The Influence of Probiotics on the Firmicutes/Bacteroidetes Ratio in the Treatment of Obesity and Inflammatory Bowel disease

Microorganisms, Journal Year: 2020, Volume and Issue: 8(11), P. 1715 - 1715

Published: Nov. 1, 2020

The two most important bacterial phyla in the gastrointestinal tract, Firmicutes and Bacteroidetes, have gained much attention recent years. Firmicutes/Bacteroidetes (F/B) ratio is widely accepted to an influence maintaining normal intestinal homeostasis. Increased or decreased F/B regarded as dysbiosis, whereby former usually observed with obesity, latter inflammatory bowel disease (IBD). Probiotics live microorganisms can confer health benefits host when administered adequate amounts. There considerable evidence of their nutritional immunosuppressive properties including reports that elucidate association probiotics ratio, IBD. Orally contribute restoration dysbiotic microbiota prevention obesity However, effects different on differ, selecting appropriate species mixture crucial. commonly tested for modifying treating IBD are from genus Lactobacillus. In this paper, we review lead weight loss immunosuppression.

Language: Английский

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Gallstone Disease, Obesity and the Firmicutes/Bacteroidetes Ratio as a Possible Biomarker of Gut Dysbiosis

Journal of Personalized Medicine, Journal Year: 2020, Volume and Issue: 11(1), P. 13 - 13

Published: Dec. 25, 2020

Obesity is a major risk factor for developing gallstone disease (GSD). Previous studies have shown that obesity associated with an elevated Firmicutes/Bacteroidetes ratio in the gut microbiota. These findings suggest development of GSD may be related to dysbiosis. This review presents and summarizes recent on microbiota patients GSD. Most significant increase phyla Firmicutes (Lactobacillaceae family, genera Clostridium, Ruminococcus, Veillonella, Blautia, Dorea, Anaerostipes, Oscillospira), Actinobacteria (Bifidobacterium genus), Proteobacteria, Bacteroidetes (genera Bacteroides, Prevotella, Fusobacterium) decrease (family Muribaculaceae, Alistipes, Paludibacter, Barnesiella), Faecalibacterium, Eubacterium, Lachnospira, Roseburia), Proteobacteria (Desulfovibrio genus). The influence microbial diversity not clear. Some report reduces bile, whereas others bile (especially family Enterobacteriaceae) (Enterococcus genus) are most commonly detected On other hand, composition shows considerable inter-individual variability. impact unclear reports contradictory. For this reason, it should stated results reviewed do allow drawing unequivocal conclusions regarding relationship between

Language: Английский

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Gut microbiota drives age-related oxidative stress and mitochondrial damage in microglia via the metabolite N6-carboxymethyllysine

Nature Neuroscience, Journal Year: 2022, Volume and Issue: 25(3), P. 295 - 305

Published: March 1, 2022

Language: Английский

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The gut microbiota and its biogeography

Nature Reviews Microbiology, Journal Year: 2023, Volume and Issue: 22(2), P. 105 - 118

Published: Sept. 22, 2023

Language: Английский

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Elucidating the role of diet in maintaining gut health to reduce the risk of obesity, cardiovascular and other age-related inflammatory diseases: recent challenges and future recommendations

Gut Microbes, Journal Year: 2024, Volume and Issue: 16(1)

Published: Jan. 4, 2024

A healthy balanced diet is crucial in protecting the immune system against infections and diseases. Poor diets, such as Western diet, contribute to development of metabolic diseases, hypertension, obesity. Microbiota, primarily composed different microorganisms residing gastrointestinal tract (GIT), also play a significant role maintaining gut health. Polyphenols probiotics found fruits, vegetables, whole grains, legumes, nuts, seeds promote health support growth beneficial bacteria. Different types their categories, impact on are mentioned. The relationship between health, risk developing obesity, cardiovascular inflammatory diseases discussed this review article. rationale behind concludes future recommendations for reducing occurrence cardiometabolic other There need standardized research methods, long-term studies, translating scientific knowledge into practical dietary recommendations.

Language: Английский

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The Firmicutes/Bacteroidetes Ratio as a Risk Factor of Breast Cancer

Journal of Clinical Medicine, Journal Year: 2023, Volume and Issue: 12(6), P. 2216 - 2216

Published: March 13, 2023

The gut microbiome can reflect the health condition of entire body. Firmicutes and Bacteroidetes, major phyla colon, influence diseases related to obesity which are also risk factors for breast cancer. Therefore, Firmicutes/Bacteroidetes (F/B) ratio was analyzed in patients with Bacterial extracellular vesicles were extracted from serum cancer healthy controls. Phyla Bacteroidetes using sequencing. Prognostic serological test results correlations F/B ratio. three times lower than In addition, factor cancer, such as fasting glucose, found be used a clue explain underlying mechanisms affecting development

Language: Английский

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Neurodegenerative and Neurodevelopmental Diseases and the Gut-Brain Axis: The Potential of Therapeutic Targeting of the Microbiome

International Journal of Molecular Sciences, Journal Year: 2023, Volume and Issue: 24(11), P. 9577 - 9577

