ACS Applied Bio Materials,
Journal Year:
2023,
Volume and Issue:
6(4), P. 1525 - 1535
Published: March 9, 2023
With
the
development
of
antimicrobial
resistance,
rapid
and
effective
killing
bacteria
is
required
for
infected
wound
healing
after
skin
trauma.
Herein,
we
reported
a
one-pot
reaction
strategy
to
prepare
composite
hydrogel
with
antibacterial
activity
through
high-efficiency
photothermal
therapy.
We
take
poly(vinyl
alcohol)
as
matrix,
lignin-derived
from
biomass
was
introduced
into
increase
tensile
strength
prepared
108.58
kPa,
elongation
at
break
reaches
200.8%.
The
electrostatic
interaction
between
lignin
chitosan
enhanced
reactivity
lignin.
Carbon
nanotubes
endow
that
can
kill
more
than
97%
either
Escherichia
coli
or
Staphylococcus
aureus
within
5
min,
avoiding
problem
bacterial
resistance.
Experimental
evaluation
on
mice
showed
could
effectively
promote
full-thickness
defects.
hydrogels
good
mechanical
properties,
antioxidant
activity,
excellent
ability
show
potential
repair
damaged
tissue
are
expected
be
used
in
clinical
transformation
dressing.
Bioactive Materials,
Journal Year:
2022,
Volume and Issue:
23, P. 129 - 155
Published: Nov. 11, 2022
One
of
the
challenges
posed
by
current
antibacterial
therapy
is
that
expanded
and
massive
use
antibiotics
endows
bacteria
with
ability
to
resist
almost
all
kinds
antibiotics.
Therefore,
developing
alternative
strategies
for
efficient
treatment
urgently
needed.
Antibacterial
gas
has
attracted
much
attention
in
past
decade.
Nitric
oxide
(NO),
carbon
monoxide
(CO),
sulfur
dioxide
(SO2),
hydrogen
sulfide
(H2S),
(H2)
are
not
only
known
as
endogenous
signaling
molecules,
but
also
play
critical
roles
many
pathological
processes.
These
gases
considered
attractive
bactericidal
agents
because
they
able
kill
bacteria,
disperse
biofilms,
promote
bacteria-infected
wound
healing
while
avoiding
resistance.
In
this
review,
we
discuss
properties
these
gases,
well
recent
advances
gas-involving
systems
antibacterial,
antibiofilm,
applications.
Moreover,
summarize
various
donors
utilized
treatment.
We
hope
review
will
shed
new
light
on
future
design
applications
advanced
therapy.
Advanced Functional Materials,
Journal Year:
2022,
Volume and Issue:
33(10)
Published: Dec. 23, 2022
Abstract
Wound
infection
is
arguably
the
most
common,
and
potentially
devastating,
complication
of
wound
healing
process.
The
ideal
treatment
strategy
has
to
eliminate
bacteria,
alleviate
inflammation,
promote
skin
formation.
Herein,
a
multifunctional
heterostructure
designed
consisting
ultrasmall
platinum–ruthenium
nanoalloys
porous
graphitic
carbon
nitride
C
3
N
5
nanosheets
(denoted
as
PtRu/C
),
which
concurrently
possesses
piezoelectric
enhanced
oxidase
‐mimic
nanozyme
activity
photocatalytic
hydrogen
gas
production
capacity.
Moreover,
these
hybrid
nanotherapeutics
are
integrated
in
natural
hyaluronic
acid
microneedles,
exhibit
almost
100%
broad‐spectrum
antibacterial
efficacy
against
multiple
bacterial
strains
vitro
vivo
within
10
min
ultrasound
treatment,
effectively
inhibit
inflammation
reactions
after
1
h
visible
light
irradiation,
promising
for
accelerating
cutaneous
infected
mice.
This
study
highlights
competitive
development
all‐in‐one
anti‐inflammatory
therapies.
Advanced Healthcare Materials,
Journal Year:
2022,
Volume and Issue:
12(6)
Published: Nov. 14, 2022
Abstract
The
rising
dangers
of
bacterial
infections
have
created
an
urgent
need
for
the
development
a
new
generation
antibacterial
technologies
and
therapeutics.
Antibacterial
photodynamic
therapy
(PDT),
considered
as
noninvasive
treatment
with
no
drug
resistance,
has
become
promising
photochemistry‐involved
strategy.
Titanium
oxide
(TiO
2
)
is
proved
to
be
very
efficient
PDT
agent
among
photosensitive
materials,
while
property
large
bandgap
TiO
makes
it
only
excited
by
ultraviolet
light,
which
harmful
organisms.
In
this
work,
novel
ligand‐to‐metal
charge
transfer
(LMCT)
mediated
strategy
proposed
via
harmless
near‐infrared
light
irradiation.
By
choosing
mussel‐inspired
material,
polydopamine
(PDA)
involved
in
forming
mesoporous
@PDA
nanoparticles
(mTiO
NPs).
catechol
groups
PDA
can
attach
tightly
even
colloidal
environments,
also
form
LMCT
bridge,
exciting
exert
function
808
nm
Combining
sonodynamic
(SDT)
photothermal
properties
PDA,
simple
structure
mTiO
enables
synergistic
applications
multiple
functions
under
dual
excitation
NIR
ultrasound.
