International Journal of Molecular Sciences,
Journal Year:
2023,
Volume and Issue:
24(4), P. 3061 - 3061
Published: Feb. 4, 2023
Exosome,
a
subpopulation
of
extracellular
vesicles,
plays
diverse
roles
in
various
biological
processes.
As
one
the
most
abundant
components
exosomes,
exosomal
proteins
have
been
revealed
to
participate
development
many
diseases,
such
as
carcinoma,
sarcoma,
melanoma,
neurological
disorders,
immune
responses,
cardiovascular
and
infection.
Thus,
understanding
functions
mechanisms
potentially
assists
clinical
diagnosis
targeted
delivery
therapies.
However,
current
knowledge
about
function
application
is
still
limited.
In
this
review,
we
summarize
classification
proteins,
exosome
biogenesis
disease
development,
well
applications.
Journal of Translational Medicine,
Journal Year:
2023,
Volume and Issue:
21(1)
Published: July 17, 2023
Abstract
Immunotherapy,
including
immunostimulation
and
immunosuppression,
has
seen
significant
development
in
the
last
10
years.
Immunostimulation
been
verified
as
effective
anti-cancer
treatment,
while
immunosuppression
is
used
treatment
of
autoimmune
disease
inflammation.
Currently,
with
update
newly-invented
simplified
isolation
methods
findings
potent
triggered
immune
responses,
extracellular
vesicle-based
immunotherapy
very
eye-catching.
However,
research
on
three
main
types
vesicles,
exosomes,
microvesicles
apoptotic
bodies,
needs
to
be
more
balanced.
These
subtypes
share
a
certain
level
similarity,
at
same
time,
they
have
their
own
properties
caused
by
different
biogensis.
Herein,
we
summarized
respectively
status
based
each
kind
vesicle
discuss
possible
involved
mechanisms.
In
conclusion,
highlighted
that
effect
body
clear
strong.
Apoptotic
bodies
an
excellent
potential
immunosuppressive
anti-inflammatory
therapies
.
Proteomes,
Journal Year:
2022,
Volume and Issue:
10(2), P. 12 - 12
Published: April 22, 2022
In
the
era
of
multi-omic
sciences,
dogma
on
singular
cause-effect
in
physio-pathological
processes
is
overcome
and
system
biology
approaches
have
been
providing
new
perspectives
to
see
through.
this
context,
extracellular
vesicles
(EVs)
are
offering
a
level
complexity,
given
their
role
cellular
communication
activity
as
mediators
specific
signals
target
cells
or
tissues.
Indeed,
heterogeneity
terms
content,
function,
origin
potentiality
contribute
cross-interaction
almost
every
molecular
process
occurring
complex
system.
Such
features
make
EVs
proper
biological
systems
being,
therefore,
optimal
targets
omic
sciences.
Currently,
most
studies
focus
dissecting
content
order
either
characterize
it
explore
its
various
pathogenic
at
transcriptomic,
proteomic,
metabolomic,
lipidomic
genomic
levels.
Despite
valuable
results
being
provided
by
individual
studies,
categorization
data
might
represent
limit
be
overcome.
For
reason,
integrative
approach
tissue-specific
potentiality.
This
review
summarizes
state-of-the-art
addressing
recent
research
integration
multi-level
challenging
developments
origin.
Frontiers in Immunology,
Journal Year:
2024,
Volume and Issue:
15
Published: Feb. 12, 2024
Complement
is
an
ancient
and
complex
network
of
the
immune
system
and,
as
such,
it
plays
vital
physiological
roles,
but
also
involved
in
numerous
pathological
processes.
The
proper
regulation
complement
important
to
allow
its
sufficient
targeted
activity
without
deleterious
side-effects.
Factor
H
a
major
regulator,
together
with
splice
variant
factor
H-like
protein
1
five
human
H-related
(FHR)
proteins,
they
have
been
linked
various
diseases.
role
inhibiting
activation
well
studied,
function
FHRs
less
characterized.
Current
evidence
supports
main
enhancers
opsonization,
i.e.,
counter-balancing
inhibitory
effect
H.
emerge
soluble
pattern
recognition
molecules
positive
regulators
system.
In
addition,
some
FHR
proteins
were
shown
modulate
cells,
non-canonical
outside
cascade.
