Spotlight on the impact of viral infections on Hematopoietic Stem Cells (HSCs) with a focus on COVID-19 effects DOI Creative Commons
Kamyar Nasiri, Saman Mohammadzadehsaliani,

Hadis Kheradjoo

et al.

Cell Communication and Signaling, Journal Year: 2023, Volume and Issue: 21(1)

Published: May 8, 2023

Hematopoietic stem cells (HSCs) are known for their significant capability to reconstitute and preserve a functional hematopoietic system in long-term periods after transplantation into conditioned hosts. HSCs thus crucial cellular targets the continual repair of inherited hematologic, metabolic, immunologic disorders. In addition, can undergo various fates, such as apoptosis, quiescence, migration, differentiation, self-renewal. Viruses continuously pose remarkable health risk request an appropriate, balanced reaction from our immune system, which well affects bone marrow (BM). Therefore, disruption due viral infection is essential. patients whom risk-to-benefit ratio HSC (HSCT) acceptable have seen increase use HSCT recent years. suppression, BM failure, exhaustion all linked chronic infections. Virus infections continue be leading cause morbidity mortality recipients, despite advancements field. Furthermore, whereas COVID-19 manifests initially respiratory tract, it now understood systemic illness that significantly impacts hematological system. Patients with advanced often thrombocytopenia blood hypercoagulability. era COVID-19, Hematological manifestations (i.e., lymphopenia), response, may affected by SARS-CoV-2 virus ways. important determine whether exposure affect used HSCT, this, turn, engraftment efficiency. this article, we reviewed features HSCs, effects on SARS-CoV-2, HIV, cytomegalovirus, Epstein-Barr virus, etc. Video Abstract.

Language: Английский

Polymeric and non-polymeric oxaliplatin nanomedicine for cancer therapy: A comprehensive review DOI
Mehrab Pourmadadi,

Meysam Shaghaghi,

Rabia Arshad

et al.

European Polymer Journal, Journal Year: 2024, Volume and Issue: 208, P. 112870 - 112870

Published: Feb. 23, 2024

Language: Английский

Citations

11
Fabrication of magnetic niosomal platform for delivery of resveratrol: potential anticancer activity against human pancreatic cancer Capan-1 cell DOI Creative Commons

Akram Firouzi Amandi,

Zahra Bahmanyar,

Mehdi Dadashpour

et al.

Cancer Cell International, Journal Year: 2024, Volume and Issue: 24(1)

Published: Jan. 29, 2024

Abstract Recently, the presence of different nanoparticles (NPs) has developed targeting drug delivery in treatment cancer cell. Targeted systems using NPs have shown great promise improving efficacy intracellular uptake as well local concentration therapeutics with minimizing side effects. The current study planned to synthesized resveratrol-loaded magnetic niosomes (RSV-MNIONPs) and evaluate their cytotoxicity activity pancreatic cells. For this aim, (MNPs) were loaded into (NIOs) by thin film hydration technique then characterized via DLS, FT-IR, TEM, SEM VSM techniques. Moreover, cytotoxic RSV-MNIONPs on Capan-1 cells line was assessed MTT test. distribution number gained about 80 nm 95 surface charge − 14.0 mV TEM analysis, respectively. RSV loading NIOs 85%, releases pattern displayed a sustained discharge maximum amount 35% 40%, within 4 h pH = 7.4 5.8, an external field is higher than that RSV, indicating enhanced cellular encapsulated states. Furthermore, MNNPs found induce more cell cycle arrest at G0/G1 checkpoint free RSV. Compared RSV-treated cells, mRNA expression levels BAX, Bcl2, FAS, P 53, Cyclin D hTERT, significantly changed treated MNNPs. approaches been widely used attain solubility, improved bioavailability, stability, control Our formulation antitumor can be considered appropriate carrier potential for future usage therapy.

Language: Английский

Citations

10
Surface plasmon resonance biosensors for early troponin detection DOI
Faride Ranjbari,

Ali Nosrat,

Farzaneh Fathi

et al.

Clinica Chimica Acta, Journal Year: 2024, Volume and Issue: 558, P. 118670 - 118670

Published: April 4, 2024

Language: Английский

Citations

9
Mesenchymal stem cells and their extracellular vesicle therapy for neurological disorders: traumatic brain injury and beyond DOI Creative Commons
Aref Yarahmadi,

Masoumeh Dorri Giv,

Reza Hosseininejad

et al.

