Recent advances of multifunctional zwitterionic polymers for biomedical application

Acta Biomaterialia, Journal Year: 2024, Volume and Issue: 181, P. 19 - 45

Published: May 8, 2024

Language: Английский

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Electrospun silk fibroin/fibrin vascular scaffold with superior mechanical properties and biocompatibility for applications in tissue engineering

Scientific Reports, Journal Year: 2024, Volume and Issue: 14(1)

Published: Feb. 16, 2024

Abstract Electrospun scaffolds play important roles in the fields of regenerative medicine and vascular tissue engineering. The aim research described here was to develop a scaffold that mimics structural functional properties natural scaffolding. mechanical artificial represent key issue for successful transplantation small diameter engineering blood vessels. We blended silk fibroin (SF) fibrin fabricate composite using electrospinning overcome shortcomings with respect its properties. Subsequently, we then carefully investigated morphological, properties, hydrophilicity, hemocompatibility, degradation, cytocompatibility biocompatibility SF/fibrin (0:100), (15:85), (25:75), (35:65) scaffolds. Based on these vitro results, implanted (25:75) subcutaneously analyzed vivo degradation histocompatibility. fiber structure hybrid smooth uniform, diameters were relatively small. Compared scaffold, clearly displayed increased strength, but hydrophilicity weakened correspondingly. All showed excellent compatibility appropriate biodegradation rates. proliferation adhesion MSCs. results animal experiments confirmed faster than SF effectively promoted regeneration cell infiltration. all, electrospun balanced controllable biomechanical degradability, good compatibility. Thus, this proved be an ideal candidate material

Language: Английский

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Advanced Biomedical Applications of Multifunctional Natural and Synthetic Biomaterials

Processes, Journal Year: 2023, Volume and Issue: 11(9), P. 2696 - 2696

Published: Sept. 8, 2023

Biomaterials are mostly any natural and synthetic materials which compatible from a biological point of view with the human body. widely used to sustain, increase, reestablish or substitute function injured tissue organ Additionally, biomaterials uninterruptedly in contact body, i.e., tissue, blood fluids. For this reason, an essential feature is their biocompatibility. Consequently, review summarizes classification different types based on origin, as ones. Moreover, advanced applications pharmaceutical medical domains highlighted specific mechanical physical properties biomaterials, concerning use. The high-priority challenges field also discussed, especially those regarding transfer implementation valuable scientific results practice.

Language: Английский

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Development of Biocompatible 3D-Printed Artificial Blood Vessels through Multidimensional Approaches

Journal of Functional Biomaterials, Journal Year: 2023, Volume and Issue: 14(10), P. 497 - 497

Published: Oct. 8, 2023

Within the human body, intricate network of blood vessels plays a pivotal role in transporting nutrients and oxygen maintaining homeostasis. Bioprinting is an innovative technology with potential to revolutionize this field by constructing complex multicellular structures. This technique offers advantage depositing individual cells, growth factors, biochemical signals, thereby facilitating functional vessels. Despite challenges fabricating vascularized constructs, bioprinting has emerged as advance organ engineering. The continuous evolution biomaterial knowledge provides avenue overcome hurdles associated tissue fabrication. article overview biofabrication process used create vascular constructs. It delves into various techniques engineering, including extrusion-, droplet-, laser-based methods. Integrating these prospect crafting artificial remarkable precision functionality. Therefore, impact engineering significant. With technological advances, it holds promise revolutionizing transplantation, regenerative medicine. By mimicking natural complexity vessels, brings us one step closer organs vasculature, ushering new era medical advancement.