Recent
efforts
intensified
study
develop
new
tools
for
distinction,
quantification
functional
characterization
members
this
family.
Here,
we
provide
update
overview
on
versatile
roles
family
what
know
about
their
biological
functions
healthy
conditions
Aging and Disease,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Jan. 1, 2024
Although
significant
progress
has
been
made
in
early
lung
cancer
screening
over
the
past
decade,
it
remains
one
of
most
prevalent
and
deadliest
forms
worldwide.
Exosomal
proteomics
emerged
as
a
transformative
field
research,
with
potential
to
redefine
diagnostics,
prognostic
assessments,
therapeutic
strategies
through
lens
precision
medicine.
This
review
discusses
recent
advances
exosome-related
proteomic
glycoproteomic
technologies,
highlighting
their
revolutionise
treatment
by
addressing
issues
heterogeneity,
integrating
multiomics
data,
utilising
advanced
analytical
methods.
While
these
technologies
show
promise,
there
are
obstacles
overcome
before
they
can
be
widely
implemented,
such
need
for
standardization,
gaps
clinical
application,
importance
dynamic
monitoring.
Future
directions
should
aim
challenges
fully
utilize
exosomal
cancer.
promises
new
era
personalized
medicine
that
leverages
molecular
complexity
exosomes
groundbreaking
advancements
detection,
prognosis,
treatment.
ACS Measurement Science Au,
Journal Year:
2023,
Volume and Issue:
3(3), P. 143 - 161
Published: Feb. 14, 2023
Around
the
world,
lung
cancer
has
long
been
main
factor
in
cancer-related
deaths,
with
small-cell
(SCLC)
being
deadliest
form
of
cancer.
Cancer
cell-derived
exosomes
and
exosomal
miRNAs
are
considered
promising
biomarkers
for
diagnosing
prognosis
various
diseases,
including
SCLC.
Due
to
rapidity
SCLC
metastasis,
early
detection
diagnosis
can
offer
better
therefore
increase
patient's
chances
survival.
Over
past
several
years,
many
methodologies
have
developed
analyzing
non-SCLC-derived
exosomes.
However,
minimal
advances
made
SCLC-derived
exosome
analysis
methodologies.
This
Review
discusses
epidemiology
prominent
Followed
by
a
discussion
about
effective
strategies
isolating
detecting
miRNA,
highlighting
critical
challenges
limitations
current
Finally,
an
overview
is
provided
detailing
future
perspectives
exosome-based
research.
Bionatura journal :,
Journal Year:
2025,
Volume and Issue:
2(1), P. 1 - 17
Published: Jan. 11, 2025
El
cáncer
es
un
problema
de
salud
a
nivel
mundial,
siendo
una
sus
principales
problemáticas
la
detección
tiempo.
Es
por
eso,
que
se
ha
propuesto
determinación
biomarcadores
exosomales
como
posible
herramienta
al
momento
diagnosticar
esta
patología,
ya
que,
además
ser
elementos
importantes
en
comunicación
intracelular
transportar
biomoléculas
celulares
lípidos,
ácidos
nucleicos,
proteínas
y
metabolitos
asociados
su
célula
productora,
actúan
reguladores
del
microambiente
tumoral,
encargado
angiogénesis,
progresión
desarrollo
metástasis.
Para
aislamiento,
existen
diversas
técnicas
relacionadas
con
ultracentrifugación,
ultrafiltración
e
inmunoafinidad
permiten
separación
diferentes
fuentes,
sean,
fluidos
biológicos
o
medios
cultivo,
facilitando
estudio
el
contexto
cáncer.
Palabras
clave:
Exosomas;
Biomarcadores
Tumor;
Cáncer,
Diagnóstico
clínico.
ABSTRACT
Bronchoalveolar
lavage
fluid
(BALF)
has
long
been
used
for
diagnosing
various
lung
diseases
through
its
cellular
components.
However,
the
clinical
utility
of
biomolecules
in
BALF
remains
largely
unexplored.
Recently,
mass
spectrometry‐based
proteomics
applied
to
profile
proteomes
identify
novel
biomarkers
diseases.
This
review
discusses
current
progress
field
and
highlights
potential
as
a
valuable
source
different
Additionally,
we
explored
latest
advancements
findings
from
studies.
Finally,
address
limitations
propose
future
directions
research
opportunities
advance
study
BALF.
