Folic Acid and Its Role in Oral Health: A Narrative Review

Processes, Journal Year: 2023, Volume and Issue: 11(7), P. 1994 - 1994

Published: July 2, 2023

Vitamins, exogenous organic compounds that play a vital role in metabolic reactions, and fundamental powerful antioxidants with crucial the genetic transcription process, are considered essential nutritional factors. Folic acid (FA), also known as folate, or Vitamin B9, plays an indispensable various intracellular being main pawn, strong impact on medical dental science. The aim of this paper mainly focuses presenting latest most advanced aspects related to following topics: (1) resonance FA, more specifically FA deficiency, has at level oral cavity; (2) elements involved molecular landscape, which reflect interaction possible mechanisms action, through influences health; (3) particular processes by deficiency causes certain clinical conditions. Moreover, we draw attention trigger curiosity health professionals need know specific host–environment interactions, particularly linkage between individual genotype phenotypic variability, future could represent basis novel effective treatment methods. From perspective, begin providing overview general radar echo human body induced before focusing strategic substrate biochemical acts cellular level. Finally, resulting conclusions: complex interrelationships different types cytokines (CKs) abnormal folate metabolism occurrence neural tube defects (NTDs) orofacial clefts (OFCs); increased oxidative stress, endothelial dysfunction, genomic instability, have major periodontal glutamate carboxypeptidase II, GCP2 1561C>T allelic variant, constitutes bioavailability natural folates actors, roles health.

Language: Английский

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Restoring periodontal tissue homoeostasis prevents cognitive decline by reducing the number of Serpina3nhigh astrocytes in the hippocampus

The Innovation, Journal Year: 2023, Volume and Issue: 5(1), P. 100547 - 100547

Published: Nov. 24, 2023

Language: Английский

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Dementia exacerbates periodontal bone loss in females

Journal of Periodontal Research, Journal Year: 2024, Volume and Issue: 59(3), P. 512 - 520

Published: Jan. 20, 2024

Abstract Background Periodontitis is a chronic inflammatory disease defined by the pathologic loss of periodontal ligament and alveolar bone in relation to aging. Although clinical cohort studies reported that periodontitis significantly elevated males compared females, emerging evidence indicates females with dementia are at greater risk for decreased bone. Objective This study aimed evaluate whether potential sex‐dependent factor using an experimental model induced triple transgenic (3x‐Tg) dementia‐like mice samples collected from senior 65 plus age patients diagnosed dementia. Materials Methods We triple‐transgenic male female age‐matched wild‐type (WT) control ligature placement. Then, osteoclast activity were evaluated micro‐CT situ imaging assays. In addition, we performed dental examinations on Finally, dementia‐associated Aβ42 p‐Tau (T181) osteoclastogenic receptor activator nuclear kappa‐Β ligand (RANKL) gingival crevicular fluid (GCF) measured enzyme‐linked immunosorbent assay (ELISA). Results Alveolar lesions 3x‐Tg but not males, mice. also observed probing pocket depth (PPD) was Using ELISA assay, had levels RANKL GCF samples. Conclusion Altogether, demonstrate have increased males.

Language: Английский

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Systemic Inflammation Disrupts Circadian Rhythms and Diurnal Neuroimmune Dynamics

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(13), P. 7458 - 7458

Published: July 7, 2024

Circadian rhythms regulate physiological processes in approximately 24 h cycles, and their disruption is associated with various diseases. Inflammation may perturb circadian rhythms, though these interactions remain unclear. This study examined whether systemic inflammation induced by an intraperitoneal injection of lipopolysaccharide (LPS) could alter central peripheral diurnal neuroimmune dynamics. Mice were randomly assigned to two groups: the saline control group LPS group. The expression clock genes inflammatory cytokines measured hypothalamus, hippocampus, liver. Diurnal dynamic behaviors microglia also assessed. Our results revealed that perturbed gene oscillations Furthermore, trigger neuroinflammation behavior hippocampus. These findings shed light on intricate link between disruption, underscoring significance relation neurodegenerative

Language: Английский

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Activity and levels of TNF-α, IL-6 and IL-8 in saliva of children and young adults with dental caries: a systematic review and meta-analysis

BMC Oral Health, Journal Year: 2024, Volume and Issue: 24(1)

Published: July 18, 2024

Abstract Background Cytokines play an important role in the immunopathogenesis of dental caries. A systematic review and meta-analysis was carried out with following three objectives: 1)To deepen discuss through a comprehensive analysis literature effects caries on activity levels TNF-α, IL-6 IL-8 saliva children young adults, 2)To compare this cytokines exposure group (moderate-severe caries) control (caries-free or mild caries), 3)To determine whether these could be used as complementary clinical diagnostic tool to assess severity Methods The protocol followed PRISMA Cochrane guidelines registered Open Science Framework (OSF): https://doi.org/10.17605/OSF.IO/MF74V . digital search performed PubMed/MEDLINE, Cochrane, Scopus, Google Schoolar databases from February 15th, 2012, January 13th, 2024. methodological validity selected studies assessed using Joanna Briggs Institute (JBI) tool. random-effects model evaluate association between caries/health, concentration IL-8. Results strategy provided total 126 articles, which 15 investigations met inclusion criteria. number patients studied 1,148, 743 represented case/exposure group, 405 group. age ranged 3 25 years. most prevalent cytokine adults active revealed that there are significant differences TNF-α compared their groups. Conclusions findings suggest may have potential biomarkers for assessing severity. However, further research is needed validate larger more diverse populations before application.

