Recent Clinical Treatment and Basic Research on the Alveolar Bone DOI Creative Commons
Sachio Tsuchida, Tomohiro Nakayama

Biomedicines, Journal Year: 2023, Volume and Issue: 11(3), P. 843 - 843

Published: March 10, 2023

The periodontal ligament is located between the bone (alveolar bone) and cementum of tooth, it connected by tough fibers called Sharpey's fibers. To maintain healthy teeth, foundation supporting teeth must be healthy. Periodontal diseases, also known as tooth loss, cause alveolar to dissolve. bone, similar bones in other body parts, repeatedly resorbed osteoclasts renewed osteogenic cells. This means that an old constantly being replaced a new bone. In around absorbed, disease progresses, shrinks gradually. most cases, does not return its original form even after cured. Gum covers surface so matches shape exposing more than before, making look longer, leaving gaps some cases causing sting. Previously, only treatment for diseases was stop from progressing further before fell out, restoration condition almost impossible. However, method can help regeneration tissues destroyed their state much possible introduced. Recently, with improvements implant material properties, therapy has become indispensable dentistry important prosthetic option. Treatment methods techniques, which are mainly based on experience, have gradually accumulated scientific evidence, number indications increased. development augmentation contributed remarkably expansion indications, this been made various advances materials science. induced pluripotent stem cell (iPS) technology regenerating tissues, including expected applied such loss periodontitis. review focuses describes clinical practice, latest basic research.

Language: Английский

Clinical application of mesenchymal stem cell in regenerative medicine: a narrative review DOI Creative Commons
Ria Margiana, Alexander Markov, Angelina Olegovna Zekiy

et al.

Stem Cell Research & Therapy, Journal Year: 2022, Volume and Issue: 13(1)

Published: July 28, 2022

Abstract The multipotency property of mesenchymal stem cells (MSCs) has attained worldwide consideration because their immense potential for immunomodulation and therapeutic function in tissue regeneration. MSCs can migrate to injury areas contribute immune modulation, secrete anti-inflammatory cytokines hide themselves from the system. Certainly, various investigations have revealed anti-inflammatory, anti-aging, reconstruction, wound healing potentials many vitro vivo models. Moreover, current progresses field biology facilitated progress particular guidelines quality control approaches, which eventually lead clinical application MSCs. In this literature, we provided a brief overview immunoregulatory characteristics immunosuppressive activities addition, discussed enhancement, utilization, responses neural, liver, kidney, bone, heart diseases, healing.

Language: Английский

Citations

230
Mesenchymal stem/stromal cells in cancer therapy DOI Creative Commons

Tianxia Lan,

Min Luo,

Xiawei Wei

et al.

Journal of Hematology & Oncology, Journal Year: 2021, Volume and Issue: 14(1)

Published: Nov. 17, 2021

Abstract The multipotent mesenchymal stem/stromal cells (MSCs), initially discovered from bone marrow in 1976, have been identified nearly all tissues of human body now. multipotency MSCs allows them to give rise osteocytes, chondrocytes, adipocytes, and other lineages. Moreover, armed with the immunomodulation capacity tumor-homing property, are special relevance for cell-based therapies treatment cancer. However, hampered by lack knowledge about controversial roles that MSC plays crosstalk tumors, limited progress has made regard translational medicine. Therefore, this review, we discuss prospects MSC-associated anticancer strategies light therapeutic mechanisms signal transduction pathways. In addition, clinical trials designed appraise efficacy safety MSC-based will be assessed according published data.

Language: Английский

Citations

216
Mesenchymal stromal/stem cell (MSC)-derived exosomes in clinical trials DOI Creative Commons
Ahmed Lotfy, Noha M. AboQuella, Hongjun Wang

et al.

Stem Cell Research & Therapy, Journal Year: 2023, Volume and Issue: 14(1)

Published: April 7, 2023

Abstract Mesenchymal stromal/stem cells (MSCs) are widely utilized in cell therapy because of their robust immunomodulatory and regenerative properties. Their paracrine activity is one the most important features that contribute to efficacy. Recently, it has been demonstrated production various factors via extracellular vesicles, especially exosomes, governs principal efficacy MSCs after infusion experimental models. Compared themselves, MSC-derived exosomes (MSC-Exos) have provided significant advantages by efficiently decreasing unfavorable adverse effects, such as infusion-related toxicities. MSC-Exos becoming a promising cell-free therapeutic tool an increasing number clinical studies started assess effect different diseases. In this review, we summarized ongoing completed using for immunomodulation, medicine, gene delivery, beyond. Additionally, methods these with emphasis on source, isolation methods, characterization, dosage, route administration. Lastly, discussed current challenges future directions exosome utilization novel strategy.

Language: Английский

Citations

187
Hybrid exosomes, exosome-like nanovesicles and engineered exosomes for therapeutic applications DOI
Jagannath Mondal, Shameer Pillarisetti, Vijayabhaskarreddy Junnuthula

et al.

Journal of Controlled Release, Journal Year: 2022, Volume and Issue: 353, P. 1127 - 1149

Published: Dec. 26, 2022

Language: Английский

Citations

170
Mesenchymal stem cells-derived exosomes for drug delivery DOI Creative Commons
Yao Sun, Guoliang Liu, Kai Zhang

et al.

