Molecular Probes, Chemosensors, and Nanosensors for Optical Detection of Biorelevant Molecules and Ions in Aqueous Media and Biofluids

Chemical Reviews, Journal Year: 2022, Volume and Issue: 122(3), P. 3459 - 3636

Published: Jan. 7, 2022

Synthetic molecular probes, chemosensors, and nanosensors used in combination with innovative assay protocols hold great potential for the development of robust, low-cost, fast-responding sensors that are applicable biofluids (urine, blood, saliva). Particularly, metabolites, neurotransmitters, drugs, inorganic ions is highly desirable due to a lack suitable biosensors. In addition, monitoring analysis metabolic signaling networks cells organisms by optical probes chemosensors becoming increasingly important biology medicine. Thus, new perspectives personalized diagnostics, theranostics, biochemical/medical research will be unlocked when standing limitations artificial binders receptors overcome. this review, we survey synthetic sensing systems have promising (future) application detection small molecules, cations, anions aqueous media biofluids. Special attention was given provide readily measurable signal through dynamic covalent chemistry, supramolecular host-guest interactions, or nanoparticles featuring plasmonic effects. This review shall also enable reader evaluate current performance terms sensitivity selectivity respect practical requirement, thereby inspiring ideas further advanced systems.

Language: Английский

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Physiological roles of hydrogen sulfide in mammalian cells, tissues, and organs

Physiological Reviews, Journal Year: 2022, Volume and Issue: 103(1), P. 31 - 276

Published: April 18, 2022

Over the last two decades, hydrogen sulfide (H2S) has emerged as an endogenous regulator of a broad range physiological functions. H2S belongs to class molecules known gasotransmitters, which typically include nitric oxide (NO) and carbon monoxide (CO). Three enzymes are recognized sources in various cells tissues: cystathionine γ-lyase (CSE), β-synthase (CBS), 3-mercaptopyruvate sulfurtransferase (3-MST). The present article reviews regulation these well pathways their enzymatic nonenzymatic degradation elimination. multiple interactions with other labile (e.g., NO) reactive oxygen species also outlined. Next, biological targets signaling outlined, special reference or oxidative posttranscriptional modification (persulfidation sulfhydration) proteins effect on channels intracellular second messenger pathways, gene transcription translation, cellular bioenergetics metabolism. pharmacological molecular tools currently available study physiology reviewed, including utility limitations. In subsequent sections, role functions is membrane potential, endo- exocytosis, cell organelles (endoplasmic reticulum, Golgi, mitochondria), movement, cycle, differentiation, aspects regulated death. roles types organ systems overviewed, red blood cells, immune central peripheral nervous (with focus neuronal transmission, learning, memory formation), vascular function (including angiogenesis its specialized cerebrovascular, renal, pulmonary beds) senses, vision, hearing, taste smell, pain-sensing. Finally, (lung, heart, liver, kidney, urogenital organs, reproductive system, bone cartilage, skeletal muscle, endocrine organs) presented, aging) but extending some common pathophysiological conditions. From data, wide array significant all emerges characteristic bell-shaped biphasic effects highlighted. addition, key aspects, debated areas, future research translational areas identified.

Language: Английский

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Desulfovibrio Bacteria Are Associated With Parkinson’s Disease

Frontiers in Cellular and Infection Microbiology, Journal Year: 2021, Volume and Issue: 11

Published: May 3, 2021

Parkinson’s disease (PD) is the most prevalent movement disorder known and predominantly affects elderly. It a progressive neurodegenerative wherein α-synuclein, neuronal protein, aggregates to form toxic structures in nerve cells. The cause of remains unknown. Intestinal dysfunction changes gut microbiota, common symptoms PD, are evidently linked pathogenesis PD. Although multitude studies have investigated microbial etiologies role progression unclear. Here, we show that Gram-negative sulfate-reducing bacteria genus Desulfovibrio may play potential development Conventional quantitative real-time PCR analysis feces from twenty PD patients healthy controls revealed all harbored their microbiota these were present at higher levels than controls. Additionally, concentration species correlated with severity produce hydrogen sulfide lipopolysaccharide, several strains synthesize magnetite, which likely induce oligomerization aggregation α-synuclein protein. substances originating take part These findings open new avenues for treatment identification people risk developing

Language: Английский

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NIR responsive nitric oxide nanogenerator for enhanced biofilm eradication and inflammation immunotherapy against periodontal diseases

Nano Today, Journal Year: 2022, Volume and Issue: 43, P. 101447 - 101447

Published: March 3, 2022

Language: Английский

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A large-scale causal analysis of gut microbiota and delirium: A Mendelian randomization study

Journal of Affective Disorders, Journal Year: 2023, Volume and Issue: 329, P. 64 - 71

