Considerations toward an epigenetic and common pathways theory of mental disorder. DOI Creative Commons
Joel T. Nigg

Journal of Psychopathology and Clinical Science, Journal Year: 2023, Volume and Issue: 132(3), P. 297 - 313

Published: April 1, 2023

Psychopathology emerges from the dynamic interplay of physiological and mental processes ecological context. It can be seen as a failure recursive, homeostatic to achieve adaptive re-equilibrium. This general statement actualized with consideration polygenic liability, early exposures, multiunit (multi-"level") analysis psychological action associated neural operations, all in context developmental exposome. article begins by identifying key principles clarifying terms necessary disorder theory. then ventures sketch model that highlights epigenetic dynamics proposes common pathways hypothesis toward psychopathology. An perspective elevates importance systems, particularly life, while opening door new mechanistic discovery. The proposal is finite number biological mechanisms are shared across most risky environments (and possibly many genetic liabilities) for Perturbation these mediating leads development A focus on changes multiple units time points render problem explaining psychopathology tractable. Key questions include mapping recursive over time, at adequate density, disorders unfold development. (PsycInfo Database Record (c) 2023 APA, rights reserved).

Language: Английский

Multimorbidity DOI Open Access
Søren Thorgaard Skou, Frances S Mair, Martin Fortin

et al.

Nature Reviews Disease Primers, Journal Year: 2022, Volume and Issue: 8(1)

Published: July 14, 2022

Language: Английский

Citations

580
Associations of risk perception of COVID-19 with emotion and mental health during the pandemic DOI Open Access
Qing Han, Bang Zheng, Maximilian Agostini

et al.

Journal of Affective Disorders, Journal Year: 2021, Volume and Issue: 284, P. 247 - 255

Published: Jan. 26, 2021

Language: Английский

Citations

156
What We Have Learned from Two Decades of Epidemics and Pandemics: A Systematic Review and Meta-Analysis of the Psychological Burden of Frontline Healthcare Workers DOI Open Access
Isolde Martina Busch, Francesca Moretti,

Mariangela Mazzi

et al.

Psychotherapy and Psychosomatics, Journal Year: 2021, Volume and Issue: 90(3), P. 178 - 190

Published: Jan. 1, 2021

In light of the current coronavirus disease 2019 (COVID-19) pandemic and potential future infectious outbreaks, a comprehensive understanding negative effects epidemics pandemics on healthcare workers’ mental health could inform appropriate support interventions. Thus, we aimed to synthesize quantify psychological psychosomatic symptoms among frontline medical staff. We searched four databases up March 19, 2020 additional literature, with daily search alerts set until October 26, 2020. Studies reporting and/or workers caring for patients severe acute respiratory syndrome, H1N1, Ebola, Middle East or COVID-19 were eligible inclusion. Two reviewers independently conducted search, study selection, quality appraisal, data extraction, synthesis involved third reviewer in case disagreement. used random modeling estimate overall prevalence rates psychological/psychosomatic I2 statistic. included 86 studies, from 75,991 participants. Frontline staff showed wide range symptoms, including concern about transmitting virus family (60.39%, 95% CI 42.53–76.96), perceived stress (56.77%, 34.21–77.95), concerns own (45.97%, 31.08–61.23), sleeping difficulties (39.88%, 27.70–52.72), burnout (31.81%, 13.32–53.89), depression (25.72%, 18.34–33.86), anxiety (25.36%, 17.90–33.64), posttraumatic disorder (24.51%, 18.16–31.46), issues (23.11%, 15.98–31.10), somatization (14.68%, 10.67–19.18). found consistent evidence pervasive profound impact large-scale outbreaks workers. As CO­VID-19 crisis continues unfold, guaranteeing easy access structures entire workforce is vitally important.

Language: Английский

Citations

156
Impaired insulin signalling and allostatic load in Alzheimer disease DOI
Fernanda G. De Felice, Rafaella A. Gonçalves, Sérgio T. Ferreira

et al.

Nature reviews. Neuroscience, Journal Year: 2022, Volume and Issue: 23(4), P. 215 - 230

Published: Feb. 28, 2022

Language: Английский

Citations

126
Treatment of Posttraumatic Stress Disorder: A State-of-the-art Review DOI Creative Commons
Lisa Burback, Suzette Brémault‐Phillips, Mirjam J. Nijdam

et al.

