Gut brain interaction theory reveals gut microbiota mediated neurogenesis and traditional Chinese medicine research strategies DOI Creative Commons
Chenxi Zhang, Peng Xue, Haiyan Zhang

et al.

Frontiers in Cellular and Infection Microbiology, Journal Year: 2022, Volume and Issue: 12

Published: Dec. 8, 2022

Adult neurogenesis is the process of differentiation neural stem cells (NSCs) into neurons and glial in certain areas adult brain. Defects can lead to neurodegenerative diseases, mental disorders, other maladies. This directionally regulated by transcription factors, Wnt Notch pathway, extracellular matrix, various growth factors. External factors like stress, physical exercise, diet, medications, etc., affect gut microbiota. The microbiota may NSCs through vagal, immune chemical pathways, pathways. Traditional Chinese medicine (TCM) has been proven proliferation regulate abundance metabolites produced intestinal microorganisms. However, underlying mechanisms which these are not fully understood. In this review, we describe recent evidence on role neurogenesis. Moreover, hypothesize characteristics microbiota-gut-brain axis based bacterial phyla, including microbiota’s metabolites, neuronal pathways while providing an outlook TCM’s potential effects regulating

Language: Английский

Gut microbiota: A magical multifunctional target regulated by medicine food homology species DOI Creative Commons

Wei‐Fang Zuo,

Qiwen Pang,

Lai-Ping Yao

et al.

Journal of Advanced Research, Journal Year: 2023, Volume and Issue: 52, P. 151 - 170

Published: June 2, 2023

The relationship between gut microbiota and human health has gradually been recognized. Increasing studies show that the disorder of is related to occurrence development many diseases. Metabolites produced by are responsible for their extensive regulatory roles. In addition, naturally derived medicine food homology species with low toxicity high efficiency have clearly defined owing outstanding physiological pharmacological properties in disease prevention treatment.Based on supporting evidence, current review summarizes representative work targeting regulate host pathophysiology discusses challenges prospects this field. It aims facilitate understanding among species, microbiota, further stimulate advancement more relevant research.As reveals, from initial practical application mechanism studies, evolved into an irrefutable interaction. On one hand, through affecting population structure, metabolism, function maintain homeostasis intestinal microenvironment microbiota. other also involved bioconversion active ingredients thus influences properties.

Language: Английский

Citations

28
Astragalus improves intestinal barrier function and immunity by acting on intestinal microbiota to treat T2DM: a research review DOI Creative Commons

Su Min,

Ting Tang,

Weiwei Tang

et al.

Frontiers in Immunology, Journal Year: 2023, Volume and Issue: 14

Published: Aug. 10, 2023

Diabetes is a significant chronic endocrine/metabolism disorder that can result in number of life-threatening consequences. According to research, the gut microbiota strongly linked development diabetes, making it viable target for diabetes treatment. The intestinal affects barrier function, organism immunity, and thus glucose metabolism lipid metabolism. disruption causes decrease short-chain fatty acids (SCFAs), alters bile (BAs), branched-chain amino (BCAAs), lipopolysaccharide (LPS), endotoxin secretion, resulting insulin resistance, inflammation, progression type 2 mellitus (T2DM). Astragali Radix medicinal herb same genus as food has been extensively researched treating with promising results recent years. Polysaccharides, saponins, flavonoids, other components are important. Among them, Astragaloside role protecting cellular integrity pancreas liver, leading alleviation resistance reducing blood triglyceride (TC) levels; primary impact Astragalus polysaccharides (APS) on encouragement islet cell proliferation, suppression β death; flavonoids known enhance anti-inflammatory, regulate control diabetes. This study summarizes studies its group formulations treatment by modulating microbiota.

Language: Английский

Citations

28
m6A modification in inflammatory bowel disease provides new insights into clinical applications DOI Open Access
Jiamin Zhang,

Bimei Song,

Yue Zeng

et al.

