American Journal of Stem Cells,
Journal Year:
2024,
Volume and Issue:
13(2), P. 87 - 100
Published: Jan. 1, 2024
Diabetes
mellitus
(DM)
is
a
significant
public
health
problem
and
one
of
the
most
challenging
medical
conditions
worldwide.
It
severe
complications
that
make
this
disease
more
intricate.
A
diabetic
wound
these
complications.
Patients
with
diabetes
are
at
higher
risk
developing
foot
ulcers
(DFU).
Due
to
ineffectiveness
Conventional
treatments,
growth
in
limb
amputation,
morbidity,
mortality
have
been
recognized,
which
indicates
need
for
additional
treatment.
Mesenchymal
stem
cells
(MSCs)
can
significantly
improve
healing.
However,
there
some
risks
related
cell
therapy.
Exosome
therapy
new
treatment
option
wounds
has
shown
promising
results.
an
even
advanced
form
called
cell-free
using
exosomes
emerged.
This
upgraded
version
offers
improved
efficacy
eliminates
cancer
progression.
promotes
healing
from
multiple
angles,
unlike
traditional
methods
primarily
rely
on
body's
self-healing
ability
only
provide
protection.
Therefore,
exosome
potential
replace
conventional
treatments
effectively.
further
research
necessary
distinguish
optimal
type
therapy,
ensure
their
safety,
establish
appropriate
dosing,
identify
best
management
trail.
The
present
study
focused
current
literature
ulcers,
treatment,
mesenchymal
DFU.
Military Medical Research,
Journal Year:
2023,
Volume and Issue:
10(1)
Published: Aug. 17, 2023
Abstract
Skin
wounds
are
characterized
by
injury
to
the
skin
due
trauma,
tearing,
cuts,
or
contusions.
As
such
injuries
common
all
human
groups,
they
may
at
times
represent
a
serious
socioeconomic
burden.
Currently,
increasing
numbers
of
studies
have
focused
on
role
mesenchymal
stem
cell
(MSC)-derived
extracellular
vesicles
(EVs)
in
wound
repair.
cell-free
therapy,
MSC-derived
EVs
shown
significant
application
potential
field
repair
as
more
stable
and
safer
option
than
conventional
therapy.
Treatment
based
can
significantly
promote
damaged
substructures,
including
regeneration
vessels,
nerves,
hair
follicles.
In
addition,
inhibit
scar
formation
affecting
angiogenesis-related
antifibrotic
pathways
promoting
macrophage
polarization,
angiogenesis,
proliferation,
migration,
inhibiting
excessive
matrix
production.
Additionally,
these
structures
serve
scaffold
for
components
used
repair,
be
developed
into
bioengineered
support
trauma
Through
formulation
standardized
culture,
isolation,
purification,
drug
delivery
strategies,
exploration
detailed
mechanism
will
allow
them
clinical
treatments
conclusion,
EVs-based
therapies
important
prospects
Here
we
provide
comprehensive
overview
their
current
status,
potential,
associated
drawbacks.
Burns & Trauma,
Journal Year:
2024,
Volume and Issue:
12
Published: Jan. 1, 2024
Abstract
The
healing
process
at
a
wound
is
made
up
of
many
types
cells,
growth
factors,
the
extracellular
matrix,
nerves
and
blood
vessels
all
interacting
with
each
other
in
complex
changing
ways.
Microbial
colonization
proliferation
are
possible
place
injury,
which
makes
infection
more
likely.
Because
this,
any
cut
has
chance
getting
an
infection.
Researchers
have
found
that
infections
make
patients
upset
cost
healthcare
system
lot
money.
Surgical
site
happen
to
people
who
recently
had
surgery.
This
study
shows
such
surgical
linked
high
rate
illness
death.
shown
by
fact
25%
get
serious
sepsis
need
be
transferred
intensive
care
unit.
In
both
animal
models
people,
mesenchymal
stem
cells
(MSCs)
play
active
role
stages
positive
effects.
Exosomes
one
main
things
MSCs
release.
They
effects
similar
those
parent
MSCs.
Various
effector
proteins,
messenger
RNA
microRNAs
can
transported
vesicles
control
activity
target
cells.
big
impact
on
process.
These
results
suggest
using
MSC-exosomes
as
new
type
cell-free
therapy
could
better
safer
option
than
whole
cell
therapy.
review
mostly
about
how
use
parts
help
heal.