Current Neuropharmacology, Journal Year: 2023, Volume and Issue: 22(4), P. 557 - 635

Published: May 3, 2023

Abstract: This narrative state-of-the-art review paper describes the progress in understanding and treatment of Posttraumatic Stress Disorder (PTSD). Over last four decades, scientific landscape has matured, with many interdisciplinary contributions to its diagnosis, etiology, epidemiology. Advances genetics, neurobiology, stress pathophysiology, brain imaging have made it apparent that chronic PTSD is a systemic disorder high allostatic load. The current state includes wide variety pharmacological psychotherapeutic approaches, which are evidence-based. However, myriad challenges inherent disorder, such as individual barriers good outcome, comorbidity, emotional dysregulation, suicidality, dissociation, substance use, trauma-related guilt shame, often render response suboptimal. These discussed drivers for emerging novel including early interventions Golden Hours, interventions, medication augmentation use psychedelics, well targeting nervous system. All this aims improve symptom relief clinical outcomes. Finally, phase orientation recognized tool strategize position step progression pathophysiology. Revisions guidelines systems care will be needed incorporate innovative treatments evidence emerges they become mainstream. generation well-positioned address devastating disabling impact traumatic events through holistic, cutting-edge efforts research.

Language: Английский

Citations

96
Allostatic Load and Mortality: A Systematic Review and Meta-Analysis DOI Creative Commons
Haley Parker, Alyssa Abreu, Mary C. Sullivan

et al.

American Journal of Preventive Medicine, Journal Year: 2022, Volume and Issue: 63(1), P. 131 - 140

Published: April 4, 2022

Language: Английский

Citations

81
Guiding principles for the responsible development of artificial intelligence tools for healthcare DOI Creative Commons
Kimberly Badal, Carmen M. Lee, Laura J. Esserman

et al.

Communications Medicine, Journal Year: 2023, Volume and Issue: 3(1)

Published: April 1, 2023

Several principles have been proposed to improve use of artificial intelligence (AI) in healthcare, but the need for AI longstanding healthcare challenges has not sufficiently emphasized. We propose that should be designed alleviate health disparities, report clinically meaningful outcomes, reduce overdiagnosis and overtreatment, high value, consider biographical drivers health, easily tailored local population, promote a learning system, facilitate shared decision-making. These are illustrated by examples from breast cancer research we provide questions can used developers when applying each principle their work.

Language: Английский

Citations

43
Racial disparities in uterine fibroids and endometriosis: a systematic review and application of social, structural, and political context DOI Creative Commons

Jodie G. Katon,

Torie C. Plowden, Erica E. Marsh

et al.

Fertility and Sterility, Journal Year: 2023, Volume and Issue: 119(3), P. 355 - 363

Published: Jan. 20, 2023

Language: Английский

Citations

42
An urgent call to address work‐related psychosocial hazards and improve worker well‐being DOI Creative Commons
Paul A. Schulte,

Steven L. Sauter,

Sudha P. Pandalai

et al.

American Journal of Industrial Medicine, Journal Year: 2024, Volume and Issue: 67(6), P. 499 - 514

Published: April 10, 2024

Abstract Work‐related psychosocial hazards are on the verge of surpassing many other occupational in their contribution to ill‐health, injury, disability, direct and indirect costs, impact business national productivity. The risks associated with exposure at work compounded by increasing background prevalence mental health disorders working‐age population. extensive cumulative impacts these exposures represent an alarming public problem that merits immediate, increased attention. In this paper, we review linkage between work‐related adverse effects, economic burden, interventions prevent control hazards. We identify six crucial societal actions: (1) increase awareness critical issue through a comprehensive campaign; (2) etiologic, intervention, implementation research; (3) initiate or augment surveillance efforts; (4) translation research findings into guidance for employers workers; (5) number diversity professionals skilled preventing addressing hazards; (6) develop regulatory consensus standard

Language: Английский

Citations

17
All-cause, cardiovascular disease and cancer mortality in the population of a large Italian area contaminated by perfluoroalkyl and polyfluoroalkyl substances (1980–2018) DOI Creative Commons
Annibale Biggeri, Giorgia Stoppa,

Laura Facciolo

et al.

Environmental Health, Journal Year: 2024, Volume and Issue: 23(1)

Published: April 16, 2024

Abstract Background Per- and polyfluoroalkyl substances (PFAS) are associated with many adverse health conditions. Among the main effects is carcinogenicity in humans, which deserves to be further clarified. An evident association has been reported for kidney cancer testicular cancer. In 2013, a large episode of surface, ground drinking water contamination PFAS was uncovered three provinces Veneto Region (northern Italy) involving 30 municipalities population about 150,000. We report on temporal evolution all-cause mortality selected cause-specific by calendar period birth cohort local between 1980 2018. Methods The Italian National Institute Health pre-processed made available anonymous data from Statistics death certificate archives residents Vicenza, Padua Verona (males, n = 29,629; females, 29,518) who died Calendar analysis done calculating standardised ratios using total same as reference. performed 20–84 years cumulative ratios. Exposure defined being resident one Red area , where aqueduct supplying fed contaminated groundwater. Results During 34 1985 (assumed beginning date contamination) 2018 (last year availability data), we observed 51,621 deaths vs. 47,731 expected (age- sex-SMR: 108; 90% CI: 107–109). found evidence raised cardiovascular disease (in particular, heart diseases ischemic disease) malignant neoplastic diseases, including Conclusions For first time, an exposure formally demonstrated. regarding consistent previously data.

Language: Английский

Citations

17