Piezo1 Channels as Force Sensors in Mechanical Force-Related Chronic Inflammation

Frontiers in Immunology, Journal Year: 2022, Volume and Issue: 13

Published: Jan. 26, 2022

Mechanical damage is one of the predisposing factors inflammation, and it runs through entire inflammatory pathological process. Repeated or persistent damaging mechanical irritation leads to chronic diseases. The mechanism how forces induce inflammation not fully understood. Piezo1 a newly discovered mechanically sensitive ion channel. channel opens in response stimuli, transducing signals into an cascade cell leading tissue inflammation. A large amount evidence shows that plays vital role occurrence progression This mini-review briefly presents new responds different stresses trigger various tissues. discovery provides insights for treatment diseases related stress. Inhibiting transduction can inhibit improve outcome at early stage. pharmacology has shown bright prospects. development tissue-specific drugs clinical use may be target treating

Language: Английский

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Inflamm-ageing: how cytokines and nutrition shape the trajectory of ageing

Cytokine & Growth Factor Reviews, Journal Year: 2024, Volume and Issue: unknown

Published: Sept. 1, 2024

Population ageing is increasing in prevalence most developed countries. Ageing the decline of functional properties at cellular, tissue, and organ level. Biochemical changes that occur all organisms experience biological are referred to as "Hallmarks ageing". Inflammation a common denominator hallmarks ageing, being mechanistically involved age-related health consequences. Inflamm-ageing refers inflammatory immune systems which somehow drive process towards healthy or unhealthy ageing. Current evidences, support that, reversing pro-inflammatory status inflamm-ageing, able modulate associated with increased levels molecules (e.g. cytokines, chemokines), ultimately producing chronic low-grade state typically observed older individuals. It commonly accepted balance between pro- anti-inflammatory cytokines/chemokines one factors determining whether occurs. Malnutrition nutritional imbalances, highly prevalent elderly, playing role driving immunoactive molecules. In particular, malnutrition major risk factor for sarcopenia, phenomenon characterized by loss muscle mass, often basis frailty. Given close relationship there also evidence link Indeed, cytokine/chemokine elderly patients were demonstrated. The demonstration specific cytokines play modulating appetite nutrient sensing taste reception, provided further existence nutrition shaping trajectory present review will overview current supporting circulating chemokines inflammation, malnutrition.

Language: Английский

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Diagnostics of inflammaging in relation to sarcopenia

Frontiers in Public Health, Journal Year: 2023, Volume and Issue: 11

Published: July 3, 2023

One of the theories about aging focuses on immune response and relates to activation subclinical chronic inflammation. This study was designed investigate relationship between inflammation sarcopenia evaluate influence lifestyle inflammatory profile. Finally, therapeutic strategies counteract pathophysiological effect skeletal muscle were also indicated. hundred seventy-three individuals aged 71.5 ± 6.8 years divided into two groups: probable ( n = 39) no 134). Sarcopenia assessed according algorithm European Working Group in older adults 2. C-reactive protein (CRP) p 0.011) CRP/albumin ratio 0.030) as well IL-1β 0.002), cfDNA < 0.001) bilirubin levels 0.002) significantly higher group opposed group. No significant differences observed groups concentration TNFα 0.429) IL-6 0.300). An inverse correlation found gait speed r s −0.234, 0.01) −0.263, 0.01). The ROC analysis cfDNA, CRP, ranged from 0.6 0.7, which confirms association mediators indicates high clinical usefulness prediction. We indicated a link fitness level adult thereby providing evidence that exercise should be key strategy prevention.

Language: Английский

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Inflammaging at the Time of COVID-19

Clinics in Geriatric Medicine, Journal Year: 2022, Volume and Issue: 38(3), P. 473 - 481

Published: March 21, 2022

Language: Английский

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Global research trends in inflammaging from 2005 to 2024: a bibliometric analysis

Frontiers in Aging, Journal Year: 2025, Volume and Issue: 6

Published: April 10, 2025

Background Inflammaging, defined as chronic low-grade inflammation associated with aging, is considered a key factor in many age-related diseases. Despite growing research, comprehensive assessments of trends and focuses on this field over the past 2 decades remain lacking. Objective To comprehensively analyze literature development trends, scientific priorities, their evolution inflammaging from 2005 to 2024 using bibliometric analysis. Methods Academic was retrieved Web Science Core Collection. CiteSpace software used tool annual publication contributing countries/regions, leading research institutions, primary journals, keyword co-occurrence, including clustering burst analysis field. Results The study included 1,800 eligible articles, demonstrating consistent growth publications 20 years. United States Italy were principal contributors. University Bologna had highest publication. Professor Claudio Franceschi has been figure Journal shows that themes predominantly focus molecular biology/immunology medicine/clinical fields. Keyword identifies major hotspots “inflammaging,” “Crohn’s disease,” “periodontitis,” “immunosenescence,” “skeletal muscle,” “gut microbiota,” “Parkinson’s disease.” Emerging term indicates shift specific inflammatory diseases broader aging immune modulation studies. Conclusion This first systematic assessment reveals sustained academic an increasingly deep focus.

