Emergence of nanoplastics in the aquatic environment and possible impacts on aquatic organisms

The Science of The Total Environment, Journal Year: 2023, Volume and Issue: 906, P. 167404 - 167404

Published: Sept. 26, 2023

Language: Английский

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Microplastic-mediated new mechanism of liver damage: From the perspective of the gut-liver axis

The Science of The Total Environment, Journal Year: 2024, Volume and Issue: 919, P. 170962 - 170962

Published: Feb. 13, 2024

Language: Английский

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The uses of zebrafish (Danio rerio) as an in vivo model for toxicological studies: A review based on bibliometrics

Ecotoxicology and Environmental Safety, Journal Year: 2024, Volume and Issue: 272, P. 116023 - 116023

Published: Jan. 30, 2024

An in vivo model is necessary for toxicology. This review analyzed the uses of zebrafish (Danio rerio) toxicology based on bibliometrics. Totally 56,816 publications about from 2002 to 2023 were found Web Science Core Collection, with Toxicology as top 6 among all disciplines. Accordingly, bibliometric map reveals that "toxicity" has become a hot keyword. It further most common exposure types include acute, chronic, and combined exposure. The toxicological effects behavioral, intestinal, cardiovascular, hepatic, endocrine toxicity, neurotoxicity, immunotoxicity, genotoxicity, reproductive transgenerational toxicity. mechanisms oxidative stress, inflammation, autophagy, dysbiosis gut microbiota. toxicants commonly evaluated by using nanomaterials, arsenic, metals, bisphenol, dioxin. Overall, provide unique well-accepted investigate mechanisms. We also discussed possible ways address some limitations model, such combination human organoids avoid species differences.

Language: Английский

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Benzimidazole Fungicide Carbendazim Induces Gut Inflammation through the TLR5/NF-κB Pathway in Grass Carp

Environmental Science & Technology, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 2, 2025

Fungicides have been increasingly used across various sectors, including agriculture and textiles. The biocidal properties of fungicides may negatively impact the stability intestinal microbiota, thereby posing a threat to health. In this study, we investigated mechanisms damage functional abnormalities in grass carp following 42-day exposure widely fungicide carbendazim at environmentally relevant concentrations (0.2 20 μg/L). Histopathological observations, mRNA protein expression analyses, biochemical analysis, quantification short-chain fatty acids (SCFAs), cytokines, lipopolysaccharide (LPS), 16S ribosomal ribonucleic acid (rRNA), as well internal transcribed spacer (ITS) sequencing, were performed. At concentrations, strongly induced inflammation, leading increased transcriptional translational levels genes involved toll-like receptor five (TLR5)/nuclear factor kappa B (NF-κB) pathway, TLR5, NF-κB, interleukin-1 beta (IL-1β), tumor necrosis factor-alpha (TNFα). Additionally, damaged barriers reduced tight junction proteins (e.g., occludin zonula occludens-1/2), goblet cells, immunoglobulin M levels, while also disrupting gut microbiome, metabolic disorders, particularly decreases SCFAs increases LPS. Treatment with TLR5 antagonist TH1020 mitigated inflammation caused by carbendazim, subsequently improving mechanical barrier function. Overall, our findings provide new insights into toxicological underlying carp, indicating that poses significant nontarget organisms. Given its widespread detection environment, these results underscore substantial ecological risks health fish living carbendazim-contaminated water bodies.

Language: Английский

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Tris(2-chloroethyl) Phosphate Exerts Hepatotoxic Impacts on Zebrafish by Disrupting Hypothalamic–Pituitary–Thyroid and Gut–Liver Axes

Environmental Science & Technology, Journal Year: 2023, Volume and Issue: 57(24), P. 9043 - 9054

Published: June 5, 2023

The ubiquitous environmental presence of tris(2-chloroethyl) phosphate (TCEP) poses a potential threat to animals; however, little is known about its hepatotoxicity. In this study, the effects TCEP exposure (0.5 and 5.0 μg/L for 28 days) on liver health underlying toxification mechanisms were investigated in zebrafish. Our results demonstrated that led hepatic tissue lesions resulted significant alterations liver-injury-specific markers. Moreover, TCEP-exposed fish had significantly lower levels thyrotropin-releasing hormone thyroid-stimulating brain, evidently less triiodothyronine whereas more thyroxine plasma, markedly altered expressions genes from hypothalamic-pituitary-thyroid (HPT) axis brain or liver. addition, higher proportion Bacteroidetes gut microbiota, an elevated bacterial source endotoxin lipopolysaccharide (LPS) upregulated expression LPS-binding protein Toll-like receptor 4 liver, proinflammatory cytokines detected Furthermore, also suffered severe oxidative damage, possibly due disruption antioxidant system. These findings suggest may exert hepatotoxic zebrafish by disrupting HPT gut-liver axes thereafter inducing inflammation stress.

