Research progress on the relationship between intestinal microecology and intestinal bowel disease DOI Creative Commons
Qian-Hui Fu, Tianyuan Song, Xiaoqin Ma

et al.

Animal Models and Experimental Medicine, Journal Year: 2022, Volume and Issue: 5(4), P. 297 - 310

Published: Aug. 1, 2022

Abstract Intestinal microecology is the main component of human microecology. consists intestinal microbiota, epithelial cells, and mucosal immune system. These components are interdependent establish a complex interaction network that restricts each other. According to impact on body, there three categories symbiotic bacteria, opportunistic pathogens, pathogenic bacteria. The participates in digestion absorption, material metabolism, inhibits growth microorganisms. It also acts as body's natural barrier, regulates innate immunity intestine, controls barrier function, cells' physiological activities such hyperplasia or apoptosis. When steady‐state balance disturbed, existing core microbiota changes leads obesity, diabetes, many other diseases, especially irritable bowel syndrome, inflammatory disease (IBD), colorectal malignancy. including tumors, particularly closely related This article systematically discusses research progress relationship between IBD from pathogenesis, treatment methods IBD, microbiota.

Language: Английский

Behçet's syndrome DOI
Giacomo Emmi, Alessandra Bettiol, Gülen Hatemi

et al.

The Lancet, Journal Year: 2024, Volume and Issue: 403(10431), P. 1093 - 1108

Published: Feb. 22, 2024

Language: Английский

Citations

40
A core microbiome signature as an indicator of health DOI Creative Commons
Guojun Wu, Ting Xu, Naisi Zhao

et al.

Cell, Journal Year: 2024, Volume and Issue: 187(23), P. 6550 - 6565.e11

Published: Oct. 7, 2024

Highlights•Integrates diverse microbiome datasets within the same analytical framework•Uncovers stable relationships among gut bacteria across interventions and disease states•Reveals a core structure of two competing guilds populations health status•Offers stably interacting microbial as novel targets for modulationSummaryThe microbiota is crucial human health, functioning complex adaptive system akin to vital organ. To identify health-relevant microbes, we followed systems biology tenet that signify components. By analyzing metagenomic from high-fiber dietary intervention in type 2 diabetes 26 case-control studies 15 diseases, identified set correlated genome pairs co-abundance networks perturbed by diseases. These genomes formed "two guilds" (TCGs) model, with one guild specialized fiber fermentation butyrate production other characterized virulence antibiotic resistance. Our random forest models successfully distinguished cases controls multiple diseases predicted immunotherapy outcomes through use these genomes. guild-based approach, which specific, database independent, interaction focused, identifies signature serves holistic indicator potential common target enhancement.Graphical abstract

Language: Английский

Citations

38
A genomic compendium of cultivated human gut fungi characterizes the gut mycobiome and its relevance to common diseases DOI

Qiulong Yan,

Shenghui Li, Qingsong Yan

et al.

Cell, Journal Year: 2024, Volume and Issue: 187(12), P. 2969 - 2989.e24

Published: May 21, 2024

Language: Английский

Citations

35
Metagenomic profiling of the pro-inflammatory gut microbiota in ankylosing spondylitis DOI
Chen Zhou, Hui Zhao,

Xinyue Xiao

et al.

Journal of Autoimmunity, Journal Year: 2019, Volume and Issue: 107, P. 102360 - 102360

Published: Dec. 2, 2019

Language: Английский

Citations

141
Lactobacillus plantarum KLDS1.0344 and Lactobacillus acidophilus KLDS1.0901 Mixture Prevents Chronic Alcoholic Liver Injury in Mice by Protecting the Intestinal Barrier and Regulating Gut Microbiota and Liver-Related Pathways DOI
Huizhen Li, Jialu Shi, Li Zhao

et al.

Journal of Agricultural and Food Chemistry, Journal Year: 2020, Volume and Issue: 69(1), P. 183 - 197

Published: Dec. 22, 2020

Health and wellbeing are significantly impaired by alcoholic liver disease (ALD), although some lactic acid bacteria strains have been shown previously to relieve ALD symptoms, the mechanisms behind these effects still unclear. Here, Lieber–DeCarli liquid diet containing alcohol was fed C57BL/6J mice for 6 weeks build a chronic lesion model study protective possible of Lactobacillus mixture (Lactobacillus plantarum KLDS1.0344 acidophilus KLDS1.0901). The results showed that improved intestinal epithelial permeability reduced serum lipopolysaccharide (LPS) levels. Furthermore, inhibited lipid accumulation, oxidative stress, inflammation regulating AMPK, Nrf-2, TLR4/NF-κB pathways. Importantly, modulated gut microbiota, resulting in increased short-chain fatty (SCFA) producers decreased Gram-negative bacteria. Taken together, findings indicated could positively regulate causing levels SCFAs, which alcohol-induced accumulation stress through gut–liver axis. Moreover, following administration mixture, improvement reduction led decrease LPS entering portal vein, thereby inhibiting inflammation.