Frontiers in Neurology, Journal Year: 2025, Volume and Issue: 16

Published: Feb. 5, 2025

Traumatic brain injury (TBI) is a complex condition involving mechanisms that lead to dysfunction and nerve damage, resulting in significant morbidity mortality globally. Affecting ~50 million people annually, TBI's impact includes high death rate, exceeding of heart disease cancer. Complications arising from TBI encompass concussion, cerebral hemorrhage, tumors, encephalitis, delayed apoptosis, necrosis. Current treatment methods, such as pharmacotherapy with dihydropyridines, high-pressure oxygen therapy, behavioral non-invasive stimulation, have shown limited efficacy. A comprehensive understanding vascular components essential for developing new treatments improve blood vessel-related damage. Recently, mesenchymal stem cells (MSCs) promising results repairing mitigating Studies indicate MSCs can promote neurogenesis angiogenesis through various mechanisms, including releasing bioactive molecules extracellular vesicles (EVs), which help reduce neuroinflammation. In research, the distinctive characteristics positioned them highly desirable cell sources. Extensive investigations been conducted on regulatory properties their manipulation, tagging, transportation techniques brain-related applications. This review explores progress prospects MSC therapy TBI, focusing action, therapeutic benefits, challenges potential limitations using treating neurological disorders.

Language: Английский

Citations

1
Nanotherapeutics and nanotheranostics in miscellaneous fungal infections DOI
Amandeep Kaur,

Khadga Raj,

Prabha Rajput

et al.

Elsevier eBooks, Journal Year: 2025, Volume and Issue: unknown, P. 473 - 491

Published: Jan. 1, 2025

Language: Английский

Citations

1
Therapeutic and diagnostic applications of nanoparticles in the management of COVID-19: a comprehensive overview DOI Creative Commons
Omid Gholizadeh, Saman Yasamineh, Parya Amini

et al.

Virology Journal, Journal Year: 2022, Volume and Issue: 19(1)

Published: Dec. 3, 2022

In December 2019, Coronavirus Disease 2019 (COVID-19) was reported in Wuhan, China. Comprehensive strategies for quick identification, prevention, control, and remedy of COVID-19 have been implemented until today. Advances various nanoparticle-based technologies, including organic inorganic nanoparticles, created new perspectives this field. These materials were extensively used to control because their specific attribution preparing antiviral face masks, safety sensors, etc. review, the most current applications, achievements against coronavirus summarized highlighted. This paper also offers nanoparticle preventive, diagnostic, treatment options combat pandemic.

Language: Английский

Citations

29
An overview of SARS-CoV-2 transmission and engineering strategies to mitigate risk DOI Open Access
Bey Fen Leo, Chin Yik Lin, Kalaimani Markandan

et al.

Journal of Building Engineering, Journal Year: 2023, Volume and Issue: 73, P. 106737 - 106737

Published: May 8, 2023

Language: Английский

Citations

21
Recent advances on high-efficiency of microRNAs in different types of lung cancer: a comprehensive review DOI Creative Commons

Mohammad Saleh Sadeghi,

Mohadeseh lotfi,

Narges Soltani

et al.

Cancer Cell International, Journal Year: 2023, Volume and Issue: 23(1)

Published: Nov. 20, 2023

Abstract Carcinoma of the lung is among most common types cancer globally. Concerning its histology, it categorized as a non-small cell carcinoma (NSCLC) and small (SCLC) subtype. MicroRNAs (miRNAs) are member non-coding RNA whose nucleotides range from 19 to 25. They known be critical regulators via epigenetic control oncogenes expression by regulating tumor suppressor genes. miRNAs have an essential function in tumorous microenvironment modulating growth, metastasis, angiogenesis, metabolism, apoptosis. Moreover, wide information produced several investigations indicates their tumor-suppressing, oncogenic, diagnostic assessment, predictive marker functions different malignancy. miRNA mimics or anti-miRNAs can transferred into cell, with possible curative implications. As result, hold promise targets for treatment detection. In this study, we investigate various malignancy, which been achieved recent years that show cancer-associated regulation expression, concerning beginning, development, resistance chemotherapy, also probability utilize biomarkers therapy reaction. Graphical abstract

Language: Английский

Citations

21
Association Between Inflammatory Bowel Disease and Viral Infections DOI Open Access

Tannaz Dehghani,

Omid Gholizadeh, Maziar Daneshvar

et al.

Current Microbiology, Journal Year: 2023, Volume and Issue: 80(6)

Published: April 27, 2023

Language: Английский

Citations

19
The potential use of bacteria and bacterial derivatives as drug delivery systems for viral infection DOI Creative Commons
Amirhosein Faghihkhorasani,

Hanan Hassan Ahmed,

Noor Muhammad Mashool

et al.

Virology Journal, Journal Year: 2023, Volume and Issue: 20(1)

Published: Oct. 3, 2023

Abstract Viral infections in humans are responsible for fatalities worldwide and contribute to the incidence of various human ailments. Controllable targeted medicine delivery against many illnesses, including viral infection, may be significantly aided by using bacteria bacteria-derived products. They accumulate diseased tissues despite physical obstacles, where they can launch antiviral immunity. The ability genetically chemically modify them means that vaccinations manufactured delivered affected more safely effectively. objective this study is provide an overview latest advancements field utilizing bacterial derivatives as carriers administering medication treat diseases such SARS-CoV-2, hepatitis B virus, C immunodeficiency papillomavirus, influenza, Ebola virus. Graphical

Language: Английский

Citations

17