Oxidative Stress, Inflammation and Colorectal Cancer: An Overview

Antioxidants, Journal Year: 2023, Volume and Issue: 12(4), P. 901 - 901

Published: April 9, 2023

Colorectal cancer (CRC) represents the second leading cause of cancer-related deaths worldwide. The pathogenesis CRC is a complex multistep process. Among other factors, inflammation and oxidative stress (OS) have been reported to be involved in initiation development CRC. Although OS plays vital part life all organisms, its long-term effects on human body may different chronic diseases, including diseases. Chronic can lead oxidation biomolecules (nucleic acids, lipids proteins) or activation inflammatory signaling pathways, resulting several transcription factors dysregulation gene protein expression followed by tumor cell survival. In addition, it well known that intestinal diseases such as bowel disease (IBD) are associated with an increased risk cancer, link between IBD progression has reported. This review focuses role causative agent colorectal cancer.

Language: Английский

---

Nrf2 signaling pathway: current status and potential therapeutic targetable role in human cancers

Frontiers in Oncology, Journal Year: 2023, Volume and Issue: 13

Published: Sept. 22, 2023

Cancer is a borderless global health challenge that continues to threaten human health. Studies have found oxidative stress (OS) often associated with the etiology of many diseases, especially aging process and cancer. Involved in OS reaction as key transcription factor, Nrf2 pivotal regulator cellular redox state detoxification. can prevent damage by regulating gene expression antioxidant response elements (ARE) promote process. generated an imbalance promotes accumulation mutations genome instability, thus establishment development different cancers. activation regulates plethora processes inducing proliferation, differentiation death, strongly OS-mediated What’s more, also involved anti-inflammatory effects metabolic disorders, neurodegenerative multidrug resistance. highly expressed multiple body parts digestive system, respiratory reproductive system nervous system. In oncology research, has emerged promising therapeutic target. Therefore, certain natural compounds drugs exert anti-cancer through signaling pathway, blocking pathway reduce some types tumor recurrence rates increase sensitivity chemotherapy. However, Nrf2’s dual role controversial impact cancer are inevitable consideration factors when treating this review, we summarized current biological characteristics its mechanism cells, discussed Keap1/Nrf2/ARE downstream genes, elaborated related pathways such AMPK/mTOR NF-κB. Besides, main target strategies using inhibitors or activators, well possible positive negative were reviewed. It be concluded serves important factor formation development, provides basis for targeted therapy

Language: Английский

---

A DNA/Upconversion Nanoparticle Complex Enables Controlled Co‐Delivery of CRISPR‐Cas9 and Photodynamic Agents for Synergistic Cancer Therapy

Advanced Materials, Journal Year: 2024, Volume and Issue: 36(15)

Published: Jan. 11, 2024

Photodynamic therapy (PDT) depends on the light-irradiated exciting of photosensitizer (PS) to generate reactive oxygen species (ROS), which faces challenges and limitations in hypoxia antioxidant response cancer cells, limited tissue-penetration light. Herein, a multifunctional DNA/upconversion nanoparticles (UCNPs) complex is developed enables controlled co-delivery CRISPR-Cas9, hemin, protoporphyrin (PP) for synergistic PDT. An ultralong single-stranded DNA (ssDNA) prepared via rolling circle amplification (RCA), contains recognition sequences single guide RNA (sgRNA) loading Cas9 ribonucleoprotein (RNP), G-quadruplex hemin PP, linker combining UCNP. RNP cleaves regulator nuclear factor E2-related 2 (Nrf2), improving sensitivity cells ROS, enhancing PDT effect. The G-quadruplex/hemin DNAzyme mimicks horseradish peroxidase (HRP) catalyze endogenous H

Language: Английский

---

Pharmacological Activities, Therapeutic Effects, and Mechanistic Actions of Trigonelline

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(6), P. 3385 - 3385

Published: March 16, 2024

Trigonelline (TRG) is a natural polar hydrophilic alkaloid that found in many plants such as green coffee beans and fenugreek seeds. TRG potentially acts on multiple molecular targets, including nuclear factor erythroid 2-related 2 (Nrf2), peroxisome proliferator-activated receptor γ, glycogen synthase kinase, tyrosinase, nerve growth factor, estrogen receptor, amyloid-β peptide, several neurotransmitter receptors. In this review, we systematically summarize the pharmacological activities, medicinal properties, mechanistic actions of potential therapeutic agent. Mechanistically, can facilitate maintenance restoration metabolic homeostasis glucose lipids. It counteract inflammatory constituents at levels by hampering pro-inflammatory release, alleviating propagation, attenuating tissue injury. concurrently modulates oxidative stress blockage detrimental Nrf2 pathway when autophagy impaired. Therefore, it exerts diverse effects variety pathological conditions associated with chronic diseases age-related disorders. shows multidimensional effects, neuroprotection from neurodegenerative disorders diabetic peripheral neuropathy, neuromodulation, mitigation cardiovascular disorders, skin diseases, mellitus, liver kidney injuries, anti-pathogen anti-tumor activities. Further validations are required to define its specific targeting molecules, dissect underlying networks, corroborate efficacy clinical trials.

