Lipid bilayer-coated nanoparticles: mimetism for biomedical applications DOI Open Access
Alejandro Magallanes-Puebla, Luz M. López-Marı́n

Mundo Nano Revista Interdisciplinaria en Nanociencia y Nanotecnología, Journal Year: 2023, Volume and Issue: 16(31), P. 1e - 15e

Published: June 7, 2023

Living organisms are made of self-assembled nanostructures. Therefore, the control sizes, shapes, textures, or chemical functions during synthesis, as managed by nanotechnology, leads to a myriad possibilities in field biomedical applications. One main approaches this area, also known nanomedicine, is production biomimetic nanoparticles, which take profit from either natural products bioinspired materials. Cell-cell communications strongly dependent on molecular arrays displayed at cell surface context lipid bilayers. mimicry such coatings has gained great interest last decades. Herein we summarize rationale and methodologies related approach, with special focus delivery drugs vaccines. The challenges opportunities along some selected examples will be discussed well.

Language: Английский

PAMPs and DAMPs in Sepsis: A Review of Their Molecular Features and Potential Clinical Implications DOI Open Access
Sara Cicchinelli, Giulia Pignataro, Stefania Gemma

et al.

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(2), P. 962 - 962

Published: Jan. 12, 2024

Sepsis is a serious organ dysfunction caused by dysregulated immune host reaction to pathogen. The innate immunity programmed react immediately conserved molecules, released the pathogens (PAMPs), and (DAMPs). We aimed review molecular mechanisms of early phases sepsis, focusing on PAMPs, DAMPs, their related pathways, identify potential biomarkers. included studies published in English searched PubMed® Cochrane®. After detailed discussion actual knowledge PAMPs/DAMPs, we analyzed role different organs affected trying elucidate basis some most-used prognostic scores for sepsis. Furthermore, described chronological trend release PAMPs/DAMPs that may be useful subsets septic patients, who benefit from targeted therapies. These findings are preliminary since these pathways seem strongly influenced peculiar characteristics features. Due reasons, while initial promising, additional necessary clarify involvement patterns natural evolution sepsis facilitate transition into clinical setting.

Language: Английский

Citations

25
Revolutionizing Prostate Cancer Therapy: Artificial intelligence – based Nanocarriers for Precision Diagnosis and Treatment DOI
Moein Shirzad,

Afsaneh Salahvarzi,

Sobia Razzaq

et al.

Critical Reviews in Oncology/Hematology, Journal Year: 2025, Volume and Issue: unknown, P. 104653 - 104653

Published: Feb. 1, 2025

Language: Английский

Citations

4
Advancing Inflammatory Bowel Disease Treatment by Targeting the Innate Immune System and Precision Drug Delivery DOI Open Access
Kat F. Kiilerich, Trine Andresen, Behrooz Darbani

et al.

International Journal of Molecular Sciences, Journal Year: 2025, Volume and Issue: 26(2), P. 575 - 575

Published: Jan. 11, 2025

Inflammatory bowel disease (IBD), encompassing Crohn's and ulcerative colitis, involves chronic inflammation of the gastrointestinal tract. Current immune-modulating therapies are insufficient for 30-50% patients or cause significant side effects, emphasizing need new treatments. Targeting innate immune system enhancing drug delivery to inflamed gut regions promising strategies. Neutrophils play a central role in IBD by releasing reactive oxygen species (ROS) neutrophil extracellular traps (NETs) -DNA-based structures with cytotoxic proteins-that contribute mucosal damage inflammation. Recent studies linking ROS production, DNA repair, NET formation have identified NETs as potential therapeutic targets, preclinical models showing positive outcomes from inhibition. Innovative oral systems designed target directly-without systemic absorption-could improve treatment precision reduce effects. Advanced formulations utilize properties such particle size, surface modifications, ROS-triggered release selectively distal ileum colon. A dual strategy that combines deeper understanding pathophysiology identify inflammation-related targets advanced may offer promise. For instance, pairing inhibition ROS-responsive nanocarriers could enhance efficacy, though further research is needed. This synergistic approach has greatly patients.

