Global vascular guidelines on the management of chronic limb-threatening ischemia

Journal of Vascular Surgery, Journal Year: 2019, Volume and Issue: 69(6), P. 3S - 125S.e40

Published: May 28, 2019

Language: Английский

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Global Vascular Guidelines on the Management of Chronic Limb-Threatening Ischemia

European Journal of Vascular and Endovascular Surgery, Journal Year: 2019, Volume and Issue: 58(1), P. S1 - S109.e33

Published: June 7, 2019

Language: Английский

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A Modern Approach to Dyslipidemia

Endocrine Reviews, Journal Year: 2021, Volume and Issue: 43(4), P. 611 - 653

Published: Oct. 22, 2021

Lipid disorders involving derangements in serum cholesterol, triglycerides, or both are commonly encountered clinical practice and often have implications for cardiovascular risk overall health. Recent advances knowledge, recommendations, treatment options necessitated an updated approach to these disorders. Older classification schemes outlived their usefulness, yielding based on the primary lipid disturbance identified a routine panel as practical starting point. Although monogenic dyslipidemias exist important identify, most individuals with polygenic predisposition, context of secondary factors such obesity type 2 diabetes. With regard disease, elevated low-density lipoprotein cholesterol is essentially causal, guidelines worldwide recommended thresholds targets this variable. Furthermore, recent studies established triglycerides factor, whereas depressed high-density now appears less contributory than was previously believed. An diagnosis assessment may include measurement variables apolipoprotein B lipoprotein(a), together selective use genetic testing diagnose rare familial hypercholesterolemia chylomicronemia syndrome. The ongoing development new agents-especially antisense RNA monoclonal antibodies-targeting will provide additional management options, which turn motivates discussion how best incorporate them into current algorithms.

Language: Английский

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Atherogenic Index of Plasma: Novel Predictive Biomarker for Cardiovascular Illnesses

Archives of Medical Research, Journal Year: 2019, Volume and Issue: 50(5), P. 285 - 294

Published: July 1, 2019

Language: Английский

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Ten things to know about ten cardiovascular disease risk factors

American Journal of Preventive Cardiology, Journal Year: 2021, Volume and Issue: 5, P. 100149 - 100149

Published: Jan. 23, 2021

Given rapid advancements in medical science, it is often challenging for the busy clinician to remain up-to-date on fundamental and multifaceted aspects of preventive cardiology maintain awareness latest guidelines applicable cardiovascular disease (CVD) risk factors. The "American Society Preventive Cardiology (ASPC) Top Ten CVD Risk Factors 2021 Update" a summary document (updated yearly) regarding This "ASPC reflects perspective section authors ten things know about sentinel It also includes quick access references (applicable select reviews) each factor section. factors include unhealthful nutrition, physical inactivity, dyslipidemia, hyperglycemia, high blood pressure, obesity, considerations populations (older age, race/ethnicity, sex differences), thrombosis/smoking, kidney dysfunction genetics/familial hypercholesterolemia. For individual patient, other may be relevant, beyond discussed here. However, intent provide succinct overview common cardiology.

Language: Английский

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Apolipoprotein C1: Its Pleiotropic Effects in Lipid Metabolism and Beyond

International Journal of Molecular Sciences, Journal Year: 2019, Volume and Issue: 20(23), P. 5939 - 5939

Published: Nov. 26, 2019

Apolipoprotein C1 (apoC1), the smallest of all apolipoproteins, participates in lipid transport and metabolism. In humans, APOC1 gene is linkage disequilibrium with APOE on chromosome 19, a proximity that spurred its investigation. associates triglyceride-rich lipoproteins HDL exchanges between lipoprotein classes. These interactions occur via amphipathic helix motifs, as demonstrated by biophysical studies wild-type polypeptide representative mutants. acts receptors inhibiting binding mediated apolipoprotein E, modulating activities several enzymes. Thus, apoC1 downregulates lipase, hepatic phospholipase A2, cholesterylester transfer protein, activates lecithin-cholesterol acyl transferase. By controlling plasma levels lipids, relates directly to cardiovascular physiology, but activity extends beyond, inflammation immunity, sepsis, diabetes, cancer, viral infectivity, and-not last-to cognition. Such correlations were established based using transgenic mice, associated recent years GWAS, transcriptomic proteomic analyses. The presence duplicate gene, pseudogene APOC1P, stimulated evolutionary more recently, regulatory properties corresponding non-coding RNA are steadily emerging. Nonetheless, this prototypical still underexplored deserves further research for understanding physiology exploiting therapeutic potential.

