SOX10 and microRNAs: decoding their interplay in regulating melanoma plasticity DOI Creative Commons
Xin Lai,

Chunyan Luan,

Z. Zhang

et al.

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown

Published: Oct. 14, 2024

Abstract Recent studies show that the dysregulation of transcription factor SOX10 is essential for development and progression melanoma. MicroRNAs (miRNAs) can regulate expression factors at post-transcriptional level. The interactions between its targeting miRNAs form network motifs such as feedforward feedback loops. Such result in non-linear dynamics gene levels, therefore playing a crucial role regulating tumor proliferation metastasis well tumor’s responses to therapies. Here, we reviewed discussed intricate interplay melanoma biology including melanogenesis, phenotype switch, therapy resistance. Additionally, investigated regulatory melanoma, identifying involve both miRNAs. We also analyzed levels components within these motifs. From control theory perspective, explained how are linked phenotypic plasticity cells. In summary, underscored importance employing data-driven approach elucidate complex mechanisms identify driver network. This methodology facilitates deeper understanding regulation by insight gained could potentially contribute miRNA-based treatments SOX10, thereby enhancing clinical management this malignancy.

Language: Английский

Mesenchymal Stem Cell-based Scaffolds in Regenerative Medicine of Dental Diseases DOI

Mohammad Kiarashi,

Hannaneh Bayat,

Seyed Abbas Shahrtash

et al.

Stem Cell Reviews and Reports, Journal Year: 2024, Volume and Issue: 20(3), P. 688 - 721

Published: Feb. 3, 2024

Language: Английский

Citations

23
p63: a crucial player in epithelial stemness regulation DOI Creative Commons
Yanan Li, Sara Giovannini, Tingting Wang

et al.

Oncogene, Journal Year: 2023, Volume and Issue: 42(46), P. 3371 - 3384

Published: Oct. 17, 2023

Abstract Epithelial tissue homeostasis is closely associated with the self-renewal and differentiation behaviors of epithelial stem cells (ESCs). p63, a well-known marker ESCs, an indispensable factor for their biological activities during development. The diversity p63 isoforms expressed in distinct tissues allows this transcription to have wide array effects. coordinates genes involved cell survival, self-renewal, migration, differentiation, epithelial-to-mesenchymal transition. Through regulation these processes, contributes to, not only normal development, but also epithelium-derived cancer pathogenesis. In review, we provide overview role stemness regulation, including proliferation, senescence. We describe differential expression TAp63 ΔNp63 functional tumors. Furthermore, summarize signaling cascades modulating as well downstream pathways regulation.

Language: Английский

Citations

31
Recent advances on high-efficiency of microRNAs in different types of lung cancer: a comprehensive review DOI Creative Commons

Mohammad Saleh Sadeghi,

Mohadeseh lotfi,

Narges Soltani

et al.

Cancer Cell International, Journal Year: 2023, Volume and Issue: 23(1)

Published: Nov. 20, 2023

Abstract Carcinoma of the lung is among most common types cancer globally. Concerning its histology, it categorized as a non-small cell carcinoma (NSCLC) and small (SCLC) subtype. MicroRNAs (miRNAs) are member non-coding RNA whose nucleotides range from 19 to 25. They known be critical regulators via epigenetic control oncogenes expression by regulating tumor suppressor genes. miRNAs have an essential function in tumorous microenvironment modulating growth, metastasis, angiogenesis, metabolism, apoptosis. Moreover, wide information produced several investigations indicates their tumor-suppressing, oncogenic, diagnostic assessment, predictive marker functions different malignancy. miRNA mimics or anti-miRNAs can transferred into cell, with possible curative implications. As result, hold promise targets for treatment detection. In this study, we investigate various malignancy, which been achieved recent years that show cancer-associated regulation expression, concerning beginning, development, resistance chemotherapy, also probability utilize biomarkers therapy reaction. Graphical abstract

Language: Английский

Citations

21
Recent Advances in Crimean-Congo Hemorrhagic Fever Virus Detection, Treatment, and Vaccination: Overview of Current Status and Challenges DOI Creative Commons
Khursheed Muzammil,

Saba Rayyani,

Ahmed Abbas Sahib

et al.

Biological Procedures Online, Journal Year: 2024, Volume and Issue: 26(1)

Published: June 26, 2024

Crimean-Congo hemorrhagic fever virus (CCHFV) is a tick-borne virus, and zoonosis, affects large regions of Asia, Southwestern Southeastern Europe, Africa. CCHFV can produce symptoms, including no specific clinical mild to severe or deadly infections. Virus isolation attempts, antigen-capture enzyme-linked immunosorbent assay (ELISA), reverse transcription polymerase chain reaction (RT-PCR) are all possible diagnostic tests for CCHFV. Furthermore, an efficient, quick, cheap technology, biosensors, must be designed developed detect The goal this article offer overview modern laboratory available as well other innovative detection methods such biosensors CCHFV, the benefits limits assays. confirmed cases CCHF managed with symptomatic assistance general supportive care. This study examined various treatment modalities, their respective limitations developments, immunotherapy antivirals. Recent biotechnology advancements availability suitable animal models have accelerated development vaccines by substantial margin. We range potential in research, comprising nucleic acid, viral particles, inactivated, multi-epitope vaccines, present obstacles developments field. Thus, purpose review comprehensive summary endeavors dedicated advancing diagnostic, therapeutic, preventive strategies infection anticipation forthcoming hazards.