Language: Английский

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Effectiveness of Resistance Exercise on Inflammatory Biomarkers in Patients with Type 2 Diabetes Mellitus: A Systematic Review with Meta-Analysis

Diabetes & Metabolism Journal, Journal Year: 2022, Volume and Issue: 47(1), P. 118 - 134

Published: April 29, 2022

Type 2 diabetes mellitus (T2DM) is related to increased inflammatory processes. The effects of resistance exercise on biomarkers in T2DM are controversial. Our purpose was determine the effectiveness patients diagnosed with T2DM. We searched four databases until September 2021. included randomized clinical trials (RCTs) (C-reactive protein [CRP], tumor necrosis factor alpha, interleukin-6, and interleukin-10) A random meta-analysis conducted standardized mean difference (SMD) raw (MD) for CRP. Thirteen RCTs were review, 11 Lower CRP levels observed when compared control groups (SMD=-0.20; 95% confidence interval [CI], -0.37 -0.02). When conducting MD meta-analysis, showed a significant decrease -0.59 mg/dL (95% CI, -0.88 -0.30); otherwise, groups, values 0.19 0.17 0.21). Evidence supports as an effective strategy manage systemic inflammation by decreasing evidence still inconclusive other biomarkers.

Language: Английский

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Anemia and Its Connections to Inflammation in Older Adults: A Review

Journal of Clinical Medicine, Journal Year: 2024, Volume and Issue: 13(7), P. 2049 - 2049

Published: April 2, 2024

Anemia is a common hematological disorder that affects 12% of the community-dwelling population, 40% hospitalized patients, and 47% nursing home residents. Our understanding impact inflammation on iron metabolism erythropoiesis still lacking. In older adults, anemia can be divided into nutritional deficiency anemia, bleeding unexplained anemia. The last type might caused by reduced erythropoietin (EPO) activity, progressive EPO resistance bone marrow erythroid progenitors, chronic subclinical pro-inflammatory state. Overall, one-third patients with demonstrate deficiency, have state kidney disease, suffer from unknown etiology. Understanding anemia’s pathophysiology in people aged 65 over crucial because it contributes to frailty, falls, cognitive decline, decreased functional ability, higher mortality risk. Inflammation produces adverse effects cells system. These include (hypoferremia), production, elevated phagocytosis erythrocytes hepatic splenic macrophages. Additionally, causes enhanced eryptosis due oxidative stress circulation. Identifying mechanisms behind age-related essential for better preventing adults.

Language: Английский

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Inflammatory Profile of Older Adults in Response to Physical Activity and Diet Supplementation: A Systematic Review

International Journal of Environmental Research and Public Health, Journal Year: 2023, Volume and Issue: 20(5), P. 4111 - 4111

Published: Feb. 25, 2023

Chronic, low-grade inflammation in the elderly, usually known as inflammaging, accelerates development of age-related diseases, including cancer, obesity, sarcopenia, and cardio-metabolic diseases. Two most studied interventions against are diet supplementation regular practice exercise. The search for this systematic review was performed Scopus, EBSCO, PubMed databases within last 10 years. Only randomized controlled trials that evaluated effect exercise inflammatory markers older adults were included. After applying eligibility criteria risk-of-bias assessment, 11 studies included review. In total, 638 participants analyzed main supplements amino acid or protein from different sources. counterpart, applied evaluations strengthening exercises aerobic training. had a range duration between 4 24 weeks, effects on showed decrease pro-inflammatory cytokines non- slightly significant change anti-inflammatory cytokines. However, these results suggest supplement can contribute to diminishing process elderly. We also conclude further well-designed needed confirm possible synergistic food elderly due limited currently exist. This registered PROSPERO, ID CRD42023387184.

Language: Английский

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Association between the Finnish Diabetes Risk Score and cancer in middle-aged and older adults: Involvement of inflammation

Metabolism, Journal Year: 2023, Volume and Issue: 144, P. 155586 - 155586

Published: May 8, 2023

BackgroundDiabetes is associated with increased risk of common cancers. However, evidence cancer in individuals different diabetes still scarce, and the underlying mechanism remains unknown. Therefore, we aimed to evaluate relationship between Finnish Diabetes Risk Score (FINDRISC) risks incidence mortality a prospective study, explore whether low-grade inflammation partially mediated association.MethodsA total 330,384 participants aged 37 73 at baseline from UK Biobank database was included this study. The Cox proportional hazards model used examine FINDRISC mortality. Then, estimated contribution higher overall site-specific In addition, role association investigated through mediation analysis.ResultsThe dose-dependently an overwhelming majority strong contributor eighteen cancers fourteen cancers, population-attributable 8.1 %–39.1 %, 14.2 %–39.7 respectively. Additionally, mainly cancer, colorectal etc.ConclusionsOur findings highlighted as critical factors mortality, by inflammation. Individuals are also needed be concerned about prevention.

Language: Английский

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The Role of Inflammation in Age-Associated Changes in Red Blood System

International Journal of Molecular Sciences, Journal Year: 2023, Volume and Issue: 24(10), P. 8944 - 8944

Published: May 18, 2023

Aging-related anemia contributes to frailty syndrome, cognitive decline and early mortality. The study aim was evaluate inflammaging in relation as a prognostic indicator affected older patients. participants (73.0 ± 7.2 years) were allocated into anemic (n = 47) non-anemic 66) groups. hematological variables RBC, MCV, MCH, RDW, iron ferritin significantly lower, whereas erythropoietin EPO transferrin Tf tended toward higher values the group. Approx. 26% of individuals demonstrated saturation TfS < 20%, which clearly indicates age-related deficiency. cut-off for pro-inflammatory cytokine IL-1β, TNFα hepcidin 5.3 ng/mL, 97.7 ng/mL 9.4 respectively. High IL-1β negatively Hb concentration (rs -0.581, p 0.0001). Relatively high odds ratios observed (OR 72.374, 95%Cl 19.688-354.366) peripheral blood mononuclear cells CD34 3.264, 1.263-8.747) CD38 4.398, 1.701-11.906), together probability developing anemia. results endorse interplay between inflammatory status metabolism usefulness identification underlying causes anemia, while appeared useful compensatory response assessment and, longer term, part comprehensive approach monitoring adults.

Language: Английский

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