Pharmacology & Therapeutics, Journal Year: 2019, Volume and Issue: 205, P. 107423 - 107423
Published: Oct. 17, 2019
Language: Английский
Metabolomics, Journal Year: 2019, Volume and Issue: 15(6)
Published: June 1, 2019
Obesity is a disorder characterized by disproportionate increase in body weight relation to height, mainly due the accumulation of fat, and considered pandemic present century many international health institutions. It associated with several non-communicable chronic diseases, namely, metabolic syndrome, type 2 diabetes mellitus (T2DM), cardiovascular diseases (CVD), cancer. Metabolomics useful tool evaluate changes metabolites being overweight obesity at fluid cellular levels ascertain metabolically unhealthy obese individuals (MUHO) compared healthy (MHO).We aimed conduct systematic review (SR) human studies focused on identifying metabolomic signatures obesity-related alterations, such as inflammation or oxidative stress.We reviewed literature identify investigating metabolomics profile that were published up May 7th, 2019 SCOPUS PubMed through an SR. The quality reporting was evaluated using adapted QUADOMICS.Thirty-three articles included classified according four types approaches. (i) studying signature obesity, (ii) differential responses non-obese subjects dietary challenges (iii) used predict loss assess effects interventions profiles (iv) studied specific patterns compounds alterations humans.The SR provides state-of-the-art information about use approach understanding dynamics processes involved emphasizes related phenotypes.
Language: Английский
Citations
196
The International Journal of Biochemistry & Cell Biology, Journal Year: 2020, Volume and Issue: 125, P. 105776 - 105776
Published: May 29, 2020
Language: Английский
Citations
171
Pharmaceuticals, Journal Year: 2021, Volume and Issue: 14(3), P. 238 - 238
Published: March 8, 2021
Atypical antipsychotics (AAPs) are commonly prescribed medications to treat schizophrenia, bipolar disorders and other psychotic disorders. However, they might cause metabolic syndrome (MetS) in terms of weight gain, dyslipidemia, type 2 diabetes (T2D), high blood pressure, which responsible for reduced life expectancy poor adherence. Importantly, there is clear evidence that early disturbances can precede even if the latter still remains hallmark AAPs use. In fact, interfere profoundly with glucose lipid homeostasis acting mostly on hypothalamus, liver, pancreatic β-cells, adipose tissue, skeletal muscle. Their actions hypothalamic centers via dopamine, serotonin, acetylcholine, histamine receptors affect neuropeptides 5′AMP-activated protein kinase (AMPK) activity, thus producing a supraphysiological sympathetic outflow augmenting levels glucagon hepatic production. addition, altered insulin secretion, fat deposition liver tissues, resistance become aggravating factors MetS. clinical practice, among AAPs, olanzapine clozapine associated highest risk MetS, whereas quetiapine, risperidone, asenapine amisulpride moderate alterations. The new such as ziprasidone, lurasidone partial agonist aripiprazole seem more tolerable profile. these aspects must be considered together differences their efficacy, where most effective. Intriguingly, seems correlation between AAP’s higher efficacy increase Finally, multidisciplinary approach combining psychoeducation therapeutic drug monitoring (TDM) proposed first-line strategy avoid pharmacological treatments discussed well.
Language: Английский
Citations
164
Obesity Reviews, Journal Year: 2021, Volume and Issue: 22(7)
Published: Feb. 9, 2021
The role of serotonin in food intake has been studied for decades. Food is mainly regulated by two brain circuitries: (i) the homeostatic circuitry, which matches energy to expenditure, and (ii) hedonic involved rewarding motivational aspects consumption. In serotonergic signaling contributes integration metabolic signals that convey body's status facilitates ability suppress when needs have met. may reduce reward-related, contrast, peripherally acting promotes absorption storage. Disturbed associated with obesity, emphasizing importance understand intake. However, unraveling serotonin-mediated regulation complex, as effects different regions depend on regional expression receptor subtypes downstream via connections other regions. We therefore provide an overview regulatory systems Furthermore, we discuss disturbances obesity its potential therapeutic implications.
Language: Английский
Citations
141
International Journal of Molecular Sciences, Journal Year: 2021, Volume and Issue: 22(15), P. 7931 - 7931
Published: July 25, 2021
Serotonin, also known as 5-hydroxytryptamine (5-HT), is a metabolite of tryptophan and reported to modulate the development neurogenesis enteric nervous system, gut motility, secretion, inflammation, sensation, epithelial development. Approximately 95% 5-HT in body synthesized secreted by enterochromaffin (EC) cells, most common type neuroendocrine cells gastrointestinal (GI) tract, through sensing signals from intestinal lumen circulatory system. Gut microbiota, nutrients, hormones are main factors that play vital role regulating secretion EC cells. Apart being an important neurotransmitter paracrine signaling molecule gut, gut-derived was shown exert other biological functions (in autism depression) far beyond gut. Moreover, studies conducted on regulation immune system demonstrated exerts anti-inflammatory proinflammatory effects binding different receptors under inflammatory conditions. Understanding regulatory mechanisms which participates cell metabolism physiology can provide potential therapeutic strategies for treating diseases. Herein, we review recent evidence recapitulate synthesis, regulation, biofunction improve nutrition health humans.
