Regenerative Therapy, Journal Year: 2025, Volume and Issue: 29, P. 303 - 318
Published: April 5, 2025
Language: Английский
Vaccines, Journal Year: 2023, Volume and Issue: 11(3), P. 687 - 687
Published: March 17, 2023
Rheumatoid arthritis (RA) is a chronic inflammatory joint disorder that causes systemic inflammation, autoimmunity, and abnormalities result in permanent disability. Exosomes are nanosized extracellular particles found mammals (40–100 nm). They transporter of lipids, proteins, genetic material involved mammalian cell–cell signaling, biological processes, cell signaling. have been identified as playing role rheumatoid arthritis-related inflammation (RA). Uniquely functioning vesicles (EVs) responsible for the transport autoantigens mediators between distant cells. In addition, paracrine factors, such exosomes, modulate immunomodulatory function mesenchymal stem cells (MSCs). addition to transporting information, exosomes convey miRNAs studied drug delivery vehicles. animal models, it has observed MSCs secrete EVs with properties, promising results this area. By understanding diversity exosomal contents their corresponding targets, may be possible diagnose autoimmune diseases. can employed diagnostic biomarkers immunological disorders. We here discuss most recent findings regarding diagnostic, prognostic, therapeutic potential these nanoparticles provide an overview evidence pertaining biology RA.
Language: Английский
Citations
45
Biomedicines, Journal Year: 2024, Volume and Issue: 12(1), P. 123 - 123
Published: Jan. 7, 2024
Lung cancer demands innovative approaches for early detection and targeted treatment. In addressing this urgent need, exosomes play a pivotal role in revolutionizing both the treatment of lung cancer. Their remarkable capacity to encapsulate diverse range biomolecules, traverse biological barriers, be engineered with specific targeting molecules makes them highly promising diagnostic markers precise drug delivery cells. Furthermore, an in-depth analysis exosomal content biogenesis offers crucial insights into molecular profile tumors. This knowledge holds significant potential development therapies strategies Despite notable progress field, challenges standardization cargo loading persist. Collaborative research efforts are imperative maximize advance field precision medicine benefit patients.
Language: Английский
Citations
29
Clinical Medicine Insights Oncology, Journal Year: 2024, Volume and Issue: 18
Published: Jan. 1, 2024
Small extracellular vesicles called exosomes are produced by cells and contain a range of biomolecules, including proteins, lipids, nucleic acids. Exosomes have been implicated in the development spread cancer, recent studies shown that their contents may be exploited as biomarkers for early detection ongoing surveillance disease. In this review article, we summarize current knowledge on cancer. We discuss various methods used exosome isolation characterization, well different types biomolecules found within relevant cancer diagnosis prognosis. also highlight demonstrated utility exosomal such lung breast pancreatic Overall, show great promise noninvasive monitoring. ability to transform diagnostic therapeutic paradigms, providing more efficient individualized. This seeks serve an inspiration new ideas research never-ending fight against Moreover, further needed validate clinical establish standardized protocols analysis. With continued development, potential revolutionize treatment.
Language: Английский
Citations
17
Journal of Nanobiotechnology, Journal Year: 2025, Volume and Issue: 23(1)
Published: Feb. 10, 2025
Alzheimer's disease (AD) is a distinctive form of dementia characterized by age-related cognitive decline and memory impairment. A key hallmark AD the irreversible overaccumulation beta-amyloid (Aβ) in brain, associated with neuroinflammation neuronal death. Although Aβ clearance immunoregulation have been major therapeutic strategies for AD, highly selective transport across blood–brain barrier (BBB) negatively affects delivery efficacy drugs without ability to cross BBB. In this review, we discuss potential lipid-based nanoparticles (LBNs) as promising vehicles drug treatment. LBNs, composed phospholipid mono- or bilayer, attracted attention due their exceptional cellular penetration capabilities loading capabilities, which also facilitate cargo transcytosis Recent advances development engineering LBNs overcome existing limitations current clinical approaches treatment addressing off-target effects low efficacy. Here, review pathways BBB, well various types therapy, including exosomes, liposomes, solid lipid (SLNs), nanostructured carriers (NLCs), elucidate properties, preparation methodologies, efficacy, thereby offering innovative avenues novel translation therapy.
Language: Английский
Citations
4
Frontiers in Pharmacology, Journal Year: 2025, Volume and Issue: 15
Published: Jan. 6, 2025
Glioblastoma (GBM) remains one of the most aggressive and treatment-resistant brain tumors, necessitating innovative therapeutic approaches. Polymer-based nanotechnology has emerged as a promising solution, offering precise drug delivery, enhanced blood-brain barrier (BBB) penetration, adaptability to tumor microenvironment (TME). This review explores diverse applications polymeric nanoparticles (NPs) in GBM treatment, including delivery chemotherapeutics, targeted therapeutics, immunotherapeutics, other agents for radiosensitization photodynamic therapy. Recent advances multifunctional polymer highlight their potential overcome challenges that brought, such heterogeneity tumor, BBB limitation, immunosuppressive TME, consideration biocompatibility safety. Meanwhile, future directions address these are also proposed. By addressing obstacles, polymer-based represents transformative strategy improving treatment outcomes, paving way more effective patient-specific therapies.
