Remnant cholesterol is correlated with retinal vascular morphology and diabetic retinopathy in type 2 diabetes mellitus: a cross-sectional study DOI Creative Commons
Shuli Chen,

Yi Xu,

Bo Chen

et al.

Lipids in Health and Disease, Journal Year: 2024, Volume and Issue: 23(1)

Published: March 11, 2024

Abstract Background The association between remnant cholesterol (RC) and diabetic retinopathy (DR) in type 2 diabetes mellitus (T2DM) remains unclear. Morphological changes retinal vessels have been reported to predict vascular complications of diabetes, including DR. Methods This cross-sectional study included 6535 individuals with T2DM. RC value was calculated using the recognized formula. parameters were measured fundus photography. independent relationship DR analyzed binary logistic regression models. Multiple linear subgroup analyses employed investigate link parameters, arteriolar diameter (CRAE), venular (CRVE), fractal dimension (D f ). Mediation analysis performed assess whether morphology could explain Results independently associated patients a longer duration T2DM (> 7 years). Patients highest quartile levels had larger CRAE (5.559 [4.093, 7.025] μm), CRVE (7.620 [5.298, 9.941] μm) D (0.013 [0.009, 0.017]) compared lowest levels. robust across different subgroups. mediated by (0.020 ± 0.005; 95% confidence interval: 0.012–0.032). Conclusions may be risk factor for among those who period time. Higher correlated wider arterioles venules as well higher , it contribute through dilation venules.

Language: Английский

Efferocytosis in atherosclerosis DOI
Shaunak Adkar, Nicholas J. Leeper

Nature Reviews Cardiology, Journal Year: 2024, Volume and Issue: 21(11), P. 762 - 779

Published: May 15, 2024

Language: Английский

Citations

33
Elevated blood remnant cholesterol and triglycerides are causally related to the risks of cardiometabolic multimorbidity DOI Creative Commons
Yimin Zhao, Zhenhuang Zhuang, Yueying Li

et al.

Nature Communications, Journal Year: 2024, Volume and Issue: 15(1)

Published: March 19, 2024

Abstract The connection between triglyceride-rich lipoproteins and cardiometabolic multimorbidity, characterized by the concurrence of at least two type 2 diabetes, ischemic heart disease, stroke, has not been definitively established. We aim to examine prospective associations serum remnant cholesterol, triglycerides, risks progression from first disease multimorbidity via multistate modeling in UK Biobank. also evaluate causality these Mendelian randomization using 13 biologically relevant SNPs as genetic instruments. Here we show that elevated cholesterol triglycerides are significantly associated with gradually higher particularly diabetes. These results advocate for effective management a potential strategy mitigating multimorbidity.

Language: Английский

Citations

23
In Vivo Fluorescent Labeling of Foam Cell-Derived Extracellular Vesicles as Circulating Biomarkers for In Vitro Detection of Atherosclerosis DOI

Moxuan Ji,

Yongchun Wei,

Zhuo Ye

et al.

Journal of the American Chemical Society, Journal Year: 2024, Volume and Issue: 146(14), P. 10093 - 10102

Published: March 28, 2024

Real-time monitoring of the development atherosclerosis (AS) is key to management cardiovascular disease (CVD). However, existing laboratory approaches lack sensitivity and specificity, mostly due dearth reliable AS biomarkers. Herein, we developed an in vivo fluorescent labeling strategy that allows specific staining foam cell-derived extracellular vesicles (EVs) atherosclerotic plaques, which are released into blood as circulating biomarkers for vitro detection AS. This relies on a self-assembled nanoprobe could recognize cells specifically, where probe degraded by intracellular HClO produce trifluoromethyl-bearing boron-dipyrromethene fluorophore (termed B-CF3), lipophilic dye can be transferred exosomal membranes. These B-CF3-stained EVs detected directly fluorescence spectrometer or microplate reader without resorting any sophisticated analytical method. liquid-biopsy format enables early real-time differentiation lesion vulnerability during progression, facilitating effective CVD management.

Language: Английский

Citations

19
Causal associations of remnant cholesterol with cardiometabolic diseases and risk factors: a mendelian randomization analysis DOI Creative Commons
Baoyi Guan, Anlu Wang, Haojie Xu

et al.

Cardiovascular Diabetology, Journal Year: 2023, Volume and Issue: 22(1)

Published: Aug. 10, 2023

Emerging evidence suggests that remnant cholesterol (RC) is strongly associated with an increased incidence of cardiometabolic diseases (CMD). However, the causality have not been confirmed. We aimed to evaluate causal associations RC CMD and relative risk factors using two-sample Mendelian randomization (MR) methods.Summary-level statistics RC, CMD, were obtained from published data individuals a predominantly European ancestry mainly UK Biobank FinnGen biobank. Univariable multivariable MR analyses used relationships between CMD. A bidirectional analysis was performed estimate factors. The main method conducted inverse-variance weighted method.Univariable showed genetically predicted causally higher ischemic heart disease, myocardial infarction, atrial fibrillation flutter, peripheral artery non-rheumatic valve (all P < 0.05). Multivariable provided compelling harmful effects on disease (P Bidirectional demonstrated bidirectionally linked total cholesterol, triglycerides, low-density lipoprotein hypercholesterolemia no genetic association found metabolic disorders or other factors.This study demonstrates driven increases several factors, suggesting targeted RC-lowering therapies may be effective for primary prevention

Language: Английский

Citations

25
Remnant cholesterol and risk of incident hypertension: a population-based prospective cohort study DOI

Da-Chuan Guo,

Jing‐Wei Gao, Xiang Wang

et al.

