Epigenetic regulation of aging: implications for interventions of aging and diseases

Signal Transduction and Targeted Therapy, Journal Year: 2022, Volume and Issue: 7(1)

Published: Nov. 7, 2022

Abstract Aging is accompanied by the decline of organismal functions and a series prominent hallmarks, including genetic epigenetic alterations. These aging-associated changes include DNA methylation, histone modification, chromatin remodeling, non-coding RNA (ncRNA) regulation, all which participate in regulation aging process, hence contribute to aging-related diseases. Therefore, understanding mechanisms will provide new avenues develop strategies delay aging. Indeed, interventions based on manipulating have led alleviation or extension lifespan animal models. Small molecule-based therapies reprogramming that enable rejuvenation been developed for ameliorating reversing conditions. In addition, adopting health-promoting activities, such as caloric restriction, exercise, calibrating circadian rhythm, has demonstrated Furthermore, various clinical trials intervention are ongoing, providing more evidence safety efficacy these therapies. Here, we review recent work outline advances age-associated A better critical roles epigenetics process lead prevention human therapy

Language: Английский

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Royal Jelly and Its Components Promote Healthy Aging and Longevity: From Animal Models to Humans

International Journal of Molecular Sciences, Journal Year: 2019, Volume and Issue: 20(19), P. 4662 - 4662

Published: Sept. 20, 2019

Aging is a natural phenomenon that occurs in all living organisms. In humans, aging associated with lowered overall functioning and increased mortality out of the risk for various age-related diseases. Hence, researchers are pushed to find effective interventions can promote healthy extend lifespan. Royal jelly (RJ) product fed bee queens throughout their entire life. Thanks RJ, enjoy an excellent reproductive function lengthened lifespan compared workers, despite fact they have same genome. This review aimed investigate effect RJ and/or its components on lifespan/healthspan species by evaluating most relevant studies. Moreover, we briefly discussed positive effects health maintenance disorders humans. Whenever possible, explored metabolic, molecular, cellular mechanisms through which modulate ingredients—proteins derivatives e.g., royalactin; lipids 10-hydroxydecenoic acid; vitamins pantothenic acid—improved healthspan extended worker honeybees Apis mellifera, Drosophila Melanogaster flies, Gryllus bimaculatus crickets, silkworms, Caenorhabditis elegans nematodes, mice. The longevity was attained via mechanisms: downregulation insulin-like growth factors targeting rapamycin, upregulation epidermal factor signaling, dietary restriction, enhancement antioxidative capacity. protein lipid ingredients potential creatures prevent senescence human tissues cell cultures. These findings pave way inventing specific anti-aging drugs. However, much work needed understand interactions microbiome, diet, activity level, gender, other genetic variation affect longevity.

Language: Английский

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Host development overwhelms environmental dispersal in governing the ecological succession of zebrafish gut microbiota

npj Biofilms and Microbiomes, Journal Year: 2021, Volume and Issue: 7(1)

Published: Jan. 19, 2021

Clarifying mechanisms underlying the ecological succession of gut microbiota is a central theme ecology. Under experimental manipulations zebrafish hatching and rearing environments, we test our core hypothesis that host development will overwhelm environmental dispersal in governing fish microbial community due to genetics, immunology, nutrient niches. We find developmental stage substantially explains succession, whereas effects do not significantly affect from larvae adult fish. The microbiotas are clearly separated according stages, degree homogeneous selection increasing with development. This study advances mechanistic understanding assembly by integrating effects, which also provides new insights into ecology other aquatic animals.

Language: Английский

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Lactobacilli Have a Niche in the Human Nose

Cell Reports, Journal Year: 2020, Volume and Issue: 31(8), P. 107674 - 107674

Published: May 1, 2020

Language: Английский

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Characterization of Apis mellifera Gastrointestinal Microbiota and Lactic Acid Bacteria for Honeybee Protection—A Review

Cells, Journal Year: 2021, Volume and Issue: 10(3), P. 701 - 701

Published: March 22, 2021

Numerous honeybee (Apis mellifera) products, such as honey, propolis, and bee venom, are used in traditional medicine to prevent illness promote healing. Therefore, this insect has a huge impact on humans’ way of life the environment. While population A. mellifera is large, there concern that widespread commercialization beekeeping, combined with environmental pollution action pathogens, caused significant problems for health populations. One strategies preserve welfare honeybees better understand protect their natural microbiota. This paper provides unique overview latest research features functioning mellifera. Honeybee microbiome analysis focuses both function numerous factors affecting it. In addition, we present characteristics lactic acid bacteria (LAB) an important part gut community special beneficial activities health. The idea probiotics promising tool improve widely discussed. Knowledge microbiota opportunity create broad strategy vitality, including development modern probiotic preparations use instead conventional antibiotics, environmentally friendly biocides, biological control agents.