Published: May 31, 2023

The human gut microbiome contains the largest number of bacteria in body and has potential to greatly influence metabolism, not only locally but also systemically. There is an established link between a healthy, balanced, diverse overall health. When becomes unbalanced (dysbiosis) through dietary changes, medication use, lifestyle choices, environmental factors, ageing, this profound effect on our health linked many diseases, including metabolic inflammatory neurological diseases. While humans largely association dysbiosis with disease, animal models, causative can be demonstrated. brain particularly important maintaining health, strong neurodegenerative neurodevelopmental This suggests that microbiota composition used make early diagnosis diseases modifying microbiome-gut-brain axis might present therapeutic target for have proved intractable, aim altering trajectory such as Alzheimer's Parkinson's multiple sclerosis, autism spectrum disorder, attention-deficit hyperactivity among others. other potentially reversible migraine, post-operative cognitive dysfunction, long COVID, which considered models therapy disease. role traditional methods microbiome, well newer, more novel treatments faecal transplants photobiomodulation, are discussed.

Language: Английский

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Role of the intestinal microbiome and its therapeutic intervention in cardiovascular disorder

Frontiers in Immunology, Journal Year: 2024, Volume and Issue: 15

Published: Jan. 26, 2024

The gut microbiome is a heterogeneous population of microbes comprising viruses, bacteria, fungi, and protozoa. Such essential for sustaining host equilibrium, its impact on human health can be altered by variety factors such as external variables, social behavior, age, nutrition, genetics. Gut microbes’ imbalances are related to chronic diseases including cancer, obesity, digestive disorders. Globally, recent findings show that intestinal have significant role in the formation cardiovascular disease (CVD), which still primary cause fatalities. Atherosclerosis, hypertension, diabetes, inflammation, some inherited variables all risk variables. However, studies found correlations between metabolism, flora, dietary intake. Variations diversity changes their activity thought influence CVD etiology. Furthermore, microbiota acts an endocrine organ, producing bioactive metabolites TMA (trimethylamine)/TMAO (trimethylamine N-oxide), SCFA (short-chain fatty acids), bile acids, substantial wellness multiple mechanisms. purpose this overview compile current evidence highlighting intricate links microbiota, metabolites, development CVD. It focuses how dysbiosis promotes heart failure, atherosclerosis. This review explores normal physiology potential techniques targeting bacteria treatment using various microbial metabolites. also examines significance treatment, supplements, prebiotics, probiotics, antibiotic therapies, fecal transplantation, innovative approach management As result, metabolic pathways become increasingly attractive targets intervention.

Language: Английский

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A Comprehensive Review of the Triangular Relationship among Diet–Gut Microbiota–Inflammation

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(17), P. 9366 - 9366

Published: Aug. 29, 2024

The human gastrointestinal tract hosts a complex and dynamic community of microorganisms known as the gut microbiota, which play pivotal role in numerous physiological processes, including digestion, metabolism, immune function. Recent research has highlighted significant impact diet on microbiota composition functionality, consequential effects host health. Concurrently, there is growing evidence linking to inflammation, key factor many chronic diseases such inflammatory bowel disease (IBD), obesity, diabetes, cardiovascular (CVDs). This review explores how dietary components influence composition, these microbial changes affect pathways, therapeutic implications modulating this axis for prevention management. Beneficial patterns, Mediterranean (MD) plant-based diets, promote diverse balanced supporting anti-inflammatory pathways. Conversely, Western (WD), high saturated fats refined sugars, associated with dysbiosis increased inflammation. With all links between three variables considered, attempts offer thorough examination triangle formed by food.

Language: Английский

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The microbiota–gut–brain axis in Huntington's disease: pathogenic mechanisms and therapeutic targets

FEBS Journal, Journal Year: 2024, Volume and Issue: unknown

Published: March 1, 2024

Huntington's disease (HD) is a currently incurable neurogenerative disorder and typically characterized by progressive movement (including chorea), cognitive deficits (culminating in dementia), psychiatric abnormalities (the most common of which depression), peripheral symptoms gastrointestinal dysfunction). There are no approved disease‐modifying therapies available for HD, with death usually occurring approximately 10–25 years after onset, but some hold promising potential. HD subjects often burdened chronic diarrhea, constipation, esophageal gastric inflammation, susceptibility to diabetes. Our understanding the microbiota–gut–brain axis its infancy growing evidence from preclinical clinical studies suggests role gut microbial population imbalance (gut dysbiosis) pathophysiology. The brain can communicate through enteric nervous system, immune vagus nerve, microbiota‐derived‐metabolites including short‐chain fatty acids, bile branched‐chain amino acids. This review summarizes supporting demonstrating alterations bacterial fungal composition that may be associated HD. We focus on mechanisms dysbiosis compromise health, thus triggering neuroinflammatory responses, further highlight outcomes attempts modulate microbiota as therapeutic strategies Ultimately, we discuss dearth data need more longitudinal translational this nascent field. suggest future directions improve our association between microbes pathogenesis other ‘brain body disorders’.

Language: Английский

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