Cell Death Discovery,
Journal Year:
2024,
Volume and Issue:
10(1)
Published: Oct. 29, 2024
Abstract
Mitophagy,
a
form
of
selective
autophagy
that
removes
damaged
or
dysfunctional
mitochondria,
plays
crucial
role
in
maintaining
mitochondrial
and
cellular
homeostasis.
Recent
findings
suggest
defective
mitophagy
is
closely
associated
with
various
diseases,
including
breast
cancer.
Moreover,
better
understanding
the
multifaceted
roles
cancer
progression
for
treatment
this
disease.
Here,
we
will
summarize
molecular
mechanisms
process.
In
addition,
highlight
expression
patterns
mitophagy-related
signaling
molecules
potential
implications
development
cancer,
aiming
to
provide
therapeutic
strategies
treatment.
Antioxidants,
Journal Year:
2023,
Volume and Issue:
12(3), P. 769 - 769
Published: March 21, 2023
During
oxidative
stress,
an
important
factor
in
the
development
of
many
diseases,
cellular
and
antioxidant
activities
are
imbalanced
due
to
various
internal
external
factors
such
as
inflammation
or
diet.
The
administration
probiotic
Lactobacillus
strains
has
been
shown
confer
a
range
antibacterial,
anti-inflammatory,
antioxidant,
immunomodulatory
effects
host.
This
review
focuses
on
potential
role
stress
inflammatory
bowel
diseases
(IBD),
cancer,
liver-related
context
preventive
therapeutic
associated
with
Lactobacillus.
article
reviews
studies
cell
lines
animal
models
well
some
clinical
population
reports
that
suggest
could
alleviate
basic
symptoms
related
abnormal
indicators
IBD,
cancers,
liver
damage,
covers
evidence
supporting
for
Nrf2,
NF-κB,
MAPK
signaling
pathways
alleviating
inflammation,
aberrant
proliferation,
apoptosis.
also
discusses
unmet
needs
future
directions
research
including
more
extensive
mechanistic
analyses
trials
Lactobacillus-based
treatments.
Polymers,
Journal Year:
2023,
Volume and Issue:
15(13), P. 2953 - 2953
Published: July 5, 2023
Breast
cancer
is
a
major
cause
of
death
globally,
accounting
for
around
13%
all
deaths.
Chemotherapy,
the
common
treatment
cancer,
can
have
side
effects
that
lead
to
production
reactive
oxygen
species
(ROS)
and
an
increase
in
oxidative
stress
body.
Antioxidants
are
important
maintaining
health
cells
helping
immune
system
function
properly.
They
play
crucial
role
balancing
body's
internal
environment.
Using
natural
antioxidants
alternative
mitigate
harmful
stress.
However,
80%
limited
effectiveness
when
taken
orally
because
they
do
not
dissolve
well
water
or
other
solvents.
This
poor
solubility
affects
their
ability
be
absorbed
by
body
limits
bioavailability.
One
strategy
has
been
considered
oral
Chitosan-based
nanoparticle
(CSNP)
systems
extensively
explored
due
reliability
simpler
synthesis
routes.
review
focuses
on
various
methods
chitosan-based
nanoformulation
developing
effective
dosage
forms
based
pharmacokinetics
pharmacodynamics
properties.
Chitosan
(CS)
could
model,
its
wide
use
polymeric
NPs
research,
thus
providing
better
understanding
vehicles
carry
stability
enhancing
performance
drugs.
Small,
Journal Year:
2024,
Volume and Issue:
unknown
Published: April 30, 2024
Natural
polyphenolic
compound
rosmarinic
acid
(RA)
has
good
antitumor
activity.
However,
the
distinctive
tumor
microenvironment,
characterized
by
low
pH
and
elevated
levels
of
glutathione
(GSH),
enhances
tolerance
tumors
to
singular
anti-tumor
treatment
mode
using
RA,
resulting
in
unsatisfactory
therapeutic
efficacy.
Targeting
nonapoptotic
programmed
cell
death
processes
may
provide
another
impetus
inhibit
growth.
RA
possesses
capability
coordinate
with
metal
elements.
To
solve
effect
restriction
above
single
mode,
it
is
proposed
construct
a
self-assembled
nanocomposite,
Fe-RA.