Language: Английский

Citations

2
Protection against Paraquat-Induced Oxidative Stress by Curcuma longa Extract-Loaded Polymeric Nanoparticles in Zebrafish Embryos DOI Open Access
Ana Teixeira, Marisa P. Sárria, Inês Pinto

et al.

Polymers, Journal Year: 2022, Volume and Issue: 14(18), P. 3773 - 3773

Published: Sept. 9, 2022

The link between oxidative stress and environmental factors plays an important role in chronic degenerative diseases; therefore, exogenous antioxidants could be effective alternative to combat disease progression and/or most significant symptoms. Curcuma longa L. (CL), commonly known as turmeric, is mostly composed of curcumin, a multivalent molecule described having antioxidant, anti-inflammatory neuroprotective properties. Poor chemical stability low oral bioavailability and, consequently, poor absorption, rapid metabolism, limited tissue distribution are major restrictions its applicability. advent nanotechnology, by combining nanosacale with multi-functionality improvement, offers opportunity overcome these limitations. Therefore, this work, poly-Ɛ-caprolactone (PCL) nanoparticles were developed incorporate the methanolic extract CL, their bioactivity was assessed comparison free or encapsulated curcumin. Their toxicity evaluated using zebrafish embryos applying Fish Embryo Acute Toxicity test, following recommended OECD guidelines. protective effect against paraquat-induced damage CL extract, PCL nanoparticles, evaluated. This herbicide cause greatly affect neuromotor functions. overall results indicate that CL-loaded have interesting capacity damage, particularly neuromuscular development goes well beyond itself other antioxidants.

Language: Английский

Citations

32
Active ingredients of traditional Chinese medicine for enhancing the effect of tumor immunotherapy DOI Creative Commons

Chao Yang,

Dan Li,

Chung‐Nga Ko

et al.

Frontiers in Immunology, Journal Year: 2023, Volume and Issue: 14

Published: March 10, 2023

Immunotherapy is a type of treatment that uses our own immune system to fight cancer. Studies have shown traditional Chinese medicine (TCM) has antitumor activity and can enhance host immunity. This article briefly describes the immunomodulatory escape mechanisms in tumors, as well highlights summarizes activities some representative active ingredients TCM. Finally, this puts forward opinions on future research clinical application TCM, aiming promote applications TCM tumor immunotherapy provide new ideas for using

Language: Английский

Citations

18
Multifunctional Lipidated Protein Carrier with a Built-In Adjuvant as a Universal Vaccine Platform Potently Elevates Immunogenicity of Weak Antigens DOI
Shihao Zhou, Ru-Yan Zhang, Yu Wen

et al.

Journal of Medicinal Chemistry, Journal Year: 2024, Volume and Issue: 67(8), P. 6822 - 6838

Published: April 8, 2024

Weak antigens represented by MUC1 are poorly immunogenic, which greatly constrains the development of relevant vaccines. Herein, we developed a multifunctional lipidated protein as carrier, in TLR1/2 agonist Pam3CSK4 was conjugated to N-terminus MUC1-loaded carrier BSA through pyridoxal 5′-phosphate-mediated transamination reaction. The resulting Pam3CSK4–BSA-MUC1 conjugate subsequently incorporated into liposomes, biomimics membrane structure tumor cells. results indicated that this significantly enhanced antigen uptake APCs and obviously augmented retention vaccine at injection site. Compared with BSA-MUC1 + groups, evoked 22- 11-fold increases MUC1-specific IgG titers. Importantly, elicited robust cellular immunity inhibited growth. This is first time constructed enhance immunogenicity, universal platform exhibits promise for utilization various vaccines, holding potential further clinical application.