Language: Английский

Citations

7
Natural Products Treat Colorectal Cancer by Regulating miRNA DOI Creative Commons

Shuoxi Guo,

Meiqi Chen, Shuangyang Li

et al.

Pharmaceuticals, Journal Year: 2023, Volume and Issue: 16(8), P. 1122 - 1122

Published: Aug. 9, 2023

Diseases are evolving as living standards continue to improve. Cancer is the main cause of death and a major public health problem that seriously threatens human life. Colorectal cancer one top ten most common malignant tumors in China, ranking second after gastric among gastrointestinal tumors, its incidence rate increasing dramatically each year due changes dietary habits lifestyle world’s population. Although conventional therapies, such surgery, chemotherapy, radiotherapy, have profoundly impacted treatment colorectal (CRC), drug resistance toxicity remain substantial challenges. Natural products, therapeutic agents, considered safest alternative for treating CRC. In addition, there evidence natural products can induce apoptosis, inhibit cell cycle arrest, reduce invasion migration colon cells by targeting regulating expression function miRNAs. Here, we summarize recent research findings on miRNA-regulation-based antitumor mechanisms various active ingredients highlighting how target miRNA regulation prevention treatment. The application delivery systems predictive disease biomarkers also discussed. Such approaches will contribute discovery new regulatory associated with pathways provide theoretical basis developing novel drugs compounds identifying targets.

Language: Английский

Citations

14
Insight into microRNAs’ involvement in hematopoiesis: current standing point of findings DOI Creative Commons
Seyed Mahdi Nassiri,

Neda Afshar,

Parsa Almasi

et al.

Stem Cell Research & Therapy, Journal Year: 2023, Volume and Issue: 14(1)

Published: Oct. 4, 2023

Abstract Hematopoiesis is a complex process in which hematopoietic stem cells are differentiated into all mature blood (red cells, white and platelets). Different microRNAs (miRNAs) involve several steps of this process. Indeed, miRNAs small single-stranded non-coding RNA molecules, control gene expression by translational inhibition mRNA destabilization. Previous studies have revealed that increased or decreased some these targeting proto-oncogenes could inhibit stimulate the myeloid erythroid lineage commitment, proliferation, differentiation. During last decades, development molecular bioinformatics techniques has led to comprehensive understanding role various hematopoiesis. The critical roles cell processes such as cycle, apoptosis, differentiation been confirmed well. However, main contribution still unclear. Therefore, it seems undeniable future required focus on miRNA activities during stages hematological malignancy.

Language: Английский

Citations

12
Fibroblast function recovery through rejuvenation effect of nanovesicles extracted from human adipose-derived stem cells irradiated with red light DOI
Jiyu Hyun, Jiin Eom,

Jisoo Im

et al.

Journal of Controlled Release, Journal Year: 2024, Volume and Issue: 368, P. 453 - 465

Published: March 8, 2024

Language: Английский

Citations

4
MicroRNAs Function in Dental Stem Cells as a Promising Biomarker and Therapeutic Target for Dental Diseases DOI
Kamyar Nasiri, Mohammad Jahri,

Shirin Kolahdouz

et al.

Molecular Diagnosis & Therapy, Journal Year: 2023, Volume and Issue: 27(6), P. 703 - 722

Published: Sept. 29, 2023

Language: Английский

Citations

10
miRNA-Mediated Mechanisms in the Generation of Effective and Safe Oncolytic Viruses DOI Creative Commons

Мария Сергеевна Торопко,

Sergey Chuvpilo,

Alexander Karabelsky

et al.

Pharmaceutics, Journal Year: 2024, Volume and Issue: 16(8), P. 986 - 986

Published: July 25, 2024

MicroRNAs (miRNAs) are short non-coding RNAs that regulate gene expression by inhibiting the translation of target transcripts. The profiles miRNAs vary in different tissues and change with development diseases, including cancer. This feature has begun to be used for modification oncolytic viruses (OVs) order increase their selectivity efficacy. OVs represent a relatively new class anticancer drugs; they designed replicate cancer tumors destroy them. These can natural within tumor cells, or recombinant created laboratories. There some concerns regarding OVs’ toxicity, due ability partially healthy tissues. In addition, lytic immunological responses upon OV therapy not always sufficient, so various editing methods used. review discusses latest results preclinical clinical studies OVs, modifications which associated miRNA-mediated mechanism silencing.

Language: Английский

Citations

3
The Role of Dental-derived Stem Cell-based Therapy and Their Derived Extracellular Vesicles in Post-COVID-19 Syndrome-induced Tissue Damage DOI
Mitra Rostami,

Pouria Farahani,

Samar Esmaelian

et al.

Stem Cell Reviews and Reports, Journal Year: 2024, Volume and Issue: 20(8), P. 2062 - 2103

Published: Aug. 16, 2024

Language: Английский

Citations

3