Versatile function of NF-ĸB in inflammation and cancer

Experimental Hematology and Oncology, Journal Year: 2024, Volume and Issue: 13(1)

Published: July 16, 2024

Abstract Nuclear factor-kappaB (NF-ĸB) plays a crucial role in both innate and adaptive immune systems, significantly influencing various physiological processes such as cell proliferation, migration, differentiation, survival, stemness. The function of NF-ĸB cancer progression response to chemotherapy has gained increasing attention. This review highlights the inflammation control, biological mechanisms, therapeutic implications treatment. is instrumental altering release inflammatory factors TNF-α, IL-6, IL-1β, which are key regulation carcinogenesis. Specifically, conditions including colitis, upregulation can intensify inflammation, potentially leading development colorectal cancer. Its pivotal extends regulating tumor microenvironment, impacting components macrophages, fibroblasts, T cells, natural killer cells. influences tumorigenesis dampen anti-tumor responses. Additionally, modulates death notably by inhibiting apoptosis ferroptosis. It also dual stimulating or suppressing autophagy cancers. Beyond these functions, controlling stem fostering angiogenesis, metastatic potential through EMT induction, reducing sensitivity radiotherapy. Given its oncogenic capabilities, research focused on products small molecule compounds that suppress NF-ĸB, offering promising avenues for therapy.

Language: Английский

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Targeting ferroptosis for leukemia therapy: exploring novel strategies from its mechanisms and role in leukemia based on nanotechnology

European journal of medical research, Journal Year: 2024, Volume and Issue: 29(1)

Published: April 9, 2024

Abstract The latest findings in iron metabolism and the newly uncovered process of ferroptosis have paved way for new potential strategies anti-leukemia treatments. In current project, we reviewed summarized role nanomedicine treatment diagnosis leukemia through a comparison made between traditional approaches applied via existing investigations about molecular mechanisms involved various anti-tumor application nanotechnology other novel technologies may provide direction ferroptosis-driven therapies. article explores targeting ferroptosis, form regulated cell death, as therapeutic strategy leukemia. It discusses its how can enhance delivery efficacy ferroptosis-inducing agents. not only highlights promise ferroptosis-targeted therapies revolutionizing treatment, but also calls further research to overcome challenges fully realize clinical this innovative approach. Finally, it opportunities applications ferroptosis.

Language: Английский

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Chemical Design of Magnetic Nanomaterials for Imaging and Ferroptosis-Based Cancer Therapy

Chemical Reviews, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 14, 2025

Ferroptosis, an iron-dependent form of regulatory cell death, has garnered significant interest as a therapeutic target in cancer treatment due to its distinct characteristics, including lipid peroxide generation and redox imbalance. However, clinical application oncology is currently limited by issues such suboptimal efficacy potential off-target effects. The advent nanotechnology provided new way for overcoming these challenges through the development activatable magnetic nanoparticles (MNPs). These innovative MNPs are designed improve specificity ferroptosis induction. This Review delves into chemical biological principles guiding design ferroptosis-based therapies imaging-guided therapies. It discusses mechanisms attributes ferroptosis, composition MNPs, their mechanism action inducers, integration with advanced imaging techniques monitoring. Additionally, we examine convergence other strategies, chemodynamic therapy, photothermal photodynamic sonodynamic immunotherapy, within context nanomedicine strategies utilizing MNPs. highlights multifunctional surpass limitations conventional treatments, envisioning future drug-resistance-free, precision diagnostics treating recalcitrant cancers.

Language: Английский

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Echinacoside: A promising active natural products and pharmacological agents

Pharmacological Research, Journal Year: 2023, Volume and Issue: 197, P. 106951 - 106951

Published: Oct. 5, 2023

Echinacoside, a natural phenylethanoid glycoside, was discovered and isolated from the garden plant Echinacea angustifolia DC., belonging to Compositae family, approximately sixty years ago. Extensive investigations have revealed that it possesses wide array of pharmacologically beneficial activities for human health, particularly notable its neuroprotective anticancer activity. Several crucial concerns surfaced, encompassing recognition active metabolites exhibited inadequate bioavailability in their prototype form, establishment precise molecular signal pathways or targets associated with aforementioned effects echinacoside, scarcity dependable clinical trials. Hence, question remains unanswered as whether scientific research can effectively utilize this compound. To support future studies on product, is imperative provide systematic overview insights into potential prospects. The current review provides comprehensive analysis existing knowledge distribution, structural diversity metabolism, diverse therapeutic applications, improvement echinacoside utilization.

Language: Английский

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Crosstalk between Endoplasmic Reticulum Stress and Ferroptosis in Liver Diseases

Frontiers in Bioscience-Landmark, Journal Year: 2024, Volume and Issue: 29(6), P. 221 - 221

Published: June 20, 2024

The endoplasmic reticulum (ER) played an important role in the folding, assembly and post-translational modification of proteins. ER homeostasis could be disrupted by accumulation misfolded proteins, elevated reactive oxygen species (ROS) levels, abnormal Ca2+ signaling, which was referred to stress (ERS). Ferroptosis a unique programmed cell death model mediated iron-dependent phospholipid peroxidation multiple signaling pathways. changes mitochondrial structure, damage glutathione peroxidase 4 (GPX4) excess iron were main characteristics ferroptosis. ROS produced ferroptosis can interfere with activity protein-folding enzymes, leading large amounts unfolded thus causing ERS. On contrary, increase ERS level promote ion lipid peroxide, up-regulation related genes. At present, studies on relationship between one-sided lack in-depth interaction mechanism. This review aimed explore molecular mechanism cross-talk ERS, provide new strategies targets for treatment liver diseases.