This
reliable
all‐in‐one
NPs
achieve
great
effect
rapid
repair
infected
wounds.
Exploration,
Journal Year:
2024,
Volume and Issue:
4(6)
Published: March 24, 2024
Abstract
Photothermal
therapy
(PTT)
has
garnered
significant
attention
in
recent
years,
but
the
standalone
application
of
PTT
still
faces
limitations
that
hinder
its
ability
to
achieve
optimal
therapeutic
outcomes.
Nitric
oxide
(NO),
being
one
most
extensively
studied
gaseous
molecules,
presents
itself
as
a
promising
complementary
candidate
for
PTT.
In
response,
various
nanosystems
have
been
developed
enable
simultaneous
utilization
and
NO‐mediated
gas
(GT),
with
integration
photothermal
agents
(PTAs)
thermally‐sensitive
NO
donors
prevailing
approach.
This
combination
seeks
leverage
synergistic
effects
GT
while
mitigating
potential
risks
associated
toxicity
through
use
single
laser
irradiation.
Furthermore,
additional
internal
or
external
stimuli
employed
trigger
release
when
combined
different
types
PTAs,
thereby
further
enhancing
efficacy.
comprehensive
review
aims
summarize
advancements
gas‐assisted
cancer
treatment.
It
commences
by
providing
an
overview
precursors,
including
those
sensitive
photothermal,
light,
ultrasound,
reactive
oxygen
species,
glutathione.
These
precursors
are
discussed
context
dual‐modal
PTT/GT.
Subsequently,
incorporation
other
treatment
modalities
such
chemotherapy
(CHT),
photodynamic
(PDT),
alkyl
radical
therapy,
radiation
immunotherapy
(IT)
creation
triple‐modal
nanoplatforms
is
presented.
The
explores
tetra‐modal
therapies,
PTT/GT/CHT/PDT,
PTT/GT/CHT/chemodynamic
(CDT),
PTT/GT/PDT/IT,
PTT/GT/starvation
(ST)/IT,
PTT/GT/Ca
2+
overload/IT,
PTT/GT/ferroptosis
(FT)/IT,
PTT/GT/CDT/IT.
Finally,
challenges
future
perspectives
concerning
these
novel
paradigms
discussed.
anticipated
serve
valuable
resource
studies
focused
on
development
innovative
photothermal/NO‐based
nanotheranostics.
Advanced Functional Materials,
Journal Year:
2024,
Volume and Issue:
34(38)
Published: April 23, 2024
Abstract
Currently,
microbial
infections
have
posed
an
arduous
challenge
to
global
public
health,
whereas
the
rise
of
antibiotic
resistance
is
rendering
traditional
therapies
futile,
prompting
development
new
antimicrobial
technologies.
Photoactive
nanomaterials
thus
garnered
a
thriving
interest
for
disinfection
owing
their
superior
antibacterial
efficaciousness,
favorable
biosafety,
and
rapidness
spatiotemporal
precision
in
excreting
bactericidal
actions.
The
review
summarizes
recent
advances
emerging
trends
design,
nanoengineering,
bioapplications
photoactive
antimicrobials.
It
commences
by
elaborating
fundamental
theories
on
bacterial
resistance,
mechanisms
phototherapy.
Subsequently,
regulation
effectiveness
comprehensively
discussed,
centering
criteria
strategies
tuning
photoabsorption
spectra,
photothermal
conversion,
photocatalytic
efficiency,
alongside
tactics
enabling
synergistic
therapies.
This
followed
comparative
analyses
techniques
modalities
synthesizing
engineering
with
diverse
structures,
forms,
functionalities.
Thereafter,
state‐of‐the‐art
applications
phototherapies
across
various
medical
sectors
are
portrayed,
key
challenges
opportunities
finally
discussed
spur
future
innovations
translation.
envisaged
provide
useful
guidance
devising
developing
nanomaterials‐based
photoresponsive
antimicrobials
application‐specific
materials
properties
biological
functions.
Small Methods,
Journal Year:
2024,
Volume and Issue:
8(8)
Published: Jan. 9, 2024
Abstract
Oxygen
(O
2
),
nitric
oxide
(NO),
carbon
monoxide
(CO),
hydrogen
sulfide
(H
S),
and
)
with
direct
effects,
dioxide
(CO
complementary
effects
on
the
condition
of
various
diseases
are
known
as
therapeutic
gases.
The
targeted
delivery
in
situ
generation
these
gases
controllable
release
at
site
disease
has
attracted
attention
to
avoid
risk
gas
poisoning
improve
their
performance
treating
such
cancer
therapy,
cardiovascular
bone
tissue
engineering,
wound
healing.
Stimuli‐responsive
gas‐generating
sources
systems
based
biomaterials
that
enable
on‐demand
promising
approaches
for
precise
therapy.
This
work
highlights
current
advances
design
development
new
generate
deliver
behavior.
delivered
biomedical
applications
is
then
discussed.
