ACS Applied Bio Materials,
Journal Year:
2023,
Volume and Issue:
7(8), P. 4944 - 4961
Published: Dec. 5, 2023
Cancer
immunotherapy
has
revolutionized
clinical
cancer
treatments
by
taking
advantage
of
the
immune
system
to
selectively
and
effectively
target
kill
cells.
However,
often
have
limited
efficacy
and/or
present
severe
adverse
effects
associated
primarily
with
their
systemic
administration.
Localized
emerged
overcome
these
limitations
directly
targeting
accessible
tumors
via
local
administration,
reducing
potential
drug
distribution
that
hampers
safety.
Sustained-release
formulations
can
prolong
activity
at
sites,
which
maximizes
benefits
localized
increase
therapeutic
window
using
smaller
dosages
than
those
used
for
injection,
avoiding
complications
frequent
dosing.
The
performance
sustained-release
been
validated
preclinically
various
implantable
injectable
scaffold
platforms.
This
review
introduces
developed
highlights
biomaterial-based
platforms
representative
classes,
including
inorganic
scaffolds,
natural
hydrogels,
synthetic
microneedle
patches.
design
rationale
other
considerations
are
summarized
further
development
biomaterials
construction
optimal
formulations.
Signal Transduction and Targeted Therapy,
Journal Year:
2025,
Volume and Issue:
10(1)
Published: March 5, 2025
The
successful
approval
of
peptide-based
drugs
can
be
attributed
to
a
collaborative
effort
across
multiple
disciplines.
integration
novel
drug
design
and
synthesis
techniques,
display
library
technology,
delivery
systems,
bioengineering
advancements,
artificial
intelligence
have
significantly
expedited
the
development
groundbreaking
drugs,
effectively
addressing
obstacles
associated
with
their
character,
such
as
rapid
clearance
degradation,
necessitating
subcutaneous
injection
leading
increasing
patient
discomfort,
ultimately
advancing
translational
research
efforts.
Peptides
are
presently
employed
in
management
diagnosis
diverse
array
medical
conditions,
diabetes
mellitus,
weight
loss,
oncology,
rare
diseases,
additionally
garnering
interest
facilitating
targeted
platforms
advancement
vaccines.
This
paper
provides
an
overview
present
market
clinical
trial
progress
therapeutics,
platforms,
It
examines
key
areas
through
literature
analysis
emphasizes
structural
modification
principles
well
recent
advancements
screening,
design,
technologies.
accelerated
including
peptide-drug
complexes,
new
vaccines,
innovative
diagnostic
reagents,
has
potential
promote
era
precise
customization
disease
therapeutic
schedule.
Biomaterials Research,
Journal Year:
2024,
Volume and Issue:
28
Published: Jan. 1, 2024
Cancer
recurrence
and
metastasis
are
major
contributors
to
treatment
failure
following
tumor
resection
surgery.
We
developed
a
novel
implantable
drug
delivery
system
utilizing
glycol
chitosan
address
these
issues.
Glycol
is
natural
adjuvant,
inducing
dendritic
cell
activation
promote
T
helper
1
immune
responses,
macrophage
activation,
cytokine
production.
Effective
antigen
production
by
cells
initiates
T-cell-mediated
aiding
growth
control.
ACS Omega,
Journal Year:
2024,
Volume and Issue:
9(14), P. 15753 - 15767
Published: March 26, 2024
Tumors
are
one
of
the
main
diseases
threatening
human
life
and
health.
The
emergence
nanotechnology
in
recent
years
has
introduced
a
novel
therapeutic
avenue
for
addressing
tumors.
Through
amalgamation
nanotechnology's
inherent
attributes
with
those
natural
enzymes,
nanozymes
have
demonstrated
ability
to
initiate
catalytic
reactions,
modulate
biological
microenvironment,
facilitate
adoption
multifaceted
approaches,
thereby
exhibiting
considerable
promise
realm
cancer
treatment.
In
this
Review,
application
chemodynamic
therapy,
radiotherapy,
photodynamic
photothermal
starvation
therapy
summarized.
Moreover,
detailed
discussion
regarding
mechanism
conferring
physiotherapeutic
functionality
upon
nanosystems
is
provided.
It
posited
that
innovative
treatment
holds
significant
potential
play
crucial
role
within
domain
nanomedicine.
International Journal of Molecular Sciences,
Journal Year:
2024,
Volume and Issue:
25(12), P. 6556 - 6556
Published: June 14, 2024
Cancer
is
a
significant
global
public
health
issue
with
increasing
morbidity
and
mortality
rates.
To
address
this
challenge,
novel
drug
carriers
such
as
nano-materials,
liposomes,
hydrogels,
fibers,
microspheres
have
been
extensively
researched
utilized
in
oncology.
Among
them,
polymer
are
gaining
popularity
due
to
their
ease
of
preparation,
excellent
performance,
biocompatibility,
drug-release
capabilities.
This
paper
categorizes
commonly
used
materials
for
microsphere
summarizes
various
preparation
methods
(emulsification,
phase
separation,
spray
drying,
electrospray,
microfluidics,
membrane
emulsification),
reviews
the
applications
cancer
diagnosis,
therapy,
postoperative
care.
The
current
status
future
development
directions
treatment
analyzed,
highlighting
importance
potential
improving
patient
outcomes.
BMB Reports,
Journal Year:
2024,
Volume and Issue:
57(2), P. 71 - 78
Published: Jan. 3, 2024
Melanoma
is
one
of
the
most
aggressive
skin
tumors,
and
conventional
treatment
modalities
are
not
effective
in
treating
advanced
melanoma.Although
immunotherapy
an
for
melanoma,
it
has
disadvantages,
such
as
a
poor
response
rate
serious
systemic
immune-related
toxic
side
effects.The
main
solution
to
this
problem
use
biological
materials
hydrogels
reduce
these
effects
amplify
immune
killing
effect
against
tumor
cells.Hydrogels
have
great
advantages
local
slow-release
drug
carriers,
including
ability
deliver
antitumor
drugs
directly
site,
enhance
concentration
tissue,
distribution
exhibit
good
degradability.Despite
advantages,
there
been
limited
research
on
application
melanoma
treatment.Therefore,
article
provides
comprehensive
review
potential
immunotherapy.Hydrogels
can
serve
carriers
sustained
delivery,
enabling
targeted
localized
delivery
with
minimal
effects.This
approach
improve
efficacy
melanoma.Thus,
vehicles
warrants
further
exploration.
Nanoscale Advances,
Journal Year:
2024,
Volume and Issue:
6(17), P. 4275 - 4308
Published: Jan. 1, 2024
Chemotherapy
and
surgery
remain
the
primary
treatment
modalities
for
cancers;
however,
these
techniques
have
drawbacks,
such
as
cancer
recurrence
toxic
side
effects,
necessitating
more
efficient
strategies.
Recent
advancements
in
research
medical
technology
provided
novel
insights
expanded
our
understanding
of
development;
consequently,
scholars
investigated
several
delivery
vehicles
therapy
to
improve
efficiency
patient
outcomes.
Herein,
we
summarize
types
smart
therapeutic
carriers
elaborate
on
mechanism
underlying
drug
delivery.
We
reveal
advantages
treatment,
focus
their
effectiveness
immunotherapy,
discuss
application
combination
with
other
emerging
strategies
treatment.
Finally,
bottlenecks
encountered
development
suggest
directions
future
research.
This
review
will
promote
progress
facilitate
related