Language: Английский

Citations

116
Microbiome and Autoimmune Uveitis DOI Creative Commons
Reiko Horai, Rachel R. Caspi

Frontiers in Immunology, Journal Year: 2019, Volume and Issue: 10

Published: Feb. 18, 2019

Commensal microbes affect all aspects of immune development and homeostasis in health disease. Increasing evidence points to the notion that gut commensals impact not only intestinal diseases but also tissues distant from gut. Autoimmune or non-infectious uveitis is a sight-threatening intraocular inflammation affects neuroretina. It strongly T cell driven, precise causative mechanisms are fully understood. We others observed depletion microbiota animal models attenuated Using spontaneous model disease, we questioned how retina-specific uveitogenic cells primed when their cognate antigens sequestered within privileged eye. The data suggested provide signal directly through receptor cause these autoreactive trigger uveitis. This activation appears be independent endogenous retinal antigen. Rather, findings point may mimic antigen(s), however, actual has yet been identified. Microbiota serve as an "adjuvant" providing innate signals amplify direct host response for In contrast, develops AIRE-/- mice microbiota. To date, available on human association with very limited relationships difficult establish. review will summarize current knowledge role microbiome its underlying mechanisms, discuss unresolved questions issues attempt explore concept gut-retina axis.

Language: Английский

Citations

113
Investigating causality with fecal microbiota transplantation in rodents: applications, recommendations and pitfalls DOI Creative Commons
Cassandra E. Gheorghe, Nathaniel L. Ritz, Jason Martin

et al.

Gut Microbes, Journal Year: 2021, Volume and Issue: 13(1)

Published: Jan. 1, 2021

In recent years, studies investigating the role of gut microbiota in health and diseases have increased enormously – making it essential to deepen question research methodology employed. Fecal transplantation (FMT) rodent (either from human or animal donors) allows us better understand causal intestinal across multiple fields. However, this technique lacks standardization requires careful experimental design order obtain optimal results. By comparing several which rodents are final recipients FMT, we summarize common practices review, document limitations method highlight different parameters be considered while designing FMT Studies. Standardizing is challenging, as differs according topic, but avoiding pitfalls feasible. Several methodological questions remain unanswered day offer a discussion on issues explored future studies.

Language: Английский

Citations

97
Multi-omics analysis reveals the influence of genetic and environmental risk factors on developing gut microbiota in infants at risk of celiac disease DOI Creative Commons
Maureen M. Leonard, Hiren Karathia, Meritxell Pujolassos

et al.

Microbiome, Journal Year: 2020, Volume and Issue: 8(1)

Published: Sept. 11, 2020

Abstract Background Celiac disease (CD) is an autoimmune digestive disorder that occurs in genetically susceptible individuals response to ingesting gluten, a protein found wheat, rye, and barley. Research shows genetic predisposition exposure gluten are necessary but not sufficient trigger the development of CD. This suggests other environmental stimuli early life, e.g., cesarean section delivery antibiotics or formula feeding, may also play key role CD pathogenesis through yet unknown mechanisms. Here, we use multi-omics analysis investigate how risk factors alter gut microbiota infants at Results Toward this end, selected 31 from large-scale prospective birth cohort study with first-degree relative We then performed rigorous multivariate association, cross-sectional, longitudinal analyses using metagenomic metabolomic data collected birth, 3 months 6 age explore impact on composition, function, metabolome prior introduction (gluten). These revealed several microbial species, functional pathways, metabolites associated each factor differentially abundant between environmentally exposed non-exposed time points. Among our significant findings, decreased abundance Bacteroides vulgatus dorei folate biosynthesis pathway increased hydroxyphenylacetic acid, alterations implicated immune system dysfunction inflammatory conditions. Additionally, that, any factor, abundances uniformis metabolite 3-3-hydroxyphenylproprionic acid increase over time, while those for lipoic methane metabolism pathways decrease, patterns linked beneficial immunomodulatory anti-inflammatory effects. Conclusions Overall, provides unprecedented insights into major taxonomic shifts developing linking detrimental

Language: Английский

Citations

78
Metaproteomics: A strategy to study the taxonomy and functionality of the gut microbiota DOI
Yuqiu Wang, Yanting Zhou, Xiao Xiao

et al.

Journal of Proteomics, Journal Year: 2020, Volume and Issue: 219, P. 103737 - 103737

Published: March 18, 2020

Language: Английский

Citations

74
Can Gut Microbiota Affect Dry Eye Syndrome? DOI Open Access
Jayoon Moon, Chang Ho Yoon, Se Hyun Choi

et al.

International Journal of Molecular Sciences, Journal Year: 2020, Volume and Issue: 21(22), P. 8443 - 8443

Published: Nov. 10, 2020

Using metagenomics, continuing evidence has elicited how intestinal microbiota trigger distant autoimmunity. Sjögren’s syndrome (SS) is an autoimmune disease that affects the ocular surface, with frequently unmet therapeutic needs requiring new interventions for dry eye management. Current studies also suggest possible relation of gut microbiota. Herein, we review current knowledge interact immune system in homeostasis as well its influence on rheumatic and diseases, compare their characteristics SS. Both rodent human regarding SS environmental are explored, effects prebiotics probiotics discussed. Recent clinical have commonly observed a correlation between dysbiosis manifestations SS, while portrays normal autoimmune. Moreover, decrease both Firmicutes/Bacteroidetes ratio genus Faecalibacterium most been subjects. The presumable pathways forming “gut dysbiosis–ocular surface–lacrimal gland axis” introduced. This may provide perspectives into link microbiome eye, enhance our understanding pathogenesis be useful development future interventions.

Language: Английский

Citations

74