Combined photothermal and sonodynamic therapy using a 2D black phosphorus nanosheets loaded coating for efficient bacterial inhibition and bone-implant integration

Biomaterials, Journal Year: 2023, Volume and Issue: 297, P. 122122 - 122122

Published: April 11, 2023

Language: Английский

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Multifunctional nanomedicines-enabled chemodynamic-synergized multimodal tumor therapy via Fenton and Fenton-like reactions

Theranostics, Journal Year: 2023, Volume and Issue: 13(6), P. 1974 - 2014

Published: Jan. 1, 2023

Chemodynamic therapy (CDT) is well-known for using the tumor microenvironment to activate Fenton reaction or Fenton-like generate strong oxidative hydroxyl radicals tumor-specific treatment. It highly selective and safe, without depth limitation of tissue penetration, shows its potential as a new green therapeutic method with great clinical application. However, catalytic efficiency reagents involved in severely affected by inherent microenvironmental limitations tumors strict reaction-dependent conditions. With increasing application nanotechnology medical field, combined therapies based on different types functional nanomaterials have opened up avenues development next-generation CDT-enhanced system. This review will comprehensively exemplify representative results CDT other antitumor such chemotherapy, phototherapy, sonodynamic therapy, radiation magnetic hyperthermia immunotherapy, starvation gas gene oncosis combination thereof improving from hundreds latest literature, introduce strategies ingenious design nanomedicines regulations enhance further summarize challenges future perspective CDT-based multimodal anticancer therapy.

Language: Английский

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Single Atom‐Doped Nanosonosensitizers for Mutually Optimized Sono/Chemo‐Nanodynamic Therapy of Triple Negative Breast Cancer

Advanced Science, Journal Year: 2023, Volume and Issue: 10(6)

Published: Jan. 16, 2023

Sonodynamic therapy (SDT) represents a promising therapeutic modality for treating breast cancer, which relies on the generation of abundant reactive oxygen species (ROS) to induce oxidative stress damage. However, mutant cancers, especially triple-negative cancer (TNBC), have evolved acquire specific antioxidant defense functions, significantly limiting killing efficiency SDT. Herein, authors engineered distinct single copper atom-doped titanium dioxide (Cu/TiO2 ) nanosonosensitizer with highly catalytic and sonosensitive activities synergistic chemodynamic sonodynamic treatment TNBC. The single-atom Cu is anchored most stable Ti vacancies hollow TiO2 sonosensitizers, not only substantially improved activity Cu-mediated Fenton-like reaction, but also considerably augmented by facilitating separation electrons (e- holes (h+ ). Both in vitro vivo studies demonstrate that nanosonosensitizers effectively achieved inhibitory effect TNBC, providing paradigm non-invasive safe tumor elimination through mutual process sono/chemo-nanodynamic based multifunctional nanosonosensitizers.

Language: Английский

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Ultrasound-Based Micro-/Nanosystems for Biomedical Applications

Chemical Reviews, Journal Year: 2024, Volume and Issue: 124(13), P. 8307 - 8472

Published: June 26, 2024

Due to the intrinsic non-invasive nature, cost-effectiveness, high safety, and real-time capabilities, besides diagnostic imaging, ultrasound as a typical mechanical wave has been extensively developed physical tool for versatile biomedical applications. Especially, prosperity of nanotechnology nanomedicine invigorates landscape ultrasound-based medicine. The unprecedented surge in research enthusiasm dedicated efforts have led mass multifunctional micro-/nanosystems being applied biomedicine, facilitating precise diagnosis, effective treatment, personalized theranostics. deployment applications is rooted profound understanding relationship among composition, structure, property, bioactivity, application, performance. In this comprehensive review, we elaborate on general principles regarding design, synthesis, functionalization, optimization abundant particular, recent advancements imaging are meticulously summarized. Furthermore, systematically elucidate state-of-the-art studies concerning progress therapeutic targeting various pathological abnormalities including cancer, bacterial infection, brain diseases, cardiovascular metabolic diseases. Finally, conclude provide an outlook field with in-depth discussion challenges faced future developments further extensive clinical translation application.

Language: Английский

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A Distinctive Insight into Inorganic Sonosensitizers: Design Principles and Application Domains

Small, Journal Year: 2024, Volume and Issue: 20(25)

Published: Jan. 15, 2024

Abstract Sonodynamic therapy (SDT) as a promising non‐invasive anti‐tumor means features the preferable penetration depth, which nevertheless, usually can't work without sonosensitizers. Sonosensitizers produce reactive oxygen species (ROS) in presence of ultrasound to directly kill tumor cells, and concurrently activate immunity especially after integration with microenvironment (TME)‐engineered nanobiotechnologies combined therapy. Current sonosensitizers are classified into organic inorganic ones, current most reviews only cover highlighted their applications. However, there have few specific that focus on including design principles, regulation, etc. In this review, first according rationales rather than composition, action underlying chemistry highlighted. Afterward, what how TME is regulated based sonosensitizers‐based SDT nanoplatform an emphasis targets‐engineered elucidated. Additionally, applications non‐cancer diseases also outlined. Finally, setbacks challenges, proposed potential solutions future directions pointed out. This review provides comprehensive detailed horizon sonosensitizers, will arouse more attentions SDT.