Language: Английский

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Defining Pollinator Health: A Holistic Approach Based on Ecological, Genetic, and Physiological Factors

Annual Review of Animal Biosciences, Journal Year: 2019, Volume and Issue: 8(1), P. 269 - 294

Published: Oct. 16, 2019

Evidence for global bee population declines has catalyzed a rapidly evolving area of research that aims to identify the causal factors and effectively assess status pollinator populations. The term health emerged through efforts understand causes decline colony losses, but it lacks formal definition. In this review, we propose definition synthesize available literature on application standardized biomarkers at individual, colony, levels. We focus in honey bees, model species, extrapolate potential these approaches monitor wild Biomarker-guided measures can inform beekeeper management decisions, conservation efforts, environmental policies. conclude by addressing challenges from One Health perspective emphasizes interplay between quality human, animal, health.

Language: Английский

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Gut microbiota as an antioxidant system in centenarians associated with high antioxidant activities of gut-resident Lactobacillus

npj Biofilms and Microbiomes, Journal Year: 2022, Volume and Issue: 8(1)

Published: Dec. 24, 2022

The gut microbiota plays an important role in human health and longevity, the of centenarians shows unique characteristics. Nowadays, most microbial research on longevity is usually limited to bioinformatics level, lacking validating information culturing functional microorganisms. Here, we combined metagenomic sequencing large-scale vitro culture reveal structure world's town-Jiaoling, China, people different ages. Functional strains were isolated screened vitro, possible relationship between microbes was explored validated vivo. 247 healthy Cantonese natives ages participated study, including 18 centenarians. Compared with young adults, exhibits higher diversity, xenobiotics biodegradation metabolism, oxidoreductases, multiple species (the potential probiotics Lactobacillus, Akkermansia, methanogenic Methanobrevibacter, butyrate-producing members Roseburia, SCFA-producing uncl Clostridiales, Ruminococcaceae) known be beneficial host metabolism. These are constantly changing age. We also 2055 from these samples by culture, which detected metagenomics, clear complementarity two approaches. age-related gut-resident Lactobacillus independent intellectual property rights, its metabolite (L-ascorbic acid) itself have good antioxidant effects. Our findings underscore existence trajectories microbiota, that distinct as systems may contribute longevity.

Language: Английский

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Exploring the Prospective Role of Propolis in Modifying Aging Hallmarks

Cells, Journal Year: 2024, Volume and Issue: 13(5), P. 390 - 390

Published: Feb. 24, 2024

Aging populations worldwide are placing age-related diseases at the forefront of research agenda. The therapeutic potential natural substances, especially propolis and its components, has led to these products being promising agents for alleviating several cellular molecular-level changes associated with diseases. With this in mind, scientists have introduced a contextual framework guide future aging research, called hallmarks aging. This encompasses various mechanisms including genomic instability, epigenetic changes, mitochondrial dysfunction, inflammation, impaired nutrient sensing, altered intercellular communication. Propolis, rich array bioactive compounds, functions as potent functional food, modulating metabolism, gut microbiota, immune response, offering significant health benefits. Studies emphasize propolis' properties, such antitumor, cardioprotective, neuroprotective effects, well ability mitigate oxidative stress, DNA damage, pathogenic bacteria growth. article underscores current scientific evidence supporting role controlling molecular characteristics linked hallmarks, hypothesizing geroscience research. aim is discover novel strategies improve quality life older individuals, addressing existing deficits perspectives area.

Language: Английский

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A longitudinal field study of commercial honey bees shows that non-native probiotics do not rescue antibiotic treatment, and are generally not beneficial

Scientific Reports, Journal Year: 2024, Volume and Issue: 14(1)

Published: Jan. 23, 2024

Abstract Probiotics are widely used in agriculture including commercial beekeeping, but there is little evidence supporting their effectiveness. Antibiotic treatments can greatly distort the gut microbiome, reducing its protective abilities and facilitating growth of antibiotic resistant pathogens. Commercial beekeepers regularly apply antibiotics to combat bacterial infections, often followed by an application non-native probiotics advertised ease impact antibiotic-induced dysbiosis. We tested whether affect microbiome or disease prevalence, rescue negative effects induced found no difference markers probiotic recovery associated with treatment. A colony-level oxytetracycline tylosin produced immediate decrease size, over longer-term, very different persistent dysbiotic on composition membership hindgut microbiome. Our results demonstrate lack effect rescue, detail duration character states resulting from antibiotics, highlight importance for honeybee health.

Language: Английский

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An Insight into Diversity and Functionalities of Gut Microbiota in Insects

Current Microbiology, Journal Year: 2020, Volume and Issue: 77(9), P. 1976 - 1986

Published: June 14, 2020

Language: Английский

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