Periodontology 2000,
Journal Year:
2024,
Volume and Issue:
94(1), P. 257 - 414
Published: Feb. 1, 2024
Abstract
Exosomes
are
the
smallest
subset
of
extracellular
signaling
vesicles
secreted
by
most
cells
with
ability
to
communicate
other
tissues
and
cell
types
over
long
distances.
Their
use
in
regenerative
medicine
has
gained
tremendous
momentum
recently
due
their
be
utilized
as
therapeutic
options
for
a
wide
array
diseases/conditions.
Over
5000
publications
currently
being
published
yearly
on
this
topic,
number
is
only
expected
dramatically
increase
novel
strategies
continue
developed.
Today
exosomes
have
been
applied
numerous
contexts
including
neurodegenerative
disorders
(Alzheimer's
disease,
central
nervous
system,
depression,
multiple
sclerosis,
Parkinson's
post‐traumatic
stress
disorders,
traumatic
brain
injury,
peripheral
nerve
injury),
damaged
organs
(heart,
kidney,
liver,
stroke,
myocardial
infarctions,
ovaries),
degenerative
processes
(atherosclerosis,
diabetes,
hematology
musculoskeletal
degeneration,
osteoradionecrosis,
respiratory
disease),
infectious
diseases
(COVID‐19,
hepatitis),
procedures
(antiaging,
bone
regeneration,
cartilage/joint
osteoarthritis,
cutaneous
wounds,
dental
dermatology/skin
erectile
dysfunction,
hair
regrowth,
intervertebral
disc
repair,
spinal
cord
vascular
regeneration),
cancer
therapy
(breast,
colorectal,
gastric
osteosarcomas),
immune
function
(allergy,
autoimmune
regulation,
inflammatory
diseases,
lupus,
rheumatoid
arthritis).
This
scoping
review
first
its
kind
aimed
at
summarizing
extensive
potential
broad
range
disorders.
Regenerative Therapy,
Journal Year:
2023,
Volume and Issue:
24, P. 547 - 560
Published: Oct. 11, 2023
ADSCs
are
a
large
number
of
mesenchymal
stem
cells
in
Adipose
tissue,
which
can
be
applied
to
tissue
engineering.
have
the
potential
multi-directional
differentiation,
and
differentiate
into
bone
cardiac
urothelial
cells,
skin
etc.
Compared
with
other
multitude
promising
advantages,
such
as
abundant
number,
accessibility
cell
culture,
stable
function,
less
immune
rejection.
There
two
main
methods
use
for
repair
regeneration.
One
is
implant
"ADSCs-scaffold
composite"
injured
site
promote
The
cell-free
therapy:
using
ADSC-exos
or
ADSC-CM
alone
release
miRNAs,
cytokines
bioactive
substances
regeneration
regulated
by
variety
cytokines,
signaling
molecules,
external
environment.
differentiation
different
tissues
also
induced
growth
factors,
ions,
hormones,
scaffold
materials,
physical
stimulation,
factors.
specific
mechanisms
complex,
most
pathways
need
further
explored.
This
article
reviews
summarizes
mechanism
clinical
application
injury
so
far,
puts
forward
problems
that
solved
this
field,
hoping
provide
directions
research
field.
Journal of Nanobiotechnology,
Journal Year:
2023,
Volume and Issue:
21(1)
Published: Aug. 30, 2023
Chronic
diabetic
wounds
are
primarily
caused
by
infection,
inflammation,
and
angiogenesis-related
disorders.
An
ideal
approach
for
treating
chronic
is
combining
anti-infection
strategies,
immune
microenvironment
regulation,
angiogenesis
promotion.
Vascular
endothelial
growth
factor
(VEGF)
can
promote
the
proliferation
migration
of
vascular
cells,
thereby
promoting
angiogenesis.
However,
low
stability
inability
to
target
lesions
limit
its
application.
Polymorphonuclear
neutrophil-derived
exosomes
(PMNExo)
exhibit
good
delivery
properties
be
used
therapeutic
VEGF.
Furthermore,
they
retain
antibacterial
ability
polymorphonuclear
neutrophils
(PMNs).
Nonetheless,
PMNExo
generation
impedes
applications.
In
this
study,
we
prepared
exosome
mimetics
(EM)
from
PMNs
using
extrusion
process;
as
a
result,
yield
significantly
improved.
To
increase
residence
exosomes,
an
extracellular
matrix
(ECM)
hydrogel,
thermosensitive
material
that
function
in
situ
gel
vivo,
was
carrier.
