APOPTOSIS, Journal Year: 2024, Volume and Issue: 29(7-8), P. 981 - 1006
Published: June 2, 2024
Language: Английский
Chemical Reviews, Journal Year: 2024, Volume and Issue: 124(9), P. 5846 - 5929
Published: April 24, 2024
Although transition metals constitute less than 0.1% of the total mass within a human body, they have substantial impact on fundamental biological processes across all kingdoms life. Indeed, these nutrients play crucial roles in physiological functions enzymes, with redox properties many being essential to their activity. At same time, imbalances metal pools can be detrimental health. Modern analytical techniques are helping illuminate workings homeostasis at molecular and atomic level, spatial localization real implications dysregulation disease pathogenesis. Fluorescence microscopy has proven one most promising non-invasive methods for studying samples. The accuracy sensitivity bioimaging experiments predominantly determined by fluorescent metal-responsive sensor, highlighting importance rational probe design such measurements. This review covers activity- binding-based sensors that been applied cellular studies. We focus redox-active metals: iron, copper, manganese, cobalt, chromium, nickel. aim encourage further targeted efforts developing innovative approaches understanding chemistry metals.
Language: Английский
Citations
26
Cell Communication and Signaling, Journal Year: 2024, Volume and Issue: 22(1)
Published: July 5, 2024
Abstract Copper is a crucial trace element that plays role in various pathophysiological processes the human body. also acts as transition metal involved redox reactions, contributing to generation of reactive oxygen species (ROS). Under prolonged and increased ROS levels, oxidative stress occurs, which has been implicated different types regulated cell death. The recent discovery cuproptosis, copper-dependent death pathway distinct from other known forms, raised interest researchers field cancer therapy. Herein, present work aims outline current understanding with an emphasis on its anticancer activities through interplay copper-induced stress, thereby providing new ideas for therapeutic approaches targeting modes future.
Language: Английский
Citations
25
Redox Biology, Journal Year: 2024, Volume and Issue: 75, P. 103256 - 103256
Published: June 28, 2024
Higher eukaryotes' life is impossible without copper redox activity and, literally, every breath we take biochemically demonstrates this. However, this dependence comes at a considerable price to ensure target-oriented action. Thereto its uptake, distribution but also excretion are executed by specialized proteins with high affinity for the transition metal. Consequently, malfunction of enzymes/transporters, as case in hereditary Wilson disease that affects intracellular transporter ATP7B, serious cellular damage. One hallmark progressive accumulation, primarily liver brain becomes deadly if left untreated. Such excess toxicity may result from accidental ingestion or attempted suicide. Recent research has shed new light into cell-toxic mechanisms and affected targets processes such even be exploited respect cancer therapy. Moreover, therapies currently under development fight against toxic copper.
Language: Английский
Citations
20
Biomedicine & Pharmacotherapy, Journal Year: 2025, Volume and Issue: 183, P. 117814 - 117814
Published: Jan. 13, 2025
Language: Английский
Citations
2
Biomolecules, Journal Year: 2020, Volume and Issue: 10(8), P. 1176 - 1176
Published: Aug. 12, 2020
Iron (Fe), copper (Cu), and zinc (Zn) are microelements essential for the proper functioning of living organisms. These elements participatein many processes, including cellular metabolism antioxidant anti-inflammatory defenses, also influence enzyme activity, regulate gene expression, take part in protein synthesis. Fe, Cu, Zn have a significant impact on health pregnant women development fetus, as well newborn. A concentration these body during pregnancy reduces risk complications such anemia, induced hypertension, low birth weight, preeclampsia, postnatal complications. The interactions between their availability due to similar physicochemical properties. This most often occurs intestinal absorption, where metal ions compete binding sites with transport compounds. Additionally, relationships great course reactions tissues, excretion, which can be stimulated or delayed. review aims summarize reports single multiple pregnancies, discuss interdependencies mechanisms occurring Zn.
Language: Английский
Citations
136
Frontiers in Immunology, Journal Year: 2021, Volume and Issue: 12
Published: May 31, 2021
Through food intake, humans obtain a variety of nutrients that are essential for growth, cellular function, tissue development, energy, and immune defense. A special interaction between gut-associated lymphoid occurs in the intestinal tract. Enterocytes barrier act as sensors antigens from microbiota, which they deliver to underlying system lamina propria, triggering an response. Studies investigating mechanism influence nutrition on immunological outcomes have highlighted important role macronutrients (proteins, carbohydrates, fatty acids) micronutrients (vitamins, minerals, phytochemicals, antioxidants, probiotics) modulating homeostasis. Nutrients exert their innate immunity inflammation by regulating expression TLRs, pro- anti-inflammatory cytokines, thus interfering with cell crosstalk signaling. Chemical substrates derived nutrient metabolism may cofactors or blockers enzymatic activity, influencing molecular pathways chemical reactions associated microbial killing, inflammation, oxidative stress. Immune function appears be influenced certain form parts membrane structure involved energy production prevention cytotoxicity. also contribute initiation regulation adaptive responses B T lymphocyte differentiation, proliferation activation, antibody production. The purpose this review is present available data field nutritional immunology elucidate complex dynamic relationship system, delineation will lead optimized regimens disease patient care.