Language: Английский

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Nanozyme-Based Cancer Nanotheranostics: Emerging Applications and Challenges in Brain Cancer Therapeutics

Journal of Nanotheranostics, Journal Year: 2025, Volume and Issue: 6(1), P. 4 - 4

Published: Jan. 31, 2025

Regrettably, despite undeniable advances in cancer diagnosis and therapy, primary brain (or cancer) remains one of the deadliest forms malignant tumors, where glioblastoma (GBM) is known as most diffuse glioma astrocytic lineage. Fortunately, to improve this scenario, remarkable progress nanotechnology has brought new promise raised expectations treatment. Nanomedicine, principally an area amalgamating with biology medicine, demonstrated a pivotal role, starting earliest detection while also offering novel multimodal therapy alternatives. In vast realm nanotechnology, nanozymes, type nanomaterial intrinsic enzyme-like activities characteristics connecting fields nanocatalysts, enzymology, biology, have emerged powerful nanotools for theranostics. Hence, fascinating field research experienced exponential growth recent years. As it virtually impossible cover all literature on broad domain science paper, review focuses presenting multidisciplinary approach, its content extending from fundamental knowledge nanozymes enzyme-mimicking catalysis targeting cancers. Although we are at very early stages research, can be envisioned that strategic development theranostics will positively offer disruptive nanoplatforms future nano-oncology.

Language: Английский

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Nano-ROS-generating approaches to cancer dynamic therapy: Lessons from nanoparticles

Chemical Engineering Journal, Journal Year: 2022, Volume and Issue: 457, P. 141225 - 141225

Published: Dec. 29, 2022

Language: Английский

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Application of nanosonosensitizer materials in cancer sono-dynamic therapy

RSC Advances, Journal Year: 2022, Volume and Issue: 12(35), P. 22722 - 22747

Published: Jan. 1, 2022

Sonodynamic therapy (SDT) is a novel non-invasive treatment for cancer combining low-intensity ultrasound and sonosensitizers. SDT activates sonosensitizers through ultrasound, releasing energy generating reactive oxygen species to kill tumor cells. Compared with traditional photodynamic (PDT), promising anti-cancer the advantages of better targeting, deeper tissue penetration, higher focusing ability. With development broad application nanomaterials, tumor-targeting specificity can deliver deep tumors enhance microenvironment. In this review, we first review mechanisms sonodynamic therapy. addition, also focus on current types latest design strategies nanomaterials in Finally, summarize combined strategy

Language: Английский

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Rational Nanomedicine Design Enhances Clinically Physical Treatment‐Inspired or Combined Immunotherapy

Advanced Science, Journal Year: 2022, Volume and Issue: 9(29)

Published: Aug. 24, 2022

Independent of tumor type and non-invasive or minimally-invasive feature, current physical treatments including ultrasound therapy, microwave ablation (MWA), radiofrequency (RFA) are widely used as the local treatment methods in clinics for directly killing tumors activating systematic immune responses. However, activated responses inadequate incompetent recession, incomplete thermal even aggravates immunosuppressive microenvironment (ITM), resulting intractable recurrence metastasis. Intriguingly, nanomedicine provides a powerful platform they can elevate energy utilization efficiency augment oncolytic effects mitigating ITM potentiating Especially after combining with clinical immunotherapy, anti-tumor effect by enhancing human system is reached, enabling effective prevention against This review systematically introduces cutting-edge progress direction nanobiotechnologies their corresponding nanomaterials. Moreover, enhanced progression, relapse, metastasis via autologous immunity exogenous immunotherapeutic agents exemplified, rationales analyzed. offers general guidance directions to enhance from perspectives activation magnification.

Language: Английский

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Strategies to Reverse Hypoxic Tumor Microenvironment for Enhanced Sonodynamic Therapy

Advanced Healthcare Materials, Journal Year: 2023, Volume and Issue: 13(1)

Published: Sept. 6, 2023

Sonodynamic therapy (SDT) has emerged as a highly effective modality for the treatment of malignant tumors owing to its powerful penetration ability, noninvasiveness, site-confined irradiation, and excellent therapeutic efficacy. However, traditional SDT, which relies on oxygen availability, often fails generate satisfactory level reactive species because widespread issue hypoxia in tumor microenvironment solid tumors. To address this challenge, various approaches are developed alleviate improve efficiency SDT. These strategies aim either increase supply or prevent exacerbation, thereby enhancing effectiveness In view this, current review provides an overview these their underlying principles, focusing circulation from consumption external supply. The detailed research examples conducted using combination with SDT also discussed. Additionally, highlights future prospects challenges hypoxia-alleviated along key considerations clinical applications. include development efficient delivery systems, accurate methods detection, exploration therapies optimize outcomes.

Language: Английский

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