Language: Английский

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Co-exposure to polystyrene microplastics and cypermethrin enhanced the effects on hepatic phospholipid metabolism and gut microbes in adult zebrafish

Journal of Hazardous Materials, Journal Year: 2023, Volume and Issue: 465, P. 133051 - 133051

Published: Nov. 23, 2023

Language: Английский

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Concurrent impacts of polystyrene nanoplastic exposure and Aeromonas hydrophila infection on oxidative stress, immune response and intestinal microbiota of grass carp (Ctenopharyngodon idella)

The Science of The Total Environment, Journal Year: 2023, Volume and Issue: 912, P. 169225 - 169225

Published: Dec. 14, 2023

Language: Английский

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Chronic exposure to parabens promotes non-alcoholic fatty liver disease in association with the changes of the gut microbiota and lipid metabolism

Food & Function, Journal Year: 2024, Volume and Issue: 15(3), P. 1562 - 1574

Published: Jan. 1, 2024

Non-alcoholic fatty liver disease (NAFLD) has become a serious public health issue due to changing dietary patterns and composition. However, the relationship between NAFLD occurrence food additives, such as preservatives, remains unknown. This study aimed evaluate toxicity of parabens, namely methylparaben (MeP) ethylparaben (EtP), in relation mice under different conditions. Exposure MeP EtP exacerbated high-fat diet (HFD)-induced obesity, glucose intolerance, higher serum lipid concentrations, fat accumulation by upregulating genes involved metabolism. Untargeted metabolomics revealed that arachidonic acid (AA) metabolism was top enriched pathway upon exposure presence HFD. 11,12-Epoxyeicosatrienoic (11,12-EET) most abundant AA metabolite significantly reduced or EtP. Moreover, an integrative analysis differential fecal taxa at genus level metabolites significant associations. In addition, enhanced AML12 cells HepG2 cultured with oleic acid. 11,12-EET supplementation could alleviate suppressing expression metabolism-related proteins. The present suggests chronic promoted

Language: Английский

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Subchronic oral exposure to polystyrene microplastics affects hepatic lipid metabolism, inflammation, and oxidative balance in gilthead seabream (Sparus aurata)

Ecotoxicology and Environmental Safety, Journal Year: 2024, Volume and Issue: 279, P. 116455 - 116455

Published: May 20, 2024

Microplastics (MPs) pose a clear threat to aquatic organisms affecting their health. Their impact on liver homeostasis, as well the potential onset of nonalcoholic fatty disease (NAFLD), is still poorly investigated and remains almost unknown. The aim this study was evaluate outcomes subchronic exposure polystyrene MPs (PS-MPs; 1–20 μm; 0, 25, or 250 mg/kg b.w./day) lipid metabolism, inflammation, oxidative balance in gilthead seabreams (Sparus aurata Linnaeus, 1758) exposed for 21 days via contaminated food. PS-MPs induced an up-regulation mRNA levels crucial genes associated with synthesis storage (i.e., PPARy, Srebp1, Fasn) without modifications involved catabolism PPARα, HL, Pla2) transport metabolism (Fabp1) liver. increase CSF1R pro-inflammatory cytokines gene expression TNF-α IL-1β) also observed fish dose-dependent manner. These findings were confirmed by hepatic histological evaluations reporting evidence accumulation, necrosis. Moreover, caused impairment antioxidant defense system through alteration its enzymatic (catalase, superoxide dismutase, glutathione reductase) non-enzymatic (glutathione) components, resulting increased production reactive oxygen species (ROS) malondialdehyde (MDA), biomarkers damage. detoxifying enzymes inferred decreased Ethoxyresorufin-O-deethylase (EROD) activity glutathione-S-transferase (GST) at highest PS-MP dose. suggests that affect health seabream. dysfunction damage result from detrimental interplay damage, systems modifications, altering gut-liver axis homeostasis. This scenario suggestive involvement MP-induced effects progression

Language: Английский

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Enrofloxacin exposure undermines gut health and disrupts neurotransmitters along the microbiota-gut-brain axis in zebrafish

Chemosphere, Journal Year: 2024, Volume and Issue: 356, P. 141971 - 141971

Published: April 9, 2024

Language: Английский

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