Language: Английский
Citations
95
Biomedicine & Pharmacotherapy, Journal Year: 2020, Volume and Issue: 129, P. 110401 - 110401
Published: June 20, 2020
Ovarian cancer has the highest mortality rate among all gynecologic cancers, with most patients presenting advanced stage tumors. About a third of do not respond to primary platinum-based chemotherapy treatment, and over time up 80 % others develop chemoresistance, rendering recurrent disease incurable. Moreover, according latest EMSO-ESGO (European Society for Medical Oncology – European Gynecological Oncology) consensus conference manuscript on ovarian cancer, there are currently no validated molecular predictive biomarkers platinum resistance. Recent studies suggest that copper efflux transporters ATP7A ATP7B play an important role in In addition, by exploring their mediating resistance, new pathways resistance emerge, such as lysosomal storage disorders, which might be explored future target circumvent This review outlines challenging clinical hurdle therapy due links between essential trace element cytotoxic medicines, enigmatic mechanisms It then presents showing significant association response cisplatin/carboplatin prognosis. Based results vitro assays, disease-relevant animal models, date, it may concluded APT7A deserve further development markers cancer. Both could particularly early estimation identify platinum-resistant tumors adjust treatment accordingly.
Language: Английский
Citations
83
Biological Trace Element Research, Journal Year: 2020, Volume and Issue: 199(10), P. 3608 - 3617
Published: Nov. 24, 2020
SARS CoV-2 is a novel coronavirus which has caused many deaths in the recent pandemic. This study aimed to determine zinc, copper and magnesium status on pregnant women with COVID-19. 100 healthy (33/32/35) SARS-CoV-2 positive (34/33/33) were included according their trimesters. Blood samples obtained from patients along initial laboratory tests for clinical outcomes upon first admission hospital. In third trimesters serum zinc level was lower (p:0,004 p:0,02), higher (p:0,006 p:0,008), Zn / Cu ratio decreased(p < 0.0001 p 0.0001) higher(p COVID-19 group.In second trimester had (p:0,05) levels (p:0,0003) compared controls. Disease severity correlated zinc/copper COVID19 (p:0.018, r:-0.243). Serum Zn/Cu negative relationship acute phase markers such as IL-6, Erythrocyte Sedimentation Rate, procalcitonin C-reactive Protein. Also, increased may play role decreased white blood cell, neutrophil, lymphocyte cell count CRP trimester. indicated that trace element changed The effect of elements diagnosed infection investigated comparison time. will be revealed better more comprehensive studies planned future.
Language: Английский
Citations
77
Redox Biology, Journal Year: 2021, Volume and Issue: 41, P. 101912 - 101912
Published: March 1, 2021
Copper (Cu) is a trace element necessary in animals as well human beings. However, excessive Cu toxic to immunocytes, but the precise mechanism largely unclear so far. This work was conducted aiming examine Cu-mediated autophagy together with its role toxicology RAW264.7 cells. Here, we demonstrated that CuSO4 reduced cell viability depending on dose. could obviously increase According obtained results, induced through Akt/AMPK/mTOR pathway which characterized by down regulation of p-Akt (Ser473)/Akt, p-mTOR/mTOR, p-ULK1(Ser757)/ULK1 and subsequent up-regulation p-AMPKα/AMPKα p-ULK1(Ser555)/ULK1. Furthermore, significantly production mitochondrial reactive oxygen species (mtROS). In addition, CuSO4-mediated apoptosis might be suppressed suppressing mtROS generation exposure Mito-TEMPO. Intriguingly, promotion rapamycin decrease inhibition knock Atg5 enhance CuSO4. Moreover, our results suggested original cause CuSO4-induced autophagy. Additionally, mtROS-dependent signalling pathwayin activation potentially generate protection for improving apoptosis.
Language: Английский
Citations
76
International Journal of Molecular Sciences, Journal Year: 2021, Volume and Issue: 22(15), P. 7820 - 7820
Published: July 22, 2021
Copper, manganese, and iron are vital elements required for the appropriate development general preservation of good health. Additionally, these essential metals play key roles in ensuring proper brain function. They also central nervous system as significant cofactors several enzymes, including antioxidant enzyme superoxide dismutase (SOD) other enzymes that take part creation breakdown neurotransmitters brain. An imbalance levels weakens structural, regulatory, catalytic different proteins, receptors, transporters is known to provoke various neurological conditions through mechanisms, such via induction oxidative stress, increased α-synuclein aggregation fibril formation, stimulation microglial cells, thus resulting inflammation reduced production metalloproteins. In present review, authors focus on disorders with psychiatric signs associated copper, iron, manganese excess diagnosis potential treatment disorders. our we described diseases related metals, aceruloplasminaemia, neuroferritinopathy, pantothenate kinase-associated neurodegeneration (PKAN) very rare classical NBIA forms, manganism, attention-deficit/hyperactivity disorder (ADHD), ephedrone encephalopathy, HMNDYT1-SLC30A10 deficiency (HMNDYT1), HMNDYT2-SLC39A14 deficiency, CDG2N-SLC39A8 hepatic prion disease “prion-like disease”, amyotrophic lateral sclerosis, Huntington’s disease, Friedreich’s ataxia, depression.
Language: Английский
Citations
64