Language: Английский

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The crosstalk between oncogenic signaling and ferroptosis in cancer

Critical Reviews in Oncology/Hematology, Journal Year: 2024, Volume and Issue: 197, P. 104349 - 104349

Published: April 16, 2024

Language: Английский

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Beyond success: unveiling the hidden potential of radiotherapy and immunotherapy in solid tumors

Cancer Communications, Journal Year: 2024, Volume and Issue: 44(7), P. 739 - 760

Published: June 5, 2024

Abstract Immunotherapy, particularly with immune checkpoint inhibitors, has significantly transformed cancer treatment. Despite its success, many patients struggle to respond adequately or sustain long‐lasting clinical improvement. A growing consensus emerged that radiotherapy (RT) enhances the response rate and overall efficacy of immunotherapy. Although combining RT immunotherapy been extensively investigated in preclinical models shown promising results, establishing itself as a dynamic thriving area research, evidence for this combination strategy over past five years both positive disappointing suggesting need more nuanced understanding. This review provides balanced updated analysis RT. We summarized mechanisms through which boosts antitumor responses mainly focused on outcomes recently trials, including those may not have met expectations. optimization therapeutic potential combined strategy, key challenges, such fractionation scheduling, lymph node irradiation, toxicity. Finally, we offered insights into prospects challenges associated translation therapy, providing realistic perspective current state research future directions.

Language: Английский

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Hyaluronic Acid-Coated SPIONs with Attached Folic Acid as Potential T2 MRI Contrasts for Anticancer Therapies

ACS Applied Materials & Interfaces, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 29, 2025

Superparamagnetic iron oxide nanoparticles (SPIONs) are known to be good MRI contrasts, but they have a high tendency aggregate and their biocompatibility is limited. Hyaluronic acid highly biocompatible, can provide SPION with colloidal stability, interacts specifically tumor cells through the CD44 receptor; therefore, it was used as stabilizing layer. We successfully obtained coated hyaluronic further functionalized folic construct dual-targeted system. The physicochemical properties of were investigated using DLS/ELS, AFM, XRD, ATR-FTIR. Their magnetic characterization performed by magnetometry, Mössbauer spectroscopy, 1H NMR T1 T2 measurements, MRI. nanoparticles' verified on blood hepatocytes, cytotoxicity tested glioma adenocarcinoma MTT assay. spherical, colloidally stable, had low dispersity. cores formed 7 nm crystallites magnetite in its oxidized form, maghemite. Our SPIONs superparamagnetic could potentially serve effective contrasts for performance modified superior that observed commercial contrasts. also hemocompatible efficiently taken up glioblastoma cancer cells. Folic acid-modified reduce viability dose-dependent manner. Thus, proposed system has potential application both diagnostic tool therapeutic agent targeted anticancer therapies.

Language: Английский

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Therapeutic Approaches with Iron Oxide Nanoparticles to Induce Ferroptosis and Overcome Radioresistance in Cancers

Pharmaceuticals, Journal Year: 2025, Volume and Issue: 18(3), P. 325 - 325

Published: Feb. 26, 2025

The emergence of nanotechnology in medicine, particularly using iron oxide nanoparticles (IONPs), may impact cancer treatment strategies. IONPs exhibit unique properties, such as superparamagnetism, biocompatibility, and ease surface modification, making them ideal candidates for imaging, therapeutic interventions. Their application targeted drug delivery, especially with traditional chemotherapeutic agents like cisplatin, has shown potential overcoming limitations low bioavailability systemic toxicity chemotherapies. Moreover, IONPs, by releasing ions, can induce ferroptosis, a form iron-dependent cell death, which offers promising pathway to reverse radio- chemoresistance therapy. In particular, demonstrate significant radiosensitisers, enhancing the effects radiotherapy promoting reactive oxygen species (ROS) generation, lipid peroxidation, modulating tumour microenvironment stimulate antitumour immune responses. This review explores multifunctional roles radiosensitisation through ferroptosis induction, highlighting their promise advancing head neck cancers. Additional research is crucial fully addressing clinical settings, offering novel approach personalised treatment.

Language: Английский

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The role of pyroptosis and gasdermin family in tumor progression and immune microenvironment

Experimental Hematology and Oncology, Journal Year: 2023, Volume and Issue: 12(1)

Published: Dec. 8, 2023

Abstract Pyroptosis, an inflammatory programmed cell death, distinguishes itself from apoptosis and necroptosis has drawn increasing attention. Recent studies have revealed a correlation between the expression levels of many pyroptosis-related genes both tumorigenesis progression. Despite advancements in cancer treatments such as surgery, radiotherapy, chemotherapy, immunotherapy, persistent hallmark enables malignant cells to elude death develop resistance therapy. findings indicate that pyroptosis can overcome amplify treatment-induced tumor death. Moreover, triggers antitumor immunity by releasing pro-inflammatory cytokines, augmenting macrophage phagocytosis, activating cytotoxic T natural killer cells. Additionally, it transforms “cold” tumors into “hot” tumors, thereby enhancing effects various treatments. Consequently, is intricately linked development holds promise effective strategy for boosting therapeutic efficacy. As principal executive protein pyroptosis, gasdermin family plays pivotal role influencing pyroptosis-associated outcomes serve regulatory target. This review provides comprehensive summary relationship members, discusses their roles progression immune microenvironment, analyses underlying strategies treatment based on pyroptotic

Language: Английский

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