Hypertension Research, Journal Year: 2024, Volume and Issue: 47(5), P. 1157 - 1166

Published: Jan. 11, 2024

Language: Английский

Citations

12
Correlation between remnant cholesterol and hyperuricemia in American adults DOI Creative Commons
Xiaohai Zhou,

Xiaolu Weng,

Jing Xu

et al.

Lipids in Health and Disease, Journal Year: 2024, Volume and Issue: 23(1)

Published: June 8, 2024

Remnant cholesterol (RC) is an important marker for assessing the risk of metabolic syndrome. However, correlation between RC and hyperuricemia (HUA) remains unclear. This study aimed to explore HUA in American adults.

Language: Английский

Citations

9
Beyond LDL cholesterol: remnant cholesterol is associated with cardiometabolic risk factors in children DOI Creative Commons
Ana Torres‐Costoso, Vicente Martínez‐Vizcaíno, Andreia P. Oliveira

et al.

BMC Medicine, Journal Year: 2025, Volume and Issue: 23(1)

Published: Jan. 21, 2025

Language: Английский

Citations

1
Association between remnant cholesterol and chronic kidney disease: Systematic review and meta‐analysis DOI Creative Commons
Paschalis Karakasis, Dimitrios Patoulias, Manfredi Rizzo

et al.

Diabetes Obesity and Metabolism, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 14, 2025

Abstract Background and Aims Adequate lipid control has emerged as a key factor in the prevention management of chronic kidney disease (CKD). Remnant cholesterol (RC), lipoprotein with an established association cardiovascular risk, been investigated context CKD. Given conflicting results from recent studies, we performed this meta‐analysis to summarize existing evidence on between RC Methods Medline, Cochrane Library Scopus were searched until 16 September 2024. Double‐independent study selection, data extraction quality assessment performed. Evidence was pooled using random‐effects meta‐analyses. We set primary end‐point interest Results Twelve studies (4 139 674 participants) included. Participants values highest quantile had significantly greater odds CKD compared those lowest (Odds Ratio [OR] = 1.46, 95% confidence interval [CI] 1.26–1.68). In sensitivity analysis confined subjects type 2 diabetes (T2D), higher also exhibited increased (OR CI 1.20–1.78). A significant inverse observed estimated glomerular filtration rate (Mean Difference [MD] −1.43 mL/min/1.73 m for each 1 mmol/L increase RC, [−2.67, −0.19]). Additionally, individuals T2D‐related 24% risk progression end‐stage renal standard deviation (Hazard [HR] 1.24, 1.04–1.47). Conclusions is directly associated Beyond traditional markers, emphasis should be placed levels or at

Language: Английский

Citations

1
Remnant cholesterol and risk of aortic aneurysm and dissection: a prospective cohort Study from the UK biobank study and mendelian randomization analysis DOI Creative Commons
Ting Zhou,

Wenhui Lin,

Bangyuan Yang

et al.

Lipids in Health and Disease, Journal Year: 2025, Volume and Issue: 24(1)

Published: Feb. 17, 2025

This study aimed to examine the relationships between remnant cholesterol (RC) and risk of aortic aneurysm dissection (AAD). prospective cohort included 368,139 European adults from UK Biobank. Additionally, causal relationship RC AAD was investigated using Mendelian randomization (MR) analyses. During a median follow-up 13.65 years, 1,634 cases abdominal (AAA), 698 thoracic (TAA), 184 (AD) were identified. Elevated levels associated with an increased AAA compared reference group ([highest vs. lowest levels]: adjusted hazard ratio (HR) = 1.65, 95% CI: 1.36–1.99). However, no significant association observed high either TAA or AD. Two-sample MR analyses supported effect on (odds (OR) 2.08, 1.70–2.56). The persisted after adjusting for effects RC-associated genetic variants low-density lipoprotein (LDL-C). In contrast, did not indicate any associations linked greater developing AAA, confirming relationship. These findings suggest that may function as new biomarker could be integral strategies at preventing AAA.

Language: Английский

Citations

1
Association of remnant cholesterol with depression among US adults DOI Creative Commons
Yang Wang,

Ruhua Shen

BMC Psychiatry, Journal Year: 2023, Volume and Issue: 23(1)

Published: April 17, 2023

Abstract Background Remnant cholesterol is receiving increasing attention because of its association with various diseases. However, there have been no studies on remnant levels and depression. Methods A cross-sectional analysis was performed based the National Health Nutrition Examination Survey (NHANES) 2005–2016. Depression assessed using a Patient Questionnaire (PHQ-9). Fasting calculated as total minus high-density lipoprotein (HDL-C) low-density (LDL-C). Logistic regression sampling weights used to examine between concentration Results Among 8,263 adults enrolled in this study (weighted mean age, 45.65 years), 5.88% percentage) had Compared participants without depression, those depression higher mean, 26.13 vs. 23.05, P < 0.001). There significant positive relationship multivariable-adjusted OR 95% CI 1.49 (1.02–2.17). subgroup analyses, positively associated among less than 60 years (OR, 1.62; CI, 1.09–2.42), male 2.02; 1.01–4.05), BMI under 30 1.83; 1.14–2.96), diabetes 3.88; 1.43–10.49). Conclusions correlated suggesting that focus may be useful

Language: Английский

Citations

21