Language: Английский

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A polyurethane-based hydrophilic elastomer with multi-biological functions for small-diameter vascular grafts

Acta Biomaterialia, Journal Year: 2024, Volume and Issue: 176, P. 234 - 249

Published: Jan. 11, 2024

Language: Английский

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Advances in Materials with Self-Healing Properties: A Brief Review

Materials, Journal Year: 2024, Volume and Issue: 17(10), P. 2464 - 2464

Published: May 20, 2024

The development of materials with self-healing capabilities has garnered considerable attention due to their potential enhance the durability and longevity various engineering structural applications. In this review, we provide an overview recent advances in properties, encompassing polymers, ceramics, metals, composites. We outline future research directions applications (SHMs) diverse fields. This review aims insights into current state-of-the-art SHM guide efforts towards innovative sustainable enhanced self-repair capabilities. Each material type showcases unique mechanisms tailored address specific challenges. Furthermore, investigates crack healing processes, shedding light on latest developments critical aspect materials. Through extensive exploration these topics, a comprehensive understanding landscape research.

Language: Английский

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Acellular Tissue-Engineered Vascular Grafts from Polymers: Methods, Achievements, Characterization, and Challenges

Polymers, Journal Year: 2022, Volume and Issue: 14(22), P. 4825 - 4825

Published: Nov. 9, 2022

Extensive and permanent damage to the vasculature leading different pathogenesis calls for developing innovative therapeutics, including drugs, medical devices, cell therapies. Innovative strategies engineer bioartificial/biomimetic vessels have been extensively exploited as an effective replacement that seriously malfunctioned. However, further studies in polymer chemistry, additive manufacturing, rapid prototyping are required generate highly engineered vascular segments can be effectively integrated into existing of patients. One recently developed approach involves designing fabricating acellular vessel equivalents from novel polymeric materials. This review aims assess design criteria, engineering factors, approaches fabrication characterization biomimetic macro- micro-scale vessels. At same time, correlation between physical properties biological functionalities multiscale thoroughly elucidated. Moreover, several emerging techniques probing mechanical tissue-engineered grafts revealed. Finally, significant challenges clinical transformation promising derived polymers identified, unique perspectives on future research directions presented.

Language: Английский

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Spontaneous Orthogonal Alignment of Smooth Muscle Cells and Endothelial Cells Captures Native Blood Vessel Morphology in Tissue-Engineered Vascular Grafts

ACS Applied Materials & Interfaces, Journal Year: 2023, Volume and Issue: 15(29), P. 34631 - 34641

Published: July 13, 2023

Tissue-engineered vascular grafts (TEVGs) have emerged as a potential alternative to autologous for replacing small-diameter blood vessels during bypass surgery. The axial alignment of endothelial cells (ECs) and the circumferential smooth muscle (SMCs) are crucial functional native (NBVs). However, achieving this cellular in TEVGs remains formidable challenge. In study, were developed using low-cost technique that aligned ECs axially SMCs circumferentially within hours. comprised an electrospun polycaprolactone (PCL) layer gelatin methacryloyl (GelMA) cast layer. A freezing-induced was partially aligns fibers axially, thereby promoting rapid ECs. Furthermore, cultured GelMA with intermediate stiffness (5–12 kPa) surrounding PCL tube could promote conformation curvature tube, resulting their spontaneous alignment. Additionally, demonstrated mechanical properties similar those NBVs, which facilitate future translation. This approach represents significant advance tissue engineering, enabling fabrication appropriate recapitulate key NBV cell structural features hours scalable accessible method.

Language: Английский

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Anticoagulant Macromolecules

Macromolecules, Journal Year: 2023, Volume and Issue: 56(12), P. 4387 - 4430

Published: June 13, 2023

Anticoagulant macromolecules have gained widespread use in the clinical treatment of cardiovascular diseases, blood-contacting or implantable materials, and medical devices due to their excellent anticoagulant properties. Inspired by molecular characteristics physiological anticoagulants that play a vital role normal human coagulation anticoagulation mechanisms, diverse with special structures functional groups been developed, where they can be systematically applied biomedical field. In this Perspective, history recent progress synthetic methods for obtained purification natural products, semisynthetic methods, are discussed from aspect design. The critical application immense development potential these field biomedicine is proposed.

Language: Английский

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Small-diameter PCL/PU vascular graft modified with heparin-aspirin compound for preventing the occurrence of acute thrombosis

International Journal of Biological Macromolecules, Journal Year: 2023, Volume and Issue: 249, P. 126058 - 126058

Published: July 29, 2023

Language: Английский

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