Under
Fe-RA
nanocomposite
exerts
characteristics
POD-like
enzyme
activity
depletion
GSH,
producing
large
amount
hydroxyl
radical
(·OH)
while
disrupting
antioxidant
defense
system
cells.
Moreover,
due
enhanced
permeability
retention
(EPR),
can
transport
Fe
Antioxidants,
Journal Year:
2024,
Volume and Issue:
13(12), P. 1462 - 1462
Published: Nov. 28, 2024
Upregulation
of
reactive
oxygen
species
(ROS)
levels
is
a
principal
feature
observed
in
the
brains
neurodegenerative
diseases
such
as
Parkinson’s
disease
(PD)
and
Alzheimer’s
(AD).
In
these
diseases,
oxidative
stress
can
disrupt
blood–brain
barrier
(BBB).
This
disruption
allows
neurotoxic
plasma
components,
blood
cells,
pathogens
to
enter
brain,
leading
increased
ROS
production,
mitochondrial
dysfunction,
inflammation.
Collectively,
factors
result
protein
modification,
lipid
peroxidation,
DNA
damage,
and,
ultimately,
neural
cell
damage.
this
review
article,
we
present
mechanisms
by
which
damage
leads
BBB
breakdown
brain
diseases.
Additionally,
summarize
potential
therapeutic
approaches
aimed
at
reducing
that
contributes
Journal of Personalized Medicine,
Journal Year:
2025,
Volume and Issue:
15(2), P. 50 - 50
Published: Jan. 27, 2025
Drug
resistance
remains
a
significant
barrier
to
effective
cancer
therapy.
Cancer
cells
evade
treatment
by
reprogramming
their
metabolism,
switching
from
glycolysis
oxidative
phosphorylation
(OXPHOS),
and
relying
on
alternative
carbon
sources
such
as
glutamine.
These
adaptations
not
only
enable
tumor
survival
but
also
contribute
immune
evasion
through
mechanisms
reactive
oxygen
species
(ROS)
generation
the
upregulation
of
checkpoint
molecules
like
PD-L1.
This
review
explores
potential
targeting
metabolic
weaknesses
in
drug-resistant
cancers
enhance
therapeutic
efficacy.
Key
pathways
involved
resistance,
including
glycolysis,
glutamine
kynurenine
pathway,
are
discussed.
The
combination
inhibitors
with
(ICIs),
particularly
anti-PD-1/PD-L1
therapies,
represents
promising
approach
overcoming
both
mechanisms.
Clinical
trials
combining
therapies
have
shown
early
promise,
further
research
is
needed
optimize
combinations
identify
biomarkers
for
patient
selection.
In
conclusion,
metabolism
blockade
offers
novel
drug
providing
pathway
improved
outcomes
Future
directions
include
personalized
treatments
based
profiles
expanding
other
types.
Journal of Clinical Investigation,
Journal Year:
2025,
Volume and Issue:
135(7)
Published: March 31, 2025
Tertiary
lymphoid
structures
(TLS)
in
the
tumor
microenvironment
(TME)
are
emerging
solid-tumor
indicators
of
prognosis
and
response
to
immunotherapy.
Considering
that
tumorigenesis
requires
metabolic
reprogramming
subsequent
TME
remodeling,
discovery
TLS
regulators
is
expected
produce
immunotherapeutic
targets.
To
identify
such
regulators,
we
constructed
a
metabolism-focused
sgRNA
library
performed
an
vivo
CRISPR
screening
orthotopic
lung
mouse
model.
Combined
with
The
Cancer
Genome
Atlas
database
analysis
TLS-related
hub
genes,
found
loss
Acat1
cells
sensitized
tumors
anti-PD1
treatment,
accompanied
by
increased
TME.
Mechanistic
studies
revealed
ACAT1
resulted
mitochondrial
protein
hypersuccinylation
subsequently
enhanced
oxidative
metabolism,
which
impeded
formation.
Elimination
ROS
NAC
or
knockdown
promoted
B
cell
aggregation
construction.
Consistently,
data
from
tissue
microassays
305
patients
cancer
showed
were
more
abundant
non-small
(NSCLC)
tissues
lower
expression.
Intratumoral
expression
was
associated
poor
immunotherapy
outcomes
NSCLC.
In
conclusion,
our
results
identified
as
regulator
promising
target