Language: Английский

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Advances in the research of immunomodulatory mechanism of mesenchymal stromal/stem cells on periodontal tissue regeneration

Frontiers in Immunology, Journal Year: 2025, Volume and Issue: 15

Published: Jan. 3, 2025

Periodontal disease is a highly prevalent worldwide that seriously affects people's oral health, including gingivitis and periodontitis. Although the current treatment of periodontal can achieve good control inflammation, it difficult to regenerate supporting tissues satisfactory therapeutic effect. In recent years, due tissue regeneration ability, research on Mesenchymal stromal/stem cells (MSCs) MSC-derived exosomes has been gradually deepened, especially its ability interact with microenvironment body in complex immunoregulatory network, which led many new perspectives strategies for diseases. This paper systematically reviews immunomodulatory (including bone immunomodulation) properties MSCs their role inflammatory microenvironment, summarizes pathways mechanisms by MSC-EVs have promoted lists potential areas future research, describes issues should be considered basic direction development "cell-free therapies" regeneration.

Language: Английский

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Comparison of Methods of Detecting IL-1β in the Blood of Alzheimer’s Disease Subjects

International Journal of Molecular Sciences, Journal Year: 2025, Volume and Issue: 26(2), P. 831 - 831

Published: Jan. 20, 2025

Interleukin (IL)-1β is a pro-inflammatory cytokine whose levels are increased in the brains of Alzheimer’s disease (AD) patients. Despite role IL-1β pathology AD, fact that it expressed at very low makes challenging to measure, hence limiting its potential use as reliable biomarker. Moreover, being able accurately and reliably measure IL-1 β blood possible evaluate this biomarker inflammatory response AD. In study, we compared three quantification methodologies, Meso-Scale Discovery (MSD), both V-Plex S-Plex versions, Quanterix’s SIMOA (Single-Molecule Array), serum AD patients age-matched controls. These assays routinely used with high specificity sensitivity human patients, yet best our knowledge, no study has all techniques for their accuracy biomarkers. Our findings indicate two MSD can be control serum, but assay showed highest receiver operating characteristics (ROCs), an area under curve (AUC) 0.9532, which AUC values assay, 0.5660, 0.6632. Taken together, these data show although technologies useful measurement blood, 3.0 more sensitive measuring biomarkers

Language: Английский

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Exploring the Link Between Periodontitis and Alzheimer’s Disease—Could a Nanoparticulate Vaccine Break It?

Pharmaceutics, Journal Year: 2025, Volume and Issue: 17(2), P. 141 - 141

Published: Jan. 21, 2025

Alzheimer’s disease (AD) is the most prevalent neurodegenerative disorder, as approximately 55 million people worldwide are affected, with a significant tendency to increase. It reveals three main pathological features: amyloid plaques, neurofibrillary tangles, and neuroinflammation, responsible for changes that slowly lead deterioration of personality cognitive control. Over century after first case report, effective treatments remain elusive, likely due an incomplete understanding precise mechanisms driving its pathogenesis. Recent studies provide growing evidence infectious aetiology AD, hypothesis reinforced by findings beta functions antimicrobial peptide. Among microorganisms already associated Porphyromonas gingivalis (Pg), keystone pathogen periodontitis (PeD), has received particular attention possible aetiological agent AD development. Herein, we review epidemiological genetic linking PeD Pg highlighting identification periodontal bacteria in post mortem analysis patients’ brains identifying putative mechanistic links relevant biological plausibility association. With focus on research shifting from cure prevention, proposed open door unravelling new prophylactic approaches able reduce global burden AD. As hypothesised this review, these could include bionanotechnological approach involving development oral nanoparticulate vaccine based Pg-specific antigens. Such prevent antigens progressing brain triggering pathology, representing promising step toward innovative prevention.

Language: Английский

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Potential effects of inducing focal ischemia in the motor cortex in rats undergoing experimental periodontitis

Heliyon, Journal Year: 2025, Volume and Issue: unknown, P. e42158 - e42158

Published: Jan. 1, 2025

Language: Английский

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Luteolin alleviates olfactory dysfunction in eosinophilic chronic rhinosinusitis through modulation of the TLR4/NF-κB signaling pathway

International Immunopharmacology, Journal Year: 2025, Volume and Issue: 148, P. 114189 - 114189

Published: Feb. 1, 2025

Language: Английский

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