The
active
peptides
ECM
regulated
wound.
summary,
loaded
with
VEGF-encapsulated
activated
neutrophil
(aPMNEM)
develop
VEGF-aPMNEM-ECM
hybrid
hydrogel
wounds.
accelerates
regeneration
Our
study
provides
prospective
therapy
platform
involving
cytokines
different
diseases.
Frontiers in Immunology,
Journal Year:
2023,
Volume and Issue:
14
Published: Aug. 25, 2023
Wound
repair
is
a
complex
problem
for
both
clinical
practitioners
and
scientific
investigators.
Conventional
approaches
to
wound
have
been
associated
with
several
limitations,
including
prolonged
treatment
duration,
high
expenses,
significant
economic
psychological
strain
on
patients.
Consequently,
there
pressing
demand
more
efficacious
secure
modalities
enhance
the
existing
landscapes.
In
field
of
repair,
cell-free
therapy,
particularly
use
mesenchymal
stem
cell-derived
exosomes
(MSC-Exos),
has
made
notable
advancements
in
recent
years.
Exosomes,
which
are
small
lipid
bilayer
vesicles
discharged
by
MSCs,
harbor
bioactive
constituents
such
as
proteins,
lipids,
microRNA
(miRNA),
messenger
RNA
(mRNA).
These
facilitate
material
transfer
information
exchange
between
cells,
thereby
regulating
their
biological
functions.
This
article
presents
comprehensive
survey
function
mechanisms
MSC-Exos
context
healing,
emphasizing
beneficial
impact
each
phase
process,
regulation
immune
response,
inhibition
inflammation,
promotion
angiogenesis,
advancement
cell
proliferation
migration,
reduction
scar
formation.
Ageing Research Reviews,
Journal Year:
2023,
Volume and Issue:
85, P. 101858 - 101858
Published: Jan. 18, 2023
The
prevalence
of
diabetes
among
the
elderly
population
is
significant
and
rising
annually.
One
most
severe
frequent
complications
mellitus
diabetic
wound,
which
has
long-term
negative
effects
on
patients'
finances,
mental
health,
functional
abilities.
Exosomes,
a
cell-free
therapy,
have
emerged
as
promising
novel
treatment
for
wounds,
but
their
mechanism
still
not
entirely
understood.
Therefore,
we
conducted
this
meta-analysis
to
assess
effectiveness
exosomes
in
management
wounds.We
searched
PubMed,
Cochrane
Library,
EMBASE,
Web
Science
pertinent
studies
that
described
therapeutic
benefits
wound
models
were
released
before
October
17,
2022.
outcome
indicators
consisted
healing
rate,
neovascular
density,
re-epithelialization
collagen
deposition,
scar
width,
inflammatory
factors.
RevMan
5.4
software
was
used
conduct
all
statistical
analyses.A
total
21
with
323
animals
identified
meta-analysis.
Pooled
analyses
demonstrated
exosome
therapy
shown
be
superior
control
terms
rate
(SMD
=
5.42;
95
%CI
4.40-6.44;
P
<
0.00001),
density
5.48;
4.31-6.64;
5.06;
3.75-6.37;
deposition
4.78;
3.58-5.98;
width
-8.10;
-10.31
-5.89;
0.00001).
Additionally,
expression
factors
significantly
downregulated
group.According
current
trials,
can
enhance
quality
especially
when
conjunction
dressings.
To
demonstrate
efficient
parameters
future
should
sizable,
randomized,
double-blind
trials
high-quality,
follow-ups.
Nature Communications,
Journal Year:
2024,
Volume and Issue:
15(1)
Published: May 9, 2024
Abstract
Chronic
wounds
are
a
major
complication
in
patients
with
diabetes.
Here,
we
identify
therapeutic
circRNA
and
load
it
into
small
extracellular
vesicles
(sEVs)
to
treat
diabetic
preclinical
models.
We
show
that
circCDK13
can
stimulate
the
proliferation
migration
of
human
dermal
fibroblasts
epidermal
keratinocytes
by
interacting
insulin-like
growth
factor
2
mRNA
binding
protein
3
an
N6-Methyladenosine-dependent
manner
enhance
CD44
c-MYC
expression.
engineered
sEVs
overexpress
local
subcutaneous
injection
male
db/db
mouse
streptozotocin-induced
type
I
rats
could
accelerate
wound
healing
skin
appendage
regeneration.
Our
study
demonstrates
delivery
may
present
option
for
treatment.