Language: Английский

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Coronary heart disease risk: Low-density lipoprotein and beyond

Trends in Cardiovascular Medicine, Journal Year: 2021, Volume and Issue: 32(4), P. 181 - 194

Published: April 19, 2021

Language: Английский

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Insulin resistance and cardiovascular disease

Journal of International Medical Research, Journal Year: 2023, Volume and Issue: 51(3)

Published: March 1, 2023

Insulin resistance (IR) and cardiovascular disease (CVD) represent two universal public health hazards, especially in today’s Western societies. A causal-effect relationship has been established that links IR with CVD. The mediating mechanisms are perplexing, under ongoing, rigorous investigation remain to be fully elucidated. is a condition encompassing hyperglycemia compensatory hyperinsulinemia. It occurs when insulin not capable of exerting its maximum effects on target tissues, including skeletal muscles, liver adipose tissue. This alteration signaling pathways results the development cardiometabolic disorders, obesity, dyslipidemia, low-grade inflammation, endothelial dysfunction hypertension, all which predisposing factors for atherosclerosis management can achieved through dietary modifications, inclusion regular exercise routines everyday life, pharmacological agents other interventions tailored each individual patient’s needs. important underline though that, although various antidiabetic drugs may improve available, no medications as yet specifically approved treatment IR. narrative review will focus current scientific clinical evidence pertaining IR, connecting CVD, well plausible strategies holistic, personalized approach management.

Language: Английский

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Ten things to know about ten cardiovascular disease risk factors – 2022

American Journal of Preventive Cardiology, Journal Year: 2022, Volume and Issue: 10, P. 100342 - 100342

Published: April 6, 2022

The American Society for Preventive Cardiology (ASPC) "Ten things to know about ten cardiovascular disease risk factors - 2022" is a summary document regarding (CVD) factors. This 2022 update provides tables of 10 CVD and builds upon the foundation prior annual versions factors" published since 2020. version perspective ASPC members includes updated sentinel references (i.e., applicable guidelines select reviews) each factor section. include unhealthful dietary intake, physical inactivity, dyslipidemia, pre-diabetes/diabetes, high blood pressure, obesity, considerations populations (older age, race/ethnicity, sex differences), thrombosis (with smoking as potential contributor thrombosis), kidney dysfunction genetics/familial hypercholesterolemia. Other may be relevant, beyond discussed here. However, it intent provide tabular overview most common preventive cardiology ready access reviews.

Language: Английский

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Long‐Chain Acyl Carnitines Aggravate Polystyrene Nanoplastics‐Induced Atherosclerosis by Upregulating MARCO

Advanced Science, Journal Year: 2023, Volume and Issue: 10(19)

Published: May 5, 2023

Abstract Exposure to micro‐ and nanoplastics (MNPs) is common because of their omnipresence in environment. Recent studies have revealed that MNPs may cause atherosclerosis, but the underlying mechanism remains unclear. To address this bottleneck, ApoE −/− mice are exposed 2.5–250 mg kg −1 polystyrene (PS‐NPs, 50 nm) by oral gavage with a high‐fat diet for 19 weeks. It found PS‐NPs blood aorta mouse exacerbate artery stiffness promote atherosclerotic plaque formation. activate phagocytosis M1‐macrophage aorta, manifesting as upregulation macrophage receptor collagenous structure (MARCO). Moreover, disrupt lipid metabolism increase long‐chain acyl carnitines (LCACs). LCAC accumulation attributed PS‐NP‐inhibited hepatic carnitine palmitoyltransferase 2. PS‐NPs, well LCACs alone, aggravate via upregulating MARCO oxidized low‐density lipoprotein‐activated foam cells. Finally, synergistic effects on increasing total cholesterol cells found. Overall, study indicates PS‐NP‐induced atherosclerosis MARCO. This offers new insight into mechanisms MNP‐induced cardiovascular toxicity, highlights combined endogenous metabolites system, which warrant further study.

Language: Английский

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