Biomedicine & Pharmacotherapy, Journal Year: 2023, Volume and Issue: 159, P. 114298 - 114298

Published: Jan. 25, 2023

Inflammatory bowel disease (IBD) results from a complex interplay between genetic predisposition, environmental factors, and gut microbes. The role of N6-methyladenosine (m6A) methylation in the pathogenesis IBD has attracted increasing attention. m6A modification not only regulates intestinal mucosal immunity barrier function, but also affects apoptosis autophagy epithelial cells. Additionally, participated interaction microbes host, providing novel direction to explore molecular mechanisms theoretical basis for specific microorganism-oriented prevention treatment measures. regulators are expected be biomarkers predicting prognosis patients. may utilized as target management IBD. This review focused on recent advances how causes initiation development IBD, provided new insights into optimal measures

Language: Английский

Citations

24
Dietary (Poly)phenols and the Gut–Brain Axis in Ageing DOI Open Access
Léonie Láng, Simon McArthur, Alpár S. Lázár

et al.

Nutrients, Journal Year: 2024, Volume and Issue: 16(10), P. 1500 - 1500

Published: May 16, 2024

As the population ages, incidence of age-related neurodegenerative diseases is rapidly increasing, and novel approaches to mitigate this soaring prevalence are sorely needed. Recent studies have highlighted importance gut microbial homeostasis its impact on brain functions, commonly referred as gut–brain axis, in maintaining overall health wellbeing. Nonetheless, mechanisms by which system acts remains poorly defined. In review, we will explore how (poly)phenols, a class natural compounds found many plant-based foods beverages, can modulate thereby promote neural health. While evidence indicates beneficial role (poly)phenol consumption part balanced diet, human scarce mechanistic insight still lacking. regard, make case that dietary (poly)phenols should be further explored establish their therapeutic efficacy through modulation with much greater emphasis carefully designed interventions.

Language: Английский

Citations

12
Astragali radix (Huangqi): a time-honored nourishing herbal medicine DOI Creative Commons
Yuyu Zhang, Zhejie Chen, Liping Chen

et al.

Chinese Medicine, Journal Year: 2024, Volume and Issue: 19(1)

Published: Aug. 30, 2024

Astragali radix (AR, namded Huangqi in Chinese) is the dried root of Astragalus membranaceus (Fisch.) Bge. var. mongholicus (Bge.) Hsiao or As a widely used ethnomedicine, biological activities AR include immunomodulatory, anti-hyperglycemic, anti-oxidant, anti-aging, anti-inflammatory, anti-viral, anti-tumor, cardioprotective, and anti-diabetic effects, with minimum side effects. Currently, it known that polysaccharides, saponins, flavonoids are indispensable components AR. In this review, we will elaborate research advancements on ethnobotany, ethnopharmacological practices, phytochemicals, pharmacological activities, clinical uses, quality control, production developments, toxicology. The information expected to assist clinicians scientists developing useful therapeutic medicines minimal systemic

Language: Английский

Citations

10
Jaranol alleviates cognitive impairment in db/db mice through the PI3K/AKT pathway DOI
Qian Ye,

Xu Yue,

Qiuyu Zhang

et al.

Metabolic Brain Disease, Journal Year: 2025, Volume and Issue: 40(1)

Published: Jan. 6, 2025

Language: Английский

Citations

1
Metabolic disorders in prediabetes: From mechanisms to therapeutic management DOI Open Access

Wen-Xin Ping,

Shan Hu, Jingqian Su

et al.