Language: Английский
Citations
2
Frontiers in Bioengineering and Biotechnology, Journal Year: 2023, Volume and Issue: 11
Published: March 17, 2023
Lung cancer is the major cause of death worldwide. Cancer immunotherapy has been introduced as a promising and effective treatment that can improve immune system’s ability to eliminate cells help establish immunological memory. Nanoparticles contribute rapidly evolving field by simultaneously delivering variety agents target site tumor microenvironment. Nano drug delivery systems precisely biological pathways be implemented reprogram or regulate responses. Numerous investigations have conducted employ different types nanoparticles for lung cancer. Nano-based adds strong tool diverse collection therapies. This review briefly summarizes remarkable potential opportunities in its challenges.
Language: Английский
Citations
30
Biomedicine & Pharmacotherapy, Journal Year: 2023, Volume and Issue: 163, P. 114817 - 114817
Published: May 2, 2023
Cardiovascular and cerebrovascular diseases (CVDs) remain an intractable problem have high morbidity mortality worldwide, as well substantial health economic burdens, representing urgent clinical need. In recent years, the focus of research has shifted from use mesenchymal stem cells (MSCs) for transplantation to their secretory exosomes (MSC-exosomes) treatment numerous CVDs, including atherosclerosis, myocardial infarction (MI), heart failure (HF), ischemia/reperfusion (I/R), aneurysm, stroke. MSCs are pluripotent with multiple differentiation pathways that exert pleiotropic effects by producing soluble factors, most effective components which exosomes. MSC-exosomes considered be excellent promising cell-free therapy CVDs due higher circulating stability, improved biocompatibility, reduced toxicity, immunogenicity. addition, play critical roles in repairing inhibiting apoptosis, regulating inflammation, ameliorating cardiac remodeling, promoting angiogenesis. Herein, we describe knowledge about biological characteristics MSC-exosomes, investigate mechanism mediate therapeutic repair, summarize advances efficacy a view toward future applications.
Language: Английский
Citations
30
Pharmaceutics, Journal Year: 2023, Volume and Issue: 15(5), P. 1439 - 1439
Published: May 8, 2023
Cancer is designated as one of the principal causes mortality universally. Among different types cancer, brain cancer remains most challenging due to its aggressiveness, ineffective permeation ability drugs through blood–brain barrier (BBB), and drug resistance. To overcome aforementioned issues in fighting there an imperative need for designing novel therapeutic approaches. Exosomes have been proposed prospective “Trojan horse” nanocarriers anticancer theranostics owing their biocompatibility, increased stability, permeability, negligible immunogenicity, prolonged circulation time, high loading capacity. This review provides a comprehensive discussion on biological properties, physicochemical characteristics, isolation methods, biogenesis internalization exosomes, while it emphasizes diagnostic potential vehicle systems highlighting recent advances research field. A comparison activity effectiveness several exosome-encapsulated cargo including biomacromolecules underlines great supremacy over non-exosomal encapsulated delivery, accumulation, potency. Various studies cell lines animals give prominence exosome-based nanoparticles (NPs) promising alternative approach management cancer.
Language: Английский
Citations
28
Critical Reviews in Oncology/Hematology, Journal Year: 2023, Volume and Issue: 185, P. 103980 - 103980
Published: March 29, 2023
Language: Английский
Citations
27
Pharmaceutics, Journal Year: 2024, Volume and Issue: 16(2), P. 289 - 289
Published: Feb. 18, 2024
At present, stem cell-based therapies using induced pluripotent cells (iPSCs) or mesenchymal (MSCs) are being used to explore the potential for regenerative medicine in treatment of various diseases, owing their ability multilineage differentiation. Interestingly, MSCs employed not only medicine, but also as carriers drug delivery, homing target sites injured damaged tissues including brain by crossing blood–brain barrier (BBB). In research and development, membrane impermeability is a serious problem. The development central nervous system drugs neurodegenerative such Alzheimer’s disease Parkinson’s disease, remains difficult due capillary endothelial at BBB, addition complicated pathogenesis pathology. Thus, intravenously intraarterially administered MSC-mediated delivery non-invasive way solution this transendothelial problem BBB. Substances delivered divided into artificially included materials advance, low molecular weight compounds doxorubicin, expected protein expression products genetic modification, interleukins. After internalizing through fenestration between cells, release cargos cells. review, I introduce advantages across BBB carrier that moves if they acted own will.
Language: Английский
Citations
13