Language: Английский
Citations
120
Molecules, Journal Year: 2022, Volume and Issue: 27(5), P. 1680 - 1680
Published: March 3, 2022
5-Hydroxytryptamine (5-HT, serotonin) is a neurotransmitter in both the central nervous system and peripheral structures, acting also as hormone platelets. Although its concentration gut covers >90% of all organism resources, serotonin mainly known that takes part pathology mental diseases. Serotonin modulates not only CNS neurons, but pain transmission platelet aggregation. In periphery, 5-HT influences muscle motility gut, bronchi, uterus, vessels directly through neurons. synthesis starts from hydroxylation orally delivered tryptophan, followed by decarboxylation. acts via numerous types receptors clinically plays role several neural, mental, other chronic disorders, such migraine, carcinoid syndrome, some dysfunctions alimentary system. paracrine growth factor. brain are targets for drugs modifying neurotransmission. The aim present article to review gastrointestinal (GI) tract determine GI physiology pathology, including diseases pharmacotherapy.
Language: Английский
Citations
98
Journal of Advanced Research, Journal Year: 2023, Volume and Issue: 52, P. 59 - 72
Published: Jan. 11, 2023
Non-alcoholic fatty liver disease (NAFLD) with obesity seriously threats public health. Our previous studies showed that dark tea had more potential on regulating lipid metabolism than other teas, and theabrownin (TB) was considered to be a main contributor the bioactivity of tea.This in vivo study aims reveal effects molecular mechanisms TB NAFLD obesity, role gut-liver axis is explored.The histopathological examinations, biochemical tests, nuclear magnetic resonance were applied evaluate obesity. The untargeted metabolomics used find key molecule for further exploration mechanisms. 16S rRNA gene sequencing assess changes gut microbiota. antibiotic cocktail fecal microbiota transplant clarify microbiota.TB markedly reduced body weight gain (67.01%), fat rate (62.81%), hepatic TG level (51.35%) preventive experiment. Especially, decreased (32.16%), (42.56%), (42.86%) therapeutic action could improvement acid oxidation, lipolysis, oxidative stress via regulation serotonin-related signaling pathways. Also, increased abundance microbiota, such as Akkermansia, Bacteroides Parabacteroides. Antibiotics-induced bacterial dysbiosis disrupted pathways liver, whereas beneficial target proteins regained restoration microbiota.We has by serotonin related through Furthermore, co-contribute alleviating promising medicine
Language: Английский
Citations
60
Frontiers in Endocrinology, Journal Year: 2024, Volume and Issue: 14
Published: Jan. 9, 2024
In the modern era, escalating global prevalence of obesity has profound implications on female reproductive health. Obesity, transcending mere lifestyle choices, evolved into a complex disorder affecting physiological and metabolic functions. Concurrently, infertility is rising as significant health issue. with its extensive systemic effects, pinpointed major disruptor. The convergence these challenges reveals multifaceted scenario: one hand, directly impacts health, particularly in context conditions like polycystic ovary syndrome (PCOS) menstrual disturbances; other, psychosocial consequences might intensify weight-gain patterns, forming challenging cycle. Additionally, economic treating obesity-related are considerable. This review delves myriad ways affects drawing insights from epidemiological, clinical, molecular studies. It explores epidemiological relationship between PCOS, influence disturbances, broader impact infertility. Weight loss, through pharmacological interventions, surgical methods, or adjustments, emerges promising strategy. Lastly, efficacy assisted technologies, such IVF, influenced by obesity, underscoring importance an optimal body mass index. also highlights mechanisms underlying including disruption hypothalamic-pituitary-ovary axis, altered adipokine secretion, role chronic inflammation oxidative stress.
Language: Английский
Citations
35
Proceedings of the National Academy of Sciences, Journal Year: 2019, Volume and Issue: 116(40), P. 19802 - 19804
Published: Sept. 16, 2019
The gut microbiome is an established regulator of aspects host metabolism, such as glucose handling. Despite the known impacts microbiota on homeostasis, underlying mechanisms are unknown. also a potent mediator gut-derived serotonin synthesis, and this peripheral source itself homeostasis. Here, we determined whether influences homeostasis through effects serotonin. Using both pharmacological inhibition genetic deletion find that improvements in handling caused by antibiotic-induced changes composition dependent synthesis
Language: Английский
Citations
111
Diabetes Care, Journal Year: 2020, Volume and Issue: 43(6), P. 1319 - 1325
Published: April 15, 2020
Recent studies have highlighted the significance of microbiome in human health and disease. Changes metabolites produced by microbiota been implicated several diseases. Our objective was to identify that are associated with type 2 diabetes.Our study included 5,181 participants from cross-sectional Metabolic Syndrome Men (METSIM) Finnish men (age 57 ± 7 years, BMI 26.5 3.5 kg/m2) having metabolomics data available. Metabolomics analysis performed based on fasting plasma samples. On basis an oral glucose tolerance test, Matsuda ISI disposition index values were calculated as markers insulin sensitivity secretion. A total 4,851 had a 7.4-year follow-up visit, 522 developed diabetes.Creatine, 1-palmitoleoylglycerol (16:1), urate, 2-hydroxybutyrate/2-hydroxyisobutyrate, xanthine, xanthurenate, kynurenate, 3-(4-hydroxyphenyl)lactate, 1-oleoylglycerol (18:1), 1-myristoylglycerol (14:0), dimethylglycine, 2-hydroxyhippurate (salicylurate) significantly increased risk diabetes. These decreased secretion or both. Among diabetes, 1-linoleoylglycerophosphocholine (18:2) reduced diabetes.Several novel previously reported microbial related gut incident they also sensitivity. Microbial important biomarkers for
Language: Английский
Citations
109