Published: March 1, 2025
Language: Английский
Nature Reviews Microbiology, Journal Year: 2023, Volume and Issue: 21(9), P. 555 - 572
Published: May 31, 2023
Language: Английский
Citations
72
ACS Nano, Journal Year: 2024, Volume and Issue: 18(22), P. 14312 - 14326
Published: May 20, 2024
Periodontitis, a prevalent chronic inflammatory disease worldwide, is triggered by periodontopathogenic bacteria, resulting in the progressive destruction of periodontal tissue, particularly alveolar bone. To effectively address periodontitis, this study proposed nanoformulation known as CuS@MSN-SCS. This formulation involves coating citrate-grafted copper sulfide (CuS) nanoparticles with mesoporous silica (MSNs), followed surface modification using amino groups and sulfated chitosan (SCS) through electrostatic interactions. The objective to achieve efficient bacteria removal inducing ROS signaling pathways mediated Cu2+ ions. Additionally, it aims promote bone regeneration Cu2+-induced pro-angiogenesis SCS-mediated regeneration. As anticipated, regulating charges, negatively charged CuS capped sodium citrate were successfully coated MSNs, subsequent introduction amine (3-aminopropyl)triethoxysilane was incorporation SCS interactions, formation developed verified not only significantly exacerbate oxidative stress Fusobacterium nucleatum, thereby suppressing growth biofilm vitro, but also alleviate response without evident biotoxicity an vivo rat periodontitis model. These findings contribute therapeutic effect on periodontitis. Overall, for combating facilitating regeneration, demonstrating promising potential clinical treatment
Language: Английский
Citations
23
Journal of Drug Delivery Science and Technology, Journal Year: 2025, Volume and Issue: unknown, P. 106808 - 106808
Published: March 1, 2025
Language: Английский
Citations
2
Advanced Materials, Journal Year: 2023, Volume and Issue: unknown
Published: Aug. 11, 2023
Oral biofilms, which are also known as dental plaque, the culprit of a wide range oral diseases and systemic diseases, thus contributing to serious health risks. The manner how achieve good control biofilms has been an increasing public concern. Novel antimicrobial biomaterials with highly controllable fabrication functionalization have proven be promising candidates. However, previous reviews generally emphasized physicochemical properties, action mode, application effectiveness those biomaterials, whereas insufficient attention given design rationales tailored different infection types scenarios. To offer guidance for better diversification anti-oral-biofilm this review details up-to-date in three aspects: core strategies combating biofilm, well advanced antibiofilm capacity multiple functions based on improvement or combination abovementioned strategies. Thereafter, insights existing challenges future biomaterial-assisted biofilm treatments proposed, hoping provide theoretical basis reference subsequent biomaterials.
Language: Английский
Citations
30
Journal of Materials Chemistry B, Journal Year: 2023, Volume and Issue: 11(39), P. 9386 - 9403
Published: Jan. 1, 2023
Antimicrobial mechanisms of functionalized carbon dots: covalent and non-covalent interactions, reactive oxygen species, photothermal effect, size effect ( E. coli was used as a model).
Language: Английский
Citations
30
International Journal of Biological Macromolecules, Journal Year: 2023, Volume and Issue: 244, P. 125273 - 125273
Published: June 9, 2023
Language: Английский
Citations
29
ACS Applied Materials & Interfaces, Journal Year: 2023, Volume and Issue: 15(27), P. 32215 - 32225
Published: June 26, 2023
Periodontitis is a chronic inflammatory disease induced by plaque biofilm, which can lead to the destruction of periodontal support tissue and even teeth loss. The common strategies periodontitis treatment are eliminate bacterial/biofilm-related inflammation subsequently inhibit alveolar bone resorption, for antibiotic therapy most traditional one. However, impenetrable polymeric substances on bacterial biofilms make it difficult antimicrobial agents take effect. In this study, novel nanoparticle protease-loaded CuS NPs was developed, combining advances photodynamic photothermal from enzymatic degradation biofilm protease. activity reactive oxygen generation capacity designed nanoparticles were verified experimental results, constituting basis antibacterial function. Next, high CuS@A onFusobacterium nucleatumand its demonstrated. proper hemo/cytocompatibility CuS-based demonstrated in vitro assays. Last, effective against achieved rat model through significant efficacy inhibiting resorption alleviating inflammation. Thus, developed prove promising material management periodontitis.
Language: Английский
Citations
25
Saudi Pharmaceutical Journal, Journal Year: 2023, Volume and Issue: 31(7), P. 1167 - 1180
Published: May 20, 2023
Solid-lipid nanoparticles (SLNs) are an innovative group of nanosystems used to deliver medicine their respective targets with better efficiency and bioavailability in contrast classical formulations. SLNs less noxious, have fewer adverse effects, more biocompatibility, easy biodegradability. Lipophilic, hydrophilic hydrophobic drugs can be loaded into SLNs, enhance physical chemical stability critical environments. Certain antifungal agents different treatments poorly soluble medications, biologicals, proteins etc. incorporated therapeutic outcome, increase target specificity. SLNs-based currently helpful against vicious drug-resistant fungal infections. This review covers the importance drug delivery drugs, historical background, preparation, physicochemical characteristic, structure sizes composition, entrapment efficacy, clinical evaluations uses, challenges, resistance, strategies overcome limitations, novel trials special emphasis on
Language: Английский
Citations
24
Journal of Nanobiotechnology, Journal Year: 2023, Volume and Issue: 21(1)
Published: Feb. 23, 2023
Acute kidney injury (AKI) refers to a tricky clinical disease, known by its high morbidity and mortality, with no real specific medicine for AKI. The carbonization product from Pollen Typhae (i.e., Pu-huang in China) has been extensively employed clinic, it is capable of relieving the renal damage other diseases China since acient times.Inspired process Traditional Chinese Medicine (TCM), novel species carbon dots derived (PT-CDs) was separated then collected using one-pot pyrolysis method. as-prepared PT-CDs (4.85 ± 2.06 nm) negative charge abundant oxygenated groups exhibited solubility, they were stable water. Moreover, rhabdomyolysis (RM)-induced AKI rat model used, first demonstrated that had significant activity improving level BUN CRE, urine volume index, histopathological morphology RM-induced rats. It noteworthy interventions significantly reduced degree inflammatory reaction oxidative stress, which may be correlated basial potential mechanism anti-AKI activities. Furthermore, cytotoxicity assay biosafety evaluation biocompatibility PT-CDs.This study offers strategy based on suggests related candidate applications.
Language: Английский
Citations
22
ACS Applied Bio Materials, Journal Year: 2024, Volume and Issue: 7(5), P. 2604 - 2619
Published: April 16, 2024
Biofilms are an intricate community of microbes that colonize solid surfaces, communicating via a quorum-sensing mechanism. These microbial aggregates secrete exopolysaccharides facilitating adhesion and conferring resistance to drugs antimicrobial agents. The escalating global concern over biofilm-related infections on medical devices underscores the severe threat human health. Carbon dots (CDs) have emerged as promising substrate combat disrupt biofilm matrices. Their numerous advantages such facile surface functionalization specific properties, position them innovative anti-biofilm Due their minuscule size, CDs can penetrate cells, inhibiting growth cytoplasmic leakage, reactive oxygen species (ROS) generation, genetic material fragmentation. Research has demonstrated efficacy in biofilms formed by key pathogenic bacteria
Language: Английский
Citations
8