Language: Английский

---

The role of oxidative stress in intervertebral disc degeneration: Mechanisms and therapeutic implications

Ageing Research Reviews, Journal Year: 2024, Volume and Issue: 98, P. 102323 - 102323

Published: May 9, 2024

Oxidative stress is one of the main driving mechanisms intervertebral disc degeneration(IDD). has been associated with inflammation in disc, cellular senescence, autophagy, and epigenetics cells. It above pathological are closely linked through common hub reactive oxygen species(ROS), promote each other process degeneration development disease. This reveals important role oxidative IDD, importance great potential IDD therapy targeting stress. The efficacy traditional unstable or cannot be maintained. In recent years, due to rise materials science, many bioactive functional have applied treatment combination drugs, satisfactory achieved. At present, research review antioxidant not complete. Based on existing studies, mechanism were summarized this paper, strategies based emerging reviewed.

Language: Английский

---

Antioxidant Systems as Modulators of Ferroptosis: Focus on Transcription Factors

Antioxidants, Journal Year: 2024, Volume and Issue: 13(3), P. 298 - 298

Published: Feb. 28, 2024

Ferroptosis is a type of programmed cell death that differs from apoptosis, autophagy, and necrosis related to several physio-pathological processes, including tumorigenesis, neurodegeneration, senescence, blood diseases, kidney disorders, ischemia–reperfusion injuries. linked iron accumulation, eliciting dysfunction antioxidant systems, which favor the production lipid peroxides, membrane damage, ultimately, death. Thus, signaling pathways evoking ferroptosis are strongly associated with those protecting cells against excess and/or lipid-derived ROS. Here, we discuss interaction between metabolic particular focus on transcription factors implicated in regulation ferroptosis, either as triggers peroxidation or defense pathways.

Language: Английский

---

Health Benefits of Coffee Consumption for Cancer and Other Diseases and Mechanisms of Action

International Journal of Molecular Sciences, Journal Year: 2023, Volume and Issue: 24(3), P. 2706 - 2706

Published: Jan. 31, 2023

Coffee is one of the most widely consumed beverages worldwide, and epidemiology studies associate higher coffee consumption with decreased rates mortality neurological metabolic diseases, including Parkinson's disease type 2 diabetes. In addition, there also evidence that associated lower colon rectal cancer, as well breast, endometrial, other cancers, although for some these results are conflicting. These reflect chemopreventive effects coffee; may be therapeutic forms breast this needs to further investigated. The mechanisms or chemotherapeutic over 1000 individual compounds in roasted complex vary different diseases. Some related nuclear factor erythroid (Nrf2)-regulated pathways target oxidative stress induce reactive oxygen species kill diseased cells (primarily therapeutic). There involvement receptors which include aryl hydrocarbon receptor (AhR) orphan 4A1 (NR4A1), contributions from epigenetic gut microbiome. Further elucidation will facilitate potential future clinical applications extracts treating cancer inflammatory

Language: Английский

---

PROTACs: A novel strategy for cancer drug discovery and development

MedComm, Journal Year: 2023, Volume and Issue: 4(3)

Published: May 29, 2023

Proteolysis targeting chimera (PROTAC) technology has become a powerful strategy in drug discovery, especially for undruggable targets/proteins. A typical PROTAC degrader consists of three components: small molecule that binds to target protein, an E3 ligase ligand (consisting and its recruiter), chemical linker hooks first two components together. In the past 20 years, we have witnessed advancement multiple degraders into clinical trials anticancer therapies. However, one major challenges is only very limited number recruiters are currently available as targeted protein degradation (TPD), although human genome encodes more than 600 ligases. Thus, there urgent need identify additional effective TPD applications. this review, summarized existing RING-type ubiquitin their act ligands application discovery. We believe review could serve reference future development efficient cancer discovery development.

Language: Английский

---

Cancer immune evasion through KRAS and PD-L1 and potential therapeutic interventions

Cell Communication and Signaling, Journal Year: 2023, Volume and Issue: 21(1)

Published: March 2, 2023

Abstract Oncogenic driver mutations have implications that extend beyond cancer cells themselves. Aberrant tumour cell signalling has various effects on the microenvironment and anti-tumour immunity, with important consequences for therapy response resistance. We provide an overview of how mutant RAS, one most prevalent oncogenic drivers in cancer, can instigate immune evasion programs at level through remodelling interactions innate adaptive compartments. Finally, we describe networks focused checkpoint molecule PD-L1 be disrupted therapeutic intervention, discuss potential strategies combinatorial treatment.

Language: Английский

---

Polymeric and non-polymeric oxaliplatin nanomedicine for cancer therapy: A comprehensive review

European Polymer Journal, Journal Year: 2024, Volume and Issue: 208, P. 112870 - 112870

Published: Feb. 23, 2024

Language: Английский

---