Published: Feb. 25, 2023

Several studies have linked gut microbiota to human brain activity. This study used Mendelian randomization (MR) investigate the causal relationship between microbes and delirium.MR was select SNPs from large-scale GWAS summary data on 211 taxa delirium. Inverse variance weighting (IVW), weighted median, MR-Egger methods were for statistical analyses. Outliers assessed using leave-one-out method. To avoid horizontal pleiotropy, we performed MR-PRESSO intercept tests. Cochran's Q I2 values IVW assess heterogeneity.IVW suggested that genetic prediction of family Desulfovibrionaceae (1.784 (1.267-2.512), P = 0.001), order Desulfovibrionales (1.501 (1.058-2.128), 0.023), genus Candidatus Soleaferrea (1.322 (1.052-1.659), 0.016) increased risk delirium, but Oxalobacteraceae (0.841 (0.722-0.981), 0.027), genera Holdemania (0.766 (0.620-0.946), 0.013), Ruminococcus gnavus (0.806 (0.661-0.982), 0.033), Eggerthella (0.815 (0.667-0.997), 0.047) reduced delirium.(1) Limited sample size, (2) inability interactions, (3) limited European populations.Our results suggest presence microbial Desulfovibrionaceae, Desulfovibrionales, whereas family, Holdemania, gnavus, decreased However, potential probiotic interventions in prevention perioperative delirium should be emphasized.

Language: Английский

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Hydrogen Sulfide: From a Toxic Molecule to a Key Molecule of Cell Life

Antioxidants, Journal Year: 2020, Volume and Issue: 9(7), P. 621 - 621

Published: July 15, 2020

Hydrogen sulfide (H

Language: Английский

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Activatable Small-Molecule Hydrogen Sulfide Donors

Antioxidants and Redox Signaling, Journal Year: 2019, Volume and Issue: 32(2), P. 96 - 109

Published: Sept. 26, 2019

Significance: Hydrogen sulfide (H2S) is an important biological signaling molecule involved in many physiological processes. These diverse roles have led researchers to develop contemporary methods deliver H2S under physiologically relevant conditions and response various stimuli. Recent Advances: Different small-molecule donors been developed that release conditions. Key examples include activated hydrolysis, endogenous species, such as thiols, reactive oxygen enzymes, external stimuli, photoactivation bio-orthogonal chemistry. In addition, alternative approach has utilized the catalyzed hydrolysis of carbonyl (COS) by carbonic anhydrase generate libraries activatable COS-based donors. Critical Issues: Small-molecule provide research pharmacological tools perturb levels. needs, both development use donors, access new respond specific stimuli well with well-defined control compounds allow for clear delineation impact delivery from other donor byproducts. Future Directions: The abundance reported provides biologists physiologists a chemical toolbox ask key questions H2S-related therapeutic interventions. Further investigation into different releasing efficiencies contexts understanding responses gradually (e.g., hours days) versus quickly seconds minutes) needed.

Language: Английский

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Protein S-sulfhydration: Unraveling the prospective of hydrogen sulfide in the brain, vasculature and neurological manifestations

Ageing Research Reviews, Journal Year: 2022, Volume and Issue: 76, P. 101579 - 101579

Published: Feb. 3, 2022

Language: Английский

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Advances of H2S in Regulating Neurodegenerative Diseases by Preserving Mitochondria Function

Antioxidants, Journal Year: 2023, Volume and Issue: 12(3), P. 652 - 652

Published: March 6, 2023

Neurotoxicity is induced by different toxic substances, including environmental chemicals, drugs, and pathogenic toxins, resulting in oxidative damage neurodegeneration mammals. The nervous system extremely vulnerable to stress because of its high oxygen demand. Mitochondria are the main source ATP production brain neuron, stress-caused mitochondrial dysfunction implicated neurodegenerative diseases. H2S was initially identified as a gas; however, more recently, it has been recognized neuromodulator well neuroprotectant. Specifically, modulates activity, oxidation mitochondria produces various reactive sulfur species, thus modifying proteins through sulfhydration. This review focused on highlighting neuron modulation role regulating diseases anti-oxidative, anti-inflammatory, anti-apoptotic S-sulfhydration, emphasized importance therapeutic molecule for neurological

Language: Английский

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Corylin inhibits LPS-induced inflammatory response and attenuates the activation of NLRP3 inflammasome in microglia

BMC Complementary and Alternative Medicine, Journal Year: 2018, Volume and Issue: 18(1)

Published: July 20, 2018

Inflammation has been found to be associated with many neurodegenerative diseases, including Parkinson's and dementia. Attenuation of microglia-induced inflammation is a strategy that impedes the progression diseases.We used lipopolysaccharide (LPS) simulate murine microglia cells (BV2 cells) as an experimental model mimic inflammatory environment in brain. In addition, we examined anti-inflammatory ability corylin, main compound isolated from Psoralea corylifolia L. commonly Chinese herbal medicine. The production nitric oxide (NO) by LPS-activated BV2 was measured using Griess reaction. secretion proinflammatory cytokines tumor necrosis factor (TNF-α), interleukin-1β (IL-1β) interleukin-6 (IL-6) analyzed enzyme-linked immunosorbent assay (ELISA). expression inducible NO synthase (iNOS), cyclooxygenase-2 (COX-2), nucleotide-binding oligomerization domain-like receptor containing pyrin domain 3 (NLRP3), apoptosis-associated speck-like protein caspase-activation recruitment (ASC), caspase-1, IL-1β mitogen-activated kinases (MAPKs) Western blot.Our results demonstrated corylin suppressed cells. inhibited iNOS COX-2, attenuated phosphorylation ERK, JNK p38, decreased NLRP3 ASC, repressed activation caspase-1 cells.Our indicate effects acted through attenuating LPS-induced inhibiting inflammasome These suggest might have potential treating brain neurodegeneration diseases.

Language: Английский

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