Stem Cell Research & Therapy, Journal Year: 2021, Volume and Issue: 12(1)

Published: Oct. 30, 2021

Abstract Exosomes are extracellular vesicles secreted by various cells, mainly composed of lipid bilayers without organelles. In recent years, an increasing number researchers have focused on the use exosomes for drug delivery. Targeted delivery in body is a promising method treating many refractory diseases such as tumors and Alzheimer's disease (AD). Finding suitable carrier has become popular research today. studies, mesenchymal stem cells (MSC-EXOs) been broadly researched due to their immune properties, tumor-homing elastic properties. While MSC-EXOs apparent advantages, some unresolved problems also exist. This article reviews studies delivery, summarizes characteristics MSC-EXOs, introduces primary production purification methods loading provide solutions existing suggestions future studies.

Language: Английский

Citations

127
The potential use of mesenchymal stem cells-derived exosomes as microRNAs delivery systems in different diseases DOI Creative Commons

Elham Oveili,

Somayeh Vafaei,

Haniyeh Bazavar

et al.

Cell Communication and Signaling, Journal Year: 2023, Volume and Issue: 21(1)

Published: Jan. 23, 2023

Abstract MicroRNAs (miRNAs) are a group of small non-coding RNAs that regulate gene expression by targeting mRNA. Moreover, it has been shown miRNAs changed in various diseases, such as cancers, autoimmune disease, infectious and neurodegenerative Diseases. The suppression miRNA function can be easily attained utilizing anti-miRNAs. In contrast, an enhancement achieved through the utilization modified mimetics. discovery appropriate carriers body become interesting subject for investigators. Exosomes (EXOs) therapeutic efficiency safety transferring different cellular biological components to recipient cell have attracted significant attention their capability carriers. Mesenchymal stem cells (MSCs) recognized generate wide range EXOs (MSC-EXOs), showing MSCs may effective EXO generation clinically measure compared other origins. MSC-EXOs widely investigated because immune attributes, tumor-homing flexible characteristics. this article, we summarized features MSC-EXOs, including production, purification, loading methods modification targeted delivery diseases. Graphical abstract

Language: Английский

Citations

78
Adipose Mesenchymal Stem Cell Derived Exosomes Promote Keratinocytes and Fibroblasts Embedded in Collagen/Platelet‐Rich Plasma Scaffold and Accelerate Wound Healing DOI Creative Commons
Yunchuan Wang, Yue Zhang, Ting Li

et al.

Advanced Materials, Journal Year: 2023, Volume and Issue: 35(40)

Published: June 21, 2023

Abstract Engineered skin substitutes derived from human significantly reduce inflammatory reactions mediated by foreign/artificial materials and are consequently easier to use for clinical application. Type I collagen is a main component of the extracellular matrix during wound healing has excellent biocompatibility, platelet‐rich plasma can be used as initiator cascade. Adipose mesenchymal stem cell exosomes crucial tissue repair play key roles in enhancing regeneration, promoting angiogenesis, regulating inflammation, remodeling matrix. Herein, plasma, which provide natural supports keratinocyte fibroblast adhesion, migration, proliferation, mixed form stable 3D scaffold. added scaffold improve performance engineered skin. The physicochemical properties this cellular analyzed, effect evaluated full‐thickness defect mouse model. reduces level inflammation promotes proliferation angiogenesis accelerate healing. Proteomic analysis shows that exhibit anti‐inflammatory proangiogenic effects collagen/platelet‐rich scaffolds. proposed method provides new therapeutic strategy theoretical basis regeneration repair.

Language: Английский

Citations

61
Oxidative stress-induced apoptosis and autophagy: Balancing the contrary forces in spermatogenesis DOI Creative Commons
Parul Sharma, Naveen Kaushal, Leena Regi Saleth

et al.

Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease, Journal Year: 2023, Volume and Issue: 1869(6), P. 166742 - 166742

Published: May 3, 2023

Language: Английский

Citations

59
Bone Marrow Mesenchymal Stem Cell-Derived Extracellular Vesicle Infusion for the Treatment of Respiratory Failure From COVID-19 DOI Creative Commons
Amy L. Lightner,

Vikram Sengupta,

Sascha Qian

et al.

CHEST Journal, Journal Year: 2023, Volume and Issue: 164(6), P. 1444 - 1453

Published: June 24, 2023

Bone marrow mesenchymal stem cell (BM-MSC)-derived extracellular vesicles (ExoFlo) convey the immunomodulatory and regenerative properties of intact BM-MSCs. This study aimed to determine safety efficacy ExoFlo as treatment for moderate severe ARDS in patients with COVID-19.

Language: Английский

Citations

55
A New Strategy for the Regulation of Neuroinflammation: Exosomes Derived from Mesenchymal Stem Cells DOI Creative Commons
Ying Ge, Jingjing Wu, Li Zhang

et al.

Cellular and Molecular Neurobiology, Journal Year: 2024, Volume and Issue: 44(1)

Published: Feb. 19, 2024

Abstract Neuroinflammation is an important pathogenesis of neurological diseases and causes a series physiopathological changes, such as abnormal activation glial cells, neuronal degeneration death, disruption the blood‒brain barrier. Therefore, modulating inflammation may be therapeutic tool for treating diseases. Mesenchymal stem cells (MSCs), pluripotent have great potential due to their regenerative ability, immunity, ability regulate inflammation. However, recent studies shown that MSC-derived exosomes (MSC-Exos) play major role in this process key neuroprotection by regulating neuroglia. This review summarizes progress made neuroinflammation focusing on mechanisms which MSC-Exos are involved regulation through signaling pathways TLR, NF-κB, MAPK, STAT, NLRP3 provide some references subsequent research therapy. Graphical Exosomes derived from MSCs exhibit neuroprotective effects mitigating triggered cells.

Language: Английский

Citations

20