six included based specific selection criteria. To identify pertinent studies, search conducted English-language peer-reviewed journals without any restrictions publication date until October 15, 2023. carried out across multiple databases, including Embase, MEDLINE (PubMed), Cochrane Library, Web Science, Google Scholar, utilizing appropriate terms relevant research field. AMSTAR-2 ROBIS tools also used quality risk bias reviews, respectively. Two researchers independently extracted analyzed data, resolving discrepancies through consensus. note, adhered PRIOR checklist. analysis This presented robust evidence supporting positive impacts AD, irrespective mechanisms involved. It indeed indicated all unanimously concluded consumption can be effective treatment Conclusion exhibits promising benefiting individuals with various mechanisms. observed enhance cognitive function, reduce Aβ accumulation, protect BBB, support mitochondrial facilitate synaptic plasticity, stabilize tau proteins, mitigate neuroinflammation commonly associated Graphical abstract

Language: Английский

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The role of dietary antioxidants in type 2 diabetes and neurodegenerative disorders: An assessment of the benefit profile

Heliyon, Journal Year: 2022, Volume and Issue: 9(1), P. e12698 - e12698

Published: Dec. 31, 2022

Healthy diet is vital to cellular health. The human body succumbs numerous diseases which afflict severe economic and psychological burdens on the patient family. Oxidative stress a possible crucial regulator of various pathologies, including type 2 diabetes neurodegenerative diseases. It generates reactive oxygen species (ROS) that trigger dysregulation essential functions, ultimately affecting health homeostasis. However, lower levels ROS can be advantageous are implicated in variety signaling pathways. Due this dichotomy, terms oxidative "eustress," refers good event, "distress," hazardous, have developed. affects multiple pathways, leading compromised insulin secretion, resistance, β-cell dysfunction diabetes. also associated with increased mitochondrial neuroinflammation, aggravating conditions body, particularly age. Treatment includes drugs/therapies often dependence, side effects non-selectivity, toxicity, long run. imperative explore alternative medicines as an adjunct therapy, utilizing natural remedies/resources avoid all harms. Antioxidants components our fight disease by reducing or nullifying excess toxic free radicals produced under pathological conditions. In review, we focus antioxidant dietary foods such tea, coffee, wine, oils, honey role mechanism action these antioxidants alleviating disorders. We aim provide information about alternatives drug treatments used alone combined reduce intake encourage consumption ingredients at doses adequate promote combat pathologies while unwanted risks effects.

Language: Английский

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Therapeutic potential of natural molecules against Alzheimer's disease via SIRT1 modulation

Biomedicine & Pharmacotherapy, Journal Year: 2023, Volume and Issue: 161, P. 114474 - 114474

Published: March 4, 2023

Alzheimer's disease (AD) is a neurodegenerative mainly characterized by progressive cognitive dysfunction and memory impairment. Recent studies have shown that regulating silent information regulator 1 (SIRT1) expression has significant neuroprotective effect, SIRT1 may become new therapeutic target for AD. Natural molecules are an important source of drug development use in AD therapy regulate wide range biological events as well other SIRT1-mediated signaling pathways. This review aims to summarize the correlation between identify vivo vitro investigating anti-AD properties natural modulators A literature search was conducted published January 2000 October 2022 using various databases, including Web Science, PubMed, Google Scholar, Science Direct, EMBASE. molecules, such resveratrol, quercetin, icariin, bisdemethoxycurcumin, dihydromyricetin, salidroside, patchouli, sesamin, rhein, ligustilide, tetramethoxyflavanone, 1-theanine, schisandrin, curcumin, betaine, pterostilbene, ampelopsin, schisanhenol, eriodictyol, potential modulate pathways, thereby combating The modulating discussed this provide potentially novel multi-mechanistic strategy However, future clinical trials need be further investigate their beneficial determine safety efficacy activators against

Language: Английский

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Natural Phenolic Compounds with Neuroprotective Effects

Neurochemical Research, Journal Year: 2023, Volume and Issue: 49(2), P. 306 - 326

Published: Nov. 8, 2023

Language: Английский

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Nutrition: A non‐negligible factor in the pathogenesis and treatment of Alzheimer's disease

Alzheimer s & Dementia, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 27, 2025

Abstract Alzheimer's disease (AD) is a degenerative characterized by progressive cognitive dysfunction. The strong link between nutrition and the occurrence progression of AD pathology has been well documented. Poor nutritional status accelerates progress potentially aggravating amyloid beta (Aβ) tau deposition, exacerbating oxidative stress response, modulating microbiota–gut–brain axis, disrupting blood–brain barrier function. advanced stage tends to lead malnutrition due impairments, sensory dysfunctions, brain atrophy, behavioral psychological symptoms dementia (BPSD). This, in turn, produces vicious cycle AD. This review discusses how factors deteriorate each other from early terminal stages AD, focusing on potential different levels factors, ranging micronutrients diet patterns. provides novel insights into reducing risk delaying its progression, improving prognosis. Highlights Two‐fifths cases worldwide have attributed modifiable factors. Up ≈26% community‐dwelling patients with are malnourished, compared 7%∼76% institutionalized patients. Undernutrition effects onset, prognosis through multiple mechanisms. Various supports were confirmed be protective for via specific

Language: Английский

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A Review of the Changes Produced by Extrusion Cooking on the Bioactive Compounds from Vegetal Sources

Antioxidants, Journal Year: 2023, Volume and Issue: 12(7), P. 1453 - 1453

Published: July 19, 2023

The demand for healthy ready-to-eat foods like snacks is increasing. Physical modification of vegetal food matrices through extrusion generates significant changes in the chemical composition final product. There a great variety that can be used extrusion, most them being based on cereals, legumes, fruits, vegetables, or seeds. aim this review was to summarize main effects process bioactive compounds content, namely phenolics, terpenes, vitamins, minerals, and fibers mixes, as well their biological activity. literature reported contradictory results regarding after mainly due differences processing conditions, composition, physicochemical properties, nutritional value extruded material quantification methods. thermolabile phenolics vitamins were negatively affected by while fiber content proved enhanced. Further research needed interactions between components during more detailed analysis impact terpenes since there are few papers dealing with aspect.

Language: Английский

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In vitro prospective healthy and nutritional benefits of different Citrus monofloral honeys

Scientific Reports, Journal Year: 2023, Volume and Issue: 13(1)

Published: Jan. 19, 2023

Abstract We studied the total polyphenols, flavonoids, vitamin C, antioxidant and anti-inflammatory activity of six Citrus monofloral honey, in vitro inhibitory effect against cholinesterases tyrosinase. Finally, we assessed their biofilm some pathogenic bacteria. Lime honey showed best highest content polyphenols C. Lemon tangerine contained almost exclusively flavonoids. better preserved bovine serum albumin denaturation (IC 50 = 48.47 mg). Honeys inhibited acetylcholinesterase, butyrylcholinesterase, tyrosinase up to 12.04% (tangerine), 19.11% (bergamot), 94.1% (lemon), respectively. clementine Listeria monocytogenes biofilm. Bergamot acted mainly Staphylococcus aureus Acinetobacter baumannii biofilm; bergamot Pseudomonas aeruginosa particularly. Bergamot, clementine, Escherichia coli sessile cell metabolism. This exhibited prospective health benefits is applicable for future vivo studies.

Language: Английский

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