Language: Английский

Citations

7
The Necessity to Investigate In Vivo Fate of Nanoparticle-Loaded Dissolving Microneedles DOI Creative Commons

Ziyao Chang,

Yuhuan Wu,

Ping Hu

et al.

Pharmaceutics, Journal Year: 2024, Volume and Issue: 16(2), P. 286 - 286

Published: Feb. 17, 2024

Transdermal drug delivery systems are rapidly gaining prominence and have found widespread application in the treatment of numerous diseases. However, they encounter challenge a low transdermal absorption rate. Microneedles can overcome stratum corneum barrier to enhance Among various types microneedles, nanoparticle-loaded dissolving microneedles (DMNs) present unique combination advantages, leveraging strengths DMNs (high payload, good mechanical properties, easy fabrication) nanocarriers (satisfactory solubilization capacity controlled release profile). Consequently, hold considerable clinical potential precision medicine era. Despite this promise, no DMN products been approved thus far. The lack understanding regarding their vivo fate represents critical bottleneck impeding translation relevant products. This review aims elucidate current research status elaborate necessity investigate from diverse aspects. Furthermore, it offers insights into entry points for DMNs, aiming foster further advancements field.

Language: Английский

Citations

6
Nanodrug Delivery Systems for Myasthenia Gravis: Advances and Perspectives DOI Creative Commons

Jiayan Huang,

Yan Zhao, Yafang Song

et al.

Pharmaceutics, Journal Year: 2024, Volume and Issue: 16(5), P. 651 - 651

Published: May 11, 2024

Myasthenia gravis (MG) is a rare chronic autoimmune disease caused by the production of autoantibodies against postsynaptic membrane receptors present at neuromuscular junction. This condition characterized fatigue and muscle weakness, including diplopia, ptosis, systemic impairment. Emerging evidence suggests that in addition to immune dysregulation, pathogenesis MG may involve mitochondrial damage ferroptosis. Mitochondria are primary site energy production, reactive oxygen species (ROS) generated due dysfunction can induce Nanomedicines have been extensively employed treat various disorders their modifiability good biocompatibility, but application management has rather limited. Nevertheless, nanodrug delivery systems carry immunomodulatory agents, anti-oxidants, or ferroptosis inhibitors could be effective for treatment MG. Therefore, this review focuses on nanoplatforms aimed attenuating restoring function, inhibiting potentially serve as promising agents targeted therapy.

Language: Английский

Citations

6
Poly(I:C) and R848 ligands show better adjuvanticity to induce B and T cell responses against the antigen(s) DOI Creative Commons
Nikunj Tandel,

Digna Patel,

Mansi Thakkar

et al.

Heliyon, Journal Year: 2024, Volume and Issue: 10(5), P. e26887 - e26887

Published: Feb. 27, 2024

Poly(I:C) and R848, synthetic ligands that activate Toll-like receptor 3 (TLR3) TLR7/8 respectively, have been well-established for their ability to stimulate the immune system induce antigen-specific responses. These are capable of inducing production cytokines chemokines, hence support activation differentiation B T cells. We saw long-lasting perdurable responses by these adjuvants essentially required an efficacious subunit vaccine. In this study, we investigated potential poly(I:C) R848 elicit cell OVA antigen. assessed stimulatory effects on system, impact activation, enhanced generation Collectively, our findings contribute understanding how can be utilized as adjuvant enhance protein-based vaccines. end, work provides insights development novel vaccination strategies improving vaccine efficacy. Present shall help formulate newer vaccines address infectious diseases.

Language: Английский

Citations

4
Self-assembled multiepitope nanovaccine based on NoV P particles induces effective and lasting protection against H3N2 influenza virus DOI Open Access
Jiaojiao Nie, Qingyu Wang,

Shenghui Jin

et al.

Nano Research, Journal Year: 2023, Volume and Issue: 16(5), P. 7337 - 7346

Published: Feb. 16, 2023

Language: Английский

Citations

10