World Journal of Diabetes, Journal Year: 2024, Volume and Issue: 15(3), P. 361 - 377

Published: March 15, 2024

Diabetes, one of the world's top ten diseases, is known for its high mortality and complication rates low cure rate. Prediabetes precedes onset diabetes, during which effective treatment can reduce diabetes risk. risk factors include high-calorie high-fat diets, sedentary lifestyles, stress. Consequences may considerable damage to vital organs, including retina, liver, kidneys. Interventions treating prediabetes a healthy lifestyle diet pharmacological treatments. However, while these options are in short term, they fail due difficulty long-term implementation. Medications also be used treat prediabetes. This review examines prediabetic treatments, particularly metformin, glucagon-like peptide-1 receptor agonists, sodium glucose cotransporter 2 inhibitors, vitamin D, herbal medicines. Given remarkable impact on progression mellitus, it crucial intervene promptly effectively regulate current body research limited, there confusion surrounding clinically relevant medications. paper aims provide comprehensive summary pathogenesis pre-diabetes mellitus associated therapeutic drugs. The ultimate goal facilitate clinical utilization medications achieve efficient timely control mellitus.

Language: Английский

Citations

6
The blood-brain barrier, a key bridge to treat neurodegenerative diseases DOI

Zhongci Hang,

Liping Zhou, Cencan Xing

et al.

Ageing Research Reviews, Journal Year: 2023, Volume and Issue: 91, P. 102070 - 102070

Published: Sept. 11, 2023

Language: Английский

Citations

14
Flavonoids and the gut microbiome: a powerful duo for brain health DOI

Soroush Taherkhani,

Parisa Ahmadi, Leila Roozbeh Nasiraie

et al.

Critical Reviews in Food Science and Nutrition, Journal Year: 2024, Volume and Issue: unknown, P. 1 - 16

Published: Dec. 4, 2024

Flavonoids, a class of polyphenolic compounds, are widely distributed in plant-based foods and have been recognized for their potential to promote overall health well-being. Flavonoids fruits vegetables offer various beneficial effects such as anti-aging, anticancer, anti-inflammatory properties. extensively studied neuroprotective properties, which attributed ability cross the blood-brain barrier interact with neural cells. Factors like gut microbiota composition, age, genetics, diet can impact how well flavonoids absorbed gut. The enhance absorption through enzymatic processes, making composition key factor influenced by diet. modulate prebiotic antimicrobial effects, affecting production microbial metabolites short-chain fatty acids (SCFAs) butyrate, play role brain function health. microbiome also modulates immune system, is critical preventing neuroinflammation. Additionally, benefit mental psychological influencing signaling pathways cells increasing tyrosine tryptophan, precursors neurotransmitters serotonin, dopamine, norepinephrine, adrenaline, gamma-aminobutyric acid (GABA). flavonoid-gut axis complex multifaceted relationship that has significant implications neurological This review will explore genetic environmental factors flavonoid positive on network.

Language: Английский

Citations

5
Gut microbiome plays a vital role in post-stroke injury repair by mediating neuroinflammation DOI Creative Commons

Airu Huang,

Ling Ji, Yamei Li

et al.

International Immunopharmacology, Journal Year: 2023, Volume and Issue: 118, P. 110126 - 110126

Published: April 7, 2023

Cerebral stroke is a common neurological disease and often causes severe deficits. With high morbidity, mortality, disability rates, threatens patients' life quality brings heavy economic burden on society. Ischemic cerebral lesions incur pathological changes as well spontaneous nerve repair following stroke. Strategies such drug therapy, physical surgical treatment, can ameliorate blood oxygen supply in the brain, hamper inflammatory responses maintain structural functional integrity of brain. The gut microbiome, referred to "second genome" human body, participates regulation multiple physiological functions including metabolism, digestion, inflammation, immunity. microbiome not only inextricably associated with dangerous factors pertaining stroke, pressure, diabetes, obesity, atherosclerosis, but also influences occurrence prognosis. AMPK hub metabolic control responsible for events under conditions. mediators have been found exert dual roles regulating microbiota neuroinflammation/neuronal apoptosis In this study, we reviewed role underlying mechanism signaling pathway intestinal microbial balance were summarized.

Language: Английский

Citations

11